{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:55:08Z","timestamp":1786996508466,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.schres.2021.11.038","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T11:35:25Z","timestamp":1638617725000},"page":"128-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Through the prism of comorbidity: A strategic rethinking of early intervention in obsessive-compulsive disorder"],"prefix":"10.1016","volume":"239","author":[{"given":"Antonio","family":"Preti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Meneghelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Raballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.schres.2021.11.038_bb0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jpsychires.2016.07.017","article-title":"Pre- and perinatal complications in relation to tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit\/hyperactivity disorder","volume":"82","author":"Abdulkadir","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0010","first-page":"221","article-title":"Obsessive-compulsive disorder in the DSM-5","volume":"21","author":"Abramowitz","year":"2014","journal-title":"Clin. Psychol."},{"key":"10.1016\/j.schres.2021.11.038_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.eurpsy.2019.01.017","article-title":"Duration of untreated illness and response to SRI treatment in obsessive-compulsive disorder","volume":"58","author":"Albert","year":"2019","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0020","series-title":"Diagnostic and Statistical Manual of Mental Disorders","article-title":"Obsessive-compulsive and related disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.schres.2021.11.038_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jad.2015.06.005","article-title":"The prevalence and predictors of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review and meta-analysis","volume":"186","author":"Amerio","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jad.2019.06.015","article-title":"Updates in treating comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review","volume":"256","author":"Amerio","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"10.1016\/j.schres.2021.11.038_bb0040","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s00787-019-01461-y","article-title":"Predicting the individual risk of psychosis conversion in at-risk mental state (ARMS): a multivariate model reveals the influence of nonpsychotic prodromal symptoms","volume":"29","author":"Bourgin","year":"2020","journal-title":"Eur. Child Adolesc. Psychiatry."},{"key":"10.1016\/j.schres.2021.11.038_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.psychres.2016.03.047","article-title":"The familiality of specific symptoms of obsessive-compulsive disorder","volume":"239","author":"Brakoulias","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0050","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/eip.12535","article-title":"A call for prevention and early intervention in obsessive-compulsive disorder","volume":"12","author":"Brakoulias","year":"2018","journal-title":"Early Interv. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.comppsych.2021.152268","article-title":"Short communication: a report of the first twelve months of an early intervention service for obsessive-compulsive disorder (OCD)","volume":"110","author":"Brakoulias","year":"2021","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/jamapsychiatry.2014.2656","article-title":"Familial clustering of tic disorders and obsessive-compulsive disorder","volume":"72","author":"Browne","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0065","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1177\/0269881111431751","article-title":"Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study","volume":"26","author":"Bruno","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.schres.2021.11.038_bb0070","series-title":"New Oxford Textbook of Psychiatry","first-page":"987","article-title":"Obsessive-compulsive disorder","author":"Carmi","year":"2020"},{"key":"10.1016\/j.schres.2021.11.038_bb0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fpsyt.2020.00188","article-title":"The burden of comorbidity between bipolar Spectrum and obsessive-compulsive disorder in an italian community survey","volume":"11","author":"Carta","year":"2020","journal-title":"Front. Psychiat."},{"key":"10.1016\/j.schres.2021.11.038_bb0080","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/schbul\/sbu169","article-title":"Obsessive-compulsive disorder, psychosis, and bipolarity: a longitudinal cohort and multigenerational family study","volume":"41","author":"Cederl\u00f6f","year":"2015","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2021.11.038_bb0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.schres.2019.05.024","article-title":"Risk of schizophrenia among people with obsessive-compulsive disorder: a nationwide population-based cohort study","volume":"209","author":"Cheng","year":"2019","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1017\/S1092852917000177","article-title":"Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)","volume":"23","author":"Dell'Osso","year":"2018","journal-title":"CNS Spectr."},{"key":"10.1016\/j.schres.2021.11.038_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpsychires.2021.08.017","article-title":"The effect of childhood trauma on the severity of obsessive-compulsive symptoms: a systematic review","volume":"142","author":"Destr\u00e9e","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1037\/cap0000196","article-title":"Transdiagnostic neurocognitive deficits in psychiatry: a review of meta-analyses","volume":"61","author":"East-Richard","year":"2020","journal-title":"Can. Psychol."},{"key":"10.1016\/j.schres.2021.11.038_bb0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1744-859X-12-40","article-title":"Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia","volume":"12","author":"Ery\u0131lmaz","year":"2013","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jad.2019.11.136","article-title":"Comorbidity of obsessive-compulsive disorder in bipolar spectrum disorders: systematic review and meta-analysis of its prevalence","volume":"263","author":"Ferentinos","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0115","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/mp.2016.115","article-title":"Suicide in obsessive-compulsive disorder: a population-based study of 36 788 swedish patients","volume":"22","author":"Fern\u00e1ndez de la Cruz","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0120","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.euroneuro.2019.02.002","article-title":"Early intervention for obsessive compulsive disorder: an expert consensus statement","volume":"29","author":"Fineberg","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.schres.2021.11.038_bb0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/YIC.0000000000000314","article-title":"Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders","volume":"35","author":"Fineberg","year":"2020","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.schres.2021.11.038_bb0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eclinm.2019.01.014","article-title":"A clinical staging model for obsessive-compulsive disorder: is it ready for prime time?","volume":"7","author":"Fontenelle","year":"2019","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.schres.2021.11.038_bb0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pnpbp.2005.11.001","article-title":"The descriptive epidemiology of obsessive-compulsive disorder","volume":"30","author":"Fontenelle","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2014.07.009","article-title":"Factors associated with non-treatment or delayed treatment seeking in OCD sufferers: a review of the literature","volume":"220","author":"Garc\u00eda-Soriano","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0145","article-title":"Developmental considerations in obsessive compulsive disorder: comparing pediatric and adult-onset cases","volume":"12","author":"Geller","year":"2021","journal-title":"Front. Psych."},{"key":"10.1016\/j.schres.2021.11.038_bb0150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.psychres.2016.09.031","article-title":"Induced obsessive compulsive symptoms (OCS) in schizophrenia patients under atypical 2 antipsychotics (AAPs): review and hypotheses","volume":"246","author":"Grillault Laroche","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0155","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/cap.2018.0127","article-title":"Establishing a pediatric acute-onset neuropsychiatric syndrome clinic: baseline clinical features of the pediatric acute-onset neuropsychiatric syndrome cohort at Karolinska Institutet","volume":"29","author":"Gromark","year":"2019","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.schres.2021.11.038_bb0160","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/neu.2018.27","article-title":"Obsessive-compulsive symptoms in schizophrenia: a review","volume":"31","author":"Grover","year":"2019","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.schres.2021.11.038_bb0165","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neubiorev.2018.09.009","article-title":"Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders","volume":"95","author":"Hirjak","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.schres.2021.11.038_bb0170","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1001\/jama.2017.2200","article-title":"Obsessive-compulsive disorder: advances in diagnosis and treatment","volume":"317","author":"Hirschtritt","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.schres.2021.11.038_bb0175","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00787-019-01276-x","article-title":"Hoarding in children and adolescents with obsessive-compulsive disorder: prevalence, clinical correlates, and cognitive behavioral therapy outcome","volume":"28","author":"H\u00f8jgaard","year":"2019","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neubiorev.2017.04.012","article-title":"Meta-analytic investigations of common and distinct grey matter alterations in youths and adults with obsessive-compulsive disorder","volume":"78","author":"Hu","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.schres.2021.11.038_bb0185","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature09552","article-title":"Rethinking schizophrenia","volume":"468","author":"Insel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.schres.2021.11.038_bb0190","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/mp.2017.154","article-title":"Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis","volume":"23","author":"International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC)","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0195","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1017\/S0033291712002012","article-title":"Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis","volume":"43","author":"Jaafari","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.schres.2021.11.038_bb0200","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archgenpsychiatry.2010.180","article-title":"Development of lifetime comorbidity in the World Health Organization world mental health surveys","volume":"68","author":"Kessler","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00004583-199001000-00004","article-title":"Childhood rituals: normal development or obsessive-compulsive symptoms?","volume":"29","author":"Leonard","year":"1990","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0210","first-page":"197","article-title":"Basic obsessions and delusions in chronic schizophrenics","volume":"9","author":"Maggini","year":"2001","journal-title":"Neurol. Psychiatry Brain Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0215","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-0327(03)00107-1","article-title":"Obsessive-compulsive bipolar comorbidity: focus on children and adolescents","volume":"78","author":"Masi","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0220","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/jamapsychiatry.2013.3","article-title":"Population-based, multigenerational family clustering study of obsessive-compulsive disorder","volume":"70","author":"Mataix-Cols","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0225","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamapsychiatry.2019.2335","article-title":"When improving symptoms is not enough-is it time for next-generation interventions for obsessive-compulsive disorder?","volume":"77","author":"Mataix-Cols","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0230","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/jamapsychiatry.2014.1011","article-title":"Obsessive-compulsive disorder as a risk factor for schizophrenia: a nationwide study","volume":"71","author":"Meier","year":"2014","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.schres.2021.11.038_bb0235","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2015.3105","article-title":"Mortality among persons with obsessive-compulsive disorder in Denmark","volume":"73","author":"Meier","year":"2016","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.schres.2021.11.038_bb0245","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1192\/bjp.bp.109.075317","article-title":"Long-term outcomes of obsessive-compulsive disorder: follow-up of 142 children and adolescents","volume":"197","author":"Micali","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0250","series-title":"New Oxford Textbook of Psychiatry","first-page":"995","article-title":"Genetics of obsessive-compulsive disorder","author":"Nestadt","year":"2020"},{"key":"10.1016\/j.schres.2021.11.038_bb0255","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/PRA.0000000000000499","article-title":"Pharmacological treatment for comorbid bipolar disorder and obsessive-compulsive disorder in adults","volume":"26","author":"Netto","year":"2020","journal-title":"J. Psychiatr. Pract."},{"key":"10.1016\/j.schres.2021.11.038_bb0260","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.eurpsy.2017.10.001","article-title":"Meta-analytical prognostic accuracy of the comprehensive assessment of at risk mental states (CAARMS): the need for refined prediction","volume":"49","author":"Oliver","year":"2018","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0265","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2015.12.002","article-title":"Childhood maltreatment and comorbid anxiety in people with bipolar disorder","volume":"192","author":"Pavlova","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0270","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.schres.2019.08.014","article-title":"Obsessively thinking through the schizophrenia spectrum: disentangling pseudo-obsessive schizophrenia from OCD","volume":"212","author":"Poletti","year":"2019","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0275","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jpsychires.2004.09.004","article-title":"Obsessive-compulsive disorder (OCD) with schizotypy vs. Schizophrenia with OCD: diagnostic dilemmas and therapeutic implications","volume":"39","author":"Poyurovsky","year":"2005","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0280","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1177\/0269881108099215","article-title":"Lamotrigine augmentation in schizophrenia and schizoaffective patients with obsessive-compulsive symptoms","volume":"24","author":"Poyurovsky","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.schres.2021.11.038_bb0285","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1891\/0889-8391.27.4.384","article-title":"The relationship of hoarding symptoms to schizotypal personality and cognitive schemas in an OCD sample","volume":"27","author":"Rasmussen","year":"2013","journal-title":"J. Cogn. Psychother."},{"key":"10.1016\/j.schres.2021.11.038_bb0290","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2019.01.046","article-title":"Obsessive-compulsive disorder: puzzles and prospects","volume":"102","author":"Robbins","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.schres.2021.11.038_bb0295","article-title":"Early intervention for people at high risk of developing bipolar disorder: a systematic review of clinical trials","author":"Saraf","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0300","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1017\/S1092852916000390","article-title":"Schizo-obsessive spectrum disorders: an update","volume":"22","author":"Scotti-Muzzi","year":"2017","journal-title":"CNS Spectr."},{"key":"10.1016\/j.schres.2021.11.038_bb0305","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1017\/S1092852918001049","article-title":"Lamotrigine-induced obsessive-compulsive disorder in patients with bipolar disorder","volume":"24","author":"Sharma","year":"2019","journal-title":"CNS Spectr."},{"key":"10.1016\/j.schres.2021.11.038_bb0310","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1017\/S0033291712000207","article-title":"Why do anxious children become depressed teenagers? The role of social evaluative threat and reward processing","volume":"42","author":"Silk","year":"2012","journal-title":"Psychol. Med."},{"key":"10.1016\/j.schres.2021.11.038_bb0315","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S2215-0366(16)30069-4","article-title":"Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis","volume":"3","author":"Skapinakis","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.schres.2021.11.038_bb0320","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jad.2015.10.061","article-title":"The classification of obsessive-compulsive and related disorders in the ICD-11","volume":"190","author":"Stein","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0325","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1192\/bjp.91.383.166","article-title":"A study on some clinical aspects of the relationship between obsessional neurosis and psychotic reaction types","volume":"91","author":"Stengel","year":"1945","journal-title":"J. Ment. Sci."},{"key":"10.1016\/j.schres.2021.11.038_bb0330","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0447.2004.00302.x","article-title":"Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature","volume":"110","author":"Stewart","year":"2004","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.schres.2021.11.038_bb0335","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.schres.2013.10.033","article-title":"The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates","volume":"152","author":"Swets","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0340","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cpr.2011.06.007","article-title":"Early versus late onset obsessive-compulsive disorder: evidence for distinct subtypes","volume":"31","author":"Taylor","year":"2011","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.schres.2021.11.038_bb0345","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ajmg.b.32407","article-title":"Disorder-specific genetic factors in obsessive-compulsive disorder: a comprehensive meta-analysis","volume":"171B","author":"Taylor","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.schres.2021.11.038_bb0350","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11920-019-1051-y","article-title":"Obsessive-compulsive symptoms in schizophrenia: an up-to-date review of literature","volume":"21","author":"Tezenas du Montcel","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.schres.2021.11.038_bb0355","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jad.2019.12.016","article-title":"The speed of progression towards obsessive-compulsive disorder","volume":"264","author":"Thompson","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.schres.2021.11.038_bb0360","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.psychres.2017.12.034","article-title":"Moderators and predictors of response to cognitive behaviour therapy for pediatric obsessive-compulsive disorder: a systematic review","volume":"261","author":"Turner","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0365","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0447.2010.01609.x","article-title":"Can obsessions drive you mad? Longitudinal evidence that obsessive-compulsive symptoms worsen the outcome of early psychotic experiences","volume":"123","author":"Van Dael","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.schres.2021.11.038_bb0370","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/7854_2020_209","article-title":"Structural imaging in OCD","volume":"49","author":"Veltman","year":"2021","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.schres.2021.11.038_bb0375","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S2352-4642(19)30376-1","article-title":"Early detection and intervention for obsessive-compulsive disorder in childhood and adolescence","volume":"4","author":"Walitza","year":"2020","journal-title":"Lancet Child Adolesc. Health."},{"key":"10.1016\/j.schres.2021.11.038_bb0380","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.psychres.2019.01.061","article-title":"Comparison of the screening ability between the 32-item hypomania checklist (HCL-32) and the mood disorder questionnaire (MDQ) for bipolar disorder: a meta-analysis and systematic review","volume":"273","author":"Wang","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2021.11.038_bb0385","series-title":"International Classification of Diseases for Mortality and Morbidity Statistics (11th Revision)","article-title":"Obsessive-compulsive or related disorders","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.schres.2021.11.038_bb0390","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S2215-0366(17)30270-5","article-title":"Antipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia: a systematic review with pairwise and network meta-analyses","volume":"4","author":"Zhu","year":"2017","journal-title":"Lancet Psychiatry"}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996421004710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996421004710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:44:58Z","timestamp":1760298298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996421004710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":77,"alternative-id":["S0920996421004710"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2021.11.038","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Through the prism of comorbidity: A strategic rethinking of early intervention in obsessive-compulsive disorder","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2021.11.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}