{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:20:39Z","timestamp":1771006839559,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Taiwanese Society of Psychiatry"},{"name":"Headquarters of University Advancement","award":["D102-35001"],"award-info":[{"award-number":["D102-35001"]}]},{"name":"Headquarters of University Advancement","award":["D103-35A09"],"award-info":[{"award-number":["D103-35A09"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.schres.2015.09.006","type":"journal-article","created":{"date-parts":[[2015,9,27]],"date-time":"2015-09-27T02:09:17Z","timestamp":1443319757000},"page":"400-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["A comparison of the effectiveness of risperidone, haloperidol and flupentixol long-acting injections in patients with schizophrenia\u2014A nationwide study"],"prefix":"10.1016","volume":"169","author":[{"given":"Hsaing-Yuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih Yin","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao Chin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Ting","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Hung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Hung","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Hui Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.schres.2015.09.006_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40258-013-0016-2","article-title":"The cost effectiveness of long-acting\/extended-release antipsychotics for the treatment of schizophrenia: a systematic review of economic evaluations","volume":"11","author":"Achilla","year":"2013","journal-title":"Appl. Health Econ. Health Policy"},{"key":"10.1016\/j.schres.2015.09.006_bb0010","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/YIC.0b013e3280de2c7f","article-title":"Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment","volume":"22","author":"Altamura","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.schres.2015.09.006_bb0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-244X-10-2","article-title":"The cost of relapse and the predictors of relapse in the treatment of schizophrenia","volume":"10","author":"Ascher-Svanum","year":"2010","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-2006-946703","article-title":"A comparative efficacy and safety study of long-acting risperidone injection and risperidone oral tablets among hospitalized patients: 12-week randomized, single-blind study","volume":"39","author":"Bai","year":"2006","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0025","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4088\/JCP.v68n0808","article-title":"Equivalent switching dose from oral risperidone to risperidone long-acting injection: a 48-week randomized, prospective, single-blind pharmacokinetic study","volume":"68","author":"Bai","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4088\/JCP.08l04447","article-title":"Long-acting injectable risperidone and hospital readmission: a mirror-image study using a national claim-based database in Taiwan","volume":"70","author":"Chang","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0035","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2165\/00023210-200721060-00001","article-title":"Long-acting formulations of atypical antipsychotics: time to reconsider when to introduce depot antipsychotics","volume":"21","author":"Chue","year":"2007","journal-title":"CNS Drugs"},{"key":"10.1016\/j.schres.2015.09.006_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1056\/NEJMoa002028","article-title":"A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia","volume":"346","author":"Csernansky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.schres.2015.09.006_bb0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.4088\/JCP.v64n1017","article-title":"Treatment of schizophrenia with long-acting injectable risperidone: a 12-month open-label trial of the first long-acting second-generation antipsychotic","volume":"64","author":"Fleischhacker","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0050","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.4088\/JCP.12m07638","article-title":"A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable: implications for dopamine D2 receptor occupancy during maintenance treatment in schizophrenia","volume":"73","author":"Ikai","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJM199601043340109","article-title":"Schizophrenia","volume":"334","author":"Kane","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 4","key":"10.1016\/j.schres.2015.09.006_bb0060","doi-asserted-by":"crossref","first-page":"S397","DOI":"10.1016\/S0924-977X(01)00109-2","article-title":"Extrapyramidal side effects are unacceptable","volume":"11","author":"Kane","year":"2001","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"Suppl. 16","key":"10.1016\/j.schres.2015.09.006_bb0065","first-page":"34","article-title":"Strategies for improving compliance in treatment of schizophrenia by using a long-acting formulation of an antipsychotic: clinical studies","volume":"64","author":"Kane","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0070","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1176\/appi.ajp.160.6.1125","article-title":"Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic","volume":"160","author":"Kane","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0075","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/wps.20060","article-title":"Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies","volume":"12","author":"Kane","year":"2013","journal-title":"World Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0080","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4088\/JCP.12r08167","article-title":"Efficacy and effectiveness of depot versus oral antipsychotics in schizophrenia: synthesizing results across different research designs","volume":"74","author":"Kirson","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/schbul\/sbs150","article-title":"Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trials","volume":"40","author":"Kishimoto","year":"2014","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2015.09.006_bb0090","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1192\/bjp.184.6.509","article-title":"Non-adherence to antipsychotic medication regimens: associations with resource use and costs","volume":"184","author":"Knapp","year":"2004","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.eurpsy.2003.11.007","article-title":"Patients with schizophrenia previously stabilized on conventional depot antipsychotics experience significant clinical improvements following treatment with long-acting risperidone","volume":"19","author":"Lasser","year":"2004","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1345\/aph.18458","article-title":"Switching antipsychotic therapies","volume":"34","author":"Masand","year":"2000","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.schres.2015.09.006_bb0105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-0447.2006.00980.x","article-title":"Thirty-five months experience of risperidone long-acting injection in a UK psychiatric service including a mirror-image analysis of in-patient care","volume":"116","author":"Niaz","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.schres.2015.09.006_bb0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/schbul\/sbu128","article-title":"Comparative effectiveness of risperidone long-acting injectable vs first-generation antipsychotic long-acting injectables in schizophrenia: results from a nationwide, retrospective inception cohort study","volume":"41","author":"Nielsen","year":"2015","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2015.09.006_bb0115","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1176\/appi.ajp.163.3.396","article-title":"A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone","volume":"163","author":"Remington","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0120","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.4088\/JCP.09m05866yel","article-title":"\u201cExtended\u201d antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial","volume":"72","author":"Remington","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0125","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1056\/NEJMoa1005987","article-title":"Long-acting risperidone and oral antipsychotics in unstable schizophrenia","volume":"364","author":"Rosenheck","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.schres.2015.09.006_bb0130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biopsych.2008.01.010","article-title":"Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery","volume":"64","author":"Samaha","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"Suppl. 16","key":"10.1016\/j.schres.2015.09.006_bb0135","first-page":"14","article-title":"Relapse and rehospitalization: comparing oral and depot antipsychotics","volume":"64","author":"Schooler","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S026418010000059X","article-title":"The natural history of schizophrenia: a five-year follow-up study of outcome and prediction in a representative sample of schizophrenics","volume":"15","author":"Shepherd","year":"1989","journal-title":"Psychol. Med. Monogr. Suppl."},{"issue":"Suppl. 3","key":"10.1016\/j.schres.2015.09.006_bb0145","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1111\/j.1524-4733.2009.00643.x","article-title":"Relapse and long-acting injectable risperidone: a 1-year mirror image study with a national claims database in Taiwan","volume":"12","author":"Su","year":"2009","journal-title":"Value Health"},{"key":"10.1016\/j.schres.2015.09.006_bb0150","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hup.2249","article-title":"The influence of switching from haloperidol decanoate depot to risperidone long-acting injection on the clinical symptoms and cognitive function in schizophrenia","volume":"27","author":"Suzuki","year":"2012","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.schres.2015.09.006_bb0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1192\/bjp.179.4.300","article-title":"Systematic review of patient and nurse attitudes to depot antipsychotic medication","volume":"179","author":"Walburn","year":"2001","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-244X-13-28","article-title":"Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication","volume":"13","author":"Wykes","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.schres.2015.09.006_bb0165","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1440-1819.2005.01390.x","article-title":"Pharmacoeconomic evaluation of schizophrenia in Taiwan: model comparison of long-acting risperidone versus olanzapine versus depot haloperidol based on estimated costs","volume":"59","author":"Yang","year":"2005","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.schres.2015.09.006_bb0170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0447.2006.00766.x","article-title":"Health resource utilization associated with switching to risperidone long-acting injection","volume":"114","author":"Young","year":"2006","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996415004752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996415004752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:25:57Z","timestamp":1760297157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996415004752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":34,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0920996415004752"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2015.09.006","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of the effectiveness of risperidone, haloperidol and flupentixol long-acting injections in patients with schizophrenia\u2014A nationwide study","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2015.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}