{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:49:16Z","timestamp":1791895756578,"version":"4.3.4"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,12]],"date-time":"2027-08-12T00:00:00Z","timestamp":1818028800000},"content-version":"am","delay-in-days":284,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002382"],"award-info":[{"award-number":["TL1TR002382"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH117315"],"award-info":[{"award-number":["R01MH117315"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Schizophrenia Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.schres.2026.07.033","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:14:24Z","timestamp":1786572864000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Negative symptom dimensions link cognitive impairment to global and social functioning in 22q11.2 deletion syndrome"],"prefix":"10.1016","volume":"297","author":[{"given":"David A.","family":"Parker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Imes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle A.","family":"Ruban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opal Y.","family":"Ousley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Henshey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Cubells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.schres.2026.07.033_bb0005","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1001\/jamapsychiatry.2022.2386","article-title":"Understanding connections and boundaries between positive symptoms, negative symptoms, and role functioning among individuals with schizophrenia: a network psychometric approach","volume":"79","author":"Abplanalp","year":"2022","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0010","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1176\/ajp.135.2.226","article-title":"A rating scale for emotional blunting","volume":"135","author":"Abrams","year":"1978","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0920-9964(91)90039-T","article-title":"Cognitive functioning and positive and negative symptoms in schizophrenia","volume":"5","author":"Addington","year":"1991","journal-title":"Schizophr. Res."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0020","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10803-013-1920-x","article-title":"Social impairments in chromosome 22q11.2 deletion syndrome (22q11.2DS): autism spectrum disorder or a different endophenotype?","volume":"44","author":"Angkustsiri","year":"2014","journal-title":"J. Autism Dev. Disord."},{"issue":"9","key":"10.1016\/j.schres.2026.07.033_bb0025","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s10803-006-0308-6","article-title":"Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)","volume":"37","author":"Antshel","year":"2007","journal-title":"J. Autism Dev. Disord."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174797","article-title":"No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: confirmation of the genetically driven risk for psychosis?","volume":"12","author":"Armando","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.schres.2026.07.033_bb0035","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Association, A. P","year":"2013"},{"issue":"5","key":"10.1016\/j.schres.2026.07.033_bb0040","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/schbul\/sby177","article-title":"Factor analysis of negative symptom items in the structured interview for prodromal syndromes","volume":"45","author":"Azis","year":"2019","journal-title":"Schizophr. Bull."},{"issue":"7","key":"10.1016\/j.schres.2026.07.033_bb0045","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0006-3223(99)00114-6","article-title":"22q11 deletion syndrome: a genetic subtype of schizophrenia","volume":"46","author":"Bassett","year":"1999","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11920-008-0026-1","article-title":"Schizophrenia and 22q11.2 deletion syndrome","volume":"10","author":"Bassett","year":"2008","journal-title":"Curr. Psychiatry Rep."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0055","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1076\/jcen.23.4.447.1228","article-title":"The neurocognitive phenotype of the 22q11.2 deletion syndrome: selective deficit in visual-spatial memory","volume":"23","author":"Bearden","year":"2001","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0060","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.9778\/cmajo.20200294","article-title":"Estimate of the contemporary live-birth prevalence of recurrent 22q11.2 deletions: a cross-sectional analysis from population-based newborn screening","volume":"9","author":"Blagojevic","year":"2021","journal-title":"CMAJ Open"},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/schbul\/sbj013","article-title":"The structure of negative symptoms within schizophrenia: implications for assessment","volume":"32","author":"Blanchard","year":"2006","journal-title":"Schizophr. Bull."},{"issue":"1\u20133","key":"10.1016\/j.schres.2026.07.033_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.schres.2009.02.016","article-title":"Pathways to functional outcomes in schizophrenia: the role of premorbid functioning, negative symptoms and intelligence","volume":"110","author":"Brill","year":"2009","journal-title":"Schizophr. Res."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000070665","article-title":"Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22","volume":"54","author":"Brzustowicz","year":"2002","journal-title":"Hum. Hered."},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/s15327906mbr0102_10","article-title":"The scree test for the number of factors","volume":"1","author":"Cattell","year":"1966","journal-title":"Multivariate Behav. Res."},{"key":"10.1016\/j.schres.2026.07.033_bb0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cpr.2016.11.009","article-title":"Cognitive remediation for negative symptoms of schizophrenia: a network meta-analysis","volume":"52","author":"Cella","year":"2017","journal-title":"Clin. Psychol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.schres.2026.07.033_bb0090","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.schres.2016.01.004","article-title":"Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study","volume":"170","author":"Chang","year":"2016","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0095","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/schbul\/sby115","article-title":"Early-stage negative symptom trajectories and relationships with 13-year outcomes in first-episode nonaffective psychosis","volume":"45","author":"Chang","year":"2019","journal-title":"Schizophr. Bull."},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/schbul\/sbaa129","article-title":"The latent structure of negative symptoms in individuals with attenuated psychosis syndrome and early psychosis: support for the 5 consensus domains","volume":"47","author":"Chang","year":"2021","journal-title":"Schizophr. Bull."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0105","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/WCO.0b013e3283052cf7","article-title":"Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition","volume":"21","author":"Chee","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.schres.2026.07.033_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2024.116147","article-title":"Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis","volume":"341","author":"Cohen","year":"2024","journal-title":"Psychiatry Res."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0115","first-page":"431","article-title":"Conners\u2019 adult ADHD rating scales (CAARS) technical manual","volume":"14","author":"Conners","year":"1999","journal-title":"Multi Health Systems"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2022.01.036","article-title":"Cell-free DNA screening for prenatal detection of 22q11.2 deletion syndrome","volume":"227","author":"Dar","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"Pt 9","key":"10.1016\/j.schres.2026.07.033_bb0125","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1365-2788.2007.00955.x","article-title":"Intellectual abilities in a large sample of children with Velo-Cardio-Facial Syndrome: an update","volume":"51","author":"De Smedt","year":"2007","journal-title":"J. Intellect. Disabil. Res."},{"key":"10.1016\/j.schres.2026.07.033_bb0130","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75482","article-title":"Sleep EEG in young people with 22q11.2 deletion syndrome: a cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms","volume":"11","author":"Donnelly","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.schres.2026.07.033_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.00230","article-title":"Goal-directed-behavior in 22q11.2 deletion syndrome: implication for social dysfunctions and the emergence of negative symptoms","volume":"11","author":"Dubourg","year":"2020","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.schres.2026.07.033_bb0140","series-title":"Encyclopedia Special Education","first-page":"2128","article-title":"Wechsler abbreviated scale of intelligence","author":"Dumont","year":"2008"},{"issue":"1\u20133","key":"10.1016\/j.schres.2026.07.033_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.schres.2015.04.040","article-title":"Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome","volume":"166","author":"Fervaha","year":"2015","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0150","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41380-022-01783-5","article-title":"A genetics-first approach to understanding autism and schizophrenia spectrum disorders: the 22q11.2 deletion syndrome","volume":"28","author":"Fiksinski","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0155","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10803-005-5036-9","article-title":"Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome","volume":"35","author":"Fine","year":"2005","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.schres.2026.07.033_bb0160","series-title":"Structured Clinical Interview for DSM-5\u2013Research Version (SCID-5-RV, Version 1.0. 0)","author":"First","year":"2015"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/1362361313500382","article-title":"Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the social responsiveness scale-2","volume":"18","author":"Frazier","year":"2014","journal-title":"Autism"},{"key":"10.1016\/j.schres.2026.07.033_bb0170","article-title":"Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia","volume":"15","author":"Giordano","year":"2024","journal-title":"Front. Psychol."},{"key":"10.1016\/j.schres.2026.07.033_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2025.116628","article-title":"Relationships between cognition and symptoms across mood and psychotic disorders","volume":"351","author":"Gombas","year":"2025","journal-title":"Psychiatry Res."},{"issue":"11","key":"10.1016\/j.schres.2026.07.033_bb0180","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jaac.2013.08.008","article-title":"Risk factors and the evolution of psychosis in 22q11.2 deletion syndrome: a longitudinal 2-site study","volume":"52","author":"Gothelf","year":"2013","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/schbul\/sbaa084","article-title":"Deconstructing negative symptoms in individuals at clinical high-risk for psychosis: evidence for volitional and diminished emotionality subgroups that predict clinical presentation and functional outcome","volume":"47","author":"Gupta","year":"2021","journal-title":"Schizophr. Bull."},{"issue":"11","key":"10.1016\/j.schres.2026.07.033_bb0190","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/mp.2013.189","article-title":"Neurocognitive development in 22q11.2 deletion syndrome: comparison with youth having developmental delay and medical comorbidities","volume":"19","author":"Gur","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"14","key":"10.1016\/j.schres.2026.07.033_bb0195","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1017\/S0033291723000259","article-title":"Psychosis spectrum features, neurocognition and functioning in a longitudinal study of youth with 22q11.2 deletion syndrome","volume":"53","author":"Gur","year":"2023","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0200","doi-asserted-by":"crossref","DOI":"10.1177\/2043808719865693","article-title":"Prediction of disability in schizophrenia: symptoms, cognition, and self-assessment","volume":"10","author":"Harvey","year":"2019","journal-title":"J. Exp. Psychopathol."},{"issue":"6","key":"10.1016\/j.schres.2026.07.033_bb0205","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jamapsychiatry.2026.0152","article-title":"Methylphenidate treatment and risk of psychotic disorder","volume":"83","author":"Healy","year":"2026","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5664\/jcsm.10238","article-title":"Sleep profiles in children with 22q deletion syndrome: a study of 100 consecutive children seen in a multidisciplinary clinic","volume":"19","author":"Ingram","year":"2023","journal-title":"J. Clin. Sleep Med."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0215","first-page":"53","article-title":"Categorical versus dimensional approaches to autism-associated intermediate phenotypes in 22q11.2 microdeletion syndrome","volume":"2","author":"Jalbrzikowski","year":"2017","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"issue":"11","key":"10.1016\/j.schres.2026.07.033_bb0220","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1001\/jamapsychiatry.2018.2165","article-title":"Prediction models of functional outcomes for individuals in the clinical high-risk state for psychosis or with recent-onset depression: a multimodal, multisite machine learning analysis","volume":"75","author":"Koutsouleris","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.schres.2026.07.033_bb0225","doi-asserted-by":"crossref","DOI":"10.1017\/S0033291724003416","article-title":"Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis","volume":"55","author":"Luther","year":"2025","journal-title":"Psychol. Med."},{"issue":"1\u20133","key":"10.1016\/j.schres.2026.07.033_bb0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.schres.2015.05.030","article-title":"Cognitive remediation for adolescents with 22q11 deletion syndrome (22q11DS): a preliminary study examining effectiveness, feasibility, and fidelity of a hybrid strategy, remote and computer-based intervention","volume":"166","author":"Mariano","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2026.07.033_bb0235","series-title":"The Psychosis-risk Syndrome: Handbook for Diagnosis and Follow-up","author":"McGlashan","year":"2010"},{"key":"10.1016\/j.schres.2026.07.033_bb0240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.schres.2016.12.023","article-title":"Negative subthreshold psychotic symptoms distinguish 22q11.2 deletion syndrome from other neurodevelopmental disorders: a two-site study","volume":"188","author":"Mekori-Domachevsky","year":"2017","journal-title":"Schizophr. Res."},{"issue":"22","key":"10.1016\/j.schres.2026.07.033_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12227095","article-title":"Correlations between negative symptoms and cognitive deficits in individuals at first psychotic episode or at high risk of psychosis: a systematic review","volume":"12","author":"Melillo","year":"2023","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0250","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.schbul.a007040","article-title":"Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability","volume":"29","author":"Miller","year":"2003","journal-title":"Schizophr. Bull."},{"issue":"11","key":"10.1016\/j.schres.2026.07.033_bb0255","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-062570","article-title":"Cognitive function and treatment response trajectories in first-episode schizophrenia: evidence from a prospective cohort study","volume":"12","author":"Millgate","year":"2022","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0260","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/s41380-023-01978-4","article-title":"The contribution of copy number variants to psychiatric symptoms and cognitive ability","volume":"28","author":"Mollon","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0265","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0022-3476(99)70415-4","article-title":"Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern","volume":"134","author":"Moss","year":"1999","journal-title":"J. Pediatr."},{"issue":"7","key":"10.1016\/j.schres.2026.07.033_bb0270","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1017\/S0033291719001119","article-title":"Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS)","volume":"50","author":"Moulding","year":"2020","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0275","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.gde.2012.02.011","article-title":"Schizophrenia genetics: progress, at last","volume":"22","author":"Mulle","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0280","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00125817-200101000-00017","article-title":"Neuropsychiatric disorders in the 22q11 deletion syndrome","volume":"3","author":"Niklasson","year":"2001","journal-title":"Genet. Med."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0285","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ridd.2008.10.007","article-title":"Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome","volume":"30","author":"Niklasson","year":"2009","journal-title":"Res. Dev. Disabil."},{"issue":"2","key":"10.1016\/j.schres.2026.07.033_bb0290","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1176\/appi.ajp.2007.07010042","article-title":"The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity","volume":"165","author":"Nuechterlein","year":"2008","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0295","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3758\/BF03200807","article-title":"SPSS and SAS programs for determining the number of components using parallel analysis and Velicer\u2019s MAP test","volume":"32","author":"O\u2019Connor","year":"2000","journal-title":"Behav. Res. Methods Instrum. Comput."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0300","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41386-025-02185-1","article-title":"Toward scalable biomarkers: the promise of sleep wearables in neurodevelopmental research","volume":"51","author":"O\u2019Hora","year":"2026","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0305","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-022-09450-0","article-title":"Copy number variation at the 22q11.2 locus influences prevalence, severity, and psychiatric impact of sleep disturbance","volume":"14","author":"O\u2019Hora","year":"2022","journal-title":"J. Neurodev. Disord."},{"issue":"5","key":"10.1016\/j.schres.2026.07.033_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051071","article-title":"Examining the overlap between autism spectrum disorder and 22q11.2 deletion syndrome","volume":"18","author":"Ousley","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s12888-023-04888-5","article-title":"Deep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes","volume":"23","author":"Parker","year":"2023","journal-title":"BMC Psychiatry"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0320","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1192\/bjp.2023.50","article-title":"Use of cognitive remediation to treat negative symptoms in schizophrenia: is it time yet?","volume":"223","author":"Penades","year":"2023","journal-title":"Br. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.schres.2026.07.033_bb0325","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00005053-199408000-00010","article-title":"Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives","volume":"182","author":"Pulver","year":"1994","journal-title":"J. Nerv. Ment. Dis."},{"issue":"10","key":"10.1016\/j.schres.2026.07.033_bb0330","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archpsyc.64.10.1123","article-title":"A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?","volume":"64","author":"Saha","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0335","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/schbul\/sbt057","article-title":"Improvements in negative symptoms and functional outcome after a new generation cognitive remediation program: a randomized controlled trial","volume":"40","author":"Sanchez","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0340","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5498\/wjp.v5.i4.352","article-title":"Conceptualization and treatment of negative symptoms in schizophrenia","volume":"5","author":"Sarkar","year":"2015","journal-title":"World J. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.schres.2026.07.033_bb0345","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.psychres.2011.08.017","article-title":"Preliminary structure and predictive value of attenuated negative symptoms in 22q11.2 deletion syndrome","volume":"196","author":"Schneider","year":"2012","journal-title":"Psychiatry Res."},{"issue":"6","key":"10.1016\/j.schres.2026.07.033_bb0350","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1176\/appi.ajp.2013.13070864","article-title":"Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome","volume":"171","author":"Schneider","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.schres.2026.07.033_bb0355","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.schres.2018.10.014","article-title":"Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome","volume":"206","author":"Schneider","year":"2019","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2026.07.033_bb0360","series-title":"The Childhood Autism Rating Scale","author":"Schopler","year":"2010"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0365","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.schres.2011.03.030","article-title":"Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder","volume":"129","author":"Shapiro","year":"2011","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0370","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ddrr.8","article-title":"A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome","volume":"14","author":"Simon","year":"2008","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.schres.2026.07.033_bb0375","article-title":"Global assessment of functioning (GAF) scale","volume":"1","author":"Spitzer","year":"1996","journal-title":"Outcome Assessment Clin. Practice"},{"issue":"6","key":"10.1016\/j.schres.2026.07.033_bb0380","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jpsychires.2013.01.015","article-title":"Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome","volume":"47","author":"Strauss","year":"2013","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0385","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/schbul\/sby169","article-title":"Reconsidering the latent structure of negative symptoms in schizophrenia: a review of evidence supporting the 5 consensus domains","volume":"45","author":"Strauss","year":"2019","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2026.07.033_bb0390","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.schres.2020.04.019","article-title":"A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis","volume":"222","author":"Strauss","year":"2020","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.schres.2026.07.033_bb0395","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1093\/schbul\/sbae206","article-title":"The Negative Symptom Inventory-Psychosis Risk (NSI-PR): psychometric validation of the final 11-item version","volume":"51","author":"Strauss","year":"2025","journal-title":"Schizophr. Bull."},{"issue":"Suppl. 3","key":"10.1016\/j.schres.2026.07.033_bb0400","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/00004850-199803003-00004","article-title":"The role of negative symptoms and cognitive dysfunction in schizophrenia outcome","volume":"13","author":"Tamminga","year":"1998","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"9","key":"10.1016\/j.schres.2026.07.033_bb0405","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jaac.2014.05.009","article-title":"Subthreshold psychotic symptoms in 22q11.2 deletion syndrome","volume":"53","author":"Tang","year":"2014","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"7","key":"10.1016\/j.schres.2026.07.033_bb0410","doi-asserted-by":"crossref","first-page":"e1180","DOI":"10.1038\/tp.2017.157","article-title":"Emergent, remitted and persistent psychosis-spectrum symptoms in 22q11.2 deletion syndrome","volume":"7","author":"Tang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.schres.2026.07.033_bb0415","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.schres.2009.03.035","article-title":"Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis","volume":"113","author":"Ventura","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.schres.2026.07.033_bb0420","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.schres.2017.10.005","article-title":"Cognitive remediation can improve negative symptoms and social functioning in first-episode schizophrenia: a randomized controlled trial","volume":"203","author":"Ventura","year":"2019","journal-title":"Schizophr. Res."},{"issue":"6","key":"10.1016\/j.schres.2026.07.033_bb0425","doi-asserted-by":"crossref","DOI":"10.1192\/bjo.2024.745","article-title":"Cognitive, adaptive and daily life functioning in adults with 22q11.2 deletion syndrome","volume":"10","author":"Vingerhoets","year":"2024","journal-title":"BJPsych Open"},{"issue":"19","key":"10.1016\/j.schres.2026.07.033_bb0430","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1523\/JNEUROSCI.0045-12.2012","article-title":"Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain","volume":"32","author":"Volkow","year":"2012","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.schres.2026.07.033_bb0435","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/01.chi.0000228131.56956.c1","article-title":"The 22q11.2 deletion in children: high rate of autistic disorders and early onset of psychotic symptoms","volume":"45","author":"Vorstman","year":"2006","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"4","key":"10.1016\/j.schres.2026.07.033_bb0440","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/jamapsychiatry.2014.2671","article-title":"Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome","volume":"72","author":"Vorstman","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.schres.2026.07.033_bb0445","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.schres.2012.01.031","article-title":"Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia","volume":"137","author":"Wallwork","year":"2012","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0450","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ajmg.a.61424","article-title":"Exploring the potential association among sleep disturbances, cognitive impairments, and immune activation in 22q11.2 deletion syndrome","volume":"182","author":"Yirmiya","year":"2020","journal-title":"Am. J. Med. Genet. A"},{"issue":"9","key":"10.1016\/j.schres.2026.07.033_bb0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138357","article-title":"Neurocognitive impairments in deficit and non-deficit schizophrenia and their relationships with symptom dimensions and other clinical variables","volume":"10","author":"Yu","year":"2015","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.schres.2026.07.033_bb0460","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/schbul\/sbab104","article-title":"Sleep disturbance in individuals at clinical high risk for psychosis","volume":"48","author":"Zaks","year":"2022","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.schres.2026.07.033_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1163361","article-title":"The genetic basis of onset age in schizophrenia: evidence and models","volume":"14","author":"Zhan","year":"2023","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.schres.2026.07.033_bb0470","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/JCP.0000000000002132","article-title":"Efficacy of low-dose adjunctive methylphenidate extended-release on cognition and functioning in individuals with schizophrenia: a randomized open-label trial","volume":"46","author":"Zhand","year":"2026","journal-title":"J. Clin. Psychopharmacol."}],"container-title":["Schizophrenia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996426002422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920996426002422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:06:47Z","timestamp":1791893207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920996426002422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":94,"alternative-id":["S0920996426002422"],"URL":"https:\/\/doi.org\/10.1016\/j.schres.2026.07.033","relation":{},"ISSN":["0920-9964"],"issn-type":[{"value":"0920-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Negative symptom dimensions link cognitive impairment to global and social functioning in 22q11.2 deletion syndrome","name":"articletitle","label":"Article Title"},{"value":"Schizophrenia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.schres.2026.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}