{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:55:12Z","timestamp":1786996512069,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000269","name":"UK Research and Innovation Economic and Social Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023232","name":"National Institute for Health and Care Research Applied Research Collaboration South London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019418","name":"National Institute for Health Research Maudsley Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"United Kingdom Department of Health &amp; Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.schres.2025.01.021","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:19:56Z","timestamp":1738819196000},"page":"196-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Impact of loneliness and living alone on negative symptoms in severe mental illness: An electronic health record data analysis"],"prefix":"10.1016","volume":"276","author":[{"given":"Dulce E.","family":"Alarc\u00f3n-Yaquetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Pinto da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.schres.2025.01.021_bb0005","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1176\/ps.2009.60.12.1642","article-title":"Community integration and associated factors among older adults with schizophrenia","volume":"60","author":"Abdallah","year":"2009","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.schres.2025.01.021_bb0010","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012750","article-title":"Adjusted indices of multiple deprivation to enable comparisons within and between constituent countries of the UK including an illustration using mortality rates","volume":"6","author":"Abel","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.schres.2025.01.021_bb0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/eb-2012-100943","article-title":"Reported loneliness rather than social isolation is a risk factor for 10-year mortality in older men","volume":"15","author":"Andrew","year":"2012","journal-title":"Evidence Based Mental Health"},{"key":"10.1016\/j.schres.2025.01.021_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/cpsp.12345","article-title":"Loneliness in psychosis: a practical review and critique for clinicians","volume":"27","author":"Badcock","year":"2020","journal-title":"Clin. Psychol. Sci. Pract."},{"key":"10.1016\/j.schres.2025.01.021_bb0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/0898264316685843","article-title":"Disentangling loneliness: differential effects of subjective loneliness, network quality, network size, and living alone on physical, mental, and cognitive health","volume":"30","author":"Beller","year":"2018","journal-title":"J. Aging Health"},{"key":"10.1016\/j.schres.2025.01.021_bb0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.schres.2017.06.006","article-title":"Neighbourhood deprivation is positively associated with detection of the ultra-high risk (UHR) state for psychosis in South East London","volume":"192","author":"Bhavsar","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17522439.2014.917433","article-title":"Intimate partner violence, sexual abuse, and the mediating role of loneliness on psychosis","volume":"7","author":"Boyda","year":"2015","journal-title":"Psychosis"},{"key":"10.1016\/j.schres.2025.01.021_bb0040","doi-asserted-by":"crossref","DOI":"10.1001\/archinternmed.2012.2649","article-title":"Loneliness and living alone","volume":"172","author":"Bucholz","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0045","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev-psych-010814-015240","article-title":"The neuroendocrinology of social isolation","volume":"66","author":"Cacioppo","year":"2015","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.schres.2025.01.021_bb0050","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2147\/NDT.S225643","article-title":"Negative symptoms in schizophrenia: a review and clinical guide for recognition, assessment, and treatment","volume":"16","author":"Correll","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.schres.2025.01.021_bb0055","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1177\/0898264312460275","article-title":"Social isolation, loneliness and health among older adults","volume":"24","author":"Coyle","year":"2012","journal-title":"J. Aging Health"},{"key":"10.1016\/j.schres.2025.01.021_bb0060","series-title":"Library of production-ready applications","author":"CRIS NLP Catalogue","year":"2024"},{"key":"10.1016\/j.schres.2025.01.021_bb0065","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0920-9964(00)00190-0","article-title":"Integrating psychopathological dimensions in functional psychoses: a hierarchical approach","volume":"52","author":"Cuesta","year":"2001","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0070","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1017\/S0033291709990651","article-title":"Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?","volume":"39","author":"Demjaha","year":"2009","journal-title":"Psychol. Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12877-018-0939-4","article-title":"The association between living alone and health care utilisation in older adults: a retrospective cohort study of electronic health records from a London general practice","volume":"18","author":"Dreyer","year":"2018","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.schres.2025.01.021_bb0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1472-6947-13-71","article-title":"Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records","volume":"13","author":"Fernandes","year":"2013","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"10.1016\/j.schres.2025.01.021_bb0085","article-title":"EPA guidance on treatment of negative symptoms in schizophrenia","volume":"64","author":"Galderisi","year":"2021","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.schres.2025.01.021_bb0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0959259898008090","article-title":"A review of loneliness: concept and definitions, determinants and consequences","volume":"8","author":"Gierveld","year":"1998","journal-title":"Rev. Clin. Gerontol."},{"key":"10.1016\/j.schres.2025.01.021_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0033291709006126","article-title":"Efficacy and effectiveness of individual family intervention on social and clinical functioning and family burden in severe schizophrenia: a 2-year randomized controlled study","volume":"40","author":"Gir\u00f3n","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-022-00355-9","article-title":"Loneliness and health","volume":"8","author":"Hawkley","year":"2022","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.schres.2025.01.021_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012012","article-title":"Natural language processing to extract symptoms of severe mental illness from clinical text: the Clinical Record Interactive Search Comprehensive Data Extraction (CRIS-CODE) project","volume":"7","author":"Jackson","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.schres.2025.01.021_bb0110","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2147\/PPA.S460210","article-title":"Effects of social support on medication adherence among patients with schizophrenia: serial multiple mediation model","volume":"18","author":"Jiang","year":"2024","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.schres.2025.01.021_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105483","article-title":"Exploring the differential impacts of social isolation, loneliness, and their combination on the memory of an aging population: a 6-year longitudinal study of the CLSA","volume":"125","author":"Kang","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.schres.2025.01.021_bb0120","article-title":"The role of peripheral inflammation in clinical outcome and brain imaging abnormalities in psychosis: a systematic review","volume":"12","author":"Kose","year":"2021","journal-title":"Front. Psych."},{"key":"10.1016\/j.schres.2025.01.021_bb0125","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1037\/0022-006X.76.3.491","article-title":"A meta-analysis of controlled research on social skills training for schizophrenia","volume":"76","author":"Kurtz","year":"2008","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.schres.2025.01.021_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/673181","article-title":"Living alone, loneliness, and psychological well-being of older persons in Singapore","volume":"2011","author":"Lim","year":"2011","journal-title":"Current Gerontology and Geriatrics Research"},{"key":"10.1016\/j.schres.2025.01.021_bb0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jomf.12963","article-title":"Racial\/ethnic differences in living arrangements, distant relations, and later-life mental health","volume":"86","author":"Liu","year":"2024","journal-title":"J. Marriage Fam."},{"key":"10.1016\/j.schres.2025.01.021_bb0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/jpm.12567","article-title":"Cognitive behavioural family intervention for people diagnosed with severe mental illness and their families: a systematic review and meta-analysis of randomized controlled trials","volume":"27","author":"Ma","year":"2020","journal-title":"J. Psychiatr. Ment. Health Nurs."},{"key":"10.1016\/j.schres.2025.01.021_bb0145","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/08039480801959307","article-title":"Negative symptoms in schizophrenia\u2014a review","volume":"62","author":"M\u00e4kinen","year":"2008","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.schres.2025.01.021_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003306","article-title":"Severe mental illness diagnosis in English general hospitals 2006-2017: a registry linkage study","volume":"17","author":"Mansour","year":"2020","journal-title":"PLoS Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0155","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00127-004-0762-4","article-title":"Schizophrenia and employment","volume":"39","author":"Marwaha","year":"2004","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.schres.2025.01.021_bb0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbi.2023.11.022","article-title":"Social isolation, loneliness, and inflammation: a multi-cohort investigation in early and mid-adulthood","volume":"115","author":"Matthews","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.schres.2025.01.021_bb0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/schbul\/sbx036","article-title":"Loneliness in psychosis: a meta-analytical review","volume":"44","author":"Michalska da Rocha","year":"2018","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2025.01.021_bb0170","series-title":"The English Indices of Deprivation 2019 (IoD2019)","author":"Ministry of Housing, C. and L.G","year":"2019"},{"key":"10.1016\/j.schres.2025.01.021_bb0175","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/schbul\/sbae022","article-title":"Loneliness in the daily lives of people with mood and psychotic disorders","volume":"50","author":"Moran","year":"2024","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2025.01.021_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2021.114339","article-title":"Does unemployment lead to greater levels of loneliness? A systematic review","volume":"287","author":"Morrish","year":"2021","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.schres.2016.05.014","article-title":"Primary and persistent negative symptoms: concepts, assessments and neurobiological bases","volume":"186","author":"Mucci","year":"2017","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0190","series-title":"Families and households in the UK: 2022","author":"Office for National Statistics","year":"2022"},{"key":"10.1016\/j.schres.2025.01.021_bb0195","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00127-021-02079-9","article-title":"Associations between loneliness and acute hospitalisation outcomes among patients receiving mental healthcare in South London: a retrospective cohort study","volume":"57","author":"Parmar","year":"2022","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.schres.2025.01.021_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.112753","article-title":"Understanding social withdrawal in euthymic bipolar patients: the role of stigma","volume":"284","author":"Pascual-Sanchez","year":"2020","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0205","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-007619","article-title":"Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method","volume":"5","author":"Patel","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.schres.2025.01.021_bb0210","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-008721","article-title":"Cohort profile of the South London and Maudsley NHS Foundation Trust biomedical research Centre (SLaM BRC) case register: current status and recent enhancement of an electronic mental health record-derived data resource","volume":"6","author":"Perera","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.schres.2025.01.021_bb0215","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1477-7525-3-76","article-title":"A review of the psychometric properties of the health of the nation outcome scales (HoNOS) family of measures","volume":"3","author":"Pirkis","year":"2005","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.schres.2025.01.021_bb0220","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.paid.2009.04.026","article-title":"Social skills, paranoid thinking, and social outcomes among young adults","volume":"47","author":"Riggio","year":"2009","journal-title":"Personal. Individ. Differ."},{"key":"10.1016\/j.schres.2025.01.021_bb0225","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/13607863.2016.1191060","article-title":"Living alone and depression: the modifying role of the perceived neighborhood environment","volume":"21","author":"Stahl","year":"2017","journal-title":"Aging Ment. Health"},{"key":"10.1016\/j.schres.2025.01.021_bb0230","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/0004867412449060","article-title":"Understanding the social costs of psychosis: the experience of adults affected by psychosis identified within the second Australian national survey of psychosis","volume":"46","author":"Stain","year":"2012","journal-title":"Australian & New Zealand Journal of Psychiatry"},{"key":"10.1016\/j.schres.2025.01.021_bb0235","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.1219686110","article-title":"Social isolation, loneliness, and all-cause mortality in older men and women","volume":"110","author":"Steptoe","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.schres.2025.01.021_bb0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.schres.2004.12.020","article-title":"Integrated treatment ameliorates negative symptoms in first episode psychosis\u2014results from the Danish OPUS trial","volume":"79","author":"Thorup","year":"2005","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167103","article-title":"Utility of the health of the nation outcome scales (HoNOS) in predicting mental health service costs for patients with common mental health problems: historical cohort study","volume":"11","author":"Twomey","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.schres.2025.01.021_bb0250","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1017\/S0033291707000657","article-title":"A psychosocial skills training approach in Mexican out-patients with schizophrenia","volume":"37","author":"Valencia","year":"2007","journal-title":"Psychol. Med."},{"key":"10.1016\/j.schres.2025.01.021_bb0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12888-018-1736-5","article-title":"Associations between loneliness and perceived social support and outcomes of mental health problems: a systematic review","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.schres.2025.01.021_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101677","article-title":"Living alone and all-cause mortality in community-dwelling adults: a systematic review and meta-analysis","volume":"54","author":"Zhao","year":"2022","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.schres.2025.01.021_bb0265","doi-asserted-by":"crossref","DOI":"10.1007\/s00406-024-01834-8","article-title":"How to assess response","author":"Zitzmann","year":"2024","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.schres.2025.01.021_bb0270","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.schres.2023.10.009","article-title":"A potential issue with PANSS responder analysis","volume":"261","author":"Zitzmann","year":"2023","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2025.01.021_bb0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.euroneuro.2024.03.008","article-title":"Taking uncertainty in the assessment of response into account: an advanced guideline for computing responder rates in clinical trials","volume":"85","author":"Zitzmann","year":"2024","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996425000295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996425000295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:43:58Z","timestamp":1740494638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996425000295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":55,"alternative-id":["S0920996425000295"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2025.01.021","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of loneliness and living alone on negative symptoms in severe mental illness: An electronic health record data analysis","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2025.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}