{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:18:59Z","timestamp":1778782739296,"version":"3.51.4"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1164494"],"award-info":[{"award-number":["APP1164494"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["909426 \/Qianyi Wu\/20"],"award-info":[{"award-number":["909426 \/Qianyi Wu\/20"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Structural Biology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.sbi.2022.102405","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T13:48:55Z","timestamp":1655128135000},"page":"102405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The twisting elevator mechanism of glutamate transporters reveals the structural basis for the dual transport-channel functions"],"prefix":"10.1016","volume":"75","author":[{"given":"Ichia","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Font","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-4610","authenticated-orcid":false,"given":"Renae M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sbi.2022.102405_bib1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1152\/physrev.00007.2013","article-title":"Mechanisms of glutamate transport","volume":"93","author":"Vandenberg","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.sbi.2022.102405_bib2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/383634a0","article-title":"Flux coupling in a neuronal glutamate transporter","volume":"383","author":"Zerangue","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/375599a0","article-title":"An excitatory amino-acid transporter with properties of a ligand-gated chloride channel","volume":"375","author":"Fairman","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0896-6273(95)90159-0","article-title":"Ion fluxes associated with excitatory amino acid transport","volume":"15","author":"Wadiche","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.sbi.2022.102405_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nsmb1230","article-title":"The uncoupled chloride conductance of a bacterial glutamate transporter homolog","volume":"14","author":"Ryan","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib6","doi-asserted-by":"crossref","first-page":"27991","DOI":"10.1074\/jbc.271.45.27991","article-title":"ASCT-1 is a neutral amino acid exchanger with chloride channel activity","volume":"271","author":"Zerangue","year":"1996","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00424-015-1765-6","article-title":"Volume-regulated anion channel--a frenemy within the brain","volume":"468","author":"Mongin","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.sbi.2022.102405_bib8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/glia.23098","article-title":"Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation","volume":"65","author":"Untiet","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.sbi.2022.102405_bib9","doi-asserted-by":"crossref","first-page":"735300","DOI":"10.3389\/fncel.2021.735300","article-title":"Glial chloride homeostasis under transient ischemic stress","volume":"15","author":"Engels","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2002.020586","article-title":"Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes","volume":"542","author":"MacAulay","year":"2002","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.sbi.2022.102405_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1469-7793.2001.0367k.x","article-title":"Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes","volume":"530","author":"MacAulay","year":"2001","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.sbi.2022.102405_bib12","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroscience.2004.06.045","article-title":"Water transport in the brain: role of cotransporters","volume":"129","author":"MacAulay","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.sbi.2022.102405_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cell.2014.12.035","article-title":"Mechanisms of anion conduction by coupled glutamate transporters","volume":"160","author":"Machtens","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2022.102405_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BJ20110905","article-title":"Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1","volume":"439","author":"Vandenberg","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.sbi.2022.102405_bib15","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/nn1793","article-title":"Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling","volume":"9","author":"Veruki","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1113\/jphysiol.2006.118281","article-title":"The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells","volume":"577","author":"Wersinger","year":"2006","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.sbi.2022.102405_bib17","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1152\/jn.00527.2019","article-title":"Light-evoked glutamate transporter EAAT5 activation coordinates with conventional feedback inhibition to control rod bipolar cell output","volume":"123","author":"Bligard","year":"2020","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.sbi.2022.102405_bib18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature05455","article-title":"Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter","volume":"445","author":"Boudker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib19","doi-asserted-by":"crossref","first-page":"13420","DOI":"10.1038\/ncomms13420","article-title":"Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk","volume":"7","author":"Guskov","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2022.102405_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature03018","article-title":"Structure of a glutamate transporter homologue from Pyrococcus horikoshii","volume":"431","author":"Yernool","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature12538","article-title":"Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters","volume":"502","author":"Erkens","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib22","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1073\/pnas.1616413114","article-title":"Direct visualization of glutamate transporter elevator mechanism by high-speed AFM","volume":"114","author":"Ruan","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature12265","article-title":"Transport dynamics in a glutamate transporter homologue","volume":"502","author":"Akyuz","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib24","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/s41589-020-0561-6","article-title":"Use of paramagnetic (19)F NMR to monitor domain movement in a glutamate transporter homolog","volume":"16","author":"Huang","year":"2020","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib25","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1038\/s41467-020-18811-z","article-title":"Millisecond dynamics of an unlabeled amino acid transporter","volume":"11","author":"Matin","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2022.102405_bib26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nsmb.2471","article-title":"Conformational heterogeneity of the aspartate transporter Glt(Ph)","volume":"20","author":"Hanelt","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature22064","article-title":"Structure and allosteric inhibition of excitatory amino acid transporter 1","volume":"544","author":"Canul-Tec","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf5814","article-title":"Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport","volume":"7","author":"Qiu","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.sbi.2022.102405_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41594-018-0076-y","article-title":"Cryo-EM structure of the human neutral amino acid transporter ASCT2","volume":"25","author":"Garaeva","year":"2018","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib30","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1016\/j.csbj.2021.09.015","article-title":"A\u00a0structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1","volume":"19","author":"Stehantsev","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.sbi.2022.102405_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48120","article-title":"Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation","volume":"8","author":"Yu","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_bib32","article-title":"Structural insights into human excitatory amino acid transporter EAAT2","author":"Kato","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.sbi.2022.102405_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nsmb.3179","article-title":"Elevating the alternating-access model","volume":"23","author":"Ryan","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nsmb.2233","article-title":"Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog","volume":"19","author":"Verdon","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_sref35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58417","article-title":"Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters","volume":"9","author":"Wang","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_bib36","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1074\/jbc.REV118.005602","article-title":"Challenges and opportunities in cryo-EM single-particle analysis","volume":"294","author":"Lyumkis","year":"2019","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_sref37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41586-021-03240-9","article-title":"Glutamate transporters have a chloride channel with two hydrophobic gates","volume":"591","author":"Chen","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_sref38","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.1c00769","article-title":"Microscopic characterization of the chloride permeation pathway in the human excitatory amino acid transporter 1 (EAAT1)","author":"Pant","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1085\/jgp.201511556","article-title":"Tuning the ion selectivity of glutamate transporter-associated uncoupled conductances","volume":"148","author":"Cater","year":"2016","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.sbi.2022.102405_bib40","doi-asserted-by":"crossref","first-page":"20742","DOI":"10.1074\/jbc.M304433200","article-title":"The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway","volume":"279","author":"Ryan","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_bib41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bpj.2014.05.046","article-title":"The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation","volume":"107","author":"Cater","year":"2014","journal-title":"Biophys J"},{"key":"10.1016\/j.sbi.2022.102405_bib42","doi-asserted-by":"crossref","first-page":"14936","DOI":"10.1074\/jbc.RA120.013704","article-title":"An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates","volume":"295","author":"Kolen","year":"2020","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_bib43","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41594-020-0402-z","article-title":"Structural and functional characterization of the bestrophin-2 anion channel","volume":"27","author":"Owji","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib44","doi-asserted-by":"crossref","first-page":"E7399","DOI":"10.1073\/pnas.1614688113","article-title":"Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel","volume":"113","author":"Vaisey","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10139","article-title":"Principles of activation and permeation in an anion-selective Cys-loop receptor","volume":"474","author":"Hibbs","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25850","article-title":"Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters","volume":"6","author":"Cheng","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_sref47","doi-asserted-by":"crossref","first-page":"15141","DOI":"10.1073\/pnas.1112216108","article-title":"Large collective motions regulate the functional properties of glutamate transporter trimers","volume":"108","author":"Jiang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib48","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1074\/jbc.M114.630590","article-title":"Transport rates of a glutamate transporter homologue are influenced by the lipid bilayer","volume":"290","author":"McIlwain","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_sref49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50576","article-title":"Large-scale state-dependent membrane remodeling by a transporter protein","volume":"8","author":"Zhou","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_sref50","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41467-020-14834-8","article-title":"Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment","volume":"11","author":"Arkhipova","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2022.102405_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225671","article-title":"Excitatory amino acid transporters in Physiology and disorders of the central nervous system","volume":"20","author":"Malik","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2022.102405_bib52","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ijnp\/pyx050","article-title":"Glutamate transport: a new bench to bedside mechanism for treating drug abuse","volume":"20","author":"Spencer","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.sbi.2022.102405_bib53","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/epi.17154","article-title":"Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function","volume":"63","author":"Kovermann","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.sbi.2022.102405_bib54","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1196\/annals.1444.016","article-title":"Hereditary episodic ataxias","volume":"1142","author":"Jen","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.sbi.2022.102405_bib55","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/brain\/awm126","article-title":"Primary episodic ataxias: diagnosis, pathogenesis and treatment","volume":"130","author":"Jen","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.sbi.2022.102405_bib56","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/jhg.2016.137","article-title":"Late-onset episodic ataxia associated with SLC1A3 mutation","volume":"62","author":"Choi","year":"2017","journal-title":"J\u00a0Hum Genet"},{"key":"10.1016\/j.sbi.2022.102405_bib57","doi-asserted-by":"crossref","first-page":"13855","DOI":"10.1038\/s41598-017-14254-7","article-title":"Genetic variants associated with episodic ataxia in korea","volume":"7","author":"Choi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.sbi.2022.102405_bib58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneurol.2008.535","article-title":"Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake","volume":"66","author":"de Vries","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.sbi.2022.102405_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s10038-017-0365-z","article-title":"A\u00a0novel mutation in SLC1A3 causes episodic ataxia","volume":"63","author":"Iwama","year":"2018","journal-title":"J\u00a0Hum Genet"},{"key":"10.1016\/j.sbi.2022.102405_bib60","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000172638.58172.5a","article-title":"Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures","volume":"65","author":"Jen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.sbi.2022.102405_sref61","doi-asserted-by":"crossref","first-page":"fcaa022","DOI":"10.1093\/braincomms\/fcaa022","article-title":"Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6","volume":"2","author":"Kovermann","year":"2020","journal-title":"Brain Commun"},{"key":"10.1016\/j.sbi.2022.102405_bib62","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1523\/JNEUROSCI.0197-16.2016","article-title":"Disruption of an EAAT-mediated chloride channel in a Drosophila model of ataxia","volume":"36","author":"Parinejad","year":"2016","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib63","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1093\/brain\/aws255","article-title":"A\u00a0point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents","volume":"135","author":"Winter","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.sbi.2022.102405_sref64","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154891","article-title":"Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function","author":"Wu","year":"2022","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.sbi.2022.102405_sref65","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/humu.24089","article-title":"Functional consequences of SLC1A3 mutations associated with episodic ataxia 6","volume":"41","author":"Chivukula","year":"2020","journal-title":"Hum Mutat"},{"key":"10.1016\/j.sbi.2022.102405_bib66","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1073\/pnas.0610470104","article-title":"On the thermodynamic stability of a charged arginine side chain in a transmembrane helix","volume":"104","author":"Dorairaj","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib67","doi-asserted-by":"crossref","first-page":"33874","DOI":"10.1074\/jbc.M804016200","article-title":"Na-K-Cl Cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling","volume":"283","author":"Jayakumar","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sbi.2022.102405_bib68","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2008.07.017","article-title":"Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells","volume":"442","author":"Ringel","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.sbi.2022.102405_bib69","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrm.2016.29","article-title":"VRACs and other ion channels and transporters in the regulation of cell volume and beyond","volume":"17","author":"Jentsch","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib70","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.18-19-07650.1998","article-title":"Macroscopic and microscopic properties of a cloned glutamate transporter\/chloride channel","volume":"18","author":"Wadiche","year":"1998","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib71","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib72","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11064-015-1699-6","article-title":"The split personality of glutamate transporters: a chloride channel and a transporter","volume":"41","author":"Cater","year":"2016","journal-title":"Neurochem Res"},{"key":"10.1016\/j.sbi.2022.102405_bib73","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46986","article-title":"Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport","volume":"8","author":"Walter","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_bib74","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1073\/pnas.93.16.8671","article-title":"Norepinephrine transporters have channel modes of conduction","volume":"93","author":"Galli","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib75","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nn920","article-title":"Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons","volume":"5","author":"Ingram","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.sbi.2022.102405_bib76","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0896-6273(03)00605-6","article-title":"Regulating the conducting states of a mammalian serotonin transporter","volume":"40","author":"Quick","year":"2003","journal-title":"Neuron"},{"issue":"Pt 3","key":"10.1016\/j.sbi.2022.102405_bib77","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1113\/jphysiol.1996.sp021178","article-title":"Sodium-dependent GABA-induced currents in GAT1-transfected HeLa cells","volume":"490","author":"Risso","year":"1996","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.sbi.2022.102405_bib78","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1529\/biophysj.106.100776","article-title":"The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates","volume":"92","author":"Zhang","year":"2007","journal-title":"Biophys J"},{"key":"10.1016\/j.sbi.2022.102405_bib79","first-page":"E2036","article-title":"Two tonoplast MATE proteins function as turgor-regulating chloride channels in Arabidopsis","volume":"114","author":"Zhang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sbi.2022.102405_bib80","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nsmb.3166","article-title":"The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism","volume":"23","author":"Mulligan","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2022.102405_bib81","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09375","article-title":"Mechanism of Na(+)-dependent citrate transport from the structure of an asymmetrical CitS dimer","volume":"4","author":"Wohlert","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.sbi.2022.102405_bib82","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature22057","article-title":"Visualizing multistep elevator-like transitions of a nucleoside transporter","volume":"545","author":"Hirschi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2022.102405_bib83","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev-biochem-060815-014520","article-title":"Shared molecular mechanisms of membrane transporters","volume":"85","author":"Drew","year":"2016","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.sbi.2022.102405_bib84","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1073\/pnas.94.8.4155","article-title":"Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance","volume":"94","author":"Arriza","year":"1997","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Current Opinion in Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X22000847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X22000847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:06:57Z","timestamp":1778782017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959440X22000847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":84,"alternative-id":["S0959440X22000847"],"URL":"https:\/\/doi.org\/10.1016\/j.sbi.2022.102405","relation":{},"ISSN":["0959-440X"],"issn-type":[{"value":"0959-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The twisting elevator mechanism of glutamate transporters reveals the structural basis for the dual transport-channel functions","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sbi.2022.102405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102405"}}