{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:09:08Z","timestamp":1788815348912,"version":"build-2803163510"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CZ.10.03.01\/00\/22_003\/0000003"],"award-info":[{"award-number":["CZ.10.03.01\/00\/22_003\/0000003"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.saa.2026.128540","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:29:58Z","timestamp":1785799798000},"page":"128540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Biophysical insights into interaction mechanism of cediranib with human serum albumin: In-vitro and in-silico perspectives"],"prefix":"10.1016","volume":"364","author":[{"given":"Md. Zahirul","family":"Kabir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Erkmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazal","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saharuddin B.","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128540_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030659","article-title":"Signaling pathways in cancer: therapeutic targets, combinatorial treatments, and new developments","volume":"10","author":"Yip","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.saa.2026.128540_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113054","article-title":"Targeting cancer signaling pathways by natural products: exploring promising anti-cancer agents","volume":"150","author":"Hashem","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.saa.2026.128540_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.143838","article-title":"The role of biological macromolecules in the regulation of angiogenesis in glioblastoma: focus on vascular growth factors, integrins, and extracellular matrix proteins","volume":"311","author":"Zabihi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120716","article-title":"Repurposing therapeutics for malignant pleural mesothelioma (MPM) \u2013 updates on clinical translations and future outlook","volume":"304","author":"Kulkarni","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s40883-018-0077-8","article-title":"Evaluating angiogenic potential of small molecules using genetic network approaches","volume":"5","author":"Das","year":"2019","journal-title":"Regen. Eng. Transl. Med."},{"key":"10.1016\/j.saa.2026.128540_bb0030","first-page":"133","article-title":"Development of small molecules targeting the wnt signaling pathway in cancer stem cells for the treatment of colorectal cancer","volume":"14","author":"Song","year":"2015","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.saa.2026.128540_bb0035","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1158\/0008-5472.CAN-04-4409","article-title":"AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer","volume":"65","author":"Wedge","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.saa.2026.128540_bb0040","doi-asserted-by":"crossref","unstructured":"M. Guo, Z. Liu, J. Si, J. Zhang, J. Zhao, Z. Guo, et al., Cediranib induces apoptosis, G1 phase cell cycle arrest, and autophagy in non-small-cell lung cancer cell A549 in vitro, Biomed. Res. Int. 2021 (2021) 5582648, doi:https:\/\/doi.org\/10.1155\/2021\/5582648.","DOI":"10.1155\/2021\/5582648"},{"key":"10.1016\/j.saa.2026.128540_bb0045","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1200\/JCO.19.00269","article-title":"Phase II trial of cediranib in combination with cisplatin and pemetrexed in chemotherapy-na\u00efve patients with unresectable malignant pleural mesothelioma (SWOG S0905)","volume":"37","author":"Tsao","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.saa.2026.128540_bb0050","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jtho.2017.05.021","article-title":"Phase I trial of cediranib in combination with cisplatin and pemetrexed in chemonaive patients with unresectable malignant pleural mesothelioma (SWOG S0905)","volume":"12","author":"Tsao","year":"2017","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.saa.2026.128540_bb0055","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s10637-014-0106-5","article-title":"A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients","volume":"32","author":"Spreafico","year":"2014","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.saa.2026.128540_bb0060","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1097\/JTO.0b013e318174e910","article-title":"The tyrosine kinase inhibitor cediranib for nonsmall cell lung cancer and other thoracic malignancies","volume":"3","author":"Nikolinakos","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.saa.2026.128540_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.3105","article-title":"Computational analysis of interactions between drugs and human serum albumin","volume":"37","author":"Yildiz","year":"2024","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.saa.2026.128540_bb0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s43094-023-00544-7","article-title":"Spectroscopic study of drug\u2013drug interactions: influence of two over-the-counter drugs on the albumin binding affinities of carbamazepine and its major metabolite","volume":"9","author":"Thomas","year":"2023","journal-title":"Future J. Pharm. Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.3010","article-title":"A biophysical approach to study the impact of muscle relaxant drug tizanidine on stability and activity of serum albumins","volume":"36","author":"Patel","year":"2023","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.saa.2026.128540_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106961","article-title":"Biophysical insight into the interaction mechanism of 4-bromo-N-(thiazol-2-yl) benzenesulfonamide and human serum albumin using multi-spectroscopic and computational studies","volume":"204","author":"Ayimbila","year":"2025","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ijbiomac.2020.01.134","article-title":"Probing the interaction of rivastigmine tartrate, an important Alzheimer's drug, with serum albumin: attempting treatment of alzheimer's disease","volume":"148","author":"Shamsi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0090","doi-asserted-by":"crossref","first-page":"20187","DOI":"10.1038\/s41598-021-99690-2","article-title":"In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent","volume":"11","author":"Ruankham","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2026.128540_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-017-0111-x","article-title":"Critical appraisal of the role of serum albumin in cardiovascular disease","volume":"5","author":"Chien","year":"2017","journal-title":"Biomark. Res."},{"key":"10.1016\/j.saa.2026.128540_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2021.107072","article-title":"Study of the binding mechanism between hydroxytyrosol and bovine serum albumin using multispectral and molecular docking","volume":"122","author":"Lv","year":"2022","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.saa.2026.128540_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2024.112992","article-title":"Exploring the binding characteristics of bovine serum albumin with CDK4\/6 inhibitors Ribociclib: multi-spectral analysis and molecular simulation studies","volume":"258","author":"Jiang","year":"2024","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2026.128540_bb0110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/acsfoodscitech.1c00361","article-title":"Effect of a metal ion in modulating the binding interaction of a dietary flavonoid with bovine serum albumin and DNA: a spectroscopic and theoretical approach","volume":"2","author":"Sengupta","year":"2022","journal-title":"ACS Food Sci. Technol."},{"key":"10.1016\/j.saa.2026.128540_bb0115","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1021\/acsomega.9b03479","article-title":"Privileged scaffold chalcone: synthesis, characterization and its mechanistic interaction studies with BSA employing spectroscopic and Chemoinformatics approaches","volume":"5","author":"Singh","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2026.128540_bb0120","doi-asserted-by":"crossref","first-page":"19521","DOI":"10.1021\/acsomega.2c01226","article-title":"Double-site binding and anti\u2212\/pro-oxidation of luteolin on bovine serum albumin mediated by copper(II) coordination","volume":"7","author":"Song","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2026.128540_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125883","article-title":"Insights into the interaction of human serum albumin with ionic liquids \u2013 thermodynamic, spectroscopic and molecular modelling studies","volume":"249","author":"Kowalska","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0130","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1016\/j.bbagen.2013.03.015","article-title":"Molecular and practical aspects of the enzymatic properties of human serum albumin and of albumin\u2013ligand complexes","volume":"1830","author":"Kragh-Hansen","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.saa.2026.128540_bb0135","first-page":"327","article-title":"Plasma protein binding to drugs","volume":"31","author":"Olson","year":"1996","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0140","series-title":"All About Albumin: Biochemistry, Genetics, and Medical Applications","author":"Peters","year":"1996"},{"key":"10.1016\/j.saa.2026.128540_bb0145","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0026-895X(25)10691-3","article-title":"The characterization of two specific drug binding sites on human serum albumin","volume":"11","author":"Sudlow","year":"1975","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.saa.2026.128540_bb0150","doi-asserted-by":"crossref","DOI":"10.1080\/07391102.2021.1911850","article-title":"Biomolecular interaction mechanism of an anticancer drug, pazopanib with human serum albumin: a multi-spectroscopic and computational approach","volume":"40","author":"Kandandapani","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128540_bb0155","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jphotobiol.2016.06.049","article-title":"Binding of an anticancer drug, axitinib to human serum albumin: fluorescence quenching and molecular docking study","volume":"162","author":"Tayyab","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2026.128540_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27041265","article-title":"Interaction characterization of a tyrosine kinase inhibitor erlotinib with a model transport protein in the presence of quercetin: a drug-protein and drug-drug interaction investigation using multi-spectroscopic and computational approaches","volume":"27","author":"Wani","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128540_bb0165","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jphotobiol.2018.05.008","article-title":"Characterization of the binding of a novel antitumor drug ibrutinib with human serum albumin: insights from spectroscopic, calorimetric and docking studies","volume":"184","author":"Tang","year":"2018","journal-title":"J. Photochem. Photobiol. B Biol."},{"issue":"18","key":"10.1016\/j.saa.2026.128540_bb0170","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1039\/a803429j","article-title":"Synthesis and interaction with human serum albumin of the first 3,18-disubstituted derivative of bilirubin","volume":"1","author":"Painter","year":"1998","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.saa.2026.128540_bb0175","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/jf048693g","article-title":"Interaction of flavonoids with bovine serum albumin: a fluorescence quenching study","volume":"53","author":"Papadopoulou","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0180","doi-asserted-by":"crossref","first-page":"362","DOI":"10.7150\/ijms.5698","article-title":"Improved culture conditions for the growth and detection of Borrelia from human serum","volume":"10","author":"Sapi","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0185","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.saa.2026.128540_bb0190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijbiomac.2017.12.011","article-title":"Enhancement of intrinsic fluorescence of human carbonic anhydrase II upon topiramate binding: some evidence for drug-induced molecular contraction of the protein","volume":"108","author":"Ghobadi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0195","doi-asserted-by":"crossref","DOI":"10.1080\/07391102.2019.1640133","article-title":"Biomolecular interaction of a platelet aggregation inhibitor, 3,4-methylenedioxy-\u03b2-nitrostyrene with human serum albumin: multi-spectral and computational characterization","volume":"38","author":"Kabir","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128540_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124284","article-title":"Biophysical insight into the binding mechanism of 1,3-benzodioxole-based lidocaine tagged ionic liquids with BSA: an in-silico, and spectroscopic studies","volume":"398","author":"Sangeeta","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.112648","article-title":"Biophysical and in silico investigations of the molecular association between a potent RNA polymerase inhibitor, thiolutin and human serum albumin","volume":"303","author":"Kabir","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0210","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molstruc.2004.05.026","article-title":"Investigation of the interaction between flavonoids and human serum albumin","volume":"703","author":"Bi","year":"2004","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128540_bb0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpba.2009.03.015","article-title":"Fluorescence spectral resolution of tryptophan residues in bovine and human serum albumins","volume":"50","author":"Tayeh","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2026.128540_bb0220","doi-asserted-by":"crossref","first-page":"91756","DOI":"10.1039\/C6RA12019A","article-title":"Interaction of an anticancer drug, gefitinib with human serum albumin: insights from fluorescence spectroscopy and computational modelling analysis","volume":"6","author":"Kabir","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2026.128540_bb0225","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/abio.2000.4880","article-title":"Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set","volume":"287","author":"Sreerama","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.saa.2026.128540_bb0230","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/nar\/gkh371","article-title":"DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data","volume":"32","author":"Whitmore","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.saa.2026.128540_bb0235","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1248\/bpb.25.695","article-title":"Practical aspects of the ligandbinding and enzymatic properties of human serum albumin","volume":"25","author":"Kragh-Hansen","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.saa.2026.128540_bb0240","first-page":"1","article-title":"Integrative analysis of the anti-diabetic inhibitor GW9508 binding to human serum albumin: computational, spectroscopic and ITC insights","author":"Rehman","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128540_bb0245","first-page":"1","article-title":"Binding interactions between ar-turmerone and human serum albumin: mechanistic and biophysical insights","author":"Asngari","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128540_bb0250","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-0716-0892-0_11","article-title":"BeStSel: from secondary structure analysis to protein fold prediction by circular dichroism spectroscopy","volume":"2199","author":"Micsonai","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.saa.2026.128540_bb0255","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0260","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminform."},{"key":"10.1016\/j.saa.2026.128540_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/jcc.20084","article-title":"UCSF chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126602","article-title":"Characterization of dovitinib\u2013human serum albumin association potential through optical spectroscopic and in silico approaches, Spectrochim","volume":"343","author":"Erkmen","year":"2025","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128540_bb0275","doi-asserted-by":"crossref","DOI":"10.1021\/ct300400x","article-title":"Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone \u03d5, \u03c8 and side-chain \u03c71 and \u03c72 dihedral angles","volume":"8","author":"Best","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.saa.2026.128540_bb0280","doi-asserted-by":"crossref","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.saa.2026.128540_bb0285","doi-asserted-by":"crossref","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.saa.2026.128540_bb0290","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.saa.2026.128540_bb0295","doi-asserted-by":"crossref","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: an N\u00b7log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.saa.2026.128540_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117337","article-title":"A critical view on the analysis of fluorescence quenching data for determining ligand-protein binding affinity, Spectrochim","volume":"223","author":"Bakar","year":"2019","journal-title":"Acta Part A Mol. Biomol. Spectrosc"},{"key":"10.1016\/j.saa.2026.128540_bb0305","first-page":"1520","article-title":"Targeting the nalidixic acid binding site on human serum albumin through computational approach: a reinvestigation","volume":"12","author":"Halim","year":"2022","journal-title":"Biointerface Res. Appl. Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0310","doi-asserted-by":"crossref","first-page":"9976","DOI":"10.1021\/bi980274n","article-title":"Toward understanding tryptophan fluorescence in proteins","volume":"37","author":"Chen","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.saa.2026.128540_bb0315","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/bmb.2002.494030030035","article-title":"Protein tryptophan accessibility studied by fluorescence quenching","volume":"30","author":"Moller","year":"2002","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.saa.2026.128540_bb0320","article-title":"Interaction of triterpenoids with human serum albumin: a review","volume":"207","author":"Abboud","year":"2017","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.saa.2026.128540_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.101875","article-title":"Spectroscopic and in silico approach to probe the binding interactions of irbesartan and human serum albumin","volume":"34","author":"Najmi","year":"2022","journal-title":"J. King Saud Univ. - Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0330","article-title":"Structural exploration of interactions of (+) catechin and (\u2212) epicatechin with bovine serum albumin: insights from molecular dynamics and spectroscopic methods","volume":"348","author":"Anitha","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/bip.23337","article-title":"Combination mode of antimalarial drug mefloquine and human serum albumin: insights from spectroscopic and docking approaches","volume":"111","author":"Musa","year":"2020","journal-title":"Biopolymers"},{"key":"10.1016\/j.saa.2026.128540_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124642","article-title":"Exploring the molecular basis of tucatinib interaction with human serum albumin: a spectroscopic and computational analysis","volume":"401","author":"Amir","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123641","article-title":"Deciphering the binding mode and structural perturbations in floxuridine-human serum albumin complexation with spectroscopic, microscopic, and computational techniques","volume":"308","author":"Rehman","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128540_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27082589","article-title":"A comprehensive investigation of interactions between antipsychotic drug quetiapine and human serum albumin using multi-spectroscopic, biochemical, and molecular modeling approaches","volume":"27","author":"Zargar","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128540_bb0355","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/j100809a020","article-title":"Oxygen quenching of fluorescence in solution: an experimental study of the diffusion process","volume":"66","author":"Ware","year":"1962","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.saa.2026.128540_bb0360","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.molliq.2018.12.026","article-title":"Study of the binding interactions between uric acid and bovine serum albumin using multiple spectroscopic techniques","volume":"276","author":"Makarska-Bialokoz","year":"2019","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136017","article-title":"Comparative investigation on interaction mechanism and native conformation of human serum albumin with organometallic iridium(III) complexes via spectroscopic and electrochemical approaches","volume":"1291","author":"Huang","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128540_bb0370","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s40262-016-0488-y","article-title":"Clinical pharmacokinetics and pharmacodynamics of cediranib","volume":"56","author":"Tang","year":"2017","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.saa.2026.128540_bb0375","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1016\/j.bpj.2008.12.3965","article-title":"Affinity and specificity of levamlodipine-human serum albumin interactions: insights into its carrier function","volume":"96","author":"Liu","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.saa.2026.128540_bb0380","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jchromb.2004.06.012","article-title":"Studies of phenytoin binding to human serum albumin by high-performance affinity chromatography","volume":"809","author":"Chen","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.saa.2026.128540_bb0385","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1023\/A:1012168020545","article-title":"Interactions of aldosterone antagonist diuretics with human serum proteins","volume":"14","author":"Takamura","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.saa.2026.128540_bb0390","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1021\/bi00514a017","article-title":"Thermodynamics of protein association reactions: forces contributing to stability","volume":"20","author":"Ross","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.saa.2026.128540_bb0395","article-title":"Uncovering the molecular and physiological processes of anticancer leads binding human serum albumin: a physical insight into drug efficacy","volume":"12","author":"Liu","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.saa.2026.128540_bb0400","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijbiomac.2017.06.122","article-title":"Qais, Unraveling the thermodynamics, binding mechanism and conformational changes of hsa with chromolyn sodium: multispectroscopy, isothermal titration calorimetry and molecular docking studies","volume":"105","author":"Yasmeen","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0405","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jphotobiol.2018.05.008","article-title":"Characterization of the binding of a novel antitumor drug ibrutinib with human serum albumin: insights from spectroscopic, calorimetric and docking studies","volume":"184","author":"Tang","year":"2018","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2026.128540_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.149613","article-title":"Molecular interaction of abemaciclib with human serum albumin: insights from spectroscopy, microscopy, and computational approaches","volume":"337","author":"Li","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106550","article-title":"Biophysical and docking study on the interaction of anticancer drugs encorafenib and binimetinib with human serum albumin","volume":"189","author":"Cavalieri","year":"2023","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0420","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbapap.2005.06.005","article-title":"How to study proteins by circular dichroism","volume":"1751","author":"Kelly","year":"2005","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.saa.2026.128540_bb0425","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biochi.2016.01.012","article-title":"The interaction of human serum albumin with selected lanthanide and actinide ions: binding affinities, protein unfolding andconformational changes","volume":"123","author":"Ali","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.saa.2026.128540_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.113270","article-title":"Intermolecular recognition between pyrimethamine, an antimalarial drug and human serum albumin: spectroscopic and docking study","volume":"311","author":"Musa","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0435","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1080\/07391102.2019.1630007","article-title":"The interaction between human serum albumin and antidiabetic agent\u2013exenatide: determination of the mechanism binding and effect on the protein conformation by fluorescence and circular dichroism techniques-part I","volume":"38","author":"\u015aliwi\u0144ska-Hill","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128540_bb0440","article-title":"Evaluation of binding mode between anticancer drug etoposide and human serum albumin by numerous spectrometric techniques and molecular docking","volume":"530","author":"Manjushree","year":"2020","journal-title":"Chem. Phys."},{"key":"10.1016\/j.saa.2026.128540_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.118831","article-title":"Exploring binding interaction of baricitinib with bovine serum albumin (BSA): multi-spectroscopic approaches combined with theoretical calculation","volume":"354","author":"Zhang","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128540_bb0450","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jpha.2016.07.004","article-title":"Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism","volume":"7","author":"Byadagi","year":"2017","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.saa.2026.128540_bb0455","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jphotobiol.2015.05.004","article-title":"Green biosynthesis of ZnO nanoparticles using Vitex negundo L. extract: spectroscopic investigation of interaction between ZnO nanoparticles and human serum albumin","volume":"149","author":"Ambika","year":"2015","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2026.128540_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111305","article-title":"Spectrofluorimetric analysis of the binding of a target molecule to serum albumin: tricky aspects and tips","volume":"216","author":"Macii","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2026.128540_bb0465","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejps.2017.11.013","article-title":"Stereoselective and domain-specific effects of ibuprofen on the thermal stability of human serum albumin","volume":"112","author":"Guglielmelli","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.saa.2026.128540_bb0470","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijbiomac.2012.10.027","article-title":"Monitoring protein denaturation using thermal conductivity probe","volume":"52","author":"Park","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128540_bb0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084552","article-title":"Oxidation enhances human serum albumin thermal stability and changes the routes of amyloid fibril formation","volume":"9","author":"Sancataldo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.saa.2026.128540_bb0480","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.saa.2017.03.059","article-title":"Comprehensive insight into the binding of sunitinib, a multi-targeted anticancer drug to human serum albumin","volume":"181","author":"Kabir","year":"2017","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128540_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.125776","article-title":"Probing the articaine\u2013human serum albumin interaction and influences of paracetamol and caffeine on the interaction by spectroscopy, voltammetry, and bioinformatics, Spectrochim","volume":"333","author":"Erkmen","year":"2025","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128540_bb0490","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1159\/000129365","article-title":"Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease","volume":"25","author":"Gerhardsson","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.saa.2026.128540_bb0495","first-page":"524","article-title":"The interpretation of trace element analysis in body fluids","volume":"128","author":"Guidotti","year":"2008","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.saa.2026.128540_bb0500","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.saa.2013.06.007","article-title":"Spectroscopic studies on the interaction between tetrandrine and two serum albumins by chemometrics methods","volume":"115","author":"Cheng","year":"2013","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectros."},{"key":"10.1016\/j.saa.2026.128540_bb0505","first-page":"101","article-title":"Interaction of flavokawain B with lysozyme: a photophysical and molecular simulation study","volume":"160","author":"Feroz","year":"2015","journal-title":"JOL"},{"key":"10.1016\/j.saa.2026.128540_bb0510","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.3390\/molecules27227858","article-title":"Insight into the interaction mechanism of HSA with aztreonam: a multispectroscopic and computational approach","volume":"27","author":"Sabour","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128540_bb0515","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1016\/j.bbagen.2013.06.018","article-title":"Binding of transition metal ions to albumin: sites, affinities and rates","volume":"1830","author":"Bal","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.saa.2026.128540_bb0520","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/jp2113957","article-title":"Structure prediction of loops with fixed and flexible stems","volume":"116","author":"Subramani","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.saa.2026.128540_bb0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119264","article-title":"Automatic identification of mobile and rigid substructures in molecular dynamics simulations and fractional structural fluctuation analysis","volume":"10","author":"Mart\u00ednez","year":"2015","journal-title":"PloS One"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252601111X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252601111X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:46:52Z","timestamp":1788814012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138614252601111X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":105,"alternative-id":["S138614252601111X"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128540","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biophysical insights into interaction mechanism of cediranib with human serum albumin: In-vitro and in-silico perspectives","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128540"}}