{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:26Z","timestamp":1792801766833,"version":"4.5.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.scib.2026.07.059","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:07:41Z","timestamp":1784822861000},"page":"4244-4271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Precise nanodelivery of screened compounds alleviates sepsis-associated encephalopathy by targeting microglial ANXA2"],"prefix":"10.1016","volume":"71","author":[{"given":"Daoyi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maokai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.07.059_b0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.scib.2026.07.059_b0010","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq7806","article-title":"Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy","volume":"9","author":"Chung","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.scib.2026.07.059_b0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis: a review","volume":"319","author":"Prescott","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.scib.2026.07.059_b0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12974-022-02464-4","article-title":"Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments","volume":"19","author":"Sekino","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108971","article-title":"Sepsis-associated encephalopathy: unraveling molecular mechanisms, emerging therapeutics, and translational frontiers","volume":"278","author":"Zhang","year":"2026","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.scib.2026.07.059_b0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2025.08.008","article-title":"Calcineurin\/NFAT1\/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy","volume":"240","author":"Ding","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.scib.2026.07.059_b0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12974-023-02975-8","article-title":"Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis","volume":"20","author":"Mein","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0040","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-011716","article-title":"Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer","volume":"13","author":"Tang","year":"2025","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.scib.2026.07.059_b0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12974-023-02941-4","article-title":"Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia-reperfusion injury by modulating various cells","volume":"20","author":"Ruan","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154481","article-title":"Computer especially AI-assisted drug virtual screening and design in traditional Chinese medicine","volume":"107","author":"Lin","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.scib.2026.07.059_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114481","article-title":"Surface micropatterning for the formation of an in vitro functional endothelial model for cell-based biosensors","volume":"214","author":"Khadir","year":"2022","journal-title":"Biosens Bioelectron"},{"key":"10.1016\/j.scib.2026.07.059_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113435","article-title":"Evodiamine prevents traumatic brain injury through inhibiting oxidative stress via PGK1\/NRF2 pathway","volume":"153","author":"Xu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.scib.2026.07.059_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-022-09772-8","article-title":"Evodiamine as an anticancer agent: a comprehensive review on its therapeutic application, pharmacokinetic, toxicity, and metabolism in various cancers","volume":"39","author":"Panda","year":"2023","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.scib.2026.07.059_b0070","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.2147\/IJN.S459510","article-title":"Evodiamine: a extremely potential drug development candidate of alkaloids from Evodia rutaecarpa","volume":"19","author":"Lin","year":"2024","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.scib.2026.07.059_b0075","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1080\/10717544.2022.2072543","article-title":"Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease","volume":"29","author":"Wang","year":"2022","journal-title":"Drug Deliv"},{"key":"10.1016\/j.scib.2026.07.059_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122277","article-title":"Improving outcomes in intracerebral hemorrhage through microglia\/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes","volume":"301","author":"Han","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.07.059_b0085","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/j.apsb.2024.03.025","article-title":"Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.scib.2026.07.059_b0090","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00011-023-01738-8","article-title":"Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4\/MyD88\/NF-\u03baB signaling pathway activation in aged mice","volume":"72","author":"Yao","year":"2023","journal-title":"Inflamm Res"},{"key":"10.1016\/j.scib.2026.07.059_b0095","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2410564121","article-title":"N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABABR1 mRNA in sepsis-associated encephalopathy","volume":"121","author":"Gao","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2026.07.059_b0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12974-025-03395-6","article-title":"Inhibition of neutrophil extracellular traps alleviates blood-brain barrier disruption and cognitive dysfunction via Wnt3\/\u03b2-catenin\/TCF4 signaling in sepsis-associated encephalopathy","volume":"22","author":"Yue","year":"2025","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0105","article-title":"Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis-associated encephalopathy","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.scib.2026.07.059_b0110","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1038\/s41467-025-62181-3","article-title":"Small intestinal \u03b3\u03b4 T17 cells promote SAE through STING\/C1q-induced microglial synaptic pruning in male mice","volume":"16","author":"Wu","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0115","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A mitigates Alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2\/GPX4 axis activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.scib.2026.07.059_b0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-023-01387-8","article-title":"Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"22","author":"Wei","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.scib.2026.07.059_b0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1164\/rccm.201909-1713LE","article-title":"Transcriptomic profiles of sepsis in the human brain","volume":"201","author":"Bustamante","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.scib.2026.07.059_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.scib.2026.07.059_b0135","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scib.2026.07.059_b0140","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.scib.2026.07.059_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v106.i01","article-title":"Elastic net regularization paths for all generalized linear models","volume":"106","author":"Tay","year":"2023","journal-title":"J Stat Softw"},{"key":"10.1016\/j.scib.2026.07.059_b0150","doi-asserted-by":"crossref","first-page":"8100","DOI":"10.1093\/nar\/gkae552","article-title":"Assessing the impact of transcriptomics data analysis pipelines on downstream functional enrichment results","volume":"52","author":"Paton","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0155","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.scib.2026.07.059_b0160","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0165","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12943-025-02276-z","article-title":"IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer","volume":"24","author":"Ranjan","year":"2025","journal-title":"Mol Cancer"},{"key":"10.1016\/j.scib.2026.07.059_b0170","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-023-02959-8","article-title":"TRIM45 aggravates microglia pyroptosis via Atg5\/NLRP3 axis in septic encephalopathy","volume":"20","author":"Huang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103387","article-title":"Reduced microRNA-744 expression in mast cell-derived exosomes triggers epithelial cell ferroptosis in acute respiratory distress syndrome","volume":"77","author":"Fang","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.scib.2026.07.059_b0180","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/s41596-023-00841-8","article-title":"Tutorial: integrative computational analysis of bulk RNA-sequencing data to characterize tumor immunity using RIMA","volume":"18","author":"Yang","year":"2023","journal-title":"Nat Protoc"},{"key":"10.1016\/j.scib.2026.07.059_b0185","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf684","article-title":"Benchmarking single-sample gene set scoring methods for application in precision medicine","volume":"26","author":"Toro-Dom\u00ednguez","year":"2025","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.scib.2026.07.059_b0190","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.7150\/ijbs.99859","article-title":"Repurposing of the antipsychotic trifluoperazine induces SLC7A11\/GPX4-mediated ferroptosis of oral cancer via the ROS\/autophagy pathway","volume":"20","author":"Tsai","year":"2024","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.scib.2026.07.059_b0195","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac051","article-title":"Improving protein-ligand docking and screening accuracies by incorporating a scoring function correction term","volume":"23","author":"Zheng","year":"2022","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.scib.2026.07.059_b0200","doi-asserted-by":"crossref","first-page":"D437","DOI":"10.1093\/nar\/gkaa1038","article-title":"RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences","volume":"49","author":"Burley","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0205","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad047","article-title":"Dockey: a modern integrated tool for large-scale molecular docking and virtual screening","volume":"24","author":"Du","year":"2023","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.scib.2026.07.059_b0210","doi-asserted-by":"crossref","first-page":"E7245","DOI":"10.1073\/pnas.1704155114","article-title":"Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2026.07.059_b0215","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.scib.2026.07.059_b0220","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1021\/acs.jcim.2c00879","article-title":"AMBER drug discovery boost tools: automated workflow for production free-energy simulation setup and analysis (ProFESSA)","volume":"62","author":"Ganguly","year":"2022","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.scib.2026.07.059_b0225","doi-asserted-by":"crossref","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0230","doi-asserted-by":"crossref","first-page":"W203","DOI":"10.1093\/nar\/gkaf365","article-title":"Cytoscape Web: bringing network biology to the browser","volume":"53","author":"Ono","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0235","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/bioinformatics\/btab549","article-title":"rPanglaoDB: an R package to download and merge labeled single-cell RNA-seq data from the PanglaoDB database","volume":"38","author":"Osorio","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scib.2026.07.059_b0240","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0245","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics Database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.07.059_b0250","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyae031","article-title":"Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse","volume":"227","author":"Baldarelli","year":"2024","journal-title":"Genetics"},{"key":"10.1016\/j.scib.2026.07.059_b0255","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3390\/nu16121957","article-title":"Effects of evodiamine on behavior and hippocampal neurons through inhibition of angiotensin-converting enzyme and modulation of the renin angiotensin pathway in a mouse model of post-traumatic stress disorder","volume":"16","author":"Wang","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.scib.2026.07.059_b0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/cvr\/cvaa110","article-title":"Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function","volume":"117","author":"Zacchigna","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.scib.2026.07.059_b0265","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1039\/D1TB00126D","article-title":"Liposomes for oral delivery of protein and peptide-based therapeutics: challenges, formulation strategies, and advances","volume":"9","author":"Jash","year":"2021","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.scib.2026.07.059_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121239","article-title":"Effects of RGD-grafted phosphatidylserine-containing liposomes on the polarization of macrophages and bone tissue regeneration","volume":"279","author":"Wu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.07.059_b0275","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12951-025-03487-8","article-title":"TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy","volume":"23","author":"Wu","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.scib.2026.07.059_b0280","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1039\/D3MH00717K","article-title":"Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results","volume":"10","author":"Filippov","year":"2023","journal-title":"Mater Horiz"},{"key":"10.1016\/j.scib.2026.07.059_b0285","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jconrel.2023.08.006","article-title":"Liposomal co-delivery of toll-like receptors 3 and 7 agonists induce a hot triple-negative breast cancer immune environment","volume":"361","author":"Nguyen","year":"2023","journal-title":"J Control Release"},{"key":"10.1016\/j.scib.2026.07.059_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124812","article-title":"Limited cellular uptake of liposomes: might thiolated phospholipids hold the key?","volume":"667","author":"Stengel","year":"2024","journal-title":"Int J Pharm"},{"key":"10.1016\/j.scib.2026.07.059_b0295","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1021\/acs.analchem.2c05166","article-title":"Efficient labeling of vesicles with lipophilic fluorescent dyes via the salt-change method","volume":"95","author":"Cha","year":"2023","journal-title":"Anal Chem"},{"key":"10.1016\/j.scib.2026.07.059_b0300","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202522813","article-title":"Ion-exchange and energy-stress strategies amplified dual-site nanozyme-mediated ferroptosis\/pyroptosis inhibition for neuroprotection","volume":"65","author":"Cao","year":"2026","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.scib.2026.07.059_b0305","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.1021\/acs.nanolett.5c01141","article-title":"A metal-phenolic network nanoresensitizer overcoming glioblastoma drug resistance through the metabolic adaptive strategy and targeting drug-tolerant cells","volume":"25","author":"Yin","year":"2025","journal-title":"Nano Lett"},{"key":"10.1016\/j.scib.2026.07.059_b0310","doi-asserted-by":"crossref","first-page":"17404","DOI":"10.1039\/D4NR02793K","article-title":"Liposome biodistribution mapping with in vivo X-ray fluorescence imaging","volume":"16","author":"Saladino","year":"2024","journal-title":"Nanoscale"},{"key":"10.1016\/j.scib.2026.07.059_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100763","article-title":"A multimodal approach to assess a liposomal carrier's biodistribution, stability, and clearance","volume":"46","author":"Wood","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.scib.2026.07.059_b0320","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/s41467-022-31492-0","article-title":"dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts","volume":"13","author":"Demichev","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100581","article-title":"Accurate label-free quantification by directLFQ to compare unlimited numbers of proteomes","volume":"22","author":"Ammar","year":"2023","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.scib.2026.07.059_b0330","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12974-023-02889-5","article-title":"Supraphysiologic doses of 17\u03b2-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism","volume":"20","author":"Li","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0335","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-025-03374-x","article-title":"PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction","volume":"22","author":"Liao","year":"2025","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.scib.2026.07.059_b0340","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/mp.2017.76","article-title":"Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs","volume":"23","author":"Li","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.scib.2026.07.059_b0345","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41419-020-2626-6","article-title":"TNF-\u03b1-induced microglia activation requires miR-342: impact on NF-\u03baB signaling and neurotoxicity","volume":"11","author":"Br\u00e1s","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.scib.2026.07.059_b0350","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-\u03baB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.scib.2026.07.059_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110285","article-title":"Microglial activation and neuroinflammation in acute and chronic cognitive deficits in sepsis","volume":"267","author":"Denver","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.scib.2026.07.059_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2024.100723","article-title":"Multi-omics profiling identifies microglial Annexin A2 as a key mediator of NF-\u03baB pro-inflammatory signaling in ischemic reperfusion injury","volume":"23","author":"Tian","year":"2024","journal-title":"Mol Cell Proteom"},{"key":"10.1016\/j.scib.2026.07.059_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112449","article-title":"Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage","volume":"137","author":"Du","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.scib.2026.07.059_b0370","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3390\/antiox13101274","article-title":"Integrative human genetic and cellular analysis of the pathophysiological roles of AnxA2 in Alzheimer's disease","volume":"13","author":"Ye","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.scib.2026.07.059_b0375","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.scib.2026.07.059_b0380","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13020-024-01056-z","article-title":"Network pharmacology: a crucial approach in traditional Chinese medicine research","volume":"20","author":"Zhai","year":"2025","journal-title":"Chin Med"},{"key":"10.1016\/j.scib.2026.07.059_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102829","article-title":"Structure-based virtual screening of vast chemical space as a starting point for drug discovery","volume":"87","author":"Carlsson","year":"2024","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.scib.2026.07.059_b0390","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae480","article-title":"Protein language models are performant in structure-free virtual screening","volume":"25","author":"Lam","year":"2024","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.scib.2026.07.059_b0395","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.1038\/s41467-024-52061-7","article-title":"An artificial intelligence accelerated virtual screening platform for drug discovery","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0400","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1021\/acschembio.2c00500","article-title":"Merits of diazirine photo-immobilization for target profiling of natural products and cofactors","volume":"17","author":"Prokofeva","year":"2022","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.scib.2026.07.059_b0405","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-physchem-050317-021332","article-title":"Chiral plasmonic nanostructures enabled by bottom-up approaches","volume":"70","author":"Urban","year":"2019","journal-title":"Annu Rev Phys Chem"},{"key":"10.1016\/j.scib.2026.07.059_b0410","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1007\/s00216-024-05367-w","article-title":"Trends in surface plasmon resonance biosensing: materials, methods, and machine learning","volume":"416","author":"Stuart","year":"2024","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.scib.2026.07.059_b0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139597","article-title":"Evodiamine rescues lipopolysaccharide-induced cognitive impairment via C\/EBP-\u03b2-COX2 axis-regulated neuroinflammation","volume":"300","author":"Yang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.scib.2026.07.059_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156866","article-title":"Evodiamine inhibits NLRP3 inflammasome-mediated microglial pyroptosis and promotes remyelination via SLC2A4-regulated autophagy","volume":"143","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.scib.2026.07.059_b0425","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2024.02.016","article-title":"The miR-25802\/KLF4\/NF-\u03baB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer\u2019s disease","volume":"118","author":"Zhao","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.scib.2026.07.059_b0430","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1021\/acs.jmedchem.4c00357","article-title":"Novel isoalantolactone-based derivatives as potent NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization","volume":"67","author":"Zhao","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.scib.2026.07.059_b0435","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0440","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.tibs.2022.07.002","article-title":"Targeting protein conformations with small molecules to control protein complexes","volume":"47","author":"Zacharioudakis","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.scib.2026.07.059_b0445","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2237222","article-title":"Annexin A2: the missing piece in the puzzle of pathogen-induced damage","volume":"14","author":"Li","year":"2023","journal-title":"Virulence"},{"key":"10.1016\/j.scib.2026.07.059_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108034","article-title":"Evodiamine attenuates neurological impairment by inducing PANoptosis in microglia after severe traumatic brain injury","volume":"222","author":"Zheng","year":"2025","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.scib.2026.07.059_b0455","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1025066","article-title":"Discovery of an evodiamine derivative for PI3K\/AKT\/GSK3\u03b2 pathway activation and AD pathology improvement in mouse models","volume":"15","author":"Pang","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.scib.2026.07.059_b0460","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s11064-014-1356-5","article-title":"Pretreatment by evodiamine is neuroprotective in cerebral ischemia: up-regulated pAkt, pGSK3\u03b2, down-regulated NF-\u03baB expression, and ameliorated BBB permeability","volume":"39","author":"Zhao","year":"2014","journal-title":"Neurochem Res"},{"key":"10.1016\/j.scib.2026.07.059_b0465","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/molecules22060943","article-title":"Evaluation of the cardiotoxicity of evodiamine in vitro and in vivo","volume":"22","author":"Yang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.scib.2026.07.059_b0470","doi-asserted-by":"crossref","first-page":"173031","DOI":"10.1016\/j.ejphar.2020.173031","article-title":"Combined effects of berberine and evodiamine on colorectal cancer cells and cardiomyocytes in vitro","volume":"875","author":"Guan","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.scib.2026.07.059_b0475","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chest.2018.08.1037","article-title":"The septic heart: current understanding of molecular mechanisms and clinical implications","volume":"155","author":"Martin","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.scib.2026.07.059_b0480","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jconrel.2024.06.005","article-title":"PEG length effect of peptide-functional liposome for blood brain barrier (BBB) penetration and brain targeting","volume":"372","author":"Du","year":"2024","journal-title":"J Control Release"},{"key":"10.1016\/j.scib.2026.07.059_b0485","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1038\/s41467-023-44319-3","article-title":"ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells","volume":"14","author":"Lee","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.07.059_b0490","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113246","article-title":"Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models","volume":"42","author":"Rueda-Carrasco","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/j.scib.2026.07.059_b0495","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","article-title":"An apoptotic \u201ceat me\u201d signal: phosphatidylserine exposure","volume":"25","author":"Segawa","year":"2015","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.scib.2026.07.059_b0500","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1016\/j.biomaterials.2011.07.069","article-title":"A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein","volume":"32","author":"Huile","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.07.059_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2026.115433","article-title":"Luteolin-loaded nanocomposites target microglia for sepsis-associated encephalopathy therapy via intranasal delivery","volume":"261","author":"Guo","year":"2026","journal-title":"Colloids Surf B Biointerfaces"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326008406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326008406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:34:52Z","timestamp":1788204892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927326008406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":101,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2095927326008406"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.07.059","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precise nanodelivery of screened compounds alleviates sepsis-associated encephalopathy by targeting microglial ANXA2","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.07.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}