{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:16:46Z","timestamp":1790299006815,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH60722"],"award-info":[{"award-number":["MH60722"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH63480"],"award-info":[{"award-number":["MH63480"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01s MH42191"],"award-info":[{"award-number":["R01s MH42191"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019274","name":"National Institute of Mental Health and Neurosciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.schres.2025.11.014","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T08:07:23Z","timestamp":1765440443000},"page":"138-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample"],"prefix":"10.1016","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9281-7696","authenticated-orcid":false,"given":"Christie W.","family":"Musket","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-1770","authenticated-orcid":false,"given":"Petra E.","family":"Rupert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-2970","authenticated-orcid":false,"given":"Susan S.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-9782","authenticated-orcid":false,"given":"David R.","family":"Roalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-1393","authenticated-orcid":false,"given":"Konasale M.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-1996","authenticated-orcid":false,"given":"Ruben C.","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-8124","authenticated-orcid":false,"given":"Laura A.","family":"Almasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-8502","authenticated-orcid":false,"given":"Raquel E.","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-5927","authenticated-orcid":false,"given":"Vishwajit L.","family":"Nimgaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-1376","authenticated-orcid":false,"given":"Michael F.","family":"Pogue-Geile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.schres.2025.11.014_bb0005","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.schres.2025.11.014_bb0010","series-title":"Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision","author":"American Psychiatric Association","year":"2022"},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0015","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1369-1600.2006.00043.x","article-title":"Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence","volume":"12","author":"Benegal","year":"2007","journal-title":"Addict. Biol."},{"issue":"1\u20132","key":"10.1016\/j.schres.2025.11.014_bb0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archpsyc.64.3.297","article-title":"Brain volumes in relatives of patients with schizophrenia: a meta-analysis","volume":"64","author":"Boos","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.schres.2025.11.014_bb0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fgene.2016.00149","article-title":"Associations between polygenic risk for psychiatric disorders and substance involvement","volume":"7","author":"Carey","year":"2016","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pscychresns.2013.07.008","article-title":"Multimodal voxel-based meta-analysis of structural and functional magnetic resonance imaging studies in those at elevated genetic risk of developing schizophrenia","volume":"221","author":"Cooper","year":"2014","journal-title":"Psychiatry Res."},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0040","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/npp.2014.187","article-title":"Shared genetic factors influence amygdala volumes and risk for alcoholism","volume":"40","author":"Dager","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"13","key":"10.1016\/j.schres.2025.11.014_bb0045","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1017\/S0033291721000969","article-title":"Genetics of substance use disorders: a review","volume":"51","author":"Deak","year":"2021","journal-title":"Psychol. Med."},{"issue":"8","key":"10.1016\/j.schres.2025.11.014_bb0050","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archgenpsychiatry.2010.86","article-title":"Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder","volume":"67","author":"Dean","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0055","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jpsychires.2012.09.023","article-title":"Family history of schizophrenia as a risk factor for axis I psychiatric conditions","volume":"47","author":"DeVylder","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.schres.2025.11.014_bb0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/15332985.2014.881457","article-title":"A systematic review of the familial co-aggregation of schizophrenia with non-psychotic disorders","volume":"12","author":"DeVylder","year":"2014","journal-title":"Soc. Work. Ment. Health"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0070","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.schres.2025.11.014_bb0075","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.neubiorev.2010.12.005","article-title":"Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis","volume":"35","author":"Fusar-Poli","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.schres.2025.11.014_bb0080","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.cpr.2006.09.004","article-title":"Reasons for increased substance use in psychosis","volume":"27","author":"Gregg","year":"2007","journal-title":"Clin. Psychol. Rev."},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12504","article-title":"Relationships between substance abuse\/dependence and psychiatric disorders based on polygenic scores","volume":"18","author":"Gurriaran","year":"2019","journal-title":"Genes Brain Behav."},{"issue":"5","key":"10.1016\/j.schres.2025.11.014_bb0090","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/schbul\/sbs118","article-title":"Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects","volume":"39","author":"Haijma","year":"2013","journal-title":"Schizophr. Bull."},{"issue":"8","key":"10.1016\/j.schres.2025.11.014_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.143","article-title":"Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis","volume":"6","author":"Harrisberger","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/j.schres.2025.11.014_bb0100","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.biopsych.2017.04.020","article-title":"Association between substance use disorder and polygenic liability to schizophrenia","volume":"82","author":"Hartz","year":"2017","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0105","first-page":"1","article-title":"Population stratification in genetic association studies","volume":"95","author":"Hellwege","year":"2017","journal-title":"Curr. Protoc. Hum. Genet."},{"issue":"6","key":"10.1016\/j.schres.2025.11.014_bb0110","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.biopsych.2017.08.017","article-title":"Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register","volume":"83","author":"Hilker","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2025.11.014_bb0115","article-title":"Amygdala volume in offspring from multiplex for alcohol dependence families: the moderating influence of childhood environment and 5-HTTLPR variation","volume":"Suppl 1","author":"Hill","year":"2013","journal-title":"J. Alcohol Drug Depend."},{"issue":"6","key":"10.1016\/j.schres.2025.11.014_bb0120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s12311-015-0747-8","article-title":"Volumetric differences in cerebellar lobes in individuals from multiplex alcohol dependence families and controls: their relationship to externalizing and internalizing disorders and working memory","volume":"15","author":"Hill","year":"2016","journal-title":"Cerebellum"},{"issue":"4","key":"10.1016\/j.schres.2025.11.014_bb0125","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1016\/j.neuroimage.2009.11.033","article-title":"Hippocampal volume deficits and shape deformities in young biological relatives of schizophrenia probands","volume":"49","author":"Ho","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.schres.2025.11.014_bb0130","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.drugalcdep.2018.07.011","article-title":"Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990\u20132017: systematic review and meta-analysis","volume":"191","author":"Hunt","year":"2018","journal-title":"Drug Alcohol Depend."},{"issue":"12","key":"10.1016\/j.schres.2025.11.014_bb0135","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S2215-0366(20)30339-4","article-title":"A large-scale genome-wide association study meta-analysis of cannabis use disorder","volume":"7","author":"Johnson","year":"2020","journal-title":"Lancet Psychiatry"},{"issue":"9","key":"10.1016\/j.schres.2025.11.014_bb0140","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/archpsyc.60.9.929","article-title":"The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women","volume":"60","author":"Kendler","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0145","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nn.3018","article-title":"Recent advances in the genetic epidemiology and molecular genetics of substance use disorders","volume":"15","author":"Kendler","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0150","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41467-019-09480-8","article-title":"Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations","volume":"10","author":"Kranzler","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.schres.2025.11.014_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neubiorev.2018.12.030","article-title":"Variation in fourteen brain structure volumes in schizophrenia: a comprehensive meta-analysis of 246 studies","volume":"98","author":"Kuo","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.schres.2025.11.014_bb0165","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1177\/0004867414525838","article-title":"Systematic meta-analysis of outcomes associated with psychosis and co-morbid substance use","volume":"48","author":"Large","year":"2014","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1360-0443.2003.00295.x","article-title":"A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins","volume":"98","author":"Li","year":"2003","journal-title":"Addiction"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0180","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1176\/appi.ajp.2018.17040415","article-title":"Mega-analysis of gray matter volume in substance dependence: general and substance-specific regional effects","volume":"176","author":"Mackey","year":"2019","journal-title":"Am. J. Psychiatry"},{"issue":"7265","key":"10.1016\/j.schres.2025.11.014_bb0185","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0190","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1176\/appi.ajp.163.3.478","article-title":"Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives","volume":"163","author":"McDonald","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"12","key":"10.1016\/j.schres.2025.11.014_bb0195","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1111\/acer.13882","article-title":"Does family history of alcohol use disorder relate to differences in regional brain volumes? A descriptive review with new data","volume":"42","author":"McPhee","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S0033291709990419","article-title":"Psychiatric family history and schizophrenia risk in Denmark: which mental disorders are relevant?","volume":"40","author":"Mortensen","year":"2010","journal-title":"Psychol. Med."},{"issue":"11","key":"10.1016\/j.schres.2025.11.014_bb0210","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1093\/cercor\/bhp026","article-title":"Distinct genetic influences on cortical surface area and cortical thickness","volume":"19","author":"Panizzon","year":"2009","journal-title":"Cereb. Cortex"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1503\/jpn.140277","article-title":"Familial and environmental influences on brain volumes in twins with schizophrenia","volume":"42","author":"Picchioni","year":"2017","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.schres.2025.11.014_bb0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.schres.2023.05.002","article-title":"Multipronged investigation of morphometry and connectivity of hippocampal network in relation to risk for psychosis using ultrahigh field MRI","volume":"256","author":"Prasad","year":"2023","journal-title":"Schizophr. Res."},{"issue":"11","key":"10.1016\/j.schres.2025.11.014_bb0205","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","article-title":"Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative","volume":"51","author":"Nurnberger","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2025.11.014_bb0230","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/adb.12496","article-title":"Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction","volume":"23","author":"Reginsson","year":"2018","journal-title":"Addict. Biol."},{"issue":"10","key":"10.1016\/j.schres.2025.11.014_bb0235","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1017\/S0033291705005167","article-title":"Brain MRI abnormalities in schizophrenia: same genes or same environment?","volume":"35","author":"Rijsdijk","year":"2005","journal-title":"Psychol. Med."},{"issue":"7510","key":"10.1016\/j.schres.2025.11.014_bb0240","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Ripke","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0245","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1037\/neu0000011","article-title":"Neuroimaging predictors of cognitive performance across a standardized neurocognitive battery","volume":"28","author":"Roalf","year":"2014","journal-title":"Neuropsychology"},{"issue":"2","key":"10.1016\/j.schres.2025.11.014_bb0250","first-page":"36","article-title":"lavaan: an R package for structural equation modeling","volume":"48","author":"Rosseel","year":"2012"},{"issue":"1\u20133","key":"10.1016\/j.schres.2025.11.014_bb0255","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.schres.2011.04.011","article-title":"The impact of substance use disorders on the course of schizophrenia\u2014a 15-year follow-up study: dual diagnosis over 15 years","volume":"130","author":"Schmidt","year":"2011","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0260","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1176\/appi.ajp.157.3.416","article-title":"Structural brain abnormalities in patients with schizophrenia and their healthy siblings","volume":"157","author":"Staal","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2025.11.014_bb3260","series-title":"Key substance use and mental health indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24\u201307-021, NSDUH Series H-59)","author":"Substance Abuse and Mental Health Services Administration","year":"2024"},{"issue":"12","key":"10.1016\/j.schres.2025.11.014_bb0265","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archpsyc.60.12.1187","article-title":"Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies","volume":"60","author":"Sullivan","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"11","key":"10.1016\/j.schres.2025.11.014_bb0270","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0006-3223(03)00702-9","article-title":"Hippocampal deformities in the unaffected siblings of schizophrenia subjects","volume":"54","author":"Tepest","year":"2003","journal-title":"Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.schres.2025.11.014_bb0275","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1038\/s41380-018-0262-7","article-title":"Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes","volume":"25","author":"Van der Meer","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.schres.2025.11.014_bb0280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.comppsych.2018.11.014","article-title":"Polygenic risk for schizophrenia and associated brain structural changes: a systematic review","volume":"88","author":"van der Merwe","year":"2019","journal-title":"Compr. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2025.11.014_bb0285","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/mp.2015.63","article-title":"Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium","volume":"21","author":"van Erp","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"9","key":"10.1016\/j.schres.2025.11.014_bb0290","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.biopsych.2018.04.023","article-title":"Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium","volume":"84","author":"van Erp","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.schres.2025.11.014_bb0295","series-title":"Explanation in Causal Inference: Methods for Mediation and Interaction","author":"VanderWeele","year":"2015"},{"issue":"5","key":"10.1016\/j.schres.2025.11.014_bb0300","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1017\/S0033291714002165","article-title":"The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies","volume":"45","author":"Verhulst","year":"2015","journal-title":"Psychol. Med."},{"issue":"13","key":"10.1016\/j.schres.2025.11.014_bb0305","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1017\/S0033291717000721","article-title":"Problematic alcohol use and reduced hippocampal volume: a meta-analytic review","volume":"47","author":"Wilson","year":"2017","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.schres.2025.11.014_bb0310","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1017\/S0033291717003166","article-title":"Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design","volume":"48","author":"Wilson","year":"2018","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.schres.2025.11.014_bb0315","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuroimage.2009.12.028","article-title":"Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies","volume":"53","author":"Winkler","year":"2010","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.schres.2025.11.014_bb0320","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/s41588-019-0516-6","article-title":"Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits","volume":"51","author":"Zhao","year":"2019","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.schres.2025.11.014_bb0325","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41593-020-0643-5","article-title":"Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits","volume":"23","author":"Zhou","year":"2020","journal-title":"Nat. Neurosci."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996425004177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996425004177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:49:53Z","timestamp":1768405793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996425004177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":65,"alternative-id":["S0920996425004177"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2025.11.014","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2025.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}