{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:40:04Z","timestamp":1782297604190,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Fonds national suisse de la recherche scientifique","doi-asserted-by":"publisher","award":["320030-200602"],"award-info":[{"award-number":["320030-200602"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Fonds national suisse de la recherche scientifique","doi-asserted-by":"publisher","award":["324730-144064"],"award-info":[{"award-number":["324730-144064"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Fonds national suisse de la recherche scientifique","doi-asserted-by":"publisher","award":["320030-173211"],"award-info":[{"award-number":["320030-173211"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Fonds national suisse de la recherche scientifique","doi-asserted-by":"publisher","award":["320030-120686"],"award-info":[{"award-number":["320030-120686"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.schres.2024.07.007","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T23:35:03Z","timestamp":1720568103000},"page":"403-409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Aripiprazole dose associations with metabolic adverse effect: Results from a longitudinal study"],"prefix":"10.1016","volume":"270","author":[{"given":"Marianna","family":"Piras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setareh","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermine","family":"Laaboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman","family":"Sentissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Lakhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Gamma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin J.","family":"Plessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"von Gunten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Conus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin B.","family":"Eap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.schres.2024.07.007_bb0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/0269881119885918","article-title":"Effects of long-term antipsychotics treatment on body weight: a population-based cohort study","volume":"34","author":"Bazo-Alvarez","year":"2020","journal-title":"J. Psychopharmacol."},{"issue":"7","key":"10.1016\/j.schres.2024.07.007_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2165\/00003088-200847070-00004","article-title":"Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia","volume":"47","author":"Boulton","year":"2008","journal-title":"Clin. Pharmacokinet."},{"issue":"6","key":"10.1016\/j.schres.2024.07.007_bb0015","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/acschemneuro.7b00087","article-title":"Classics in Chemical Neuroscience: Aripiprazole","volume":"8","author":"Casey","year":"2017","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.schres.2024.07.007_bb0020","unstructured":"Chokhawala, K., & Stevens, L. (2022). Antipsychotic Medications. In StatPearls. StatPearls Publishing Copyright \u00a9 2022, StatPearls Publishing LLC."},{"issue":"2","key":"10.1016\/j.schres.2024.07.007_bb0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmed.2010.10.010","article-title":"Antipsychotic drugs and obesity","volume":"17","author":"Correll","year":"2011","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.schres.2024.07.007_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jacl.2017.10.002","article-title":"Early changes of blood lipid levels during psychotropic drug treatment as predictors of long-term lipid changes and of new onset dyslipidemia","volume":"12","author":"Delacr\u00e9taz","year":"2018","journal-title":"J. Clin. Lipidol."},{"issue":"1","key":"10.1016\/j.schres.2024.07.007_bb0035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13148-019-0792-0","article-title":"Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients","volume":"11","author":"Delacr\u00e9taz","year":"2019","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.schres.2024.07.007_bb0040","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41398-021-01482-9","article-title":"Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort","volume":"11","author":"Dubath","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.schres.2024.07.007_bb0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/a-1525-2820","article-title":"Effect of quetiapine, from low to high dose, on weight and metabolic traits: results from a prospective cohort study","volume":"54","author":"Dubath","year":"2021","journal-title":"Pharmacopsychiatry"},{"issue":"2","key":"10.1016\/j.schres.2024.07.007_bb0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0447.2005.00612.x","article-title":"An exploratory open-label trial of aripiprazole as an adjuvant to clozapine therapy in chronic schizophrenia","volume":"113","author":"Henderson","year":"2006","journal-title":"Acta Psychiatr. Scand."},{"issue":"5","key":"10.1016\/j.schres.2024.07.007_bb0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/WNF.0b013e31819a68b5","article-title":"Effectiveness of switching to aripiprazole from atypical antipsychotics in patients with schizophrenia","volume":"32","author":"Kim","year":"2009","journal-title":"Clin. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.schres.2024.07.007_bb0060","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","article-title":"H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs","volume":"28","author":"Kroeze","year":"2003","journal-title":"Neuropsychopharmacology"},{"issue":"2\u20133","key":"10.1016\/j.schres.2024.07.007_bb0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(03)00050-1","article-title":"Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials","volume":"61","author":"Marder","year":"2003","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.schres.2024.07.007_bb0075","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2133\/dmpk.20.368","article-title":"Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus","volume":"20","author":"Matsui-Sakata","year":"2005","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"Suppl. 18","key":"10.1016\/j.schres.2024.07.007_bb0080","first-page":"47","article-title":"A comparison of weight change during treatment with olanzapine or aripiprazole: results from a randomized, double-blind study","volume":"65","author":"McQuade","year":"2004","journal-title":"J. Clin. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2024.07.007_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1517\/14740338.2015.974549","article-title":"Weight gain and antipsychotics: a drug safety review","volume":"14","author":"Musil","year":"2015","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.schres.2024.07.007_bb0090","article-title":"Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis","author":"Pillinger","year":"2019","journal-title":"Lancet Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2024.07.007_bb0095","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.21m14110","article-title":"Daily dose effects of risperidone on weight and other metabolic parameters: a prospective cohort study","volume":"83","author":"Piras","year":"2022","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.schres.2024.07.007_bb0100","article-title":"Evolutions of metabolic parameters following switches of psychotropic drugs: a longitudinal cohort study","author":"Piras","year":"2022","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2024.07.007_bb0105","series-title":"Is Clozapine-Induced Weight Gain Dose-Dependent?","author":"Piras","year":"2023"},{"issue":"4 Suppl","key":"10.1016\/j.schres.2024.07.007_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1359786806066040","article-title":"The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics","volume":"20","author":"Reynolds","year":"2006","journal-title":"J. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.schres.2024.07.007_bb0115","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.22r14490","article-title":"Comparative effects of 11 antipsychotics on weight gain and metabolic function in patients with acute schizophrenia: a dose-response Meta-analysis","volume":"84","author":"Sab\u00e9","year":"2023","journal-title":"J. Clin. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2024.07.007_bb0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/bcpt.13715","article-title":"Olanzapine-associated dose-dependent alterations for weight and metabolic parameters in a prospective cohort","volume":"130","author":"Schoretsanitis","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.schres.2024.07.007_bb0125","doi-asserted-by":"crossref","DOI":"10.4088\/PCC.20r02799","article-title":"Long-term efficacy and tolerability of adjunctive aripiprazole for major depressive disorder: systematic review and Meta-analysis","volume":"23","author":"Seshadri","year":"2021","journal-title":"Prim Care Companion CNS Disord"},{"key":"10.1016\/j.schres.2024.07.007_bb0130","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.schres.2022.11.018","article-title":"Weight changes in people with early psychosis treated with oral or long-acting injectable aripiprazole","volume":"251","author":"Shymko","year":"2023","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2024.07.007_bb0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1471-244X-11-197","article-title":"Association between second-generation antipsychotics and newly diagnosed treated diabetes mellitus: does the effect differ by dose?","volume":"11","author":"Ulcickas Yood","year":"2011","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.schres.2024.07.007_bb0140","doi-asserted-by":"crossref","unstructured":"Viktoria Simon, M. D. R. v. W., M.D., Ph.D.; and Marc De Hert, M.D., Ph.D. (2009). Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review. J Clin Psychiatry.","DOI":"10.4088\/JCP.08r04392"},{"issue":"Suppl. 4","key":"10.1016\/j.schres.2024.07.007_bb0145","first-page":"34","article-title":"Switching antipsychotics as a treatment strategy for antipsychotic-induced weight gain and dyslipidemia","volume":"68","author":"Weiden","year":"2007","journal-title":"J. Clin. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2024.07.007_bb0150","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/schbul\/sbac001","article-title":"Antipsychotic-induced weight gain: dose-response Meta-analysis of randomized controlled trials","volume":"48","author":"Wu","year":"2022","journal-title":"Schizophr. Bull."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996424003104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996424003104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T18:26:22Z","timestamp":1725301582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996424003104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":29,"alternative-id":["S0920996424003104"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2024.07.007","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aripiprazole dose associations with metabolic adverse effect: Results from a longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2024.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}