{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:37:59Z","timestamp":1792633079687,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.saa.2026.129005","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:39:49Z","timestamp":1792424389000},"page":"129005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Cascade-activated fluorescent probe for temporal imaging of H2S and microviscosity dynamics under inflammatory stress"],"prefix":"10.1016","volume":"367","author":[{"given":"Yuxi","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.129005_bb0005","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41419-024-07166-8","article-title":"Inflammation in atherosclerosis: pathophysiology and mechanisms","volume":"15","author":"Ajoolabady","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.saa.2026.129005_bb0010","doi-asserted-by":"crossref","first-page":"1611932","DOI":"10.3389\/fimmu.2025.1611932","article-title":"Oxidative stress and inflammation: roles in osteoporosis","volume":"16","author":"Luo","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.saa.2026.129005_bb0015","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/cells14070488","article-title":"The role of inflammation in cancer: mechanisms of tumor initiation, progression, and metastasis","volume":"14","author":"Nishida","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.saa.2026.129005_bb0020","doi-asserted-by":"crossref","first-page":"1592683","DOI":"10.3389\/fendo.2025.1592683","article-title":"Adipose tissue dysfunction disrupts metabolic homeostasis: mechanisms linking fat dysregulation to disease","volume":"16","author":"Bou Matar","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.saa.2026.129005_bb0025","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.saa.2026.129005_bb0030","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3390\/antiox14060656","article-title":"Redox imbalance in inflammation: the interplay of oxidative and reductive stress","volume":"14","author":"Bellanti","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.saa.2026.129005_bb0035","doi-asserted-by":"crossref","first-page":"1126309","DOI":"10.3389\/fchem.2023.1126309","article-title":"H2S-based fluorescent imaging for pathophysiological processes","volume":"11","author":"Jia","year":"2023","journal-title":"Front. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0040","doi-asserted-by":"crossref","first-page":"121378","DOI":"10.1016\/j.ica.2023.121378","article-title":"A highly selective fluorescent probe for detection of H2S based-on benzothiazole and its application","volume":"548","author":"Li","year":"2023","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.saa.2026.129005_bb0045","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3390\/antiox12081570","article-title":"Role of hydrogen sulfide in inflammatory bowel disease","volume":"12","author":"Stummer","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.saa.2026.129005_bb0050","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1039\/C4CS00298A","article-title":"Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems","volume":"44","author":"Lin","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.129005_bb0055","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.ccr.2013.02.028","article-title":"Recent developments of fluorescent probes for the detection of gasotransmitters (NO, CO and H2S)","volume":"257","author":"Kumar","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.129005_bb0060","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/acs.chemrev.3c00573","article-title":"Design and application of fluorescent probes to detect cellular physical microenvironments","volume":"124","author":"Ma","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2026.129005_bb0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1039\/D4TB01785D","article-title":"Mitochondrial membrane potential-independent near-infrared fluorescent probes for viscosity-exclusive imaging","volume":"13","author":"Pan","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2026.129005_bb0070","doi-asserted-by":"crossref","first-page":"25056","DOI":"10.1021\/acs.analchem.5c03834","article-title":"Ferroptosis pathway discrimination and anticancer therapeutic screening enabled by cascade-activated fluorescence reporting of cysteine-viscosity dynamics","volume":"97","author":"Li","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0075","doi-asserted-by":"crossref","first-page":"116802","DOI":"10.1016\/j.jphotochem.2025.116802","article-title":"Mitochondria-targeted near-infrared fluorescent probe for detecting viscosity in tumor and inflammation models","volume":"472","author":"Zhang","year":"2026","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0080","doi-asserted-by":"crossref","first-page":"106107","DOI":"10.1016\/j.bioorg.2022.106107","article-title":"Construction of an in vivo NIR fluorescent probe for revealing the correlation between inflammation and mitochondrial hydrogen sulfide and viscosity","volume":"129","author":"Cui","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0085","doi-asserted-by":"crossref","first-page":"127419","DOI":"10.1016\/j.saa.2025.127419","article-title":"A lysosome-targeted probe based on naphthalimide with dual response H2S and viscosity and its multiple applications in water samples, food spoilage and cellular inflammation","volume":"350","author":"Li","year":"2026","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.saa.2026.129005_bb0090","doi-asserted-by":"crossref","first-page":"106379","DOI":"10.1016\/j.bioorg.2023.106379","article-title":"A near infrared two-channel fluorescent probe for the detection of hydrogen sulfide and viscosity with a negligible crosstalk influence","volume":"132","author":"Liu","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0095","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.3390\/molecules28176195","article-title":"A new fluorescent probe for hydrogen sulfide detection in solution and living cells","volume":"28","author":"Feng","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.129005_bb0100","doi-asserted-by":"crossref","first-page":"136701","DOI":"10.1016\/j.foodchem.2023.136701","article-title":"Red-emitting fluorescent probe for hydrogen sulfide detection and its applications in food freshness determination and in vivo bioimaging","volume":"427","author":"Shang","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0105","doi-asserted-by":"crossref","first-page":"126847","DOI":"10.1016\/j.saa.2025.126847","article-title":"Mitochondria-immobilized fluorescent probes for viscosity and cellular imaging","volume":"346","author":"Wang","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.129005_bb0110","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s11426-023-1661-6","article-title":"Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy","volume":"66","author":"Li","year":"2023","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0115","doi-asserted-by":"crossref","first-page":"124922","DOI":"10.1016\/j.saa.2024.124922","article-title":"Novel thiomaleimide-based fluorescent probe with aggregation-induced emission for detecting H2S","volume":"323","author":"Kong","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.129005_bb0120","doi-asserted-by":"crossref","first-page":"109724","DOI":"10.1016\/j.bioorg.2026.109724","article-title":"Simultaneous detection of H2S and viscosity in pancreatic cancer with a lysosome-targeted NIR fluorescent probe","volume":"174","author":"Kong","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0125","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.cclet.2020.03.063","article-title":"Two-photon dual-channel fluorogenic probe for in situ imaging the mitochondrial H2S\/viscosity in the brain of drosophila Parkinson's disease model","volume":"31","author":"Fang","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.saa.2026.129005_bb0130","doi-asserted-by":"crossref","first-page":"134596","DOI":"10.1016\/j.snb.2023.134596","article-title":"Dual-channel fluorescent probe for simultaneously detecting H2S and viscosity\/polarity and its application in non-alcoholic fatty liver, tumor tissue, and food spoilage","volume":"397","author":"Zan","year":"2023","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0135","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1021\/acs.analchem.6c01319","article-title":"A mitochondria-targeting probe for extended imaging of H2S and viscosity in rheumatoid arthritis","volume":"98","author":"Tang","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0140","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1021\/acs.analchem.8b02068","article-title":"A dual-response fluorescent probe for the detection of viscosity and H2S and its application in studying their cross-talk influence in mitochondria","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0145","doi-asserted-by":"crossref","first-page":"109825","DOI":"10.1016\/j.dyepig.2021.109825","article-title":"NIR fluorescent probe for dual-response viscosity and hydrogen sulfide and its application in Parkinson's disease model","volume":"197","author":"Li","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.129005_bb0150","doi-asserted-by":"crossref","first-page":"343558","DOI":"10.1016\/j.aca.2024.343558","article-title":"Lysosome-targeted dual-locked NIR fluorescent probe for visualization of H2S and viscosity in drug-induced liver injury and tumor models","volume":"1337","author":"Qin","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.129005_bb0155","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00216-024-05130-1","article-title":"A multi-functional fluorescent probe for visualization of H2S and viscosity\/polarity and its application in cancer imaging","volume":"416","author":"Ma","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0160","doi-asserted-by":"crossref","first-page":"343425","DOI":"10.1016\/j.aca.2024.343425","article-title":"An AIE-TICT fluorescence probe cascade responsive to H2S, polarity and viscosity to track microenvironment changes in cellular model of ischemia-reperfusion injury","volume":"1334","author":"Ji","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.129005_bb0165","article-title":"Sequential multistep excited-state structural transformations in N,N\u2019-diphenyl-dihydrodibenzo[a,c]phenazine fluorophores","volume":"62","author":"Jin","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.saa.2026.129005_bb0170","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1021\/jacs.5b03491","article-title":"Excited-state conformational\/electronic responses of saddle-shaped N,N\u2019-disubstituted-dihydrodibenzo[a,c]phenazines: wide-tuning emission from red to deep blue and white light combination","volume":"137","author":"Zhang","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.129005_bb0175","doi-asserted-by":"crossref","first-page":"122621","DOI":"10.1016\/j.talanta.2021.122621","article-title":"A bifunctional probe reveals increased viscosity and hydrogen sulfide in zebra fish model of Parkinson's disease","volume":"234","author":"Shen","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2026.129005_bb0180","doi-asserted-by":"crossref","first-page":"20114","DOI":"10.1039\/D4NJ04573D","article-title":"A highly sensitive triple ratio viscosity probe for fluorescence response across ultra-wide viscosity ranges","volume":"48","author":"Li","year":"2024","journal-title":"New J. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"key":"10.1016\/j.saa.2026.129005_bb0195","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.saa.2026.129005_bb0200","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.carbon.2020.05.023","article-title":"An sp-hybridized all-carboatomic ring, cyclo[18]carbon: electronic structure, electronic spectrum, and optical nonlinearity","volume":"165","author":"Liu","year":"2020","journal-title":"Carbon"},{"key":"10.1016\/j.saa.2026.129005_bb0205","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.saa.2026.129005_bb0210","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1039\/C7CC05339H","article-title":"A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling","volume":"53","author":"Velusamy","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2026.129005_bb0215","doi-asserted-by":"crossref","first-page":"139127","DOI":"10.1016\/j.snb.2025.139127","article-title":"Evaluation of carbon monoxide fluctuation in ferroptosis-mediated osteoarthritis by a metal-free near-infrared fluorescent probe","volume":"449","author":"Liu","year":"2026","journal-title":"Sensors Actuators B Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526015763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526015763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:40:31Z","timestamp":1792629631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526015763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":42,"alternative-id":["S1386142526015763"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.129005","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cascade-activated fluorescent probe for temporal imaging of H2S and microviscosity dynamics under inflammatory stress","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.129005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129005"}}