{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:19:39Z","timestamp":1783408779665,"version":"3.54.6"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.saa.2026.128151","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:59:59Z","timestamp":1780070399000},"page":"128151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of porcine ear skin as a model for human skin: influence on the diffusion of different photosensitizers"],"prefix":"10.1016","volume":"362","author":[{"given":"Thais Lazzarotto","family":"Braga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiane Vizioli","family":"de Castro-Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeibson Joaquim","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Cesar","family":"Pozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Fabiano","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Luciano","family":"Baesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilker","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128151_bb0005","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.2042-7158.1992.tb05485.x","article-title":"Pig ear skin as an in-vitro model for human skin permeability","volume":"44","author":"Dick","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.saa.2026.128151_bb0010","doi-asserted-by":"crossref","DOI":"10.1046\/j.1524-475x.2001.00066.x","article-title":"The pig as a model for human wound healing","volume":"9","author":"Sullivan","year":"2001","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.saa.2026.128151_bb0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s43188-023-00185-1","article-title":"Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model","volume":"39","author":"Uhm","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.saa.2026.128151_bb0020","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1007\/s11095-006-9011-8","article-title":"Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man","volume":"23","author":"Herkenne","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.saa.2026.128151_bb0025","first-page":"207","article-title":"Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin, journal of veterinary medicine series C: Anatomia Histologia","volume":"48","author":"Khiao In","year":"2019","journal-title":"Embryologia"},{"key":"10.1016\/j.saa.2026.128151_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201600505","article-title":"Synthesis and validation of functional nanogels as pH-sensors in the hair follicle","volume":"17","author":"Dimde","year":"2017","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.saa.2026.128151_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic therapy review: principles, photosensitizers, applications, and future directions","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.saa.2026.128151_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021023","article-title":"Current advances in photodynamic therapy (PDT) and the future potential of PDT-combinatorial Cancer therapies","volume":"25","author":"Alvarez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128151_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2021.109887","article-title":"Concise behavior of curcumin in water-ethanol: critical water aggregation percentage and multivariate analysis of protolytic equilibria","volume":"197","author":"Dias Pereira","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128151_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.113320","article-title":"Multivariate analysis of protolytic and tautomeric equilibria of erythrosine B and its ester derivatives in ionic and non-ionic micelles","volume":"313","author":"de Freitas","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128151_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122111","article-title":"Pluronic\u00ae P-123 as a reductant and stabilizing agent for gold nanoparticles (AuNPs) combined with methylene blue for photodynamic and photothermal therapy","volume":"383","author":"Braga","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128151_bb0060","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128151_bb0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tifs.2021.02.006","article-title":"Recent advances to improve curcumin oral bioavailability","volume":"110","author":"Sabet","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.saa.2026.128151_bb0070","series-title":"Turmeric: The Genus Curcuma","first-page":"297","article-title":"Curcumin \u2014 Biological and Medicinal Properties","author":"Aggarwal","year":"2007"},{"key":"10.1016\/j.saa.2026.128151_bb0075","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1021\/acsapm.0c00589","article-title":"Tautomeric and aggregational dynamics of curcumin-supersaturated Pluronic nanocarriers","volume":"2","author":"Braga","year":"2020","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.saa.2026.128151_bb0080","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1002\/jsfa.11372","article-title":"Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability","volume":"101","author":"Abd El-Hack","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.saa.2026.128151_bb0085","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/ptr.6976","article-title":"Curcumin nanoformulations for antimicrobial and wound healing purposes","volume":"35","author":"Salehi","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.saa.2026.128151_bb0090","article-title":"Electrospun silver nanoparticles\/curcumin-loaded nanohybrids for photodynamic therapy","volume":"36","author":"Braga","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.saa.2026.128151_bb0095","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/php.12645","article-title":"Nanostructured polymeric micelles carrying xanthene dyes for photodynamic evaluation","volume":"92","author":"de Freitas","year":"2016","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.saa.2026.128151_bb0100","article-title":"Biotin-functionalized silica nanoparticles loaded with erythrosine B as selective photodynamic treatment for glioblastoma multiforme","volume":"345","author":"da Silva","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128151_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109923","article-title":"Biotin-targeted mixed liposomes: a smart strategy for selective release of a photosensitizer agent in cancer cells","volume":"104","author":"de Freitas","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.saa.2026.128151_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/polym13223955","article-title":"Methylene blue-based nano and microparticles: fabrication and applications in photodynamic therapy","volume":"13","author":"Lim","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.saa.2026.128151_bb0115","article-title":"Shedding light on Alzheimer\u2019s \u03b2-amyloidosis: photosensitized methylene blue inhibits self-assembly of \u03b2-amyloid peptides and disintegrates their aggregates","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2026.128151_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124974","article-title":"Nanostructured systems based on pluronics to carry gold nanoparticles and methylene blue aiming for multimodal therapy","volume":"404","author":"Braga","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128151_bb0125","author":"Wainwright"},{"key":"10.1016\/j.saa.2026.128151_bb0130","series-title":"Laser-Induced Photoacoustic Signal Phase Study of Stratum Corneum and Epidermis*","author":"Baesso","year":"1994"},{"key":"10.1016\/j.saa.2026.128151_bb0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1155\/2008\/969217","article-title":"ATR-FTIR, FT-NIR and near-FT-Raman spectroscopic studies of molecular composition in human skin in vivo and pig ear skin in vitro","volume":"22","author":"Greve","year":"2008","journal-title":"Spectroscopy"},{"key":"10.1016\/j.saa.2026.128151_bb0140","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1039\/C3AN00353A","article-title":"Changes of skin collagen orientation associated with chronological aging as probed by polarized-FTIR micro-imaging","volume":"139","author":"Nguyen","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2026.128151_bb0145","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ecoenv.2009.12.005","article-title":"UV-vis and FT-IR spectra of ultraviolet irradiated collagen in the presence of antioxidant ascorbic acid","volume":"73","author":"Metreveli","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.saa.2026.128151_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.117421","article-title":"Aluminum phthalocyanine hydroxide-loaded thermoresponsive biomedical hydrogel: a design for targeted photosensitizing drug delivery","volume":"341","author":"Barbosa","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128151_bb0155","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1021\/acs.langmuir.1c00148","article-title":"Thermoresponsive hydrogel-loading aluminum chloride phthalocyanine as a drug release platform for topical administration in photodynamic therapy","volume":"37","author":"de Oliveira","year":"2021","journal-title":"Langmuir"},{"key":"10.1016\/j.saa.2026.128151_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2020.100041","article-title":"Alterations in extracellular matrix composition during aging and photoaging of the skin","volume":"8","author":"McCabe","year":"2020","journal-title":"Matrix Biol. Plus"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526007225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526007225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:01:38Z","timestamp":1783407698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526007225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":32,"alternative-id":["S1386142526007225"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128151","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of porcine ear skin as a model for human skin: influence on the diffusion of different photosensitizers","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128151"}}