{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:13:11Z","timestamp":1790784791844,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["20XD1400700"],"award-info":[{"award-number":["20XD1400700"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930075"],"award-info":[{"award-number":["81930075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230103"],"award-info":[{"award-number":["82230103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2431054"],"award-info":[{"award-number":["W2431054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073267"],"award-info":[{"award-number":["82073267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372689"],"award-info":[{"award-number":["82372689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023YFC2506400"],"award-info":[{"award-number":["2023YFC2506400"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2020YFA0112300"],"award-info":[{"award-number":["2020YFA0112300"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.scib.2024.12.039","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T19:45:40Z","timestamp":1735328740000},"page":"1126-1138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis"],"prefix":"10.1016","volume":"70","author":[{"given":"Jie","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wucheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juchuanli","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaodan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceshi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Wu","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2024.12.039_b0005","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.scib.2024.12.039_b0010","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1056\/NEJM199105163242002","article-title":"Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid)","volume":"324","author":"Warrell","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2024.12.039_b0015","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/S0140-6736(20)32531-9","article-title":"Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial","volume":"396","author":"Cortes","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.scib.2024.12.039_b0020","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.scib.2024.12.039_b0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41573-022-00493-5","article-title":"Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities","volume":"21","author":"Kim","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.scib.2024.12.039_b0030","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/s41556-019-0373-7","article-title":"Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms","volume":"21","author":"Kim","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.scib.2024.12.039_b0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.smim.2017.12.004","article-title":"Neutrophils and PMN-MDSC: their biological role and interaction with stromal cells","volume":"35","author":"Zhou","year":"2018","journal-title":"Semin Immunol"},{"key":"10.1016\/j.scib.2024.12.039_b0040","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2024.12.039_b0045","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.scib.2024.12.039_b0050","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gutjnl-2022-327909","article-title":"Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade","volume":"72","author":"Conche","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.scib.2024.12.039_b0055","article-title":"KAT6A acetylation of SMAD3 regulates myeloid-derived suppressor cell recruitment, metastasis, and immunotherapy in triple-negative breast cancer","volume":"8","author":"Yu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2024.12.039_b0060","doi-asserted-by":"crossref","first-page":"21248","DOI":"10.1073\/pnas.1015855107","article-title":"Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes","volume":"107","author":"Kowanetz","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2024.12.039_b0065","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1471-4159.1965.tb06771.x","article-title":"Distribution of N-acetyl-aspartic and N-acetyl-aspartyl-glutamic acids in nervous tissue","volume":"12","author":"Curatolo","year":"1965","journal-title":"J Neurochem"},{"key":"10.1016\/j.scib.2024.12.039_b0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1471-4159.2000.0750453.x","article-title":"Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling","volume":"75","author":"Baslow","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.scib.2024.12.039_b0075","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.celrep.2019.03.036","article-title":"Uncovering the role of N-acetyl-aspartyl-glutamate as a glutamate reservoir in cancer","volume":"27","author":"Nguyen","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.scib.2024.12.039_b0080","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41422-022-00614-0","article-title":"Comprehensive metabolomics expands precision medicine for triple-negative breast cancer","volume":"32","author":"Xiao","year":"2022","journal-title":"Cell Res"},{"key":"10.1016\/j.scib.2024.12.039_b0085","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1158\/0008-5472.CAN-21-1337","article-title":"ALDH1A1 activity in tumor-initiating cells remodels myeloid-derived suppressor cells to promote breast cancer progression","volume":"81","author":"Liu","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.scib.2024.12.039_b0090","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add5204","article-title":"Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis","volume":"8","author":"Gong","year":"2023","journal-title":"Sci Immunol"},{"key":"10.1016\/j.scib.2024.12.039_b0095","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2024.12.039_b0100","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","article-title":"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome","volume":"1","author":"Ginestier","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scib.2024.12.039_b0105","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.stemcr.2013.11.009","article-title":"Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts","volume":"2","author":"Liu","year":"2014","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.scib.2024.12.039_b0110","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nrd1903","article-title":"NAAG peptidase inhibitors and their potential for diagnosis and therapy","volume":"4","author":"Zhou","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.scib.2024.12.039_b0115","doi-asserted-by":"crossref","unstructured":"Bratek E, Ziembowicz A, Salinska E. N-acetylaspartylglutamate (NAAG) pretreatment reduces hypoxic-ischemic brain damage and oxidative stress in neonatal rats. Antioxidants (Basel) 2020;9:877.","DOI":"10.3390\/antiox9090877"},{"key":"10.1016\/j.scib.2024.12.039_b0120","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ccell.2018.02.011","article-title":"GKAP Acts as a Genetic modulator of NMDAR signaling to govern invasive tumor growth","volume":"33","author":"Li","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.scib.2024.12.039_b0125","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/bs.apha.2016.01.003","article-title":"The good and bad sides of NAAG","volume":"76","author":"Khacho","year":"2016","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.scib.2024.12.039_b0130","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","article-title":"Synaptic proximity enables NMDAR signalling to promote brain metastasis","volume":"573","author":"Zeng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.scib.2024.12.039_b0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41586-018-0039-9","article-title":"Mechanism of NMDA receptor channel block by MK-801 and memantine","volume":"556","author":"Song","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.scib.2024.12.039_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.acr.2020.10.002","article-title":"Signaling pathways in hepatocellular carcinoma","volume":"149","author":"Garcia-Lezana","year":"2021","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.scib.2024.12.039_b0145","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1242\/jcs.035683","article-title":"The molecular logic of Notch signaling\u2013a structural and biochemical perspective","volume":"121","author":"Gordon","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.scib.2024.12.039_b0150","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.abb.2014.06.022","article-title":"CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK","volume":"558","author":"Lim","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.scib.2024.12.039_b0155","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1158\/1078-0432.CCR-21-3874","article-title":"A phase Ib\/II randomized study of RO4929097, a gamma-secretase or Notch inhibitor with or without vismodegib, a hedgehog inhibitor, in advanced sarcoma","volume":"28","author":"Gounder","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.scib.2024.12.039_b0160","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s11427-023-2499-2","article-title":"Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K\/Akt\/mTOR pathway","volume":"67","author":"Ganesan","year":"2024","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.scib.2024.12.039_b0165","first-page":"0289","article-title":"Dissection of FOXO1-induced LYPLAL1-DT impeding triple-negative breast cancer progression via mediating hnRNPK\/beta-Catenin complex","volume":"6","author":"Tang","year":"2023","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.scib.2024.12.039_b0170","article-title":"m(6)A-dependent modulation via IGF2BP3\/MCM5\/Notch axis promotes partial EMT and LUAD metastasis","volume":"10","author":"Yang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2024.12.039_b0175","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.31557\/APJCP.2022.23.8.2573","article-title":"beta-Eudesmol inhibits the migration of cholangiocarcinoma cells by suppressing epithelial-mesenchymal transition via PI3K\/AKT and p38MAPK modulation","volume":"23","author":"Acharya","year":"2022","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.scib.2024.12.039_b0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-023-01337-3","article-title":"PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.scib.2024.12.039_b0185","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.immuni.2017.10.021","article-title":"Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes","volume":"47","author":"Yanez","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.scib.2024.12.039_b0190","article-title":"The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis","volume":"148","author":"Satake","year":"2021","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.scib.2024.12.039_b0195","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2202809","article-title":"Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer","volume":"387","author":"Cortes","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2024.12.039_b0200","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJMoa2112651","article-title":"Event-free survival with pembrolizumab in early triple-negative breast cancer","volume":"386","author":"Schmid","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2024.12.039_b0205","article-title":"Tumor immunotherapy: mechanisms and clinical applications","volume":"1","author":"Nong","year":"2022","journal-title":"MedComm \u2013 O Oncology"},{"key":"10.1016\/j.scib.2024.12.039_b0210","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41388-019-1006-0","article-title":"Neurotransmitters: emerging targets in cancer","volume":"39","author":"Jiang","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.scib.2024.12.039_b0215","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1007\/s11064-017-2181-4","article-title":"NAAG peptidase inhibitors act via mGluR3: animal models of memory, Alzheimer's, and ethanol intoxication","volume":"42","author":"Olszewski","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.scib.2024.12.039_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101722","article-title":"N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: an abundant peptide neurotransmitter-enzyme system with multiple clinical applications","volume":"184","author":"Neale","year":"2020","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.scib.2024.12.039_b0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.nbd.2016.06.010","article-title":"Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal\/newborn rabbit brain","volume":"94","author":"Zhang","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.scib.2024.12.039_b0230","doi-asserted-by":"crossref","first-page":"26188","DOI":"10.1074\/jbc.M113.487553","article-title":"N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells","volume":"288","author":"Long","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.scib.2024.12.039_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019963","article-title":"Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer","volume":"6","author":"Fong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2024.12.039_b0240","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302126120","article-title":"NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages","volume":"120","author":"Yuan","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2024.12.039_b0245","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41392-020-00377-3","article-title":"Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.scib.2024.12.039_b0250","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.20171052","article-title":"Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors","volume":"215","author":"Kaittanis","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.scib.2024.12.039_b0255","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2741\/4742","article-title":"GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond","volume":"24","author":"Vorlova","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.scib.2024.12.039_b0260","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12022-017-9500-9","article-title":"Well-differentiated thyroid cancer neovasculature expresses prostate-specific membrane antigen-a possible novel therapeutic target","volume":"28","author":"Moore","year":"2017","journal-title":"Endocr Pathol"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927324009496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927324009496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:12:05Z","timestamp":1762600325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927324009496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2095927324009496"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2024.12.039","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2024.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}