{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:01:24Z","timestamp":1790625684967,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["X2026104380388"],"award-info":[{"award-number":["X2026104380388"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018627","name":"Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China","doi-asserted-by":"publisher","award":["2024KJJ035"],"award-info":[{"award-number":["2024KJJ035"]}],"id":[{"id":"10.13039\/501100018627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022QB150"],"award-info":[{"award-number":["ZR2022QB150"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023HWYQ-096"],"award-info":[{"award-number":["2023HWYQ-096"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.saa.2026.128765","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:37:52Z","timestamp":1788968272000},"page":"128765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An acidic pH-activatable fluorescent probe for MUC1 detection and the precise imaging of MCF-7 cells"],"prefix":"10.1016","volume":"365","author":[{"given":"Chenggong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangkun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128765_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2026.105275","article-title":"Progress and challenges in CAR-T cell therapy for bladder cancer","volume":"222","author":"Zhao","year":"2026","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.saa.2026.128765_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2026.118583","article-title":"Current landscape and therapeutic prospects of indole hybrids for prostate cancer treatment: a mini-review","volume":"305","author":"Xu","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128765_bb0015","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000046857","article-title":"Unraveling the significance of methyltransferase like-3 in the pathogenesis of gastrointestinal tumors: a review","volume":"105","author":"Xiong","year":"2026","journal-title":"Medicine"},{"key":"10.1016\/j.saa.2026.128765_bb0020","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.7326\/ANNALS-25-03548","article-title":"When would you screen this 39-year-old woman for breast cancer? Grand rounds discussion from Beth Israel Deaconess Medical Center","volume":"178","author":"Kanjee","year":"2025","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.saa.2026.128765_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139936","article-title":"Algae-derived polysaccharides and polysaccharide-based nanoparticles: a natural frontier in breast cancer therapy","volume":"297","author":"Cai","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128765_bb0030","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.2147\/IJN.S534422","article-title":"Application of metal-organic frameworks nanoparticles in the diagnosis and treatment of breast cancer","volume":"20","author":"Jiang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.saa.2026.128765_bb0035","doi-asserted-by":"crossref","first-page":"30720","DOI":"10.1021\/acsnano.5c02321","article-title":"Advances in nanomedicine for targeting Cancer stem cells and overcoming therapeutic resistance","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2026.128765_bb0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12964-025-02321-w","article-title":"Neutrophil membrane-coated circular RNA nanoparticles for targeted immunotherapy in HER2-positive breast cancer brain metastasis","volume":"23","author":"Liu","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.saa.2026.128765_bb0045","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.7150\/ijbs.109803","article-title":"Targeting glycolysis for treatment of breast Cancer resistance: current Progress and future prospects","volume":"21","author":"Niu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0050","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1080\/17425247.2024.2412823","article-title":"Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting","volume":"21","author":"Ibrahim","year":"2024","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.saa.2026.128765_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132710","article-title":"A new insight into the early detection of HER2 protein in breast cancer patients with a focus on electrochemical biosensors approaches: a review","volume":"272","author":"Turk","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.saa.2026.128765_bb0060","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1634\/theoncologist.2017-0343","article-title":"Emerging perspectives on mTOR inhibitor-associated pneumonitis in breast Cancer","volume":"23","author":"Alvarez","year":"2018","journal-title":"Oncologist"},{"key":"10.1016\/j.saa.2026.128765_bb0065","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/acs.analchem.5c06278","article-title":"Nanoflower-shaped peptide assemblies driven by serrated \u03b2-sheets and hydrophobic interactions for high-affinity MUC1 recognition","volume":"98","author":"Ma","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128765_bb0070","article-title":"Tumour-associated MUC1 exerts multiple effects on cholesterol and lipid metabolism-a potential pathogenic effector of atherosclerosis in cancer","volume":"27","author":"Chen","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0075","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302366","article-title":"Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry-based de novo sequencing","volume":"7","author":"Peng","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.saa.2026.128765_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.127778","article-title":"Aptamer-functionalized polydiacetylene liposomes act as a fluorescent sensor for sensitive detection of MUC1 and targeted imaging of cancer cells","volume":"309","author":"Wang","year":"2020","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128765_bb0085","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s42823-025-00887-6","article-title":"Enhancing cancer biomarker identification: precise monitoring of MUC1 using V2C\/Au nanocomposite-amplified electrochemical biosensor","volume":"35","author":"Zare","year":"2025","journal-title":"Carbon Lett."},{"key":"10.1016\/j.saa.2026.128765_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.113363","article-title":"Ultra-responsive label-free electrochemical aptamer sensor based on 3D-CdCo-ONSs@AuNPs for detection of tumour marker MUC1","volume":"212","author":"Que","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128765_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137496","article-title":"Label-free multiplexed protein quantification in clinical samples using encodable hydrogel barcode and low-aspect-ratio micropore","volume":"432","author":"Song","year":"2025","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128765_bb0100","first-page":"438","article-title":"Leveraging aptamer-based DNA nanotechnology for bioanalysis and Cancer therapeutics, accounts of","volume":"5","author":"Huang","year":"2024","journal-title":"Mater. Res."},{"key":"10.1016\/j.saa.2026.128765_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2020.113894","article-title":"Recent advances in aptamer applications for analytical biochemistry","volume":"644","author":"Zon","year":"2022","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.saa.2026.128765_bb0110","article-title":"Aptamer technologies in neuroscience, neuro-diagnostics and neuro-medicine development","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128765_bb0115","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/bios15100653","article-title":"Review of microchip analytical methods coupled with aptamer-based signal amplification strategies for high-sensitivity bioanalytical applications","volume":"15","author":"Xue","year":"2025","journal-title":"Biosensors"},{"key":"10.1016\/j.saa.2026.128765_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114842","article-title":"Site-specific aptamer immobilization via amine-to-thiol cross-linking on field-effect transistor biosensor for cortisol detection","volume":"254","author":"Hayashi","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.saa.2026.128765_bb0125","article-title":"Aptamer-based sensing in food science: precision tools for enhanced consumer safety and perception","volume":"66","author":"Das","year":"2025","journal-title":"Curr. Opin. Food Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0130","doi-asserted-by":"crossref","first-page":"24886","DOI":"10.1021\/acsanm.4c04793","article-title":"Colorimetric biosensor for early detection of MUC1-positive cells using aptamer-conjugated Plasmonic gold nanostars","volume":"7","author":"Munyayi","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.saa.2026.128765_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117497","article-title":"Multivalent aptamer-linked tetrahedron DNA assisted catalytic hairpin assembly for accurate SERS assay of cancer-derived exosomes in clinical blood","volume":"282","author":"Zhang","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2026.128765_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137287","article-title":"Ag@MNPs-based electrochemical and colorimetric dual-modal strategy for facile multiplex analysis of exosomes","volume":"429","author":"Liu","year":"2025","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128765_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126640","article-title":"Machine learning-assisted SERS-based dual-aptamer biosensor for ultrasensitive clinical screening of breast cancer","volume":"344","author":"Xia","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128765_bb0150","doi-asserted-by":"crossref","first-page":"33606","DOI":"10.1021\/acsami.5c05585","article-title":"Detection with active capture of breast Cancer marker MUC1 using a MXene-based electrochemical actuator","volume":"17","author":"Huang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2026.128765_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217194","article-title":"Aggregation-induced emission materials for fluorescence analysis: recent progress in rapid detection of pesticide and veterinary drug residues","volume":"548","author":"Chen","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128765_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2025.112637","article-title":"Advancements in NIR-based fluorescence imaging agents for oral oncology: a comprehensive review","volume":"235","author":"Adnan Ashour","year":"2025","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128765_bb0165","doi-asserted-by":"crossref","first-page":"2530003","DOI":"10.1142\/S1793545825300034","article-title":"Recent application of near-infrared fluorescence probes in food safety detection","volume":"18","author":"Li","year":"2025","journal-title":"J. Innov. Opt. Health Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0170","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00604-022-05502-3","article-title":"DNA micelle-templated copper nanoclusters for fluorescent imaging of MUC1-positive cancer cells","volume":"189","author":"Chowdhury","year":"2022","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.saa.2026.128765_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2022.130521","article-title":"A conjugated aptamer and oligonucleotides-stabilized gold nanoclusters nanoplatform for targeted fluorescent imaging and efficient drug delivery","volume":"657","author":"Li","year":"2023","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.saa.2026.128765_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340643","article-title":"Programmable bidirectional dynamic DNA nano-device for accurate and ultrasensitive fluorescent detection of trace MUC1 biomarker in serums","volume":"1238","author":"Zhou","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.128765_bb0185","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/humrep\/deu146","article-title":"Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis","volume":"29","author":"Dharmaraj","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.saa.2026.128765_bb0190","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/molehr\/7.6.505","article-title":"MUC1 in normal and impaired spermatogenesis","volume":"7","author":"Franke","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.saa.2026.128765_bb0195","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1026110417294","article-title":"Tissue and serum MUC1 mucin detection in breast Cancer patients","volume":"81","author":"Croce","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.saa.2026.128765_bb0200","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.actbio.2022.08.074","article-title":"Role of stiffness and physico-chemical properties of tumour microenvironment on breast cancer cell stemness","volume":"152","author":"Shah","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.saa.2026.128765_bb0205","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11426-016-0159-2","article-title":"Synthesis of aptamer-functionalized Ag nanoclusters for MCF-7 breast cancer cells imaging","volume":"60","author":"Li","year":"2017","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.saa.2026.128765_bb0210","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.3390\/ijms22126567","article-title":"MUC1: structure, function, and clinic application in epithelial cancers","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0215","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1021\/acsnano.6b08727","article-title":"Oscillatory reaction induced periodic C-Quadruplex DNA gating of artificial ion channels","volume":"11","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2026.128765_bb0220","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1039\/C8SC00098K","article-title":"A pre-protective strategy for precise tumor targeting and efficient photodynamic therapy with a switchable DNA\/upconversion nanocomposite","volume":"9","author":"Yu","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2026.128765_bb0225","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/acs.molpharmaceut.9b01159","article-title":"Facile construction of i-motif DNA-conjugated gold Nanostars as near-infrared and pH dual-responsive targeted drug delivery Systems for Combined Cancer Therapy","volume":"17","author":"Miao","year":"2020","journal-title":"Mol. Pharm."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526013363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526013363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:28:11Z","timestamp":1790623691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526013363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":45,"alternative-id":["S1386142526013363"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128765","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An acidic pH-activatable fluorescent probe for MUC1 detection and the precise imaging of MCF-7 cells","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128765"}}