{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:41:33Z","timestamp":1789699293771,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004517","name":"Tianjin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2015CB755602"],"award-info":[{"award-number":["2015CB755602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871088"],"award-info":[{"award-number":["31871088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61721092"],"award-info":[{"award-number":["61721092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61890953"],"award-info":[{"award-number":["61890953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871082"],"award-info":[{"award-number":["81871082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2019B030335001"],"award-info":[{"award-number":["2019B030335001"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-014"],"award-info":[{"award-number":["2019-I2M-5-014"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.scib.2021.08.003","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:58:09Z","timestamp":1628146689000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Continuous subcellular resolution three-dimensional imaging on intact macaque brain"],"prefix":"10.1016","volume":"67","author":[{"given":"Can","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozhen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2021.08.003_b0005","doi-asserted-by":"crossref","first-page":"24022","DOI":"10.1073\/pnas.2006515117","article-title":"Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research","volume":"117","author":"Feng","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2021.08.003_b0010","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/nsr\/nwz225","article-title":"From mouse to man\u2014a bridge too far?","volume":"7","author":"Kennedy","year":"2020","journal-title":"Natl Sci Rev"},{"key":"10.1016\/j.scib.2021.08.003_b0015","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrn2619","article-title":"Parallel processing strategies of the primate visual system","volume":"10","author":"Nassi","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0020","first-page":"11","article-title":"Human brain functional MRI and DTI visualization with virtual reality","volume":"1","author":"Chen","year":"2011","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.scib.2021.08.003_b0025","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.neuroimage.2011.01.040","article-title":"An MRI based average macaque monkey stereotaxic atlas and space (MNI monkey space)","volume":"55","author":"Frey","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.scib.2021.08.003_b0030","doi-asserted-by":"crossref","first-page":"116876","DOI":"10.1016\/j.neuroimage.2020.116876","article-title":"Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging","volume":"216","author":"Wang","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.scib.2021.08.003_b0035","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuroimage.2015.05.072","article-title":"A diffusion tensor MRI atlas of the postmortem rhesus macaque brain","volume":"117","author":"Calabrese","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.scib.2021.08.003_b0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/cercor\/bhs270","article-title":"A weighted and directed interareal connectivity matrix for macaque cerebral cortex","volume":"24","author":"Markov","year":"2014","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.scib.2021.08.003_b0045","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.1038\/ncomms12142","article-title":"High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level","volume":"7","author":"Gong","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2021.08.003_b0050","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.cell.2016.05.007","article-title":"Mapping of brain activity by automated volume analysis of immediate early genes","volume":"165","author":"Renier","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.scib.2021.08.003_b0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuron.2020.03.004","article-title":"Whole-brain profiling of cells and circuits in mammals by tissue clearing and light-sheet microscopy","volume":"106","author":"Ueda","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.scib.2021.08.003_b0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41583-019-0250-1","article-title":"Tissue clearing and its applications in neuroscience","volume":"21","author":"Ueda","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0065","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.cell.2020.01.030","article-title":"Cellular and molecular probing of intact human organs","volume":"180","author":"Zhao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.scib.2021.08.003_b0070","doi-asserted-by":"crossref","first-page":"e10566","DOI":"10.7554\/eLife.10566","article-title":"A platform for brain-wide imaging and reconstruction of individual neurons","volume":"5","author":"Economo","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.scib.2021.08.003_b0075","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.neuron.2017.05.017","article-title":"High-speed and scalable whole-brain imaging in rodents and primates","volume":"94","author":"Seiriki","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.scib.2021.08.003_b0080","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fnins.2020.00322","article-title":"Mapping the architecture of ferret brains at single-cell resolution","volume":"14","author":"Long","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFT","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.scib.2021.08.003_b0090","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nn.3078","article-title":"A toolbox of cre-dependent optogenetic transgenic mice for light-induced activation and silencing","volume":"15","author":"Madisen","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0095","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1002\/adma.201500534","article-title":"A mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel","volume":"27","author":"Dai","year":"2015","journal-title":"Adv Mater"},{"key":"10.1016\/j.scib.2021.08.003_b0100","doi-asserted-by":"crossref","first-page":"e0169424","DOI":"10.1371\/journal.pone.0169424","article-title":"A novel mouse segmentation method based on dynamic contrast enhanced micro-CT images","volume":"12","author":"Yan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2021.08.003_b0105","doi-asserted-by":"crossref","first-page":"13891","DOI":"10.1038\/s41598-017-14360-6","article-title":"A platform for efficient identification of molecular phenotypes of brain-wide neural circuits","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2021.08.003_b0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fncir.2017.00051","article-title":"Tdat: an efficient platform for processing petabyte-scale whole-brain volumetric images","volume":"11","author":"Li","year":"2017","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.scib.2021.08.003_b0115","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/s41598-020-59042-y","article-title":"A robust image registration interface for large volume brain atlas","volume":"10","author":"Ni","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2021.08.003_b0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41592-021-01074-x","article-title":"High-definition imaging using line-illumination modulation microscopy","volume":"18","author":"Zhong","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.scib.2021.08.003_b0125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-biophys-070317-032905","article-title":"Hydrogel-tissue chemistry: principles and applications","volume":"47","author":"Gradinaru","year":"2018","journal-title":"Annu Rev Biophys"},{"key":"10.1016\/j.scib.2021.08.003_b0130","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/nn.4107","article-title":"Scales: an optical clearing palette for biological imaging","volume":"18","author":"Hama","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0135","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nmeth.3964","article-title":"Shrinkage-mediated imaging of entire organs and organisms using udisco","volume":"13","author":"Pan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.scib.2021.08.003_b0140","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0361-9230(00)00364-6","article-title":"A comparative analysis of the morphology of corticothalamic projections in mammals","volume":"53","author":"Rouiller","year":"2000","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.scib.2021.08.003_b0145","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1073\/pnas.1704302114","article-title":"Organization and somatotopy of corticothalamic projections from l5b in mouse barrel cortex","volume":"114","author":"Sumser","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2021.08.003_b0150","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature16533","article-title":"Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2","volume":"530","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.scib.2021.08.003_b0155","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41586-019-1278-0","article-title":"Atypical behaviour and connectivity in SHANK3-mutant macaques","volume":"570","author":"Zhou","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.scib.2021.08.003_b0160","doi-asserted-by":"crossref","first-page":"e60877","DOI":"10.1371\/journal.pone.0060877","article-title":"Development of a plastic embedding method for large-volume and fluorescent-protein-expressing tissues","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2021.08.003_b0165","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3389\/fnins.2019.00752","article-title":"Maintenance of fluorescence during paraffin embedding of fluorescent protein-labeled specimens","volume":"13","author":"Zhanmu","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0170","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/nprot.2012.119","article-title":"Three-dimensional imaging of solvent-cleared organs using 3DISCO","volume":"7","author":"Ert\u00fcrk","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.scib.2021.08.003_b0175","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nn.4568","article-title":"Thalamic projections sustain prefrontal activity during working memory maintenance","volume":"20","author":"Bolkan","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0180","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biopsych.2017.11.008","article-title":"The mediodorsal thalamus: an essential partner of the prefrontal cortex for cognition","volume":"83","author":"Parnaudeau","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.scib.2021.08.003_b0185","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.neuron.2013.01.038","article-title":"Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition","volume":"77","author":"Parnaudeau","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.scib.2021.08.003_b0190","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1038\/s41598-017-03000-8","article-title":"Single-axon level morphological analysis of corticofugal projection neurons in mouse barrel field","volume":"7","author":"Guo","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2021.08.003_b0195","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41593-019-0429-9","article-title":"A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex","volume":"22","author":"Sun","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.scib.2021.08.003_b0200","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1073\/pnas.1703601115","article-title":"Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons","volume":"115","author":"Li","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2021.08.003_b0205","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41592-018-0184-y","article-title":"Cell-type-specific and projection-specific brain-wide reconstruction of single neurons","volume":"15","author":"Lin","year":"2018","journal-title":"Nat Methods"},{"key":"10.1016\/j.scib.2021.08.003_b0210","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/cr.2018.10","article-title":"Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR\/Cas9-assisted homologous recombination","volume":"28","author":"Cui","year":"2018","journal-title":"Cell Res"},{"key":"10.1016\/j.scib.2021.08.003_b0215","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nn.4362","article-title":"Opportunities and challenges in modeling human brain disorders in transgenic primates","volume":"19","author":"Jennings","year":"2016","journal-title":"Nat Neurosci"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927321005533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927321005533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:48:47Z","timestamp":1761868127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927321005533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2095927321005533"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2021.08.003","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continuous subcellular resolution three-dimensional imaging on intact macaque brain","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2021.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Science China Press. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}