{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:43:07Z","timestamp":1792233787442,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004023","name":"University of Jinan","doi-asserted-by":"publisher","award":["00389921"],"award-info":[{"award-number":["00389921"]}],"id":[{"id":"10.13039\/501100004023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MB012"],"award-info":[{"award-number":["ZR2023MB012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.saa.2026.128885","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:01:04Z","timestamp":1790611264000},"page":"128885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dual-channel fluorescence imaging of arginase\/peroxynitrite imbalance in metabolic inflammation-related macrophage models and diabetic liver tissues"],"prefix":"10.1016","volume":"366","author":[{"given":"Andong","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baocun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128885_bb0005","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2017.08.009","article-title":"Foundations of immunometabolism and implications for metabolic health and disease","volume":"47","author":"Hotamisligil","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.saa.2026.128885_bb0010","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0015","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.saa.2026.128885_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.saa.2026.128885_bb0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0030","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.saa.2026.128885_bb0035","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00011-012-0503-1","article-title":"High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-\u03b1\/\u03b4 and NF-\u03baB","volume":"61","author":"Hua","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.saa.2026.128885_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00533","article-title":"Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders","volume":"5","author":"Yang","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0055","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1476-5381.2009.00291.x","article-title":"Arginase: an emerging key player in the mammalian immune system","volume":"158","author":"Munder","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.saa.2026.128885_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.saa.2026.128885_bb0065","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1007\/s00018-021-03828-4","article-title":"Arginine-dependent immune responses","volume":"78","author":"Mart\u00ed i L\u00edndez","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.saa.2026.128885_bb0070","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0075","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrd2222","article-title":"Peroxynitrite: biochemistry, pathophysiology and development of therapeutics","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.saa.2026.128885_bb0080","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.saa.2026.128885_bb0085","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/acs.chemrev.7b00568","article-title":"Biochemistry of peroxynitrite and protein tyrosine nitration","volume":"118","author":"Ferrer-Sueta","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0090","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.redox.2017.09.009","article-title":"Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration","volume":"14","author":"Bartesaghi","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.saa.2026.128885_bb0095","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1039\/c1cs15037e","article-title":"Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species","volume":"40","author":"Chen","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0100","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/acs.accounts.9b00302","article-title":"Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species","volume":"52","author":"Wu","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.saa.2026.128885_bb0105","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1039\/D2CS00172A","article-title":"Recent progress in the development of fluorescent probes for imaging pathological oxidative stress","volume":"52","author":"Geng","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0110","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1039\/C7CS00862G","article-title":"Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging","volume":"47","author":"Liu","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0115","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1021\/jacs.4c17092","article-title":"Advances in organic small molecule-based fluorescent probes for precision detection of liver diseases: a perspective on emerging trends and challenges","volume":"147","author":"Wu","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128885_bb0120","article-title":"Twisted intramolecular charge shuttle (TICS) enables ultrafast ratiometric sensing and imaging of nitrite","author":"Ye","year":"2026","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2026.128885_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202419191","article-title":"Metabolic acidity\/H2O2 dual-cascade-activatable molecular imaging platform toward metastatic breast tumor malignancy","volume":"64","author":"Dou","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2026.128885_bb0130","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1021\/acssensors.5c01623","article-title":"Molecular design of RNA-light probes for super-resolution fluorescence imaging of nucleolar heterogeneity and dynamics","volume":"10","author":"Jiang","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.saa.2026.128885_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216181","article-title":"Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets","volume":"522","author":"Cao","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2026.217960","article-title":"Multichannel fluorescent probes for discriminative detection","volume":"562","author":"Zhou","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128885_bb0145","doi-asserted-by":"crossref","first-page":"7808","DOI":"10.1039\/D3OB00967J","article-title":"Sequential detection of inflammation-related hypochlorite ions and viscosity with a relay fluorescent probe","volume":"21","author":"Zhang","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0150","doi-asserted-by":"crossref","first-page":"10090","DOI":"10.1021\/acs.analchem.1c00911","article-title":"Two-photon, ratiometric, quantitative fluorescent probe reveals fluctuation of peroxynitrite regulated by arginase 1","volume":"93","author":"Chen","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.530","article-title":"Tracking interactions between TAMs and CAFs mediated by arginase-induced proline production during immune evasion of HCC","volume":"5","author":"Wu","year":"2024","journal-title":"Aggregate"},{"key":"10.1016\/j.saa.2026.128885_bb0160","article-title":"A peroxynitrite-specific fluorescent probe combined with phototransformation strategy for detecting nitrate and nitrite in water source and food samples","volume":"444","author":"Wang","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0165","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1021\/acsabm.9b00596","article-title":"Triphenylquinoline (TPQ)-based dual-state emissive probe for cell imaging in multicellular tumor spheroids","volume":"2","author":"Dai","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.saa.2026.128885_bb0170","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1021\/acs.analchem.4c06499","article-title":"Computational chemistry-assisted design of a dual-function fluorescent probe for viscosity sensing in liver damage and SO2 detection in vitro","volume":"97","author":"Liu","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0180","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.saa.2026.128885_bb0185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12865-020-00355-y","article-title":"Progranulin inhibits LPS-induced macrophage M1 polarization via NF-\u03baB and MAPK pathways","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Immunol."},{"key":"10.1016\/j.saa.2026.128885_bb0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.saa.2026.128885_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136714","article-title":"Visualization of labile Fe2+ within the Golgi apparatus during ferroptosis using a novel highly specific fluorescent probe","volume":"423","author":"Yan","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128885_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.567238","article-title":"Ginsenoside compound K attenuates ox-LDL-mediated macrophage inflammation and foam cell formation via autophagy induction and modulating NF-\u03baB, p38, and JNK MAPK signaling","volume":"11","author":"Lu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.saa.2026.128885_bb0205","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/01.RES.0000247034.24662.b4","article-title":"Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling","volume":"99","author":"Ryoo","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.saa.2026.128885_bb0210","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00210-021-02137-8","article-title":"Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide","volume":"394","author":"Suzuki","year":"2021","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.saa.2026.128885_bb0215","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/jre.12912","article-title":"Hyperglycemia modulates M1\/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis","volume":"56","author":"Zhang","year":"2021","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.saa.2026.128885_bb0220","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2419412","article-title":"Arginase: biological and therapeutic implications in diabetes mellitus and its complications","volume":"2022","author":"Ren","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.saa.2026.128885_bb0225","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bbamcr.2019.05.004","article-title":"Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation","volume":"1866","author":"Mazrouei","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"10.1016\/j.saa.2026.128885_bb0230","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jdiacomp.2007.06.013","article-title":"Peroxynitrite-induced protein nitration contributes to liver mitochondrial damage in diabetic rats","volume":"22","author":"Ren","year":"2008","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.saa.2026.128885_bb0235","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1016\/S0021-9258(20)82019-5","article-title":"Elevated manganese concentration and arginase activity in livers of streptozotocin-induced diabetic rats","volume":"258","author":"Bond","year":"1983","journal-title":"J. Biol. Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526014563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526014563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:57:09Z","timestamp":1792231029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526014563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":47,"alternative-id":["S1386142526014563"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128885","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-channel fluorescence imaging of arginase\/peroxynitrite imbalance in metabolic inflammation-related macrophage models and diabetic liver tissues","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"128885"}}