{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:51:01Z","timestamp":1791579061467,"version":"4.3.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","award":["AJE20171039021"],"award-info":[{"award-number":["AJE20171039021"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-23-CE11-0002-03"],"award-info":[{"award-number":["ANR-23-CE11-0002-03"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-24-CE12-1416"],"award-info":[{"award-number":["ANR-24-CE12-1416"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"La Ligue Contre Le Cancer","doi-asserted-by":"publisher","award":["JMG\/SP - n\\u00B0 01B.2021"],"award-info":[{"award-number":["JMG\/SP - n\\u00B0 01B.2021"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Structural Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.sbi.2026.103409","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:18:35Z","timestamp":1791217115000},"page":"103409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Panta rhei: Chromatin remodeling dynamics"],"prefix":"10.1016","volume":"101","author":[{"given":"Asgar Abbas","family":"Kazrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2284-9868","authenticated-orcid":false,"given":"Franck","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4663-9078","authenticated-orcid":false,"given":"Julie","family":"Lafouge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2958-0025","authenticated-orcid":false,"given":"Elisa","family":"Bergamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sbi.2026.103409_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017905","article-title":"Nucleosome remodeling and epigenetics","volume":"5","author":"Becker","year":"2013","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrm.2017.26","article-title":"Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes","volume":"18","author":"Clapier","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1146\/annurev-biochem-051810-093157","article-title":"Regulating the chromatin landscape: structural and mechanistic perspectives","volume":"83","author":"Bartholomew","year":"2014","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.sbi.2026.103409_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.cell.2013.07.011","article-title":"Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes","volume":"154","author":"Narlikar","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/cr.2011.32","article-title":"ATP-dependent chromatin remodeling: genetics, genomics and mechanisms","volume":"21","author":"Hargreaves","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.sbi.2026.103409_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.2628","article-title":"Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy","volume":"45","author":"Kadoch","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.sbi.2026.103409_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrc3068","article-title":"SWI\/SNF nucleosome remodellers and cancer","volume":"11","author":"Wilson","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.sbi.2026.103409_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41573-024-00978-5","article-title":"Chromatin remodellers as therapeutic targets","volume":"23","author":"Malone","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.sbi.2026.103409_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1690350","article-title":"Chromatin remodeling complexes: architects influencing breast cancer progression","volume":"13","author":"Giovani","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib11","doi-asserted-by":"crossref","unstructured":"Kadoch C, Crabtree GR: Mammalian SWI\/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics. Sci Adv [date unknown], 1:e1500447.","DOI":"10.1126\/sciadv.1500447"},{"key":"10.1016\/j.sbi.2026.103409_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.canlet.2018.01.046","article-title":"BAFfling pathologies: alterations of BAF complexes in cancer","volume":"419","author":"Arnaud","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.sbi.2026.103409_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.gde.2017.02.004","article-title":"Mammalian SWI\/SNF complexes in cancer: emerging therapeutic opportunities","volume":"42","author":"St Pierre","year":"2017","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.sbi.2026.103409_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fnmol.2017.00243","article-title":"Chromatin remodeling BAF (SWI\/SNF) complexes in neural development and disorders","volume":"10","author":"Sokpor","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.sbi.2026.103409_bib15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3892\/or.2014.3584","article-title":"Loss of function of SWI\/SNF chromatin remodeling genes leads to genome instability of human lung cancer","volume":"33","author":"Huang","year":"2015","journal-title":"Oncol Rep"},{"key":"10.1016\/j.sbi.2026.103409_bib16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.molcel.2026.02.010","article-title":"Functional landscape of non-canonical open reading frames in coordinating cell fate","volume":"86","author":"Zhu","year":"2026","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2021.107702","article-title":"3D variability analysis: resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM","volume":"213","author":"Punjani","year":"2021","journal-title":"J Struct Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.sbi.2026.103409_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nsmb973","article-title":"Chromatin remodeling through directional DNA translocation from an internal nucleosomal site","volume":"12","author":"Saha","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib20","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1101\/gad.995002","article-title":"Chromatin remodeling by RSC involves ATP-dependent DNA translocation","volume":"16","author":"Saha","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.sbi.2026.103409_bib21","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10051","article-title":"Stepwise nucleosome translocation by RSC remodeling complexes","volume":"5","author":"Harada","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_bib22","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1038\/emboj.2011.141","article-title":"The RSC chromatin remodelling ATPase translocates DNA with high force and small step size","volume":"30","author":"Sirinakis","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.sbi.2026.103409_bib23","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41467-019-09657-1","article-title":"Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling","volume":"10","author":"Sabantsev","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2026.103409_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nature22036","article-title":"Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure","volume":"544","author":"Liu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41586-019-1029-2","article-title":"Mechanism of DNA translocation underlying chromatin remodelling by Snf2","volume":"567","author":"Li","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_sref26","doi-asserted-by":"crossref","DOI":"10.1126\/science.adu5654","article-title":"Structural insights into chromatin remodeling by ISWI during active ATP hydrolysis","volume":"388","author":"Sia","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_sref27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41422-025-01103-w","article-title":"Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H","volume":"35","author":"Malik","year":"2025","journal-title":"Cell Res"},{"key":"10.1016\/j.sbi.2026.103409_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature20590","article-title":"Structure and regulation of the chromatin remodeller ISWI","volume":"540","author":"Yan","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib29","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1093\/nar\/gkw068","article-title":"The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo","volume":"44","author":"Ocampo","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sbi.2026.103409_sref30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41594-023-01174-6","article-title":"Structure of the ISW1a complex bound to the dinucleosome","volume":"31","author":"Li","year":"2024","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa3761","article-title":"Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler","volume":"355","author":"Sinha","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169480","article-title":"ISWI is an intrinsically dynamic nucleosome remodeler that induces large-scale histone dynamics","volume":"437","author":"Lobbia","year":"2025","journal-title":"J Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib33","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jmb.2017.02.002","article-title":"The sequence of nucleosomal DNA modulates sliding by the Chd1 chromatin remodeler","volume":"429","author":"Winger","year":"2017","journal-title":"J Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib34","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/emboj\/cdg179","article-title":"Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes","volume":"22","author":"Simic","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.sbi.2026.103409_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.166929","article-title":"Structure and function of chromatin remodelers","volume":"433","author":"Reyes","year":"2021","journal-title":"J Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.molcel.2010.08.012","article-title":"The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor","volume":"39","author":"Hauk","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature24046","article-title":"Nucleosome\u2013Chd1 structure and implications for chromatin remodelling","volume":"550","author":"Farnung","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_sref38","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s41594-025-01556-y","article-title":"A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA","volume":"32","author":"Nodelman","year":"2025","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_sref39","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.molcel.2025.04.020","article-title":"Structural basis of human CHD1 nucleosome recruitment and pausing","volume":"85","author":"James","year":"2025","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41594-021-00719-x","article-title":"Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state","volume":"29","author":"Nodelman","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nsmb1071","article-title":"Chromatin remodeling by ISW2 and SWI\/SNF requires DNA translocation inside the nucleosome","volume":"13","author":"Zofall","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib42","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nsmb1102","article-title":"Probing SWI\/SNF remodeling of the nucleosome by unzipping single DNA molecules","volume":"13","author":"Shundrovsky","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1097-2765(03)00039-X","article-title":"SWI\/SNF Unwraps, slides, and rewraps the nucleosome","volume":"11","author":"Kassabov","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.str.2017.12.015","article-title":"Structural architecture of the nucleosome remodeler ISWI determined from cross-linking, mass spectrometry, SAXS, and modeling","volume":"26","author":"Harrer","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.sbi.2026.103409_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22510","article-title":"Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes","volume":"6","author":"Sundaramoorthy","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46057","article-title":"Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome","volume":"8","author":"Armache","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_bib47","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature20590","article-title":"Structure and regulation of the chromatin remodeller ISWI","volume":"540","author":"Yan","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41586-020-2088-0","article-title":"Structure of SWI\/SNF chromatin remodeller RSC bound to a nucleosome","volume":"579","author":"Wagner","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib49","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.cell.2020.09.051","article-title":"A structural model of the endogenous human BAF complex informs disease mechanisms","volume":"183","author":"Mashtalir","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib50","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.aaz9761","article-title":"Structure of nucleosome-bound human BAF complex","volume":"367","author":"He","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_bib51","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-022-04658-5","article-title":"Structure of human chromatin-remodelling PBAF complex bound to a nucleosome","volume":"605","author":"Yuan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib52","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.aay0033","article-title":"Structure of the RSC complex bound to the nucleosome","volume":"366","author":"Ye","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54449","article-title":"Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement","volume":"8","author":"Patel","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_bib54","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1038\/s41467-022-34859-5","article-title":"Structure of nucleosome-bound human PBAF complex","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2026.103409_bib55","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.cell.2018.09.032","article-title":"Modular organization and assembly of SWI\/SNF family chromatin remodeling complexes","volume":"175","author":"Mashtalir","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2026.103409_sref56","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.molcel.2026.01.021","article-title":"The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4\u2013SOX2","volume":"86","author":"Weiss","year":"2026","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_sref57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91433","article-title":"Dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers","volume":"12","author":"Kim","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_sref58","doi-asserted-by":"crossref","first-page":"7646","DOI":"10.1038\/s41467-024-52040-y","article-title":"Single-molecule imaging of SWI\/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics","volume":"15","author":"Engl","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2026.103409_sref59","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41421-025-00858-1","article-title":"ncBAF recognizes the nucleosome through BCL7A in chromatin remodeling","volume":"11","author":"Chen","year":"2025","journal-title":"Cell Discov"},{"key":"10.1016\/j.sbi.2026.103409_sref60","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkag092","article-title":"Structural basis for BCL7B-mediated ncBAF-nucleosome engagement","volume":"54","author":"Sun","year":"2026","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sbi.2026.103409_sref61","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf273","article-title":"Structure of the nucleosome-bound human BCL7A","volume":"53","author":"Martin","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sbi.2026.103409_bib62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41594-017-0003-7","article-title":"Cryo-EM structures of the human INO80 chromatin-remodeling complex","volume":"25","author":"Aramayo","year":"2018","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib63","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41586-018-0029-y","article-title":"Structural basis for ATP-dependent chromatin remodelling by the INO80 complex","volume":"556","author":"Eustermann","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_bib64","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41586-018-0021-6","article-title":"Structure and regulation of the human INO80\u2013nucleosome complex","volume":"556","author":"Ayala","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.sbi.2026.103409_sref65","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkag138","article-title":"Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex","volume":"54","author":"Aggarwal","year":"2026","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.sbi.2026.103409_bib66","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.molcel.2022.04.026","article-title":"A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function","volume":"82","author":"Hsieh","year":"2022","journal-title":"Mol Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib67","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1126\/science.adf6287","article-title":"Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling","volume":"381","author":"Zhang","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add3189","article-title":"Structural mechanism of extranucleosomal DNA readout by the INO80 complex","volume":"8","author":"Kunert","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.sbi.2026.103409_bib69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1126\/science.adf4197","article-title":"Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility","volume":"381","author":"Wu","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.sbi.2026.103409_bib70","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.sbi.2026.103409_bib71","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s41588-023-01451-6","article-title":"Landscape of mSWI\/SNF chromatin remodeling complex perturbations in neurodevelopmental disorders","volume":"55","author":"Valencia","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.sbi.2026.103409_bib72","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.2628","article-title":"Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy","volume":"45","author":"Kadoch","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.sbi.2026.103409_bib73","doi-asserted-by":"crossref","DOI":"10.1080\/19491034.2023.2165604","article-title":"Mechanism of action of the SWI\/SNF family complexes","volume":"14","author":"Chen","year":"2023","journal-title":"Nucleus"},{"key":"10.1016\/j.sbi.2026.103409_bib74","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026930","article-title":"The many roles of BAF (mSWI\/SNF) and PBAF complexes in cancer","volume":"6","author":"Hodges","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.sbi.2026.103409_bib75","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41576-023-00666-x","article-title":"Context-specific functions of chromatin remodellers in development and disease","volume":"25","author":"Gourisankar","year":"2024","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.sbi.2026.103409_bib76","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1038\/s41467-026-71531-8","article-title":"SMARCB1 missense mutants disrupt SWI\/SNF complex stability and remodeling activity","volume":"17","author":"Cooper","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.sbi.2026.103409_bib77","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s42003-021-02050-z","article-title":"SWI\/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site","volume":"4","author":"Allen","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.sbi.2026.103409_bib78","article-title":"Pathogenic variants in SMARCA5 , a chromatin remodeler, cause a range of syndromic neurodevelopmental features","volume":"7","author":"Li","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.sbi.2026.103409_bib79","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56178","article-title":"Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations","volume":"9","author":"Farnung","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.sbi.2026.103409_sref80","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr3831","article-title":"Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning","volume":"389","author":"Kaur","year":"2025","journal-title":"Science"}],"container-title":["Current Opinion in Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X26001910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959440X26001910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:12:02Z","timestamp":1791576722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959440X26001910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":80,"alternative-id":["S0959440X26001910"],"URL":"https:\/\/doi.org\/10.1016\/j.sbi.2026.103409","relation":{},"ISSN":["0959-440X"],"issn-type":[{"value":"0959-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Panta rhei: Chromatin remodeling dynamics","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sbi.2026.103409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103409"}}