{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:21:53Z","timestamp":1791555713627,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.schres.2010.09.002","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T09:19:03Z","timestamp":1286183943000},"page":"192-199","source":"Crossref","is-referenced-by-count":191,"title":["A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder"],"prefix":"10.1016","volume":"124","author":[{"given":"Ke-Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Aragam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.schres.2010.09.002_bb0005","doi-asserted-by":"crossref","first-page":"17849","DOI":"10.1073\/pnas.0706128104","article-title":"Genome-wide analyses of human perisylvian cerebral cortical patterning","volume":"104","author":"Abrahams","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.schres.2010.09.002_bb0010","article-title":"Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs","author":"Adkins","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0015","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/humu.21042","article-title":"Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future","volume":"30","author":"Alaerts","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.schres.2010.09.002_bb0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2007.09.005","article-title":"Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene","volume":"82","author":"Alarc\u00f3n","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajhg.2007.09.015","article-title":"A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism","volume":"82","author":"Arking","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0006-3223(02)01320-3","article-title":"Genome scan for susceptibility loci for schizophrenia and bipolar disorder","volume":"52","author":"Bailer","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ajhg.2007.09.017","article-title":"Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders","volume":"82","author":"Bakkaloglu","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"2","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.schres.2010.09.002_bb0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-3223(99)00226-7","article-title":"Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia","volume":"47","author":"Berrettini","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ajmg.c.20014","article-title":"Evidence for shared susceptibility in bipolar disorder and schizophrenia","volume":"123C","author":"Berrettini","year":"2003","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0055","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11920-001-0030-1","article-title":"The common genetic liability between schizophrenia and bipolar disorder: a review","volume":"3","author":"Bramon","year":"2001","journal-title":"Curr. Psychiatry Rep."},{"issue":"10","key":"10.1016\/j.schres.2010.09.002_bb0060","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/gm102","article-title":"Genetic overlap between autism, schizophrenia and bipolar disorder","volume":"1","author":"Carroll","year":"2009","journal-title":"Genome Med."},{"key":"10.1016\/j.schres.2010.09.002_bb0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jmg.2005.030718","article-title":"The genetics of schizophrenia and bipolar disorder: dissecting psychosis","volume":"42","author":"Craddock","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0070","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/mp.2008.66","article-title":"Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype","volume":"15","author":"Craddock","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0075","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1073\/pnas.88.7.2673","article-title":"Cloning of the gamma-aminobutyric acid (GAGA) rho-1 cDNA: a GABA receptor subunit highly expressed in the retina","volume":"88","author":"Cutting","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.schres.2010.09.002_bb0080","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0888-7543(92)90312-G","article-title":"Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho-2 cDNA and colocalization of the genes encoding rho-2 (GABRR2) and rho-1 (GABRR1) to human chromosome 6q14\u2013q21 and mouse chromosome 4","volume":"12","author":"Cutting","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/j.schres.2010.09.002_bb0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biopsych.2006.01.019","article-title":"G72\/G30 in schizophrenia and bipolar disorder: review and meta-analysis","volume":"60","author":"Detera-Wadleigh","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000119108","article-title":"Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data","volume":"66","author":"Dudbridge","year":"2008","journal-title":"Hum. Hered."},{"key":"10.1016\/j.schres.2010.09.002_bb0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gepi.20297","article-title":"Estimation of significance thresholds for genomewide association scans","volume":"32","author":"Dudbridge","year":"2008","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.schres.2010.09.002_bb0100","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/mp.2009.57","article-title":"Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes","volume":"15","author":"Elia","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.mp.4002049","article-title":"CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy","volume":"13","author":"Friedman","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2010.20","article-title":"CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy","author":"Friedman","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.gene.2004.10.004","article-title":"Identification of two novel human genes, DIPLA1 and DIPAS, expressed in placenta tissue","volume":"344","author":"Garcia","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.schres.2010.09.002_bb0120","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.biopsych.2008.03.025","article-title":"Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia","volume":"64","author":"Georgieva","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0125","article-title":"The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia","author":"Green","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.31108","article-title":"Variation at the GABA(A) receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder","author":"Green","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0135","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/gm46","article-title":"Genome-wide association studies in pharmacogenomics: untapped potential for translation","volume":"1","author":"Guessous","year":"2009","journal-title":"Genome Med."},{"issue":"7256","key":"10.1016\/j.schres.2010.09.002_bb0140","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"Purcell","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.schres.2010.09.002_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/j.1601-183X.2010.00578.x","article-title":"Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder","author":"Karege","year":"2010","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.schres.2010.09.002_bb0150","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ajhg.2009.11.003","article-title":"A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression","volume":"85","author":"Knight","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0155","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.4088\/JCP.08m04807","article-title":"Bipolar disorder, schizoaffective disorder, and schizophrenia overlap: a new comorbidity index","volume":"70","author":"Laursen","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0160","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00702-008-0119-3","article-title":"Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies","volume":"115","author":"Lesch","year":"2008","journal-title":"J. Neural Transm."},{"issue":"9659","key":"10.1016\/j.schres.2010.09.002_bb0165","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.schres.2010.09.002_bb0170","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/schbul\/sbn050","article-title":"Approaches for unraveling the joint genetic determinants of schizophrenia and bipolar disorder","volume":"34","author":"Lin","year":"2008","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2010.09.002_bb0175","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2007.02.041","article-title":"The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm","volume":"129","author":"Lu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.schres.2010.09.002_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/01.yco.0000214342.52249.82","article-title":"Schizophrenia and bipolar disorder: differences and overlaps","volume":"19","author":"Maier","year":"2006","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0185","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bbrc.1997.7492","article-title":"A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs","volume":"239","author":"Matuoka","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.schres.2010.09.002_bb0190","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrg2344","article-title":"Genome-wide association studies for complex traits: consensus, uncertainty and challenges","volume":"9","author":"McCarthy","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0195","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ng.474","article-title":"Microduplications of 16p11.2 are associated with schizophrenia","volume":"41","author":"McCarthy","year":"2009","journal-title":"Nat. Genet."},{"issue":"Suppl 6","key":"10.1016\/j.schres.2010.09.002_bb0200","first-page":"23","article-title":"Bipolar disorder and schizophrenia: distinct illnesses or a continuum?","volume":"64","author":"M\u00f6ller","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0205","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2008.133","article-title":"Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk","volume":"14","author":"Moskvina","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0210","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/ng.201","article-title":"Molecular Genetics of Schizophrenia Collaboration. Identification of loci associated with schizophrenia by genome-wide association and follow-up","volume":"40","author":"O'Donovan","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0215","article-title":"Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility","author":"O'Dushlaine","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/mp.2008.122","article-title":"Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort","volume":"14","author":"Ollila","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0225","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrneurol.2009.71","article-title":"Neuropsychiatric disorders: shared genetics of bipolar disorder and schizophrenia","volume":"5","author":"Potash","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.schres.2010.09.002_bb0230","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0235","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population\u2013based linkage analyses.","volume":"3","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0240","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1176\/appi.ajp.2007.07101573","article-title":"No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics","volume":"165","author":"Sanders","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0245","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/ajmg.b.31057","article-title":"Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia","volume":"153B","author":"Scholz","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.schres.2010.09.002_bb0250","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/hmg\/ddp204","article-title":"The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations","volume":"18","author":"Schumacher","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"1\u20133","key":"10.1016\/j.schres.2010.09.002_bb0255","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.schres.2007.10.004","article-title":"Allelic association of G72\/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis","volume":"98","author":"Shi","year":"2008","journal-title":"Schizophr. Res."},{"issue":"7256","key":"10.1016\/j.schres.2010.09.002_bb0260","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature08192","article-title":"Common variants on chromosome 6p22.1 are associated with schizophrenia","volume":"460","author":"Shi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.schres.2010.09.002_bb0265","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/mp.2009.43","article-title":"Genome-wide association study of bipolar disorder in European American and African American individuals","volume":"14","author":"Smith","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0270","article-title":"Lack of association of NALCN genetic variants with schizophrenia","author":"Souza","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2010.09.002_bb0300","doi-asserted-by":"crossref","unstructured":"Storey, J.D., 2002. A direct approach to false discovery rates. Journal of the Royal Statistical Society, Series B 64, 479\u2013498.","DOI":"10.1111\/1467-9868.00346"},{"key":"10.1016\/j.schres.2010.09.002_bb0275","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1001\/archgenpsychiatry.2009.64","article-title":"Meta-analytic evidence for familial coaggregation of schizophrenia and bipolar disorder","volume":"66","author":"Van Snellenberg","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0280","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ajhg.2008.09.011","article-title":"Recurrent CNVs disrupt three candidate genes in schizophrenia patients","volume":"83","author":"Vrijenhoek","year":"2008","journal-title":"Am. J. Hum. Genet."},{"issue":"7145","key":"10.1016\/j.schres.2010.09.002_bb0285","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.schres.2010.09.002_bb0290","article-title":"Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder","author":"Williams","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2010.09.002_bb0295","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ajmg.b.30995","article-title":"GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence","volume":"153B","author":"Xuei","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996410015318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996410015318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T22:18:22Z","timestamp":1711837102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996410015318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":60,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0920996410015318"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2010.09.002","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}