{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:14:10Z","timestamp":1783412050633,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["242102310427"],"award-info":[{"award-number":["242102310427"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1704176"],"award-info":[{"award-number":["U1704176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.saa.2026.128160","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:32:58Z","timestamp":1780119178000},"page":"128160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lysosome-targeted near-infrared fluorescent probes for monitoring a\u03b2 plaques in vivo and a\u03b2 monomers dynamic degradation in vitro"],"prefix":"10.1016","volume":"362","author":[{"given":"Huiyuan","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128160_bb0005","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/C6CS00731G","article-title":"Towards an understanding of amyloid-\u03b2 oligomers: characterization, toxicity mechanisms, and inhibitors","volume":"46","author":"Lee","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216002","article-title":"Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer's disease","volume":"517","author":"Zhu","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0015","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1021\/acs.jmedchem.3c01057","article-title":"In vivo near-infrared fluorescence imaging selective for soluble amyloid \u03b2 aggregates using y-shaped BODIPY derivative","volume":"66","author":"Akasaka","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128160_bb0020","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/acs.chemrev.9b00404","article-title":"Interrogating amyloid aggregates using fluorescent probes","volume":"119","author":"Aliyan","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0025","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/ar.21209","article-title":"Detection of a\u03b2 plaques by a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n in APP\/PS1 transgenic mice","volume":"293","author":"Li","year":"2010","journal-title":"Anat. Rec."},{"key":"10.1016\/j.saa.2026.128160_bb0030","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1021\/jm201513c","article-title":"Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for \u03b2-amyloid plaques in Alzheimer's brains","volume":"55","author":"Cheng","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128160_bb0035","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s12272-013-0193-4","article-title":"Current status of PET-imaging probes of \u03b2-amyloid plaques","volume":"36","author":"Koo","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.saa.2026.128160_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11910-017-0718-1","article-title":"Future directions in imaging neurodegeneration","volume":"17","author":"Masdeu","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.saa.2026.128160_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136132","article-title":"Combined strategies for optimizing BODIPY-based near-infrared fluorescent probe targeting a\u03b2 oligomers","volume":"417","author":"Akasaka","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128160_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123637","article-title":"Rofecoxib derivatives as NIR fluorescent probes for mitochondrial viscosity and in vivo imaging of a\u03b2 plaques","volume":"307","author":"Anwar","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128160_bb0055","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1039\/C4CS00337C","article-title":"Imaging of \u03b2-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience","volume":"44","author":"Staderini","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.apsb.2014.12.006","article-title":"Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease","volume":"5","author":"Tong","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.saa.2026.128160_bb0065","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/acschemneuro.1c00810","article-title":"Strategic design of amyloid-\u03b2 species fluorescent probes for Alzheimer's disease","volume":"13","author":"Su","year":"2022","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.saa.2026.128160_bb0070","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1021\/acschemneuro.3c00304","article-title":"Recent advances in the development of near-infrared fluorescent probes for the in vivo brain imaging of amyloid-\u03b2 species in Alzheimer's disease","volume":"14","author":"Bajad","year":"2023","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.saa.2026.128160_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111982","article-title":"Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer's disease","volume":"187","author":"Gyasi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128160_bb0080","first-page":"385","volume":"26","author":"Zare-shahabadi","year":"2015","journal-title":"Autophagy in Alzheimer's disease"},{"key":"10.1016\/j.saa.2026.128160_bb0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","article-title":"Autophagy failure in Alzheimer's disease\u2014locating the primary defect","volume":"43","author":"Nixon","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.saa.2026.128160_bb0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.14283\/jpad.2023.3","article-title":"Programmed death of microglia in Alzheimer's disease: autophagy, ferroptosis, and pyroptosis","volume":"10","author":"Qiu","year":"2023","journal-title":"J. Prev Alzheimers Dis."},{"key":"10.1016\/j.saa.2026.128160_bb0095","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1038\/s41380-023-02242-5","article-title":"The role of glial autophagy in Alzheimer's disease","volume":"28","author":"Litwiniuk","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.saa.2026.128160_bb0100","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1080\/15548627.2021.1963630","article-title":"Endolysosome and autophagy dysfunction in Alzheimer disease","volume":"17","author":"Hung","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.saa.2026.128160_bb0105","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.biopsych.2019.05.008","article-title":"Autophagy dysfunction in Alzheimer's disease: mechanistic insights and new therapeutic opportunities","volume":"87","author":"Di Meco","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.saa.2026.128160_bb0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000276710","article-title":"Autophagy dysfunction in Alzheimer's disease","volume":"7","author":"Li","year":"2010","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.saa.2026.128160_bb0115","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.saa.2026.128160_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101464","article-title":"Autophagy in Alzheimer's disease pathogenesis: therapeutic potential and future perspectives","volume":"72","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0125","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1039\/C9CC00113A","article-title":"A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid","volume":"55","author":"Tan","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2026.128160_bb0130","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of a\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.saa.2026.128160_bb0135","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.3390\/ijms21186739","article-title":"Activate or inhibit? Implications of autophagy modulation as a therapeutic strategy for Alzheimer's disease","volume":"21","author":"Krishnan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128160_bb0140","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4103\/NRR.NRR-D-23-01633","article-title":"Enhanced autophagic clearance of amyloid-\u03b2 via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo","volume":"20","author":"Long","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.saa.2026.128160_bb0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification\u2014the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.saa.2026.128160_bb0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41593-023-01495-1","article-title":"Lysosome regulation of microglia in Alzheimer's disease via TFEB\u2013vacuolar ATPase","volume":"27","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.saa.2026.128160_bb0155","doi-asserted-by":"crossref","unstructured":"H. Sun, H.-x. Leng, J.-s. Liu, G. Roy, J.-w. Yan, L. Zhang, A novel fluorescent protein chromophore analogue to simultaneously probe lysosome viscosity and \u03b2-amyloid fibrils, Sens. Actuators B, 305 (2020) 127509. https:\/\/doi.org\/10.1016\/j.snb.2019.127509.","DOI":"10.1016\/j.snb.2019.127509"},{"key":"10.1016\/j.saa.2026.128160_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132003","article-title":"Quinolinium-based viscosity probes for lysosome imaging and tracing lysosomal viscosity changes in living cells","volume":"367","author":"Tantipanjaporn","year":"2022","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128160_bb0165","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.aca.2017.01.017","article-title":"In vivo near-infrared fluorescence imaging of amyloid-\u03b2 plaques with a dicyanoisophorone-based probe","volume":"961","author":"Zhu","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.128160_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342894","article-title":"Novel pyrrolidine-alkylamino-substituted dicyanoisophorone derivatives as near-infrared fluorescence probe for imaging \u03b2-amyloid in vitro and in vivo","volume":"1317","author":"Zhou","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.128160_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123403","article-title":"A dicyanoisophorone-based long-wavelength fluorescent probe for detection of cysteine in vitro and in vivo","volume":"304","author":"Zhou","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128160_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.aca.2020.07.073","article-title":"Dual-functional AIE fluorescent probes for imaging \u03b2-amyloid plaques and lipid droplets","volume":"1133","author":"Wang","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.128160_bb0185","doi-asserted-by":"crossref","first-page":"15902","DOI":"10.1021\/acs.analchem.2c04042","article-title":"Near-infrared photooxygenation theranostics used for the specific mapping and modulating of amyloid-\u03b2 aggregation","volume":"94","author":"Yang","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128160_bb0190","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1021\/acschemneuro.2c00361","article-title":"Design and development of benzothiazole-based fluorescent probes for selective detection of a\u03b2 aggregates in Alzheimer's disease","volume":"13","author":"Mallesh","year":"2022","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.saa.2026.128160_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.142932","article-title":"N,N-Dimethylaminonaphthyl-modified dicyanoisophorone near-infrared probe for dual-functional imaging of \u03b2-amyloid aggregates and lipid droplets","volume":"1344","author":"Gong","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128160_bb0200","series-title":"Gaussian, Inc., Wallingford, CT","author":"Frisch","year":"2009"},{"key":"10.1016\/j.saa.2026.128160_bb0205","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s40263-019-00643-1","article-title":"Endolysosome and autolysosome dysfunction in Alzheimer's disease: where intracellular and extracellular meet","volume":"33","author":"van Weering","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.saa.2026.128160_bb0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","article-title":"Autophagy and Alzheimer's disease","volume":"37","author":"Li","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.saa.2026.128160_bb0215","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ddr.21605","article-title":"Autophagy induction in the treatment of Alzheimer's disease","volume":"81","author":"Schmukler","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.saa.2026.128160_bb0220","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41401-023-01197-1","article-title":"Corynoxine promotes TFEB\/TFE3-mediated autophagy and alleviates a\u03b2 pathology in Alzheimer's disease models","volume":"45","author":"Guan","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.saa.2026.128160_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126011","article-title":"Intranasal delivery of rapamycin via brain-targeting polymeric micelles for Alzheimer's disease treatment","volume":"683","author":"Sugandhi","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.saa.2026.128160_bb0230","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2147\/CIA.S429440","article-title":"Rapamycin responds to Alzheimer's disease: a potential translational therapy","volume":"18","author":"Hou","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.saa.2026.128160_bb0235","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526007316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526007316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:20:18Z","timestamp":1783408818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526007316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":47,"alternative-id":["S1386142526007316"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128160","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosome-targeted near-infrared fluorescent probes for monitoring a\u03b2 plaques in vivo and a\u03b2 monomers dynamic degradation in vitro","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128160"}}