{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:53:27Z","timestamp":1791060807757,"version":"4.1.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M740152"],"award-info":[{"award-number":["2023M740152"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2021ZD0203204"],"award-info":[{"award-number":["2021ZD0203204"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400944"],"award-info":[{"award-number":["32400944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.scib.2026.09.024","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:36:57Z","timestamp":1788950217000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The musculoskeletal pain-cardiovascular axis: Chronic musculoskeletal pain as an underrecognized cardiovascular risk modifier"],"prefix":"10.1016","author":[{"given":"Si-Qi","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Xuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Nuo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Le","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Qiong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Morlion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.09.024_b0005","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/pm\/pnz217","article-title":"Co-occurrence of chronic musculoskeletal pain and cardiovascular diseases: a systematic review with meta-analysis","volume":"21","author":"Oliveira","year":"2020","journal-title":"Pain Med"},{"key":"10.1016\/j.scib.2026.09.024_b0010","article-title":"Association of musculoskeletal pain with incidence and recurrence of cardiovascular disease: a longitudinal cohort in China","author":"Chen","year":"2026","journal-title":"BMC Public Health"},{"key":"10.1016\/j.scib.2026.09.024_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2023.100295","article-title":"Multisite pain and myocardial infarction and stroke: a prospective cohort and Mendelian randomization analysis","volume":"2","author":"Tian","year":"2023","journal-title":"JACC Adv"},{"key":"10.1016\/j.scib.2026.09.024_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron-immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.scib.2026.09.024_b0025","doi-asserted-by":"crossref","first-page":"R509","DOI":"10.1152\/ajpregu.00289.2024","article-title":"Il-6 induces mitochondrial ROS production and blunts NO bioavailability in human aortic endothelial cells","volume":"328","author":"Velusamy","year":"2025","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.scib.2026.09.024_b0030","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCRESAHA.121.319077","article-title":"Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease","volume":"128","author":"Ridker","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.scib.2026.09.024_b0035","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.3390\/ijms24065378","article-title":"Chronic pain-associated cardiovascular disease: the role of sympathetic nerve activity","volume":"24","author":"Reynolds","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.scib.2026.09.024_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104622","article-title":"The cholinergic anti-inflammatory pathway in humans: state-of-the-art review and future directions","volume":"136","author":"Alen","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.scib.2026.09.024_b0045","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/jcm9061995","article-title":"Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets","volume":"9","author":"Scioli","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.scib.2026.09.024_b0050","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/pm\/pnaa426","article-title":"Markers of cardiovascular health in older adults with and without chronic low back and radicular leg pain: a comparative analysis","volume":"22","author":"Coyle","year":"2021","journal-title":"Pain Med"},{"issue":"129","key":"10.1016\/j.scib.2026.09.024_b0055","first-page":"17","article-title":"ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training","volume":"2020","author":"Khataei","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.scib.2026.09.024_b0060","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10741-024-10430-w","article-title":"Treating heart failure by targeting the vagus nerve","volume":"29","author":"Gentile","year":"2024","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.scib.2026.09.024_b0065","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/pmrj.13361","article-title":"The association between chronic pain and metabolic syndrome: a scoping review","volume":"9","author":"Encalada","year":"2025","journal-title":"PM R"},{"key":"10.1016\/j.scib.2026.09.024_b0070","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s13679-023-00520-5","article-title":"Obesity, metabolic syndrome, and osteoarthritis\u2014an updated review","volume":"12","author":"Sampath","year":"2023","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.scib.2026.09.024_b0075","article-title":"Risk of acute myocardial infarction with NSAIDs in real world use: Bayesian meta-analysis of individual patient data","volume":"357","author":"Bally","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.scib.2026.09.024_b0080","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s40122-024-00598-2","article-title":"A personalized Mediterranean diet improves pain and quality of life in patients with fibromyalgia","volume":"13","author":"Casini","year":"2024","journal-title":"Pain Ther"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326010698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326010698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:04:44Z","timestamp":1791057884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927326010698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":16,"alternative-id":["S2095927326010698"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.024","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The musculoskeletal pain-cardiovascular axis: Chronic musculoskeletal pain as an underrecognized cardiovascular risk modifier","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}