{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:35:56Z","timestamp":1793133356041,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.scib.2026.09.054","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:49:20Z","timestamp":1789746560000},"page":"5251-5263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["LEADO: unlocking functional insights from lipidomics data through mining lipid\u2013gene\u2013disease relationships"],"prefix":"10.1016","volume":"71","author":[{"given":"Lesong","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Man","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.09.054_b0005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.scib.2026.09.054_b0010","doi-asserted-by":"crossref","first-page":"11907","DOI":"10.1007\/s11356-014-3172-5","article-title":"Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry","volume":"21","author":"Gorrochategui","year":"2014","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.scib.2026.09.054_b0015","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.3390\/molecules25204864","article-title":"The function and mechanism of lipid molecules and their roles in the diagnosis and prognosis of breast cancer","volume":"25","author":"Guo","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.scib.2026.09.054_b0020","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70669","article-title":"Trans-omics integration reveals that the kidney contributes to systemic aging via sexually dimorphic accumulation of glycosphingolipids","volume":"7","author":"Ni","year":"2026","journal-title":"MedComm"},{"key":"10.1016\/j.scib.2026.09.054_b0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.scib.2024.06.005","article-title":"CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome","volume":"70","author":"Jiang","year":"2025","journal-title":"Sci Bull"},{"key":"10.1016\/j.scib.2026.09.054_b0030","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrendo.2016.98","article-title":"Lipidomics for studying metabolism","volume":"12","author":"Han","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.scib.2026.09.054_b0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.aca.2020.11.024","article-title":"High-coverage lipidomics for functional lipid and pathway analyses","volume":"1147","author":"Lam","year":"2021","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.scib.2026.09.054_b0040","doi-asserted-by":"crossref","DOI":"10.1126\/science.adp5540","article-title":"A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis","volume":"388","author":"Zhou","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.scib.2026.09.054_b0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2024.09.009","article-title":"Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation","volume":"37","author":"Lam","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.scib.2026.09.054_b0050","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s12967-026-07881-0","article-title":"Very long chain sphingolipids govern brain myelination by regulating oligodendrocyte differentiation and membrane microdomain integrity","volume":"24","author":"Sun","year":"2026","journal-title":"J Transl Med"},{"key":"10.1016\/j.scib.2026.09.054_b0055","article-title":"Circulating sphingolipids in relation to cognitive decline and incident dementia: the Cardiovascular Health Study","volume":"16","author":"Moseholm","year":"2024","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.scib.2026.09.054_b0060","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/dc19-0100","article-title":"High-coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic Chinese adults","volume":"42","author":"Lu","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.scib.2026.09.054_b0065","doi-asserted-by":"crossref","first-page":"D1677","DOI":"10.1093\/nar\/gkad896","article-title":"LIPID MAPS: update to databases and tools for the lipidomics community","volume":"52","author":"Conroy","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.09.054_b0070","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.09.054_b0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41592-022-01710-0","article-title":"Guiding the choice of informatics software and tools for lipidomics research applications","volume":"20","author":"Ni","year":"2023","journal-title":"Nat Methods"},{"key":"10.1016\/j.scib.2026.09.054_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.62304\/jieet.v3i05.216","article-title":"Advancements in natural language processing for human-computer interaction","volume":"3","author":"Rahman","year":"2024","journal-title":"JIEET"},{"key":"10.1016\/j.scib.2026.09.054_b0085","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.22214\/ijraset.2024.63408","article-title":"Advancements in natural language processing: an in-depth review of language transformer models","volume":"12","author":"Singh","year":"2024","journal-title":"Int J Res Appl Sci Eng Technol"},{"key":"10.1016\/j.scib.2026.09.054_b0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.26662\/ijiert.v8i3.pp74-83","article-title":"Advances in natural language processing: a survey of techniques","volume":"8","author":"Alladi","year":"2024","journal-title":"Int J Innov Eng Res Technol"},{"key":"10.1016\/j.scib.2026.09.054_b0095","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neucom.2021.05.103","article-title":"An introduction to deep learning in natural language processing: models, techniques, and tools","volume":"470","author":"Lauriola","year":"2022","journal-title":"Neurocomputing"},{"key":"10.1016\/j.scib.2026.09.054_b0100","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1162\/tacl_a_00349","article-title":"A primer in BERTology: what we know about how BERT works","volume":"8","author":"Rogers","year":"2020","journal-title":"Trans Assoc Comput Linguist"},{"key":"10.1016\/j.scib.2026.09.054_b0105","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1007\/s11431-020-1647-3","article-title":"Pre-trained models for natural language processing: a survey","volume":"63","author":"Qiu","year":"2020","journal-title":"Sci China Technol Sci"},{"key":"10.1016\/j.scib.2026.09.054_b0110","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1093\/bioinformatics\/btz682","article-title":"BioBERT: a pre-trained biomedical language representation model for biomedical text mining","volume":"36","author":"Lee","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scib.2026.09.054_b0115","doi-asserted-by":"crossref","first-page":"W237","DOI":"10.1093\/nar\/gkad445","article-title":"GePI: large-scale text mining, customized retrieval and flexible filtering of gene\/protein interactions","volume":"51","author":"Faessler","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.09.054_b0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41597-024-03083-9","article-title":"Cancer-Alterome: a literature-mined resource for regulatory events caused by genetic alterations in cancer","volume":"11","author":"Yao","year":"2024","journal-title":"Sci Data"},{"key":"10.1016\/j.scib.2026.09.054_b0125","doi-asserted-by":"crossref","first-page":"W540","DOI":"10.1093\/nar\/gkae235","article-title":"PubTator 3.0: an AI-powered literature resource for unlocking biomedical knowledge","volume":"52","author":"Wei","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scib.2026.09.054_b0130","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/metabo12040276","article-title":"MetaboListem and TABoLiSTM: two deep learning algorithms for metabolite named entity recognition","volume":"12","author":"Yeung","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.scib.2026.09.054_b0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12859-015-0472-9","article-title":"Extraction of relations between genes and diseases from text and large-scale data analysis: implications for translational research","volume":"16","author":"Bravo","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.scib.2026.09.054_b0140","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/acs.analchem.1c05430","article-title":"Goslin 2.0 implements the recent lipid shorthand nomenclature for MS-derived lipid structures","volume":"94","author":"Kopczynski","year":"2022","journal-title":"Anal Chem"},{"key":"10.1016\/j.scib.2026.09.054_b0145","article-title":"LipidLynxX: a data transfer hub to support integration of large scale lipidomics datasets","author":"Ni","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.scib.2026.09.054_b0150","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"Vosa","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.scib.2026.09.054_b0155","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1038\/s41467-022-30875-7","article-title":"Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease","volume":"13","author":"Cadby","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.09.054_b0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"elife"},{"key":"10.1016\/j.scib.2026.09.054_b0165","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.scib.2026.09.054_b0170","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.scib.2026.09.054_b0175","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.scib.2026.09.054_b0180","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.scib.2026.09.054_b0185","doi-asserted-by":"crossref","first-page":"0620","DOI":"10.34133\/research.0620","article-title":"Palmitoyl-carnitine regulates lung development by promoting pulmonary mesenchyme proliferation","volume":"8","author":"Liu","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.scib.2026.09.054_b0190","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12859-021-04292-4","article-title":"Mining a stroke knowledge graph from literature","volume":"22","author":"Yang","year":"2021","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.scib.2026.09.054_b0195","article-title":"BioNet: a large-scale and heterogeneous biological network model for interaction prediction with graph convolution","volume":"23","author":"Yang","year":"2022","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.scib.2026.09.054_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41746-026-02664-9","article-title":"Embeddings of clinical codes enable knowledge-grounded AI in medicine","author":"Johnson","year":"2026","journal-title":"npj Digit Med"},{"key":"10.1016\/j.scib.2026.09.054_b0205","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41591-025-04184-7","article-title":"Scaling medical AI across clinical contexts","volume":"32","author":"Li","year":"2026","journal-title":"Nat Med"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326011370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326011370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:27:48Z","timestamp":1793132868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927326011370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2095927326011370"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.054","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LEADO: unlocking functional insights from lipidomics data through mining lipid\u2013gene\u2013disease relationships","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}