{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:34:53Z","timestamp":1765233293037,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.scib.2022.03.011","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T18:49:00Z","timestamp":1647110940000},"page":"1112-1114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genistein suppresses gallbladder cancer tumorigenesis and progression via downregulating ERBB2 mediated PTK6\/AKT\/MCM pathway"],"prefix":"10.1016","volume":"67","author":[{"given":"Zhijun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barish H.","family":"Edil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2022.03.011_b0005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5114\/ceh.2019.85166","article-title":"Epidemiology of gallbladder cancer","volume":"5","author":"Rawla","year":"2019","journal-title":"Clin Exp Hepatol"},{"issue":"1483\u20131500","key":"10.1016\/j.scib.2022.03.011_b0010","article-title":"Soy, soy isoflavones, and protein intake in relation to mortality from all causes, cancers, and cardiovascular diseases: a systematic review and dose-response meta-analysis of prospective cohort studies","volume":"119","author":"Nachvak","year":"2019","journal-title":"J Acad Nutr Diet"},{"key":"10.1016\/j.scib.2022.03.011_b0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.scib.2022.01.011","article-title":"Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex","volume":"67","author":"Geng","year":"2022","journal-title":"Sci Bull"},{"key":"10.1016\/j.scib.2022.03.011_b0020","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1038\/s41467-020-17880-4","article-title":"Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate","volume":"11","author":"Pandey","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2022.03.011_b0025","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ng.3030","article-title":"Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway","volume":"46","author":"Li","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.scib.2022.03.011_b0030","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/ijc.31916","article-title":"ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer","volume":"144","author":"Iyer","year":"2019","journal-title":"Int J Cancer"},{"key":"10.1016\/j.scib.2022.03.011_b0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/nu10010040","article-title":"Soy consumption and the risk of prostate cancer: an updated systematic review and meta-analysis","volume":"10","author":"Applegate","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.scib.2022.03.011_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/574850","article-title":"MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity","volume":"2014","author":"Das","year":"2014","journal-title":"Mol Biol Int"},{"key":"10.1016\/j.scib.2022.03.011_b0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41586-020-2842-3","article-title":"Equilibrium between nascent and parental MCM proteins protects replicating genomes","volume":"587","author":"Sedlackova","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.scib.2022.03.011_b0050","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2018-316039","article-title":"Genomic ERBB2\/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis","volume":"68","author":"Li","year":"2019","journal-title":"Gut"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927322001013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927322001013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:49:13Z","timestamp":1761868153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927322001013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2095927322001013"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2022.03.011","relation":{},"ISSN":["2095-9273"],"issn-type":[{"type":"print","value":"2095-9273"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genistein suppresses gallbladder cancer tumorigenesis and progression via downregulating ERBB2 mediated PTK6\/AKT\/MCM pathway","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2022.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Science China Press. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}