{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T01:18:12Z","timestamp":1794532692600,"version":"4.9.1"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Structural Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.sbi.2026.103330","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:40:24Z","timestamp":1783957224000},"page":"103330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multimodal biophysical markers of neurodegeneration: Morphology, mechanics, and thermodynamics"],"prefix":"10.1016","volume":"100","author":[{"given":"Tonya","family":"Andreeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Tuparev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-4516","authenticated-orcid":false,"given":"Stefka G.","family":"Taneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sbi.2026.103330_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","article-title":"Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade","volume":"86","author":"Chiti","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.sbi.2026.103330_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrneurol.2018.9","article-title":"Imaging tau and amyloid-\u03b2 proteinopathies in Alzheimer disease and other conditions","volume":"14","author":"Villemagne","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.sbi.2026.103330_bib3","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.3390\/ijms21124287","article-title":"High-speed atomic force microscopy reveals the structural dynamics of the Amyloid-\u03b2 and amylin aggregation pathways","volume":"21","author":"Watanabe-Nakayama","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_sref4","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1021\/acsnano.5c20737","article-title":"Zooming into disease at the nanoscale: high-speed atomic force microscopy in biomedical discovery","volume":"20","author":"Lim","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.sbi.2026.103330_bib5","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3390\/ijms24021226","article-title":"Assessment of plasma and cerebrospinal fluid biomarkers in different stages of +-lzheimer's disease and frontotemporal dementia","volume":"24","author":"\u00c1lvarez-S\u00e1nchez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib6","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/brain\/awac407","article-title":"Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration","volume":"146","author":"Gonzalez-Ortiz","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.sbi.2026.103330_sref7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/mds.29766","article-title":"Detecting misfolded \u03b1-Synuclein in blood years before the diagnosis of parkinson's disease","volume":"39","author":"Kluge","year":"2024","journal-title":"Mov Disord"},{"key":"10.1016\/j.sbi.2026.103330_sref8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1021\/acsmeasuresciau.5c00116","article-title":"Single-oligomer characterization of tau phosphorylation and mechanical state","volume":"5","author":"Pillai","year":"2025","journal-title":"ACS Meas Sci Au"},{"key":"10.1016\/j.sbi.2026.103330_sref9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-026-04206-y","article-title":"Predicting onset of symptomatic alzheimer\u02bcs disease with plasma p-tau217 clocks","volume":"32","author":"Petersen","year":"2026","journal-title":"Nat Med"},{"key":"10.1016\/j.sbi.2026.103330_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3233\/CH-162066","article-title":"Identification of erythrocyte biomarkers in amyotrophic lateral sclerosis","volume":"63","author":"Lima","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.sbi.2026.103330_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5114\/fn.2018.74655","article-title":"Platelets, lymphocytes and erythrocytes from Alzheimer's disease patients: the quest for blood cell-based biomarkers","volume":"56","author":"Pluta","year":"2018","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.sbi.2026.103330_bib12","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.micron.2012.03.019","article-title":"Structure and function in native and pathological erythrocytes: a quantitative view from the nanoscale","volume":"43","author":"Girasole","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.sbi.2026.103330_sref13","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/biof.2030","article-title":"Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients","volume":"50","author":"Lopes","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.sbi.2026.103330_sref14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12551-025-01306-w","article-title":"Nanotechnology meets medicine: applications of atomic force microscopy in disease","volume":"17","author":"Matias","year":"2025","journal-title":"Biophys Rev"},{"key":"10.1016\/j.sbi.2026.103330_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814296","article-title":"Morphometric and nanomechanical screening of peripheral blood cells with atomic force microscopy for label-free assessment of alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis","volume":"24","author":"Taneva","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s44258-024-00022-6","article-title":"Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies","volume":"2","author":"She","year":"2024","journal-title":"Med-X"},{"key":"10.1016\/j.sbi.2026.103330_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2732","article-title":"Insight into the morphological pattern of erythrocytes' aging: coupling quantitative AFM data to microcalorimetry and raman spectroscopy","volume":"31","author":"Dinarelli","year":"2018","journal-title":"J Mol Recogn"},{"key":"10.1016\/j.sbi.2026.103330_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710180","article-title":"Mechano-transduction boosts the aging effects in human erythrocytes submitted to mechanical stimulation","volume":"23","author":"Dinarelli","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_sref19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/mps8040086","article-title":"Comparing nanomechanical properties and membrane roughness along the aging of human erythrocytes","volume":"8","author":"Longo","year":"2025","journal-title":"Methods Protoc"},{"key":"10.1016\/j.sbi.2026.103330_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cis.2017.05.011","article-title":"Atomic force microscopy: from red blood cells to immunohaematology","volume":"249","author":"Yeow","year":"2017","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib21","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1039\/C5NR03145A","article-title":"Mapping viscoelastic properties of healthy and pathological red blood cells at the nanoscale level","volume":"7","author":"Ciasca","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.sbi.2026.103330_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbbm.2005.11.003","article-title":"Stiffness of normal and pathological erythrocytes studied by means of atomic force microscopy","volume":"66","author":"Duli\u0144ska","year":"2006","journal-title":"J Biochem Biophys Methods"},{"key":"10.1016\/j.sbi.2026.103330_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1039\/C7NH00187H","article-title":"Nanoscale membrane architecture of healthy and pathological red blood cells","volume":"3","author":"Dumitru","year":"2018","journal-title":"Nanoscale Horiz"},{"key":"10.1016\/j.sbi.2026.103330_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-00152-w","article-title":"A novel red blood cell deformability biomarker is associated with hemolysis and vaso-occlusive crises in sickle cell disease","volume":"15","author":"Sahun","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.sbi.2026.103330_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2025.104278","article-title":"RBC deformability and clinical relevance in transfusion recipients","volume":"64","author":"Yazdanbakhsh","year":"2025","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2026.103330_bib27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fmed.2018.00198","article-title":"Disturbed red blood cell structure and function: an exploration of the role of red blood cells in neurodegeneration","volume":"5","author":"Bosman","year":"2018","journal-title":"Front Med"},{"key":"10.1016\/j.sbi.2026.103330_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125580","article-title":"Abnormal red cell structure and function in neuroacanthocytosis","volume":"10","author":"Cluitmans","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.sbi.2026.103330_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/ijms23010227","article-title":"Morphometry and stiffness of red blood cells - signatures of neurodegenerative diseases and aging","volume":"23","author":"Strijkova-Kenderova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib30","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1021\/nn303824j","article-title":"Structural and mechanical heterogeneity of the erythrocyte membrane reveals hallmarks of membrane stability","volume":"7","author":"Picas","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.sbi.2026.103330_bib31","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1038\/srep09768","article-title":"Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress","volume":"5","author":"Sinha","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.sbi.2026.103330_bib32","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/cells14151139","article-title":"The mechanical properties of erythrocytes are influenced by the conformational state of albumin","volume":"14","author":"Pajic-Lijakovic","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.sbi.2026.103330_sref33","doi-asserted-by":"crossref","first-page":"fcae180","DOI":"10.1093\/braincomms\/fcae180","article-title":"Protein fibril aggregation on red blood cells: a potential biomarker to distinguish neurodegenerative diseases from healthy aging","volume":"6","author":"Schneider","year":"2024","journal-title":"Brain Commun"},{"key":"10.1016\/j.sbi.2026.103330_bib34","first-page":"307","article-title":"Erythrocyte stiffness probed using atomic force microscope","volume":"42","author":"Lekka","year":"2005","journal-title":"Biorheology"},{"key":"10.1016\/j.sbi.2026.103330_bib35","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.bbrc.2009.12.133","article-title":"Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope","volume":"391","author":"Jin","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.sbi.2026.103330_sref36","first-page":"1242","article-title":"Deformability of heterogeneous red blood cells in aging and related pathologies","volume":"16","author":"Prudinnik","year":"2025","journal-title":"Aging Dis"},{"key":"10.1016\/j.sbi.2026.103330_bib37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.sbi.2026.103330_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.932354","article-title":"Sensing red blood cell nano-mechanics: toward a novel blood biomarker for Alzheimer's disease","volume":"14","author":"Nardini","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.sbi.2026.103330_bib39","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/med.21712","article-title":"Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: finding ways for prevention","volume":"41","author":"Angelova","year":"2021","journal-title":"Med Res Rev"},{"key":"10.1016\/j.sbi.2026.103330_bib40","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.3390\/ijms19092582","article-title":"Identification of oxidative stress in red blood cells with nanoscale chemical resolution by infrared nanospectroscopy","volume":"19","author":"Ruggeri","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnagi.2013.00088","article-title":"High ferritin levels have major effects on the morphology of erythrocytes in alzheimer's disease","volume":"5","author":"Bester","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.sbi.2026.103330_bib42","first-page":"67","article-title":"Iron pathophysiology in alzheimer's diseases","volume":"1173","author":"Wang","year":"2019"},{"key":"10.1016\/j.sbi.2026.103330_bib43","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.3390\/biomedicines10092239","article-title":"Platelets' nanomechanics and morphology in neurodegenerative pathologies","volume":"10","author":"Strijkova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.sbi.2026.103330_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/00207454.2010.537416","article-title":"Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with amyotrophic lateral sclerosis","volume":"121","author":"Shrivastava","year":"2011","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.sbi.2026.103330_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/09537104.2023.2267147","article-title":"\u03b1-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis","volume":"34","author":"Smith","year":"2023","journal-title":"Platelets"},{"key":"10.1016\/j.sbi.2026.103330_bib46","doi-asserted-by":"crossref","first-page":"eabj2137","DOI":"10.1126\/sciadv.abj2137","article-title":"Spatial organization of protein aggregates on red blood cells as physical biomarkers of alzheimer's disease pathology","volume":"7","author":"Nirmalraj","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.sbi.2026.103330_bib47","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbamem.2018.07.009","article-title":"Morphological changes induced in erythrocyte by amyloid beta peptide and glucose depletion: a combined 847 atomic force microscopy and biochemical study","volume":"1861","author":"Carelli-Alinovi","year":"2019","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.sbi.2026.103330_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262311361","article-title":"Amyloid \u03b2 peptide modifies membrane architecture and surface electrostatic properties of human red blood cells","volume":"26","author":"Staneva","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib49","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.3390\/biomedicines13123104","article-title":"Amyloid proteins-induced remodeling of morphometry and nanomechanics in human platelets","volume":"13","author":"Andreeva","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.sbi.2026.103330_bib50","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1096\/fj.13-243691","article-title":"Amyloid \u03b2 peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization","volume":"28","author":"Sonkar","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.sbi.2026.103330_bib51","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1111\/jth.15055","article-title":"Fibrillar amyloid peptides promote platelet aggregation through the coordinated action of ITAM- and ROS-Dependent pathways","volume":"18","author":"Visconte","year":"2020","journal-title":"J Thromb Haemostasis"},{"key":"10.1016\/j.sbi.2026.103330_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/986254","article-title":"Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease","volume":"2013","author":"Kocer","year":"2013","journal-title":"Curr Gerontol Geriatr Res"},{"key":"10.1016\/j.sbi.2026.103330_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02590","article-title":"Alpha synuclein in hematopoiesis and immunity","volume":"5","author":"Pei","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.sbi.2026.103330_bib54","doi-asserted-by":"crossref","first-page":"9880","DOI":"10.1038\/s41598-022-12886-y","article-title":"Exogenous human \u03b1-Synuclein acts in vitro as a mild platelet antiaggregant inhibiting \u03b1-thrombin-induced platelet activation","volume":"12","author":"Acquasaliente","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.sbi.2026.103330_bib55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-023-03003-5","article-title":"Peripheral blood amyloid-\u03b2 involved in the pathogenesis of Alzheimer's disease via impacting on peripheral innate immune cells","volume":"21","author":"Shi","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.sbi.2026.103330_bib56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fncel.2015.00065","article-title":"Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease","volume":"9","author":"Canobbio","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.sbi.2026.103330_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114683","article-title":"Potential links between platelets and amyloid-\u03b2 in the pathogenesis of Alzheimer's disease: evidence from in vitro, in vivo, and clinical studies","volume":"374","author":"Yubolphan","year":"2024","journal-title":"Exp Neurol"},{"key":"10.1016\/j.sbi.2026.103330_bib58","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jalz.2017.03.010","article-title":"Peripheral complement interactions with amyloid \u03b2 peptide: Erythrocyte clearance mechanisms","volume":"13","author":"Brubaker","year":"2017","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.sbi.2026.103330_bib59","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1529\/biophysj.107.119453","article-title":"Calorimetry outside the box: a new window into the plasma proteome","volume":"94","author":"Garbett","year":"2008","journal-title":"Biophys J"},{"key":"10.1016\/j.sbi.2026.103330_bib60","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yexmp.2008.12.001","article-title":"Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring","volume":"86","author":"Garbett","year":"2009","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.sbi.2026.103330_bib61","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/jpm11040295","article-title":"Thermal liquid biopsy (TLB) of blood plasma as a potential tool to help in the early diagnosis of multiple sclerosis","volume":"11","author":"Annesi","year":"2021","journal-title":"J Personalized Med"},{"key":"10.1016\/j.sbi.2026.103330_bib62","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/ijms24010789","article-title":"Thermodynamic signatures of blood plasma proteome in neurodegenerative pathologies","volume":"24","author":"Danailova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sbi.2026.103330_bib63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tca.2018.02.014","article-title":"Differential scanning calorimetry study of early and advanced stages in Parkinson's disease using human blood serum","volume":"662","author":"Michnik","year":"2018","journal-title":"Thermochim Acta"},{"key":"10.1016\/j.sbi.2026.103330_bib64","article-title":"Albumin alters the conformational ensemble of Amyloid-\u03b2 by promiscuous interactions: implications for amyloid inhibition","volume":"23","author":"Xie","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.sbi.2026.103330_bib65","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s10973-025-15269-3","article-title":"Multicriteria decision-making analysis for identifying interrelations between thermodynamic parameters of blood plasma","volume":"151","author":"Taneva","year":"2026","journal-title":"J Therm Anal Calorim"},{"key":"10.1016\/j.sbi.2026.103330_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.617370","article-title":"Evidence for peripheral immune activation in parkinson's disease","volume":"13","author":"Chen","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.sbi.2026.103330_sref67","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/cancers18010060","article-title":"Automated baseline-correction and signal-detection algorithms with web-based implementation for thermal liquid biopsy data analysis","volume":"18","author":"Reger","year":"2026","journal-title":"Cancers"},{"key":"10.1016\/j.sbi.2026.103330_sref68","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.mattod.2025.12.036","article-title":"Advancing analysis of differential scanning calorimetry data \u2013 converging DSC and AI","volume":"92","author":"Dargaville","year":"2026","journal-title":"Mater Today"},{"key":"10.1016\/j.sbi.2026.103330_bib69","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3390\/biom11101500","article-title":"Red blood cells' thermodynamic behavior in neurodegenerative pathologies and aging","volume":"11","author":"Todinova","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.sbi.2026.103330_bib70","article-title":"Preanalytical errors in clinical laboratory testing at a glance: source and control measures","volume":"16","author":"Nordin","year":"2024","journal-title":"Cureus"}],"container-title":["Current Opinion in Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X26001120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X26001120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:13:42Z","timestamp":1794273222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959440X26001120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":70,"alternative-id":["S0959440X26001120"],"URL":"https:\/\/doi.org\/10.1016\/j.sbi.2026.103330","relation":{},"ISSN":["0959-440X"],"issn-type":[{"value":"0959-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal biophysical markers of neurodegeneration: Morphology, mechanics, and thermodynamics","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sbi.2026.103330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103330"}}