{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:16:45Z","timestamp":1792793805356,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.scib.2026.07.018","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:15:12Z","timestamp":1783440912000},"page":"4194-4207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferritin-mediated copper delivery induces dual cell death across diverse leukemia types"],"prefix":"10.1016","volume":"71","author":[{"given":"Huaiji","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caopei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weier","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.07.018_b0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41420-022-01193-0","article-title":"The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: from biology to therapeutic targeting","volume":"8","author":"Chen","year":"2022","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.scib.2026.07.018_b0010","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/nm.4410","article-title":"Clonal evolution in leukemia","volume":"23","author":"Ferrando","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.scib.2026.07.018_b0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41590-025-02096-9","article-title":"The rewired immune microenvironment in leukemia","volume":"26","author":"Ciantra","year":"2025","journal-title":"Nat Immunol"},{"key":"10.1016\/j.scib.2026.07.018_b0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrc.2017.125","article-title":"Targeting minimal residual disease: a path to cure?","volume":"18","author":"Luskin","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.scib.2026.07.018_b0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41568-020-0245-2","article-title":"Bone marrow niches in haematological malignancies","volume":"20","author":"M\u00e9ndez-Ferrer","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.scib.2026.07.018_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115804","article-title":"Cell death and cancer: metabolic interconnections","volume":"44","author":"Dalseno","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.scib.2026.07.018_b0035","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41551-024-01221-7","article-title":"Strategies for the development of metalloimmunotherapies","volume":"8","author":"Sun","year":"2024","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.scib.2026.07.018_b0040","article-title":"A metal chelation therapy to effectively eliminate breast cancer and intratumor bacteria while suppressing tumor metastasis by copper depletion and zinc ions surge","volume":"64","author":"Xie","year":"2024","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.scib.2026.07.018_b0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.scib.2026.07.018_b0050","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylatedTCA cycle proteins","volume":"375","author":"Peter","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.scib.2026.07.018_b0055","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41565-024-01784-1","article-title":"A cuproptosis nanocapsule for cancer radiotherapy","volume":"19","author":"Liao","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.scib.2026.07.018_b0060","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.ccell.2025.03.031","article-title":"Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance","volume":"43","author":"Lei","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.scib.2026.07.018_b0065","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1021\/acsnano.3c07775","article-title":"Cuproptosis: harnessing transition metal for cancer therapy","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.scib.2026.07.018_b0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","article-title":"Mitochondrial metabolism promotes adaptation to proteotoxic stress","volume":"15","author":"Tsvetkov","year":"2019","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.scib.2026.07.018_b0075","article-title":"One-step symbiosis of bimetallic peroxides nanoparticles to induce ferroptosis\/cuproptosis and activate cGAS-STING pathway for enhanced tumor immunotherapy","volume":"37","author":"Liu","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.scib.2026.07.018_b0080","article-title":"Copper\u2010driven allosteric and self\u2010encapsulating polymers for tumor\u2010specific fluorescence imaging and dual\u2010enzymatic cancer therapy","volume":"38","author":"Peng","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.scib.2026.07.018_b0085","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.scib.2026.07.018_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102498","article-title":"The role of metal ions in stroke: current evidence and future perspectives","volume":"101","author":"Wang","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.scib.2026.07.018_b0095","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41579-025-01213-7","article-title":"Microbial metal physiology: ions to ecosystems","volume":"23","author":"Helmann","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.scib.2026.07.018_b0100","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41578-024-00695-w","article-title":"Precision drug delivery to the central nervous system using engineered nanoparticles","volume":"9","author":"Gao","year":"2024","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.scib.2026.07.018_b0105","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41578-023-00581-x","article-title":"New opportunities and old challenges in the clinical translation of nanotheranostics","volume":"8","author":"Gawne","year":"2023","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.scib.2026.07.018_b0110","article-title":"Shielding ferritin with a biomineralized shell enables efficient modulation of tumor microenvironment and targeted delivery of diverse therapeutic agents","volume":"34","author":"Wang","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.scib.2026.07.018_b0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nnano.2012.90","article-title":"Magnetoferritin nanoparticles for targeting and visualizing tumour tissues","volume":"7","author":"Fan","year":"2012","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.scib.2026.07.018_b0120","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/s41565-021-00980-7","article-title":"Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects","volume":"16","author":"Wang","year":"2021","journal-title":"Nat Nanotechnol"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209592732600770X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209592732600770X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:34:33Z","timestamp":1788204873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209592732600770X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S209592732600770X"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.07.018","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferritin-mediated copper delivery induces dual cell death across diverse leukemia types","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}