{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:24:19Z","timestamp":1791897859975,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301918"],"award-info":[{"award-number":["82301918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20346"],"award-info":[{"award-number":["U21A20346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX0856"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX0856"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.scib.2024.03.064","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T13:06:58Z","timestamp":1720098418000},"page":"2604-2621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["New therapeutic target NCF1-directed multi-bioactive conjugate therapies prevent preterm birth and adverse pregnancy outcomes"],"prefix":"10.1016","volume":"69","author":[{"given":"Juan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2024.03.064_b0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.addr.2021.04.021","article-title":"Next generation strategies for preventing preterm birth","volume":"174","author":"Zierden","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ijgo.13195","article-title":"Global burden of preterm birth","volume":"150","author":"Walani","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.scib.2024.03.064_b0015","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born too soon: The global epidemiology of 15 million preterm births","volume":"10","author":"Blencowe","year":"2013","journal-title":"Reprod Health"},{"key":"10.1016\/j.scib.2024.03.064_b0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/14767058.2012.735994","article-title":"A common problem for neonatal intensive care units: Late preterm infants, a prospective study with term controls in a large perinatal center","volume":"26","author":"Celik","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.scib.2024.03.064_b0025","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41581-022-00668-8","article-title":"The impact of intrauterine growth restriction and prematurity on nephron endowment","volume":"19","author":"Sutherland","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.scib.2024.03.064_b0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary dysplasia","volume":"5","author":"Th\u00e9baud","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.scib.2024.03.064_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1015622","article-title":"Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways","volume":"13","author":"Vidal","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.scib.2024.03.064_b0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/ahg.12373","article-title":"Recent advances in the genetics of preterm birth","volume":"84","author":"Wadon","year":"2020","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.scib.2024.03.064_b0045","article-title":"Associations between high temperatures in pregnancy and risk of preterm birth, low birth weight, and stillbirths: Systematic review and meta-analysis","volume":"371","author":"Chersich","year":"2020","journal-title":"Brit Med J"},{"key":"10.1016\/j.scib.2024.03.064_b0050","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.8243","article-title":"Association of air pollution and heat exposure with preterm birth, low birth weight, and stillbirth in the us: A systematic review","volume":"3","author":"Bekkar","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.scib.2024.03.064_b0055","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1530\/REP-13-0587","article-title":"Anti-inflammatory prostaglandins for the prevention of preterm labour","volume":"148","author":"Sykes","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.scib.2024.03.064_b0060","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s43032-022-01087-7","article-title":"Role of transcription factors in the management of preterm birth: Impact on future treatment strategies","volume":"30","author":"Meher","year":"2023","journal-title":"Reprod Sci"},{"key":"10.1016\/j.scib.2024.03.064_b0065","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/REP-22-0046","article-title":"The immunobiology of preterm labor and birth: Intra-amniotic inflammation or breakdown of maternal-fetal homeostasis","volume":"164","author":"Gomez-Lopez","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.scib.2024.03.064_b0070","first-page":"60","article-title":"Progesterone supplementation and the prevention of preterm birth","volume":"4","author":"Norwitz","year":"2011","journal-title":"Rev Obstet Gynecol"},{"key":"10.1016\/j.scib.2024.03.064_b0075","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000489829","article-title":"Neutrophil extracellular traps in the second decade","volume":"10","author":"Brinkmann","year":"2018","journal-title":"J Innate Immun"},{"key":"10.1016\/j.scib.2024.03.064_b0080","doi-asserted-by":"crossref","first-page":"e146089","DOI":"10.1172\/jci.insight.146089","article-title":"Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury","volume":"6","author":"Gomez-Lopez","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.scib.2024.03.064_b0085","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3389\/fimmu.2018.02628","article-title":"Hofbauer cells: Their role in healthy and complicated pregnancy","volume":"9","author":"Reyes","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.scib.2024.03.064_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101098","article-title":"The influence of the dietary exposome on oxidative stress in pregnancy complications","volume":"87","author":"Prins","year":"2022","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.scib.2024.03.064_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108181","article-title":"Inflammation and oxidative stress as mediators of the impacts of environmental exposures on human pregnancy: Evidence from oxylipins","volume":"239","author":"Welch","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.scib.2024.03.064_b0100","doi-asserted-by":"crossref","first-page":"276 e1","DOI":"10.1016\/j.ajog.2015.09.006","article-title":"Efficacy of midtrimester short cervix interventions is conditional on intraamniotic inflammation","volume":"214","author":"Kiefer","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.scib.2024.03.064_b0105","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1530\/REP-22-0226","article-title":"Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth","volume":"165","author":"Arman","year":"2023","journal-title":"Reproduction"},{"key":"10.1016\/j.scib.2024.03.064_b0110","article-title":"Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour","volume":"13","author":"Papatsonis","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0115","article-title":"Calcium channel blockers for inhibiting preterm labour and birth","volume":"2014","author":"Flenady","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1056\/NEJM198107093050209","article-title":"Indomethacin and the patent ductus arteriosus","volume":"305","author":"Nadas","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2024.03.064_b0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12920-018-0323-4","article-title":"Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects","volume":"11","author":"Seo","year":"2018","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.scib.2024.03.064_b0130","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/ki.1997.255","article-title":"Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences","volume":"51","author":"Braden","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.scib.2024.03.064_b0135","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc6245","article-title":"Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth","volume":"13","author":"Zierden","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.scib.2024.03.064_b0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jconrel.2018.12.046","article-title":"Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth","volume":"295","author":"Hoang","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.scib.2024.03.064_b0145","doi-asserted-by":"crossref","unstructured":"Paul JW, Hua S, Ilicic M, et al. Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor. Am J Obstet Gynecol 2017; 216: 283.e1\u2013283.e14.","DOI":"10.1016\/j.ajog.2016.08.027"},{"key":"10.1016\/j.scib.2024.03.064_b0150","doi-asserted-by":"crossref","first-page":"34710","DOI":"10.1038\/srep34710","article-title":"Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice","volume":"6","author":"Refuerzo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2024.03.064_b0155","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1039\/D2NA00834C","article-title":"Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions","volume":"5","author":"Taylor","year":"2023","journal-title":"Nanoscale Adv"},{"key":"10.1016\/j.scib.2024.03.064_b0160","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12591","article-title":"Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation-induced oxidative stress in a mouse model","volume":"67","author":"Lee","year":"2019","journal-title":"J Pineal Res"},{"key":"10.1016\/j.scib.2024.03.064_b0165","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tem.2004.10.009","article-title":"Animal models of preterm birth","volume":"15","author":"Elovitz","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.scib.2024.03.064_b0170","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2011643118","article-title":"Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility","volume":"118","author":"Peavey","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2024.03.064_b0175","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-physiol-032420-035509","article-title":"Uterine excitability and ion channels and their changes with gestation and hormonal environment","volume":"83","author":"Wray","year":"2021","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.scib.2024.03.064_b0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10557-021-07251-6","article-title":"Low molecular weight heparin, anti-inflammatory\/immunoregulatory and antiviral effects, a short update","volume":"37","author":"Vitiello","year":"2023","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.scib.2024.03.064_b0185","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0741-5214(98)70060-6","article-title":"Low-dose low-molecular-weight heparin is anti-inflammatory during venous thrombosis","volume":"28","author":"Downing","year":"1998","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.scib.2024.03.064_b0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mvr.2017.03.007","article-title":"Inhibition of inflammation induced shedding of the endothelial glycocalyx with low molecular weight heparin","volume":"112","author":"Lipowsky","year":"2017","journal-title":"Microvasc Res"},{"key":"10.1016\/j.scib.2024.03.064_b0195","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1038\/s41467-022-34878-2","article-title":"Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2024.03.064_b0200","first-page":"6","article-title":"Low-dose LMWH to prevent pregnancy-related VTE","volume":"20","author":"Lim","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.scib.2024.03.064_b0205","article-title":"A broad-spectrum ROS-eliminating material for prevention of inflammation and drug-induced organ toxicity","volume":"5","author":"Li","year":"2018","journal-title":"Adv Sci"},{"key":"10.1016\/j.scib.2024.03.064_b0210","doi-asserted-by":"crossref","first-page":"H1226","DOI":"10.1152\/ajpheart.00305.2007","article-title":"Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage","volume":"294","author":"Sharma","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.scib.2024.03.064_b0215","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/uog.15871","article-title":"Contraction-based uterine artery doppler velocimetry: Novel approach for prediction of preterm birth in women with threatened preterm labor","volume":"48","author":"Olgan","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.scib.2024.03.064_b0220","article-title":"Trophoblasts modulate the Ca2+ oscillation and contraction of myometrial smooth muscle cells by small extracellular vesicle-(sEV-) mediated exporting of miR-25-3p during premature labor","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.scib.2024.03.064_b0225","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/bm050620y","article-title":"Rheological characterization of bioadhesive binary polymeric systems designed as platforms for drug delivery implants","volume":"7","author":"Andrews","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.scib.2024.03.064_b0230","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1001\/jamapediatrics.2022.1622","article-title":"Global, regional, and national incidence and mortality of neonatal preterm birth, 1990\u20132019","volume":"176","author":"Cao","year":"2022","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.scib.2024.03.064_b0235","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajogmf.2019.03.001","article-title":"Oral progesterone for the prevention of recurrent preterm birth: Systematic review and metaanalysis","volume":"1","author":"Boelig","year":"2019","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.scib.2024.03.064_b0240","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/HYPERTENSIONAHA.113.01276","article-title":"Preterm birth and hypertension risk: The oxidative stress paradigm","volume":"63","author":"Sutherland","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.scib.2024.03.064_b0245","doi-asserted-by":"crossref","first-page":"10122","DOI":"10.3390\/ijms221810122","article-title":"Effect of endogenic and exogenic oxidative stress triggers on adverse pregnancy outcomes: Preeclampsia, fetal growth restriction, gestational diabetes mellitus and preterm birth","volume":"22","author":"Joo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.scib.2024.03.064_b0250","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ajog.2022.04.024","article-title":"Telomeres, oxidative stress, and timing for spontaneous term and preterm labor","volume":"227","author":"Phillippe","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.scib.2024.03.064_b0255","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1136\/annrheumdis-2017-211287","article-title":"A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus","volume":"76","author":"Olsson","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.scib.2024.03.064_b0260","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1182\/bloodadvances.2018023184","article-title":"Ncf1 (p47phox)-deficient chronic granulomatous disease: Comprehensive genetic and flow cytometric analysis","volume":"3","author":"Kuhns","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.scib.2024.03.064_b0265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113956","article-title":"Vaginal delivery of vaccines","volume":"178","author":"VanBenschoten","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113955","article-title":"Drug delivery strategies for management of women's health issues in the upper genital tract","volume":"177","author":"Patel","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.scib.2024.03.064_b0280","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jconrel.2014.04.033","article-title":"Nanoparticle-based drug delivery to the vagina: A review","volume":"190","author":"Ensign","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.scib.2024.03.064_b0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1933719115618282","article-title":"Recent progress in therapeutics for inflammation-associated preterm birth: A review","volume":"24","author":"Taguchi","year":"2017","journal-title":"Reprod Sci"},{"key":"10.1016\/j.scib.2024.03.064_b0290","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1210\/endo.141.5.7474","article-title":"Expression of myometrial activation and stimulation genes in a mouse model of preterm labor: Myometrial activation, stimulation, and preterm labor","volume":"141","author":"Cook","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.scib.2024.03.064_b0295","doi-asserted-by":"crossref","unstructured":"Vornhagen J, Quach P, Boldenow E, et al. Bacterial hyaluronidase promotes ascending GBS infection and preterm birth. mBio 2016; 7: e00781-16.","DOI":"10.1128\/mBio.00781-16"},{"key":"10.1016\/j.scib.2024.03.064_b0300","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00281-020-00808-x","article-title":"Novel pathways of inflammation in human fetal membranes associated with preterm birth and preterm pre-labor rupture of the membranes","volume":"42","author":"Menon","year":"2020","journal-title":"Semin Immunopathol"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209592732400478X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209592732400478X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:41:08Z","timestamp":1778838068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209592732400478X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":60,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S209592732400478X"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2024.03.064","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New therapeutic target NCF1-directed multi-bioactive conjugate therapies prevent preterm birth and adverse pregnancy outcomes","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2024.03.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}