{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:43:40Z","timestamp":1792233820307,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/122\/47"],"award-info":[{"award-number":["RGP2\/122\/47"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.saa.2026.128813","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:32:33Z","timestamp":1789774353000},"page":"128813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis, spectroscopic and DFT investigation of a dual-fluorophore methylene blue\u2013naphthalimide probe for selective Cu2+ ions sensing and HeLa cell imaging"],"prefix":"10.1016","volume":"366","author":[{"given":"Sobhi M.","family":"Gomha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajeeha","family":"Zareen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Merve","family":"\u015eenol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi E.A.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128813_bb0005","article-title":"Heterogeneous copper single-atom catalyzed three-component radical difunctionalization of alkenes","volume":"368","author":"Liu","year":"2026","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.saa.2026.128813_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.128101","article-title":"An imidazole-based fluorescent probe for the selective detection of copper (I) and copper (II) ions and potential applications","volume":"361","author":"Susmitha","year":"2026","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.saa.2026.128813_bb0015","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.ccr.2009.05.011","article-title":"Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)","volume":"253","author":"Kozlowski","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128813_bb0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jtemb.2014.05.003","article-title":"Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease","volume":"29","author":"Ahuja","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.saa.2026.128813_bb0025","first-page":"1415","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"Chen","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.saa.2026.128813_bb0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ncp.10328","article-title":"Copper deficiency: causes, manifestations, and treatment","volume":"34","author":"Altarelli","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.saa.2026.128813_bb0035","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s10103-025-04487-8","article-title":"Classification of disease subtypes in medical spectroscopy for multi-category sample imbalances based on grouping and hierarchical learning","volume":"40","author":"Gao","year":"2025","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.saa.2026.128813_bb0040","doi-asserted-by":"crossref","first-page":"114062","DOI":"10.1016\/j.dyepig.2026.114062","article-title":"Water-switchable multicolor fluorescence of carbon dots: a proton-transfer-regulated ternary system","volume":"255","author":"Ren","year":"2026","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128813_bb0045","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jare.2025.07.040","article-title":"Human serum albumin-derived biosensor for visualizing copper(II) and hydrogen sulfide interactions in cancer cells","volume":"82","author":"An","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.saa.2026.128813_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2026.103776","article-title":"A dual-signals peptide-based probe for fluorometric and colorimetric detection of copper(II) ions and glyphosate in multiple food samples and biological system","volume":"35","author":"Ren","year":"2026","journal-title":"Food Chem. X"},{"key":"10.1016\/j.saa.2026.128813_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.145244","article-title":"Highly selective and sensitive colorimetric and fluorescence detection of copper(II) and glyphosate using dual-functional peptide probe and its multifarious applications in food sample analysis and bioimaging","volume":"491","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.saa.2026.128813_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126942","article-title":"A novel fluorescence \u201con-off-on\u201d peptidyl probe for highly selective and consecutive detection of Cu2+ and glyphosate and its multi-functional applications","volume":"346","author":"Jia","year":"2026","journal-title":"Spectrochim. Acta Part A."},{"key":"10.1016\/j.saa.2026.128813_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.144113","article-title":"A novel fluorescent and colorimetric dual-signals peptide-based probe for multianalyte detection and its multiple applications in real sample, bioimaging, test strip, logic gate, smartphone and food spoilage determination","volume":"1350","author":"Li","year":"2026","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128813_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106603","article-title":"A mitochondria-targeted dual-response sensor for monitoring viscosity and peroxynitrite in living cells with distinct fluorescence signals","volume":"138","author":"Li","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.saa.2026.128813_bb0075","doi-asserted-by":"crossref","first-page":"2263229","DOI":"10.1080\/21645515.2023.2263229","article-title":"An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination","volume":"19","author":"Zhang","year":"2023","journal-title":"Hum. Vaccines"},{"key":"10.1016\/j.saa.2026.128813_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136982","article-title":"A near-infrared fluorescent probe for sensing cuprous ions","volume":"425","author":"Yi","year":"2025","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128813_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphys.2025.112822","article-title":"A Coumarin-Julolidine conjugated novel Schiff base: synthesis, DFT insights, and evaluation of selective and sensitive dual-responsive fluorescence sensing capabilities with cu+ and Cu2+ ions","volume":"598","author":"Niranjan","year":"2025","journal-title":"Chem. Phys."},{"key":"10.1016\/j.saa.2026.128813_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139929","article-title":"Novel coumarin-Schiff base derived electronically distinct fluorescent probes: synthesis and comparative investigations of their unique selective sensing properties with cu2+ and Cu+ ions","volume":"1321","author":"Niranjan","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128813_bb0095","doi-asserted-by":"crossref","first-page":"19068","DOI":"10.1038\/s41598-024-70052-y","article-title":"An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging","volume":"14","author":"Ahmed","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2026.128813_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112048","article-title":"A difunctional fluorescent probe to detect hypochlorite and hydrogen sulfide ions in ferroptosis and oxidative stress induced by aspirin","volume":"224","author":"Ahmed","year":"2024","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128813_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2023.111083","article-title":"Methylene blue-based near-infrared activatable probes for bioimaging","volume":"211","author":"Li","year":"2023","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128813_bb0110","doi-asserted-by":"crossref","first-page":"44023","DOI":"10.1039\/D6RA04207D","article-title":"Design, synthesis and DFT analysis of a highly selective chromenylium based fluorescent probe for cellular imaging and selective detection of sulfite ions","volume":"16","author":"Batool","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2026.128813_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/bios15030174","article-title":"Development of a rapid-response fluorescent probe for H2S: mechanism elucidation and biological applications","volume":"15","author":"Dvorak","year":"2025","journal-title":"Biosensors"},{"key":"10.1016\/j.saa.2026.128813_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123348","article-title":"A dual-responsive fluorescent probe based on cyanine and naphthalimide units for detecting HClO and H2S in living cells","volume":"304","author":"Ding","year":"2024","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.saa.2026.128813_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2023.115232","article-title":"A novel fluorescent probe based on naphthimide for H2S identification and application","volume":"677","author":"Zhang","year":"2023","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.saa.2026.128813_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117285","article-title":"A \u201cturn-on\u201d intracellular pH probe for the quantitative monitoring of lysosomal alkalization in living cells","volume":"277","author":"Ke","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2026.128813_bb0135","doi-asserted-by":"crossref","first-page":"16799","DOI":"10.1021\/jacs.2c03669","article-title":"Urea-bond scission induced by therapeutic ultrasound for biofunctional molecule release","volume":"144","author":"Tong","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128813_bb0140","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1142\/S2737416525500632","article-title":"Hydrazone-Schiff base derivatives bearing polyhydroquinoline scaffold as potent anti-microbial agents: in vitro and molecular docking and DFT insights","volume":"25","author":"Shahab","year":"2025","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.saa.2026.128813_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202402096","article-title":"Synthesis, urease inhibitory activity, molecular docking, dynamics, MMGBSA and DFT studies of hydrazone-Schiff bases bearing benzimidazole scaffold","volume":"22","author":"Shakoor","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.saa.2026.128813_bb0150","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1039\/D5RA10080A","article-title":"Synthesis, multi-target evaluation and DFT analysis of 6-hydroxychromone derived hydrazones with carbonic anhydrase I\u2013II\/acetylcholinesterase inhibition and antioxidant activity","volume":"16","author":"Zareen","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2026.128813_bb0155","article-title":"Therapeutic potential of nitrogen-substituted Oleanolic acid derivatives in Neuroinflammatory and cytokine pathways: insights from cell-based and computational models","volume":"22","author":"\u00c7elik Turgut","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.saa.2026.128813_bb0160","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1080\/07391102.2024.2309646","article-title":"Novel complex compounds of nickel with 3-(1-phenyl-2,3-dimethyl-pyrazolone-5)azopentadione-2,4: synthesis, NBO analysis, reactivity descriptors and in silico and in vitro anti-cancer and bioactivity studies","volume":"43","author":"Tahirli","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2026.128813_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.123983","article-title":"Investigations into the anti-inflammatory and anti-diabetic activity of newly synthesized derivatives of 4AP2BOB utilizing DFT, molecular docking and spectroscopic characterization","volume":"396","author":"Selvakumaran","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2026.128813_bb0170","first-page":"459","article-title":"A fluorescent sensor base on magnetic silica nanoparticles for Cu2+ ions and pyrophosphate mimicking IMPLICATION logic gate","volume":"145","author":"Tian","year":"2014","journal-title":"JOL"},{"key":"10.1016\/j.saa.2026.128813_bb0175","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s11696-023-03231-2","article-title":"An easy-to-apply fluorescent sensor for ClO\u2212 determination using merocyanine 540 in aqueous medium","volume":"78","author":"\u015eenol","year":"2024","journal-title":"Chem. Pap."},{"key":"10.1016\/j.saa.2026.128813_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111466","article-title":"Naphthalimide-phenanthroimidazole incorporated new fluorescent sensor for \u201cturn-on\u201d Cu2+ ions detection in living cancer cells","volume":"220","author":"Anbu","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2026.128813_bb0185","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1039\/b919531a","article-title":"Fluorescence turn-on detection of Cu2+ ions in water samples and living cells based on the unprecedented copper-mediated dihydrorosamine oxidation reaction","volume":"46","author":"Lin","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2026.128813_bb0190","doi-asserted-by":"crossref","first-page":"56539","DOI":"10.1039\/C4RA10936H","article-title":"Cysteine-based fluorescence \u201cturn-on\u201d sensors for Cu2+ ions and ag+","volume":"4","author":"Haridas","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2026.128813_bb0195","first-page":"2456","article-title":"Fast responsive fluorescence turn-on sensor for Cu2+ ions and its application in live cell imaging","volume":"132","author":"Wang","year":"2012","journal-title":"JOL"},{"key":"10.1016\/j.saa.2026.128813_bb0200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.snb.2015.08.035","article-title":"A \u201cturn-on\u201d fluorescent and colorimetric sensor for selective detection of Cu2+ ions in aqueous media and living cells","volume":"222","author":"An","year":"2016","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2026.128813_bb0205","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s10895-017-2161-8","article-title":"Dansyl based \u201cturn-on\u201d fluorescent sensor for Cu2+ ions detection and the application to living cell imaging","volume":"27","author":"Nasomphan","year":"2017","journal-title":"J. Fluoresc."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526013843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526013843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:01:16Z","timestamp":1792231276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526013843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":41,"alternative-id":["S1386142526013843"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128813","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, spectroscopic and DFT investigation of a dual-fluorophore methylene blue\u2013naphthalimide probe for selective Cu2+ ions sensing and HeLa cell imaging","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128813","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128813"}}