{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:12:21Z","timestamp":1784855541286,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB39000000"],"award-info":[{"award-number":["XDB39000000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085QH265"],"award-info":[{"award-number":["2308085QH265"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YD9100002033"],"award-info":[{"award-number":["YD9100002033"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.scib.2023.10.019","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:08:33Z","timestamp":1698358113000},"page":"2817-2826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["High burdens of phosphorylated tau protein and distinct precuneus atrophy in sporadic early-onset Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"68","author":[{"given":"Xinyi","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2023.10.019_b0005","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/s41380-022-01531-9","article-title":"Dissecting the clinical heterogeneity of early-onset Alzheimer's disease","volume":"27","author":"Sirkis","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.scib.2023.10.019_b0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neurobiolaging.2016.09.008","article-title":"Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array","volume":"49","author":"Barber","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.scib.2023.10.019_b0015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archneur.1983.04050030037006","article-title":"A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two?","volume":"40","author":"Seltzer","year":"1983","journal-title":"Arch Neurol"},{"key":"10.1016\/j.scib.2023.10.019_b0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1212\/CON.0000000000000687","article-title":"Early-onset Alzheimer disease and its variants","volume":"25","author":"Mendez","year":"2019","journal-title":"Continuum"},{"key":"10.1016\/j.scib.2023.10.019_b0025","doi-asserted-by":"crossref","first-page":"e512","DOI":"10.1212\/NXG.0000000000000512","article-title":"Late-onset vs nonMendelian early-onset Alzheimer disease: a distinction without a difference?","volume":"6","author":"Reitz","year":"2020","journal-title":"Neurol Genet"},{"key":"10.1016\/j.scib.2023.10.019_b0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archneurol.2011.221","article-title":"Autosomal recessive causes likely in early-onset Alzheimer disease","volume":"69","author":"Wingo","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.scib.2023.10.019_b0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ncl.2017.01.005","article-title":"Early-onset Alzheimer disease","volume":"35","author":"Mendez","year":"2017","journal-title":"Neurol Clin"},{"key":"10.1016\/j.scib.2023.10.019_b0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/WNL.46.1.136","article-title":"Clinical and neuropsychological differences between patients with earlier and later onset of Alzheimer's disease: a CERAD analysis, part XII","volume":"46","author":"Koss","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cortex.2015.10.014","article-title":"Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment","volume":"74","author":"Joubert","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.scib.2023.10.019_b0050","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2023.10.019_b0055","doi-asserted-by":"crossref","first-page":"e1295","DOI":"10.1212\/WNL.0000000000006277","article-title":"Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease","volume":"91","author":"McDade","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/alz.12700","article-title":"A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study","volume":"19","author":"Gao","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.scib.2023.10.019_b0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.scib.2023.10.019_b0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.scib.2023.10.019_b0075","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/acschemneuro.2c00120","article-title":"Correlation between cerebrospinal fluid core Alzheimer's disease biomarkers and beta-amyloid PET in Chinese dementia population","volume":"13","author":"Xie","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.scib.2023.10.019_b0080","series-title":"Neuropsychological assessment","author":"Lezak","year":"1983"},{"key":"10.1016\/j.scib.2023.10.019_b0085","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1037\/1040-3590.8.3.324","article-title":"Digit span performance of persons 75\u201396 years of age: base rates and associations with selected demographic variables","volume":"8","author":"Ryan","year":"1996","journal-title":"Psychol Assess"},{"key":"10.1016\/j.scib.2023.10.019_b0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/geronj\/47.3.P154","article-title":"Boston Naming Test: shortened versions for use in Alzheimer's disease","volume":"47","author":"Mack","year":"1992","journal-title":"J Gerontol"},{"key":"10.1016\/j.scib.2023.10.019_b0095","series-title":"Cognitive assessment for clinicians","author":"Hodges","year":"1994"},{"key":"10.1016\/j.scib.2023.10.019_b0100","series-title":"A compendium of neuropsychological tests: administration, norms, and commentary","author":"Spreen","year":"1998"},{"key":"10.1016\/j.scib.2023.10.019_b0105","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scib.2023.10.019_b0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.scib.2023.10.019_b0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acschemneuro.2c00636","article-title":"Plasma core Alzheimer's disease biomarkers predict amyloid deposition burden by positron emission tomography in Chinese individuals with cognitive decline","volume":"14","author":"Ni","year":"2023","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.scib.2023.10.019_b0120","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/brain\/awp326","article-title":"Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden","volume":"133","author":"Rabinovici","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.scib.2023.10.019_b0125","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s00415-015-7698-3","article-title":"Differentiated clinical presentation of early and late-onset Alzheimer's disease: is 65 years of age providing a reliable threshold?","volume":"262","author":"Palasi","year":"2015","journal-title":"J Neurol"},{"key":"10.1016\/j.scib.2023.10.019_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.563559","article-title":"Association of subcortical structural shapes with tau, amyloid, and cortical atrophy in early-onset and late-onset Alzheimer's disease","volume":"12","author":"Lee","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.scib.2023.10.019_b0135","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/brain\/awl377","article-title":"The topography of grey matter involvement in early and late onset Alzheimer's disease","volume":"130","author":"Frisoni","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.scib.2023.10.019_b0140","doi-asserted-by":"crossref","first-page":"e650","DOI":"10.1212\/WNL.0000000000011270","article-title":"Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET","volume":"96","author":"La Joie","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0145","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-021-00512-w","article-title":"Dynamic changes of CSF sPDGFRbeta during ageing and AD progression and associations with CSF ATN biomarkers","volume":"17","author":"Wang","year":"2022","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.scib.2023.10.019_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00210","article-title":"Cerebrospinal fluid abeta43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to abeta42","volume":"9","author":"Lauridsen","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.scib.2023.10.019_b0155","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1212\/WNL.0000000000013107","article-title":"Association of neurofibrillary tangle distribution with age at onset-related clinical heterogeneity in Alzheimer disease: an autopsy study","volume":"98","author":"Smirnov","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0160","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/brain\/awx171","article-title":"Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease","volume":"140","author":"Scholl","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.scib.2023.10.019_b0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neurobiolaging.2017.01.024","article-title":"Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease","volume":"53","author":"Cho","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.scib.2023.10.019_b0170","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.scib.2023.10.019_b0175","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease","volume":"26","author":"Barthelemy","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.scib.2023.10.019_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2020.570045","article-title":"Tau protein and its role in blood-brain barrier dysfunction","volume":"13","author":"Michalicova","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.scib.2023.10.019_b0185","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.scib.2023.10.019_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.scib.2023.10.019_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.scib.2023.10.019_b0200","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1212\/WNL.0b013e318233b33d","article-title":"Age-related changes in the default mode network are more advanced in Alzheimer disease","volume":"77","author":"Jones","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0205","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1212\/01.wnl.0000277459.83543.99","article-title":"The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old","volume":"69","author":"Barkhof","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0210","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1212\/WNL.0000000000201479","article-title":"Validity and performance of blood biomarkers for Alzheimer disease to predict dementia risk in a large clinic-based cohort","volume":"100","author":"Planche","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0215","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01093-6","article-title":"Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias","volume":"14","author":"Baiardi","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.scib.2023.10.019_b0220","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3390\/life13061301","article-title":"Serum neurofilaments in motor neuron disease and their utility in differentiating ALS, PMA and PLS","volume":"13","author":"McCluskey","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.scib.2023.10.019_b0225","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/STROKEAHA.120.030302","article-title":"Association of plasma neurofilament light with small vessel disease burden in nondemented elderly: a longitudinal study","volume":"52","author":"Qu","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.scib.2023.10.019_b0230","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","article-title":"Blood-based biomarkers for Alzheimer's disease: towards clinical implementation","volume":"21","author":"Teunissen","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.scib.2023.10.019_b0235","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/S2666-7568(20)30061-1","article-title":"Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study","volume":"2","author":"Verberk","year":"2021","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.scib.2023.10.019_b0240","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/s41591-023-02380-x","article-title":"Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer's disease","volume":"29","author":"Bellaver","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.scib.2023.10.019_b0245","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.scib.2023.07.009","article-title":"Blood-based biomarkers for Alzheimer's disease: a multicenter-based cross-sectional and longitudinal study in China","volume":"68","author":"Gao","year":"2023","journal-title":"Sci Bull"},{"key":"10.1016\/j.scib.2023.10.019_b0250","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ana.25183","article-title":"[18F] AV-1451 tau-PET and primary progressive aphasia","volume":"83","author":"Josephs","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.scib.2023.10.019_b0255","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1212\/CON.0000000000000696","article-title":"Posterior cortical atrophy","volume":"25","author":"Schott","year":"2019","journal-title":"Continuum"},{"key":"10.1016\/j.scib.2023.10.019_b0260","first-page":"253","article-title":"Similar pattern of atrophy in early- and late-onset Alzheimer's disease","volume":"10","author":"Eckerstrom","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.scib.2023.10.019_b0265","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neurobiolaging.2017.02.010","article-title":"Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease","volume":"54","author":"Aziz","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.scib.2023.10.019_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102804","article-title":"Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer's disease","volume":"32","author":"Contador","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.scib.2023.10.019_b0275","doi-asserted-by":"crossref","first-page":"e775","DOI":"10.1212\/WNL.0000000000200667","article-title":"Novelty-related fMRI responses of precuneus and medial temporal regions in individuals at risk for Alzheimer disease","volume":"99","author":"Billette","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2023.10.019_b0280","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/bpa.12331","article-title":"Pathophysiology of hypoperfusion of the precuneus in early Alzheimer's disease","volume":"26","author":"Miners","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1016\/j.scib.2023.10.019_b0285","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000492945","article-title":"The Precuneus \u2013 a witness for excessive abeta gathering in Alzheimer's disease pathology","volume":"18","author":"Aghakhanyan","year":"2018","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.scib.2023.10.019_b0290","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.neurobiolaging.2013.02.013","article-title":"Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease","volume":"34","author":"Moller","year":"2013","journal-title":"Neurobiol Aging"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927323007193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927323007193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:59:23Z","timestamp":1761868763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927323007193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":58,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2095927323007193"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2023.10.019","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High burdens of phosphorylated tau protein and distinct precuneus atrophy in sporadic early-onset Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2023.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}