{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:53:03Z","timestamp":1787856783994,"version":"build-2784847793"},"reference-count":63,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["7252148"],"award-info":[{"award-number":["7252148"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2021ZD0203204"],"award-info":[{"award-number":["2021ZD0203204"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271247"],"award-info":[{"award-number":["82271247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750140"],"award-info":[{"award-number":["2024M750140"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.scib.2026.05.062","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:09:49Z","timestamp":1780013389000},"page":"3363-3379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence"],"prefix":"10.1016","volume":"71","author":[{"given":"Zi-Le","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Zhou","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Qi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.05.062_b0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41572-024-00523-z","article-title":"Trigeminal neuralgia","volume":"10","author":"Ashina","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.scib.2026.05.062_b0010","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJMra1914484","article-title":"Trigeminal neuralgia","volume":"383","author":"Cruccu","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.scib.2026.05.062_b0015","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S1474-4422(20)30233-7","article-title":"Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia","volume":"19","author":"Bendtsen","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.scib.2026.05.062_b0020","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/j.pain.0000000000000853","article-title":"Evaluating the impact of trigeminal neuralgia","volume":"158","author":"Zakrzewska","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0025","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1177\/0333102411424619","article-title":"Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study","volume":"31","author":"Mueller","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.scib.2026.05.062_b0030","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.adaj.2016.02.014","article-title":"Prevalence of trigeminal neuralgia: a systematic review","volume":"147","author":"De Toledo","year":"2016","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.scib.2026.05.062_b0035","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38:1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"10.1016\/j.scib.2026.05.062_b0040","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1212\/WNL.0000000000002840","article-title":"Trigeminal neuralgia: new classification and diagnostic grading for practice and research","volume":"87","author":"Cruccu","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.scib.2026.05.062_b0045","doi-asserted-by":"crossref","unstructured":"International Classification of Orofacial Pain Steering Committee. International classification of orofacial pain, 1st edition (ICOP). Cephalalgia 2020;40:129\u2013221.","DOI":"10.1177\/0333102419893823"},{"key":"10.1016\/j.scib.2026.05.062_b0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.job.2024.07.003","article-title":"Cytoarchitecture and intercellular interactions in the trigeminal ganglion: associations with neuropathic pain in the orofacial region","volume":"66","author":"Goto","year":"2024","journal-title":"J Oral Biosci"},{"key":"10.1016\/j.scib.2026.05.062_b0055","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroscience.2004.02.029","article-title":"Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn","volume":"125","author":"Takeda","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.scib.2026.05.062_b0060","doi-asserted-by":"crossref","first-page":"G949","DOI":"10.1152\/ajpgi.00493.2012","article-title":"Emerging neuropeptide targets in inflammation: NPY and VIP","volume":"304","author":"Chandrasekharan","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.scib.2026.05.062_b0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10555-024-10237-z","article-title":"Neuropeptide Y in cancer-biological functions and potential clinical implications","volume":"44","author":"Sigorski","year":"2025","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.scib.2026.05.062_b0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159247","article-title":"mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain","volume":"7","author":"Chen","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.scib.2026.05.062_b0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0304-3940(91)90093-9","article-title":"Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy","volume":"124","author":"Wakisaka","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.scib.2026.05.062_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2025.105385","article-title":"De novo expression of neuropeptide Y in sensory neurons does not contribute to peripheral neuropathic pain","volume":"30","author":"Cooper","year":"2025","journal-title":"J Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0085","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/ALN.0000000000005184","article-title":"Neuropeptide Y Y2 receptors in sensory neurons tonically suppress nociception and itch but facilitate postsurgical and neuropathic pain hypersensitivity","volume":"141","author":"Basu","year":"2024","journal-title":"Anesthesiology"},{"key":"10.1016\/j.scib.2026.05.062_b0090","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0165-6147(91)90610-5","article-title":"Receptors for neuropeptide Y: multiple subtypes and multiple second messengers","volume":"12","author":"Michel","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.scib.2026.05.062_b0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tips.2006.12.003","article-title":"Neuropeptide tyrosine and pain","volume":"28","author":"Brumovsky","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.scib.2026.05.062_b0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fendo.2013.00005","article-title":"Neuropeptide Y receptors: how to get subtype selectivity","volume":"4","author":"Pedragosa-Badia","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.scib.2026.05.062_b0105","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.nut.2008.06.022","article-title":"Y1 receptor knockout increases nociception and prevents the anti-allodynic actions of NPY","volume":"24","author":"Kuphal","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.scib.2026.05.062_b0110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0304-3959(01)00481-X","article-title":"Antihyperalgesic effects of intrathecal neuropeptide Y during inflammation are mediated by Y1 receptors","volume":"96","author":"Taiwo","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2016.11.027","article-title":"Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination","volume":"93","author":"Arcourt","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.scib.2026.05.062_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580378","article-title":"Neuropeptide Y is an immunomodulatory factor: direct and indirect","volume":"11","author":"Chen","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.scib.2026.05.062_b0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/brbi.1993.1007","article-title":"Effect of neuropeptide Y on natural killer activity of normal human lymphocytes","volume":"7","author":"Nair","year":"1993","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.scib.2026.05.062_b0130","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1046\/j.1471-4159.2000.0752464.x","article-title":"Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay","volume":"75","author":"Straub","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.scib.2026.05.062_b0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-0115(01)00262-2","article-title":"Neuropeptide Y effects on murine natural killer activity: changes with ageing and cAMP involvement","volume":"101","author":"De La Fuente","year":"2001","journal-title":"Regul Pept"},{"key":"10.1016\/j.scib.2026.05.062_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/c2432ace-1dd7-4b02-8980-e4e6c085beba","article-title":"Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation","volume":"8","author":"Singer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2026.05.062_b0145","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.peptides.2011.06.007","article-title":"Neuropeptide Y modulates functions of inflammatory cells in the rat: distinct role for Y1, Y2 and Y5 receptors","volume":"32","author":"Miti\u0107","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.scib.2026.05.062_b0150","doi-asserted-by":"crossref","first-page":"13009","DOI":"10.3390\/ijms232113009","article-title":"Neuropeptide Y promotes human M2 macrophage polarization and enhances p62\/SQSTM1-dependent autophagy and NRF2 activation","volume":"23","author":"Profumo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.scib.2026.05.062_b0155","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1158\/1078-0432.CCR-18-2912","article-title":"Depression-induced neuropeptide Y secretion promotes prostate cancer growth by recruiting myeloid cells","volume":"25","author":"Cheng","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.scib.2026.05.062_b0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40478-020-00922-9","article-title":"Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia","volume":"8","author":"Cui","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.scib.2026.05.062_b0165","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1385-299X(03)00072-2","article-title":"A procedure to deliver herpes simplex virus to the murine trigeminal ganglion","volume":"12","author":"Whitehead","year":"2003","journal-title":"Brain Res Brain Res Protoc"},{"key":"10.1016\/j.scib.2026.05.062_b0170","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/emmm.201000100","article-title":"Therapeutic potential of neuropeptide Y (NPY) receptor ligands","volume":"2","author":"Brothers","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.scib.2026.05.062_b0175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/joim.20118","article-title":"The pharmacotherapeutic potential of neuropeptide Y for chronic pain","volume":"298","author":"Nie","year":"2025","journal-title":"J Intern Med"},{"key":"10.1016\/j.scib.2026.05.062_b0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4939-7837-3_23","article-title":"Depleting macrophages in vivo with clodronate-liposomes","volume":"1784","author":"Moreno","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.scib.2026.05.062_b0185","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1460-9568.1993.tb00219.x","article-title":"Large calibre primary afferent neurons projecting to the gracile nucleus express neuropeptide Y after sciatic nerve lesions: an immunohistochemical and in situ hybridization study in rats","volume":"5","author":"Zhang","year":"1993","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.scib.2026.05.062_b0190","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuroscience.2009.10.052","article-title":"Topography and time course of changes in spinal neuropeptide Y immunoreactivity after spared nerve injury","volume":"165","author":"Intondi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.scib.2026.05.062_b0195","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(92)90206-O","article-title":"Effects of peripheral nerve injuries and tissue inflammation on the levels of neuropeptide Y-like immunoreactivity in rat primary afferent neurons","volume":"598","author":"Wakisaka","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.scib.2026.05.062_b0200","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.adl0544","article-title":"Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model","volume":"385","author":"Kaag Rasmussen","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.scib.2026.05.062_b0205","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169554","article-title":"Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp","volume":"8","author":"Nelson","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.scib.2026.05.062_b0210","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1523\/JNEUROSCI.22-22-09858.2002","article-title":"Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y","volume":"22","author":"Ossipov","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.scib.2026.05.062_b0215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(94)01265-J","article-title":"Peripheral hyperalgesia in experimental neuropathy: exacerbation by neuropeptide Y","volume":"669","author":"Tracey","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.scib.2026.05.062_b0220","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(93)90179-Q","article-title":"Cell size-specific appearance of neuropeptide Y in the trigeminal ganglion following peripheral axotomy of different branches of the mandibular nerve of the rat","volume":"620","author":"Wakisaka","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.scib.2026.05.062_b0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12990-015-0029-y","article-title":"Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain","volume":"11","author":"Magnussen","year":"2015","journal-title":"Mol Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0230","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.scib.2026.05.062_b0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(01)00492-4","article-title":"Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity","volume":"97","author":"Lariviere","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0240","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jot.2025.01.016","article-title":"Emerging role of macrophages in neuropathic pain","volume":"51","author":"Tong","year":"2025","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.scib.2026.05.062_b0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78515","article-title":"Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling","volume":"12","author":"Guimar\u00e3es","year":"2023","journal-title":"elife"},{"key":"10.1016\/j.scib.2026.05.062_b0250","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41467-019-13839-2","article-title":"Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain","volume":"11","author":"Yu","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.05.062_b0255","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11033-023-09149-y","article-title":"The CSF1-CSF1R pathway in the trigeminal ganglion mediates trigeminal neuralgia via inflammatory responses in mice","volume":"51","author":"He","year":"2024","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.scib.2026.05.062_b0260","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12974-017-1022-3","article-title":"Macrophages in trigeminal ganglion contribute to ectopic mechanical hypersensitivity following inferior alveolar nerve injury in rats","volume":"14","author":"Batbold","year":"2017","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.05.062_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.691396","article-title":"Orofacial neuropathic pain-basic research and their clinical relevancies","volume":"14","author":"Shinoda","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.scib.2026.05.062_b0270","doi-asserted-by":"crossref","first-page":"28188","DOI":"10.1038\/srep28188","article-title":"TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2026.05.062_b0275","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s10194-021-01244-4","article-title":"P2X(3) receptor upregulation in trigeminal ganglion neurons through TNF\u03b1 production in macrophages contributes to trigeminal neuropathic pain in rats","volume":"22","author":"Koizumi","year":"2021","journal-title":"J Headache Pain"},{"key":"10.1016\/j.scib.2026.05.062_b0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2013.04.019","article-title":"The neuropeptides \u03b1-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells","volume":"260","author":"Phan","year":"2013","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.scib.2026.05.062_b0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/eji.201747389","article-title":"Obesity and dysregulated central and peripheral macrophage-neuron cross-talk","volume":"49","author":"Boura-Halfon","year":"2019","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.scib.2026.05.062_b0290","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12264-008-0130-6","article-title":"Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor","volume":"24","author":"Zhou","year":"2008","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.scib.2026.05.062_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109666","article-title":"Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons","volume":"36","author":"Cheng","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.scib.2026.05.062_b0300","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000330195","article-title":"Neuronal injury marker ATF-3 is induced in primary afferent neurons of monoarthritic rats","volume":"19","author":"Nascimento","year":"2011","journal-title":"Neurosignals"},{"key":"10.1016\/j.scib.2026.05.062_b0305","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/14737175.2024.2365946","article-title":"An update on pharmacotherapy for trigeminal neuralgia","volume":"24","author":"Pergolizzi","year":"2024","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.scib.2026.05.062_b0310","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70360","article-title":"Noradrenergic locus coeruleus-CA3 activation alleviates neuropathic pain and anxiety- and depression-like behaviors by suppressing microglial neuroinflammation in SNI mice","volume":"31","author":"Zou","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.scib.2026.05.062_b0315","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41583-020-0310-6","article-title":"Qualitative sex differences in pain processing: emerging evidence of a biased literature","volume":"21","author":"Mogil","year":"2020","journal-title":"Nat Rev Neurosci"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326005906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326005906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:46:53Z","timestamp":1785887213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927326005906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":63,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2095927326005906"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.05.062","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.05.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}