{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:37:12Z","timestamp":1792589832983,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","schres-journal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.schres.2014.07.053","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T10:57:13Z","timestamp":1409914633000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Maternal complement C1q and increased odds for psychosis in adult offspring"],"prefix":"10.1016","volume":"159","author":[{"given":"Emily G.","family":"Severance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Gressitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Buka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrone D.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.schres.2014.07.053_bb0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6890-11-10","article-title":"Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia","volume":"11","author":"Arakelyan","year":"2011","journal-title":"BMC Clin. Pathol."},{"issue":"4","key":"10.1016\/j.schres.2014.07.053_bb0010","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.biopsych.2013.06.025","article-title":"Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring","volume":"75","author":"Bauman","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.schres.2014.07.053_bb0015","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1523\/JNEUROSCI.3932-10.2011","article-title":"Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression","volume":"31","author":"Benoit","year":"2011","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.schres.2014.07.053_bb0020","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.schres.2014.07.053_bb0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.schres.2012.06.035","article-title":"Maternal antibodies to infectious agents and risk for non-affective psychoses in the offspring\u2013a matched case\u2013control study","volume":"140","author":"Blomstrom","year":"2012","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2009.09.001","article-title":"Immune proteins in brain development and synaptic plasticity","volume":"64","author":"Boulanger","year":"2009","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.schres.2014.07.053_bb0035","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.clinbiochem.2007.11.014","article-title":"Cryoglobulins as indicators of upregulated immune response in schizophrenia","volume":"41","author":"Boyajyan","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.schres.2014.07.053_bb0040","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1038\/tp.2013.50","article-title":"Autism-specific maternal autoantibodies recognize critical proteins in developing brain","volume":"3","author":"Braunschweig","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"11","key":"10.1016\/j.schres.2014.07.053_bb0045","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/mp.2013.101","article-title":"Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder","volume":"18","author":"Brimberg","year":"2013","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2014.07.053_bb0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2014.07.053_bb0055","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1176\/appi.ajp.157.3.438","article-title":"Nonaffective psychosis after prenatal exposure to rubella","volume":"157","author":"Brown","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2014.07.053_bb0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/oxfordjournals.schbul.a033453","article-title":"Maternal exposure to respiratory infections and adult schizophrenia spectrum disorders: a prospective birth cohort study","volume":"26","author":"Brown","year":"2000","journal-title":"Schizophr. Bull."},{"issue":"8","key":"10.1016\/j.schres.2014.07.053_bb0050","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archpsyc.61.8.774","article-title":"Serologic evidence of prenatal influenza in the etiology of schizophrenia","volume":"61","author":"Brown","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.schres.2014.07.053_bb0065","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1176\/appi.ajp.161.5.889","article-title":"Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring","volume":"161","author":"Brown","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.schres.2014.07.053_bb0075","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.biopsych.2007.09.022","article-title":"Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring","volume":"63","author":"Buka","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2014.07.053_bb0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fimmu.2012.00055","article-title":"The complement system at the embryo implantation site: friend or foe?","volume":"3","author":"Bulla","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.schres.2014.07.053_bb0085","doi-asserted-by":"crossref","DOI":"10.1176\/appi.ajp.2014.13121579","article-title":"Elevated maternal c-reactive protein and increased risk of schizophrenia in a national birth cohort","author":"Canetta","year":"2014","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2014.07.053_bb0090","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/oxfordjournals.schbul.a033458","article-title":"A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia","volume":"26","author":"Cannon","year":"2000","journal-title":"Schizophr. Bull."},{"issue":"9","key":"10.1016\/j.schres.2014.07.053_bb0095","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.biopsych.2008.04.012","article-title":"Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia","volume":"64","author":"Cannon","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.schres.2014.07.053_bb0100","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.biopsych.2008.12.015","article-title":"Cognitive functioning prior to the onset of psychosis: the role of fetal exposure to serologically determined influenza infection","volume":"65","author":"Ellman","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"34","key":"10.1016\/j.schres.2014.07.053_bb0105","doi-asserted-by":"crossref","first-page":"13791","DOI":"10.1523\/JNEUROSCI.2366-13.2013","article-title":"MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease","volume":"33","author":"Elmer","year":"2013","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.schres.2014.07.053_bb0110","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cell.2007.11.031","article-title":"Synapse remodeling, compliments of the complement system","volume":"131","author":"Fourgeaud","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.schres.2014.07.053_bb0115","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1038\/tp.2012.24","article-title":"Effects of maternal immune activation on gene expression patterns in the fetal brain","volume":"2","author":"Garbett","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biopsych.2011.01.030","article-title":"The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia","volume":"70","author":"Havik","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"5499","key":"10.1016\/j.schres.2014.07.053_bb0125","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1126\/science.290.5499.2155","article-title":"Functional requirement for class I MHC in CNS development and plasticity","volume":"290","author":"Huh","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.schres.2014.07.053_bb0130","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1176\/appi.ajp.2012.11081197","article-title":"Maternal antibodies to dietary antigens and risk for nonaffective psychosis in offspring","volume":"169","author":"Karlsson","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2014.07.053_bb0135","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.neuro.25.112701.142754","article-title":"Schizophrenia as a disorder of neurodevelopment","volume":"25","author":"Lewis","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.schres.2014.07.053_bb0140","first-page":"55","article-title":"Concentration and protein composition of circulating immune complexes in the blood of patients with schizophrenia and subjects with positive familial history of disease","volume":"105","author":"Mailian","year":"2005","journal-title":"Zh. Nevropatol. Psikhiatr. Im. S. S. Korsakova"},{"issue":"5","key":"10.1016\/j.schres.2014.07.053_bb0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-0897.1996.tb00172.x","article-title":"Evolution of maternofetal transport of immunoglobulins during human pregnancy","volume":"36","author":"Malek","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"issue":"4","key":"10.1016\/j.schres.2014.07.053_bb0150","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1358\/dnp.2008.21.4.1213349","article-title":"The complement system in schizophrenia","volume":"21","author":"Mayilyan","year":"2008","journal-title":"Drug New Perspect."},{"key":"10.1016\/j.schres.2014.07.053_bb0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pnpbp.2011.11.003","article-title":"Developmental neuroinflammation and schizophrenia","volume":"42","author":"Meyer","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.schres.2014.07.053_bb0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.schres.2010.06.010","article-title":"A Danish National Birth Cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring","volume":"122","author":"Mortensen","year":"2010","journal-title":"Schizophr. Res."},{"issue":"8","key":"10.1016\/j.schres.2014.07.053_bb0165","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1176\/appi.ajp.2011.10091351","article-title":"Toxoplasma infection and later development of schizophrenia in mothers","volume":"168","author":"Pedersen","year":"2011","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2014.07.053_bb0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.psc.2012.06.002","article-title":"The neurodevelopmental hypothesis of schizophrenia: convergent clues from epidemiology and neuropathology","volume":"35","author":"Piper","year":"2012","journal-title":"Psychiatr. Clin. N. Am."},{"issue":"12","key":"10.1016\/j.schres.2014.07.053_bb0175","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/mp.2012.23","article-title":"Neurodevelopmental model of schizophrenia: update 2012","volume":"17","author":"Rapoport","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.schres.2014.07.053_bb0185","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.schres.2009.12.030","article-title":"Subunit and whole molecule specificity of the anti-bovine casein immune response in recent onset psychosis and schizophrenia","volume":"118","author":"Severance","year":"2010","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0180","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.schres.2012.02.025","article-title":"Gastrointestinal inflammation and associated immune activation in schizophrenia","volume":"138","author":"Severance","year":"2012","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.schres.2014.07.053_bb0190","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.nbd.2012.07.005","article-title":"Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia","volume":"48","author":"Severance","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.schres.2014.07.053_bb0195","doi-asserted-by":"crossref","first-page":"e50991","DOI":"10.1371\/journal.pone.0050991","article-title":"Anti-gluten immune response following Toxoplasma gondii infection in mice","volume":"7","author":"Severance","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuron.2009.09.044","article-title":"MHC class I: an unexpected role in neuronal plasticity","volume":"64","author":"Shatz","year":"2009","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0205","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbi.2008.07.012","article-title":"Activation of the maternal immune system alters cerebellar development in the offspring","volume":"23","author":"Shi","year":"2009","journal-title":"Brain Behav. Immun."},{"issue":"24","key":"10.1016\/j.schres.2014.07.053_bb0210","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/S0264-410X(03)00334-7","article-title":"Placental transport of immunoglobulin G","volume":"21","author":"Simister","year":"2003","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.schres.2014.07.053_bb0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.0022-202X.2005.23673.x","article-title":"C1q: its functions within the innate and adaptive immune responses and its role in lupus autoimmunity","volume":"125","author":"Sontheimer","year":"2005","journal-title":"J. Investig. Dermatol."},{"issue":"33","key":"10.1016\/j.schres.2014.07.053_bb0220","doi-asserted-by":"crossref","first-page":"13460","DOI":"10.1523\/JNEUROSCI.1333-13.2013","article-title":"A dramatic increase of C1q protein in the CNS during normal aging","volume":"33","author":"Stephan","year":"2013","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.schres.2014.07.053_bb0225","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.schres.2014.07.053_bb0230","first-page":"422","article-title":"Circulating immune complexes in the serum of mental patients and healthy subjects","volume":"84","author":"Vetlugina","year":"1984","journal-title":"Zh. Nevropatol. Psikhiatr. Im. S. S. Korsakova"},{"issue":"14","key":"10.1016\/j.schres.2014.07.053_bb0235","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"15","key":"10.1016\/j.schres.2014.07.053_bb0240","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","article-title":"Complement. Second of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"13","key":"10.1016\/j.schres.2014.07.053_bb0245","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.micinf.2009.07.007","article-title":"Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring","volume":"11","author":"Xiao","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.schres.2014.07.053_bb0250","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-2350-12-126","article-title":"Association of C1QB gene polymorphism with schizophrenia in Armenian population","volume":"12","author":"Zakharyan","year":"2011","journal-title":"BMC Med. Genet."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996414004137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996414004137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T18:04:52Z","timestamp":1565805892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996414004137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0920996414004137"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2014.07.053","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal complement C1q and increased odds for psychosis in adult offspring","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2014.07.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}