{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:53:16Z","timestamp":1782118396296,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Scientific Research Fund of Liaoning Science and Technology Agency, China"},{"name":"2011225020"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.schres.2012.02.021","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T18:49:30Z","timestamp":1330973370000},"page":"54-57","source":"Crossref","is-referenced-by-count":65,"title":["Metformin for treatment of antipsychotic-induced weight gain: A randomized, placebo-controlled study"],"prefix":"10.1016","volume":"138","author":[{"given":"Man","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hua","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-ming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.schres.2012.02.021_bb0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.clinthera.2006.03.004","article-title":"Metformin-associated lactic acidosis treated with continuous renal replacement therapy","volume":"28","author":"Alivanis","year":"2006","journal-title":"Clin. Ther."},{"key":"10.1016\/j.schres.2012.02.021_bb0010","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.schres.2012.02.021_bb0015","series-title":"Scale for Assessment of Negative and Positive Symptoms","author":"Andreasen","year":"1984"},{"issue":"7","key":"10.1016\/j.schres.2012.02.021_bb0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2165\/11589060-000000000-00000","article-title":"Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder","volume":"31","author":"Citrome","year":"2011","journal-title":"Clin. Drug Investig."},{"issue":"12","key":"10.1016\/j.schres.2012.02.021_bb0025","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.2337\/diabetes.53.12.3258","article-title":"Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms","volume":"53","author":"Cleasby","year":"2004","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.schres.2012.02.021_bb0030","first-page":"A42","article-title":"Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states","volume":"3","author":"Colton","year":"2006","journal-title":"Prev. Chron. Dis."},{"key":"10.1016\/j.schres.2012.02.021_bb0035","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders\u2014 Clinician Version (SCID-CV)","author":"First","year":"1997"},{"issue":"9","key":"10.1016\/j.schres.2012.02.021_bb0040","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/diacare.19.9.920","article-title":"The effect of metformin on the metabolic abnormalities associated with upperbody fat distribution","volume":"19","author":"Fontbonne","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.schres.2012.02.021_bb0045","first-page":"341","article-title":"ECDEU Assessment Manual for Psychopharmacology, Revised","author":"Guy","year":"1976"},{"issue":"7","key":"10.1016\/j.schres.2012.02.021_bb0050","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2337\/diacare.20.7.1087","article-title":"The homeostasis model in the San Antonio heart study","volume":"20","author":"Haffner","year":"1997","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.schres.2012.02.021_bb0055","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1176\/appi.ajp.162.5.954","article-title":"A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain","volume":"162","author":"Henderson","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2012.02.021_bb0060","first-page":"304","article-title":"Current option in the management of olanzapine-associated weight gain","volume":"39","author":"Hester","year":"2004","journal-title":"Ann. Pharmacother."},{"issue":"8","key":"10.1016\/j.schres.2012.02.021_bb0065","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.2337\/diabetes.54.8.2404","article-title":"Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in diabetes prevention program: effects of lifestyle intervention and metformin","volume":"54","author":"Kitabchi","year":"2005","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.schres.2012.02.021_bb0070","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1176\/ajp.2006.163.12.2072","article-title":"A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents","volume":"163","author":"Klein","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2012.02.021_bb0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","article-title":"H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs","volume":"28","author":"Kroeze","year":"2003","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.schres.2012.02.021_bb0080","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2337\/db06-0918","article-title":"Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program","volume":"56","author":"Lachin","year":"2007","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.schres.2012.02.021_bb0085","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ageing\/afj042","article-title":"Metformin-related vitamin B12 deficiency","volume":"35","author":"Liu","year":"2006","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.schres.2012.02.021_bb0090","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2133\/dmpk.20.368","article-title":"Receptor occupancy-based analysis of the contribution of various receptors to antipsychotic-induced weight gain and diabetes mellitus","volume":"20","author":"Matsui-Sakata","year":"2005","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"10","key":"10.1016\/j.schres.2012.02.021_bb0095","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1176\/ps.2006.57.10.1482","article-title":"Mortality and medical comorbidity among patients with serious mental illness","volume":"57","author":"Miller","year":"2006","journal-title":"Psychiatr. Serv."},{"issue":"10","key":"10.1016\/j.schres.2012.02.021_bb0100","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.annfar.2006.05.009","article-title":"Metformin-associated lactic acidosis","volume":"25","author":"Orban","year":"2006","journal-title":"Ann. Fr. Anesth. R\u00e8anim."},{"issue":"6","key":"10.1016\/j.schres.2012.02.021_bb0105","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2362.1998.00304.x","article-title":"Effect of metformin on food intake in obese subjects","volume":"28","author":"Paolisso","year":"1998","journal-title":"Eur. J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.schres.2012.02.021_bb0110","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1152\/ajpendo.00221.2006","article-title":"Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes","volume":"292","author":"Rasouli","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.schres.2012.02.021_bb0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S1461145705005110","article-title":"Clozapine, risperidone, olanzapine, and conventional antipsychotic drug effects on glucose, lipids, and leptin in schizophrenia patients","volume":"8","author":"Smith","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.schres.2012.02.021_bb0120","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1176\/appi.ajp.2007.07010079","article-title":"Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study","volume":"165","author":"Wu","year":"2008","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2012.02.021_bb0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/jama.2007.56-b","article-title":"Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial","volume":"299","author":"Wu","year":"2008","journal-title":"JAMA"}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092099641200117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092099641200117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T09:50:35Z","timestamp":1543139435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092099641200117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S092099641200117X"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2012.02.021","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}