{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:36:39Z","timestamp":1791117399873,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.schres.2007.04.028","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T07:13:01Z","timestamp":1183187581000},"page":"137-151","source":"Crossref","is-referenced-by-count":137,"title":["A meta-analysis of P50 studies in patients with schizophrenia and relatives: Differences in methodology between research groups"],"prefix":"10.1016","volume":"97","author":[{"given":"O.M.","family":"de Wilde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Bour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Dingemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.T.M.","family":"Koelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.H.","family":"Linszen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.schres.2007.04.028_bib1","first-page":"639","article-title":"Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia","volume":"17","author":"Adler","year":"1982","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.schres.2007.04.028_bib2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/0006-3223(85)90113-1","article-title":"Neurophysiologic studies of sensory gating in schizophrenia: comparison of auditory and visual responses","volume":"20","author":"Adler","year":"1985","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0920-9964(90)90046-A","article-title":"Lack of relationship of auditory gating defects to negative symptoms in schizophrenia","volume":"3","author":"Adler","year":"1990","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2007.04.028_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0006-3223(92)90073-9","article-title":"Normalization by nicotine of deficient auditory sensory gating in relatives of schizophrenics","volume":"32","author":"Adler","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib5","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1176\/ajp.150.12.1856","article-title":"Normalization of auditory physiology by cigarette smoking in schizophrenic patients","volume":"150","author":"Adler","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.schbul.a033320","article-title":"Schizophrenia, sensory gating and nicotine receptors","volume":"24","author":"Adler","year":"1998","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2007.04.028_bib7","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1176\/ajp.161.10.1822","article-title":"Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients","volume":"161","author":"Adler","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"1\u22123","key":"10.1016\/j.schres.2007.04.028_bib8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.schres.2006.08.009","article-title":"Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study","volume":"89","author":"Anokhin","year":"2007","journal-title":"Schizophr. Res."},{"issue":"12","key":"10.1016\/j.schres.2007.04.028_bib9","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1176\/appi.ajp.160.12.2236","article-title":"Normal P50 gating in unmedicated schizophrenia outpatients","volume":"160","author":"Arnfred","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0006-3223(87)90188-0","article-title":"Neurophysiological assesment of sensory gating in psychiatric patients: comparison between schizophrenia and other diagnoses","volume":"22","author":"Baker","year":"1987","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2007.04.028_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.clinph.2003.09.018","article-title":"Clozapine, but not typical antipsychotics, correct P50 suppression deficit in patients with schizophrenia","volume":"115","author":"Becker","year":"2004","journal-title":"Clin. Neurophysiol."},{"issue":"1","key":"10.1016\/j.schres.2007.04.028_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/155005949102200109","article-title":"Replications and extensions of P50 findings in schizophrenia","volume":"22","author":"Boutros","year":"1991","journal-title":"Clin. Electroencephalogr."},{"key":"10.1016\/j.schres.2007.04.028_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-1781(99)00074-8","article-title":"Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report","volume":"88","author":"Boutros","year":"1999","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.schres.2007.04.028_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.psychres.2004.01.007","article-title":"Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients","volume":"126","author":"Boutros","year":"2004","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.schres.2004.01.004","article-title":"Meta-analysis of the P300 and P50 waveforms in schizophrenia","volume":"70","author":"Bramon","year":"2004","journal-title":"Schizophr. Res."},{"issue":"4","key":"10.1016\/j.schres.2007.04.028_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s002210100744","article-title":"Multichannel electroencephalographic assesment of auditory evoked response suppression in schizophrenia","volume":"139","author":"Clementz","year":"2001","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.schres.2007.04.028_bib15","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0006-3223(96)00208-9","article-title":"P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis","volume":"41","author":"Clementz","year":"1997","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0920-9964(97)00122-9","article-title":"Multiple site evaluation of P50 suppression among schizophrenia and normal control subjects","volume":"30","author":"Clementz","year":"1998","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2007.04.028_bib17","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1176\/ajp.155.12.1691","article-title":"Poor P50 suppression among schizophrenia patients and their first-degree biological relatives","volume":"155","author":"Clementz","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0920-9964(93)90048-N","article-title":"Neurophysiological and neuropsychological attentional dysfuntion in schizophrenia","volume":"10","author":"Cullum","year":"1993","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2007.04.028_bib43","doi-asserted-by":"crossref","unstructured":"de Wilde, O.M., Bour, L.J., Dingemans, P.M., Koelman, J.H.T.M., Linszen, D.H., in press. Failure to find P50 suppression deficits in young first episode patients with schizophrenia and clinically unaffected siblings. Schizophr. Bull. doi:10.1093\/schbul\/sbm001.","DOI":"10.1093\/schbul\/sbm001"},{"key":"10.1016\/j.schres.2007.04.028_bib20","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/archpsyc.1996.01830120052009","article-title":"Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects","volume":"53","author":"Freedman","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2007.04.028_bib21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1073\/pnas.94.2.587","article-title":"Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus","volume":"94","author":"Freedman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.schres.2007.04.028_bib22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1469-8986.1995.tb02097.x","article-title":"Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects","volume":"32","author":"Griffith","year":"1995","journal-title":"Psychophysiology"},{"key":"10.1016\/j.schres.2007.04.028_bib24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10519-006-9091-6","article-title":"Heritability and reliability of P300, P50 and duration mismatch negativity","volume":"36","author":"Hall","year":"2006","journal-title":"Behav. Genet."},{"issue":"130(2)","key":"10.1016\/j.schres.2007.04.028_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pscychresns.2002.12.001","article-title":"Memory impairment and auditory evoked potential gating deficit in schizophrenia","volume":"15","author":"Hsieh","year":"2004","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib26","series-title":"Correcting Error and Bias in Research Findings","article-title":"Methods of Meta-Analysis","author":"Hunter","year":"1990"},{"key":"10.1016\/j.schres.2007.04.028_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-1781(01)00297-9","article-title":"P300 asymmetry in schizophrenia: a meta-analysis","volume":"104","author":"Jeon","year":"2001","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-1781(97)03091-6","article-title":"Effects of P50 temporal variability on sensory gating in schizophrenia","volume":"70","author":"Jin","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0006-3223(98)00115-2","article-title":"Is P50 suppression a measure of sensory gating in schizophrenia?","volume":"43","author":"Jin","year":"1998","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2007.04.028_bib30","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1176\/ajp.149.4.488","article-title":"Sensory gating deficits in schizophrenia: new results","volume":"149","author":"Judd","year":"1992","journal-title":"Am. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.schres.2007.04.028_bib31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.157.5.767","article-title":"Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications","volume":"157","author":"Light","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1176\/appi.ajp.162.3.466","article-title":"A concordance study of three electrophysiological measures in schizophrenia","volume":"261","author":"Louchart de la Chapelle","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"12","key":"10.1016\/j.schres.2007.04.028_bib33","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1176\/appi.ajp.159.12.2007","article-title":"P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate","volume":"159","author":"Myles-Worsley","year":"2002","journal-title":"Am. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.schres.2007.04.028_bib48","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0006-3223(89)90215-1","article-title":"Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval","volume":"25","author":"Nagamoto","year":"1989","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0920-9964(91)90007-E","article-title":"Gating of auditory response in schizophrenics and normal controls: effects of recording site and stimulation interval on the P50 wave","volume":"4","author":"Nagamoto","year":"1991","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2007.04.028_bib35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-3223(95)00371-1","article-title":"Gating of auditory P50 in schizophrenics: unique effects of clozapine","volume":"40","author":"Nagamoto","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0006-3223(00)00239-0","article-title":"The P50 auditory event-evoked potential in adult attention-deficit disorder: comparison with schizophrenia","volume":"47","author":"Olincy","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib37","first-page":"157","article-title":"A fail-safe N for effect size","volume":"8","author":"Orwin","year":"1983","journal-title":"J. Educ. Stat."},{"key":"10.1016\/j.schres.2007.04.028_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsych.2005.09.010","article-title":"A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater utility than any single feature in the Western Australian family study of schizophrenia","volume":"60","author":"Price","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2007.04.028_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.psychres.2004.01.004","article-title":"Sensory gating deficit in a subtype of chronic schizophrenic patients","volume":"125","author":"Ringel","year":"2004","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archpsyc.1984.01790170081009","article-title":"Deficits in sensory gating in schizophrenia patients and their relatives; evidence obtains with auditory evoked responses","volume":"41","author":"Siegel","year":"1984","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.schres.2007.04.028_bib41","unstructured":"SPSS 12.0 for Windows, Chicago, IL."},{"key":"10.1016\/j.schres.2007.04.028_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-1781(96)02876-4","article-title":"Replication of a P50 auditory gating deficit in Australian patients with schizophrenia","volume":"64","author":"Ward","year":"1996","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2007.04.028_bib44","series-title":"Meta-analysis: Quantitative Methods for Research Synthesis","author":"Wolf","year":"1986"},{"issue":"4","key":"10.1016\/j.schres.2007.04.028_bib45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1037\/0021-843X.107.4.691","article-title":"P50 suppression in recent-onset schizophrenia: clinical correlates and risperidone effects","volume":"107","author":"Yee","year":"1998","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.schres.2007.04.028_bib46","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/arclin\/16.7.653","article-title":"Statistics to tell the truth, the whole truth, and nothing but the truth: formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers","volume":"16","author":"Zakzanis","year":"2001","journal-title":"Arch. Gen. Neuropsychol."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996407001806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996407001806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T19:53:54Z","timestamp":1556567634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996407001806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":48,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0920996407001806"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2007.04.028","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718095309.793483035","asserted-by":"object"}]},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}