{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:14:51Z","timestamp":1792239291131,"version":"4.4.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200425"],"award-info":[{"award-number":["32200425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370577"],"award-info":[{"award-number":["32370577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070573"],"award-info":[{"award-number":["32070573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA0913403"],"award-info":[{"award-number":["2023YFA0913403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100503"],"award-info":[{"award-number":["2021YFA1100503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.scib.2025.08.023","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T08:41:41Z","timestamp":1755506501000},"page":"3489-3493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["G9a-mediated H3K9 di-methylation protects centromere integrity and chromosome stability"],"prefix":"10.1016","volume":"70","author":[{"given":"Yanyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2025.08.023_b0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nrm.2015.5","article-title":"The molecular basis for centromere identity and function","volume":"17","author":"McKinley","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.scib.2025.08.023_b0010","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1126\/science.270.5242.1591","article-title":"The centromere: hub of chromosomal activities","volume":"270","author":"Pluta","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.scib.2025.08.023_b0015","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nsmb845","article-title":"Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin","volume":"11","author":"Sullivan","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.scib.2025.08.023_b0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature23267","article-title":"Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription","volume":"547","author":"Jih","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.scib.2025.08.023_b0025","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41580-022-00483-w","article-title":"Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance","volume":"23","author":"Padeken","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.scib.2025.08.023_b0030","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1101\/gad.1284005","article-title":"Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9","volume":"19","author":"Tachibana","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.scib.2025.08.023_b0035","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.3390\/cancers16122175","article-title":"G9a in cancer: mechanisms, therapeutic advancements, and clinical implications","volume":"16","author":"Ni","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.scib.2025.08.023_b0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41594-023-00943-7","article-title":"Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis","volume":"30","author":"Djeghloul","year":"2023","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.scib.2025.08.023_b0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(01)00542-6","article-title":"Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability","volume":"107","author":"Peters","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.scib.2025.08.023_b0050","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.cub.2006.07.022","article-title":"Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors","volume":"16","author":"Cimini","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.scib.2025.08.023_b0055","doi-asserted-by":"crossref","first-page":"12997","DOI":"10.1074\/jbc.M311128200","article-title":"Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis","volume":"279","author":"Yasui","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.scib.2025.08.023_b0060","article-title":"Dynamic phosphorylation of G9a regulates its repressive activity on chromatin accessibility and mitotic progression","volume":"10","author":"Geng","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2025.08.023_b0065","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl4178","article-title":"Complete genomic and epigenetic maps of human centromeres","volume":"376","author":"Altemose","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.scib.2025.08.023_b0070","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1097-2765(03)00279-X","article-title":"Transcription within a functional human centromere","volume":"12","author":"Saffery","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.scib.2025.08.023_b0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.aan6490","article-title":"A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation","volume":"359","author":"Kabeche","year":"2018","journal-title":"Science"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927325008540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927325008540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:11:10Z","timestamp":1772896270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927325008540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":15,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2095927325008540"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2025.08.023","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"G9a-mediated H3K9 di-methylation protects centromere integrity and chromosome stability","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2025.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}