{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:52:11Z","timestamp":1789980731964,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.schres.2011.06.004","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T02:46:03Z","timestamp":1309142763000},"page":"90-95","source":"Crossref","is-referenced-by-count":69,"title":["Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: An animal model"],"prefix":"10.1016","volume":"131","author":[{"given":"Margaret","family":"Hahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araba","family":"Chintoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adria","family":"Giacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Guenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Wolever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Arenovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Remington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0005","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2337\/diabetes.54.3.862","article-title":"Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs","volume":"54","author":"Ader","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/sj.bjp.0705754","article-title":"Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice","volume":"142","author":"Bell","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"Suppl 3","key":"10.1016\/j.schres.2011.06.004_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2362.32.s3.5.x","article-title":"The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes","volume":"32","author":"Bergman","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0014-2999(90)90370-L","article-title":"Effects of the 5-HT1C\/5-5-HT2 receptor agonists DOI and alpha-methyl-5-HT on plasma glucose and insulin levels in the rat","volume":"187","author":"Chaouloff","year":"1990","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0165-1838(00)00106-5","article-title":"Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats","volume":"83","author":"Cheng","year":"2000","journal-title":"Auton. Neurosci."},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0030","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/JCP.0b013e318184b4c5","article-title":"Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration","volume":"28","author":"Chintoh","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"issue":"1\u20133","key":"10.1016\/j.schres.2011.06.004_bb0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.schres.2008.12.012","article-title":"Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model","volume":"108","author":"Chintoh","year":"2009","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0040","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/01.jcp.0000237947.80764.d9","article-title":"The early effect of olanzapine and risperidone on insulin secretion in atypical-naive schizophrenic patients","volume":"26","author":"Chiu","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0045","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am. J. Physiol."},{"issue":"7","key":"10.1016\/j.schres.2011.06.004_bb0050","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s001250051467","article-title":"Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis","volume":"43","author":"Devedjian","year":"2000","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2337\/diacare.19.3.278","article-title":"In praise of the hyperglycemic clamp. A method for assessment of beta-cell sensitivity and insulin resistance","volume":"19","author":"Elahi","year":"1996","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.schres.2011.06.004_bb0060","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1210\/en.2009-0996","article-title":"Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance","volume":"151","author":"Garcia-Tornadu","year":"2010","journal-title":"Endocrinology"},{"issue":"Suppl 2","key":"10.1016\/j.schres.2011.06.004_bb0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1463-1326.2007.00781.x","article-title":"Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis","volume":"9","author":"Gautam","year":"2007","journal-title":"Diabetes Obes. Metab."},{"issue":"15","key":"10.1016\/j.schres.2011.06.004_bb0070","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1073\/pnas.0900977106","article-title":"Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth","volume":"106","author":"Gautam","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.schres.2011.06.004_bb0075","first-page":"124","article-title":"Serotonin receptor involvement in an animal model of the acute effects of hallucinogens","volume":"146","author":"Geyer","year":"1994","journal-title":"NIDA Res. Monogr."},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0080","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/01.psy.0000174994.91245.34","article-title":"Antagonism of the serotonin (5-HT)-2 receptor and insulin sensitivity: implications for atypical antipsychotics","volume":"67","author":"Gilles","year":"2005","journal-title":"Psychosom. Med."},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1210\/er.22.5.565","article-title":"Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function","volume":"22","author":"Gilon","year":"2001","journal-title":"Endocr. Rev."},{"issue":"19","key":"10.1016\/j.schres.2011.06.004_bb0090","doi-asserted-by":"crossref","first-page":"13563","DOI":"10.1074\/jbc.274.19.13563","article-title":"Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle","volume":"274","author":"Hajduch","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0095","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.npp.1301209","article-title":"Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects","volume":"32","author":"Houseknecht","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.schres.2011.06.004_bb0100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/10401230209147399","article-title":"Phenomenology of and risk factors for new-onset diabetes mellitus and diabetic ketoacidosis associated with atypical antipsychotics: an analysis of 45 published cases","volume":"14","author":"Jin","year":"2002","journal-title":"Ann. Clin. Psychiatry"},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0105","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.2337\/diabetes.54.5.1552","article-title":"Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia","volume":"54","author":"Johnson","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.schres.2011.06.004_bb0110","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1176\/appi.ajp.157.4.514","article-title":"Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia","volume":"157","author":"Kapur","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.schres.2011.06.004_bb0115","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1176\/appi.ajp.161.9.1709","article-title":"Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications","volume":"161","author":"Leslie","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0303-7207(96)03918-4","article-title":"Glucose-stimulated expressed sequence tags from rat pancreatic islets","volume":"123","author":"MacDonald","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000079137","article-title":"Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding","volume":"72","author":"Mahar Doan","year":"2004","journal-title":"Pharmacology"},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0130","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2337\/diabetes.50.2.385","article-title":"Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice","volume":"50","author":"Masaki","year":"2001","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0135","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2133\/dmpk.20.368","article-title":"Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus","volume":"20","author":"Matsui-Sakata","year":"2005","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.schres.2011.06.004_bb0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-2999(88)90698-X","article-title":"5-HT2 receptor agonists increase spontaneous sympathetic nerve discharge","volume":"151","author":"McCall","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0145","first-page":"390","article-title":"The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs","volume":"25","author":"Meltzer","year":"1989","journal-title":"Psychopharmacol. Bull."},{"issue":"Suppl 1","key":"10.1016\/j.schres.2011.06.004_bb0150","first-page":"1","article-title":"Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review","volume":"19","author":"Newcomer","year":"2005","journal-title":"CNS Drugs."},{"issue":"4","key":"10.1016\/j.schres.2011.06.004_bb0155","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/archpsyc.59.4.337","article-title":"Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia","volume":"59","author":"Newcomer","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"issue":"10","key":"10.1016\/j.schres.2011.06.004_bb0160","doi-asserted-by":"crossref","first-page":"e1000229","DOI":"10.1371\/journal.pbio.1000229","article-title":"Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation","volume":"7","author":"Paulmann","year":"2009","journal-title":"PLoS. Biol."},{"issue":"8","key":"10.1016\/j.schres.2011.06.004_bb0165","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2337\/diacare.23.8.1154","article-title":"Bromocriptine: a novel approach to the treatment of type 2 diabetes","volume":"23","author":"Pijl","year":"2000","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.schres.2011.06.004_bb0170","doi-asserted-by":"crossref","first-page":"655","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00006","article-title":"Medical hazards of obesity","volume":"119","author":"Pi-Sunyer","year":"1993","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0175","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2337\/diabetes.48.3.564","article-title":"Acute vasoconstriction-induced insulin resistance in rat muscle in vivo","volume":"48","author":"Rattigan","year":"1999","journal-title":"Diabetes"},{"issue":"Suppl 10","key":"10.1016\/j.schres.2011.06.004_bb0180","first-page":"5","article-title":"Receptor pharmacology of neuroleptics: relation to clinical effects","volume":"60","author":"Richelson","year":"1999","journal-title":"J. Clin. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2011.06.004_bb0185","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","article-title":"Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia","volume":"3","author":"Roth","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"44","key":"10.1016\/j.schres.2011.06.004_bb0190","doi-asserted-by":"crossref","first-page":"36824","DOI":"10.1074\/jbc.M505560200","article-title":"Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion","volume":"280","author":"Rubi","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0195","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF01941710","article-title":"Feeding induced by blockade of histamine H1-receptor in rat brain","volume":"44","author":"Sakata","year":"1988","journal-title":"Experientia"},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1385\/ENDO:8:3:213","article-title":"Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit?","volume":"8","author":"Satin","year":"1998","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.schres.2011.06.004_bb0205","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0165-6147(94)90323-9","article-title":"Dopamine receptor pharmacology","volume":"15","author":"Seeman","year":"1994","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.schres.2011.06.004_bb0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1358\/mf.2005.27.5.908643","article-title":"Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes","volume":"27","author":"Silvestre","year":"2005","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.schres.2011.06.004_bb0215","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.eurpsy.2009.01.001","article-title":"How can antipsychotics cause Diabetes Mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins","volume":"24","author":"Starrenburg","year":"2009","journal-title":"Eur. Psychiatry"},{"issue":"11","key":"10.1016\/j.schres.2011.06.004_bb0220","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1210\/jc.2003-032094","article-title":"Prolonged mild hyperglycemia induces vagally mediated compensatory increase in C-Peptide secretion in humans","volume":"89","author":"Teff","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.schres.2011.06.004_bb0225","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s002130000466","article-title":"Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats","volume":"150","author":"Wadenberg","year":"2000","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.schres.2011.06.004_bb0230","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2353\/ajpath.2010.091198","article-title":"Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice","volume":"177","author":"Wang","year":"2010","journal-title":"Am. J. Pathol."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996411003094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996411003094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T16:23:36Z","timestamp":1543681416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996411003094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":46,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0920996411003094"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2011.06.004","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}