{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:35:12Z","timestamp":1793133312337,"version":"4.5.0"},"reference-count":135,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2019ZT08Y485"],"award-info":[{"award-number":["2019ZT08Y485"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2019JC01Y182"],"award-info":[{"award-number":["2019JC01Y182"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M771771"],"award-info":[{"award-number":["2025M771771"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100600"],"award-info":[{"award-number":["2021YFA1100600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science Bulletin"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.scib.2026.09.057","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:49:14Z","timestamp":1789746554000},"page":"5336-5348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal stem\/stromal cells and regenerative medicine"],"prefix":"10.1016","volume":"71","author":[{"given":"Manjin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianmin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longquan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scib.2026.09.057_b0005","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1126\/science.add6492","article-title":"Emerging frontiers in regenerative medicine","volume":"380","author":"McKinley","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.scib.2026.09.057_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114131","article-title":"Future regenerative medicine developments and their therapeutic applications","volume":"158","author":"Altyar","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.scib.2026.09.057_b0015","article-title":"Hypoxia-preconditioned BMSC-derived exosomes induce mitophagy via the BNIP3-ANAX2 axis to alleviate intervertebral disc degeneration","volume":"11","author":"Jin","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2026.09.057_b0020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jconrel.2025.02.030","article-title":"3d mesenchymal stem cell exosome-functionalized hydrogels for corneal wound healing","volume":"380","author":"Xu","year":"2025","journal-title":"J Control Release"},{"key":"10.1016\/j.scib.2026.09.057_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202304879","article-title":"Development of physiologically relevant skin organoids from human induced pluripotent stem cells","volume":"20","author":"Shafiee","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.scib.2026.09.057_b0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq6700","article-title":"Stem cell-homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling","volume":"10","author":"Wei","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.scib.2026.09.057_b0035","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.stem.2024.04.002","article-title":"Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease","volume":"31","author":"Huang","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scib.2026.09.057_b0040","article-title":"Egr1 promotes craniofacial bone regeneration via activation of ALPL+PDGFD+ periosteal stem cells","volume":"12","author":"Li","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2026.09.057_b0045","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/sctm.21-0151","article-title":"A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers","volume":"10","author":"Rogers","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.scib.2026.09.057_b0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","article-title":"Mesenchymal stem cells and their microenvironment","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0055","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J Orthop Res"},{"key":"10.1016\/j.scib.2026.09.057_b0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.scib.2026.09.057_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.918565","article-title":"Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome","volume":"13","author":"Fern\u00e1ndez-Santos","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13287-021-02222-y","article-title":"Human umbilical cord-derived mesenchymal stem\/stromal cells: a promising candidate for the development of advanced therapy medicinal products","volume":"12","author":"Mebarki","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0075","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.7150\/thno.96723","article-title":"Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity","volume":"14","author":"Court","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.scib.2026.09.057_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167442","article-title":"Characterization and immunomodulatory effects of canine adipose tissue- and bone marrow-derived mesenchymal stromal cells","volume":"11","author":"Russell","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2026.09.057_b0085","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3389\/fimmu.2018.01642","article-title":"Characteristics and immunomodulating functions of adipose-derived and bone marrow-derived mesenchymal stem cells across defined human leukocyte antigen barriers","volume":"9","author":"Waldner","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0090","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jcp.21068","article-title":"Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors","volume":"212","author":"Kilroy","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.scib.2026.09.057_b0095","first-page":"1017","article-title":"Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials","volume":"91","author":"Lu","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.scib.2026.09.057_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13287-017-0501-x","article-title":"Compared with the amniotic membrane, Wharton's jelly may be a more suitable source of mesenchymal stem cells for cardiovascular tissue engineering and clinical regeneration","volume":"8","author":"Pu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0105","first-page":"1022","article-title":"Isolation and characterization of human mesenchymal stromal cells derived from placental decidua basalis; umbilical cord Wharton's jelly and amniotic membrane","volume":"30","author":"Shaer","year":"2014","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.scib.2026.09.057_b0110","doi-asserted-by":"crossref","first-page":"28061","DOI":"10.1038\/s41598-024-79063-1","article-title":"Proteomic analysis of human Wharton\u2019s jelly mesenchymal stem\/stromal cells and human amniotic epithelial stem cells: a comparison of therapeutic potential","volume":"14","author":"Ge","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2026.09.057_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121223","article-title":"Odontogenesis-related developmental microenvironment facilitates deciduous dental pulp stem cell aggregates to revitalize an avulsed tooth","volume":"279","author":"Guo","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.09.057_b0120","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/ncb1008","article-title":"Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential","volume":"5","author":"Cao","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.scib.2026.09.057_b0125","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.actbio.2023.06.041","article-title":"Substrate mechanical properties bias MSC paracrine activity and therapeutic potential","volume":"168","author":"Vilar","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.scib.2026.09.057_b0130","first-page":"45","article-title":"Human mesenchymal stem cells respond to fibroblast growth factors","volume":"10","author":"van den Bos","year":"1997","journal-title":"Hum Cell"},{"key":"10.1016\/j.scib.2026.09.057_b0135","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/01.RES.0000118601.37875.AC","article-title":"Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms","volume":"94","author":"Kinnaird","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.scib.2026.09.057_b0140","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1136\/ard.2011.150607","article-title":"Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro","volume":"70","author":"Guiducci","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.scib.2026.09.057_b0145","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCULATIONAHA.111.082453","article-title":"Myocardial cxcr4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction","volume":"126","author":"Dong","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.scib.2026.09.057_b0150","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/15548627.2025.2536449","article-title":"Apoptotic bodies derived from human umbilical cord mesenchymal stem cells improve recovery from myocardial infarction in swine","volume":"22","author":"Luo","year":"2026","journal-title":"Autophagy"},{"key":"10.1016\/j.scib.2026.09.057_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088319","article-title":"Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells","volume":"9","author":"Yamahara","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2026.09.057_b0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/bmb\/ldt031","article-title":"The angiogenic properties of mesenchymal stem\/stromal cells and their therapeutic potential","volume":"108","author":"Watt","year":"2013","journal-title":"Br Med Bull"},{"key":"10.1016\/j.scib.2026.09.057_b0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejcb.2016.04.003","article-title":"Angiogenic and anti-inflammatory properties of mesenchymal stem cells from cord blood: soluble factors and extracellular vesicles for cell regeneration","volume":"95","author":"Montemurro","year":"2016","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.scib.2026.09.057_b0170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2007.10.046","article-title":"Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats","volume":"430","author":"Okazaki","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.scib.2026.09.057_b0175","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.scib.2026.09.057_b0180","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.scib.2026.09.057_b0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.scib.2026.09.057_b0190","doi-asserted-by":"crossref","DOI":"10.4028\/b-fjiIt3","article-title":"Engineering approaches to modify immunomodulatory functions of mesenchymal stromal cells (MSCs): tissue regeneration and clinical application","author":"Yang","year":"2026","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2026.09.057_b0195","article-title":"Harnessing mesenchymal stromal cells for liver disease therapy: from mechanistic discoveries to clinical breakthroughs","volume":"12","author":"Huang","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.scib.2026.09.057_b0200","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12830","article-title":"Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis","volume":"53","author":"Qiu","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.scib.2026.09.057_b0205","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnad013","article-title":"Apoptotic vesicles: emerging concepts and research progress in physiology and therapy","volume":"2","author":"Fu","year":"2023","journal-title":"Life Med"},{"key":"10.1016\/j.scib.2026.09.057_b0210","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.7150\/thno.40122","article-title":"Mesenchymal stromal\/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities","volume":"10","author":"Varderidou-Minasian","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.scib.2026.09.057_b0215","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3727\/096368913X667709","article-title":"Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives","volume":"23","author":"Liang","year":"2014","journal-title":"Cell Transplant"},{"key":"10.1016\/j.scib.2026.09.057_b0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13287-021-02344-3","article-title":"A procedure for in vitro evaluation of the immunosuppressive effect of mouse mesenchymal stem cells on activated T cell proliferation","volume":"12","author":"Marinescu","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0225","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.scib.2025.03.011","article-title":"Exploring mesenchymal stem cell niches for regeneration","volume":"70","author":"Zhang","year":"2025","journal-title":"Sci Bull (Beijing)"},{"key":"10.1016\/j.scib.2026.09.057_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.12929","article-title":"The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?","volume":"188","author":"Carty","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0235","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.stem.2012.03.007","article-title":"Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-\/FAS-mediated T cell apoptosis","volume":"10","author":"Akiyama","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scib.2026.09.057_b0240","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1615\/CritRevImmunol.2018027821","article-title":"Regulatory mechanism of the induction of regulatory T cells through growth factors released by human mesenchymal stem cells","volume":"38","author":"Miyagawa","year":"2018","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0245","doi-asserted-by":"crossref","first-page":"38308","DOI":"10.1038\/srep38308","article-title":"Human mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism","volume":"6","author":"Vasandan","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2026.09.057_b0250","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.imlet.2007.10.002","article-title":"Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation","volume":"115","author":"English","year":"2008","journal-title":"Immunol Lett"},{"key":"10.1016\/j.scib.2026.09.057_b0255","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2026.09.057_b0260","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.scib.2026.09.057_b0265","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"Shed: Stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.scib.2026.09.057_b0270","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1371\/journal.pone.0000079","article-title":"Mesenchymal stem cell-mediated functional tooth regeneration in swine","volume":"1","author":"Sonoyama","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.scib.2026.09.057_b0275","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/0022034513497961","article-title":"Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells","volume":"92","author":"Xu","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.scib.2026.09.057_b0280","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41368-022-00206-z","article-title":"Expert consensus on regenerative endodontic procedures","volume":"14","author":"Wei","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.scib.2026.09.057_b0285","first-page":"333","article-title":"Tissue formation in the root canal following pulp removal","volume":"79","author":"Nygaard-Ostby","year":"1971","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.scib.2026.09.057_b0290","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1177\/0022034518772260","article-title":"Pulp regeneration by 3-dimensional dental pulp stem cell constructs","volume":"97","author":"Itoh","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.scib.2026.09.057_b0295","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biomaterials.2016.09.029","article-title":"Exosomes as biomimetic tools for stem cell differentiation: applications in dental pulp tissue regeneration","volume":"111","author":"Huang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.09.057_b0300","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13287-017-0506-5","article-title":"Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study","volume":"8","author":"Nakashima","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0305","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf3227","article-title":"Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth","volume":"10","author":"Xuan","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.scib.2026.09.057_b0310","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10735-020-09896-3","article-title":"Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis","volume":"51","author":"Wei","year":"2020","journal-title":"J Mol Histol"},{"key":"10.1016\/j.scib.2026.09.057_b0315","doi-asserted-by":"crossref","first-page":"20662","DOI":"10.1002\/jcp.28671","article-title":"Exosomal microRNA-155-5p from PDLSCs regulated Th17\/Treg balance by targeting sirtuin-1 in chronic periodontitis","volume":"234","author":"Zheng","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.scib.2026.09.057_b0320","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13026","article-title":"Periodontitis-compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA-378a promote local angiogenesis by targeting sufu to activate the Hedgehog\/Gli1 signalling","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif"},{"key":"10.1016\/j.scib.2026.09.057_b0325","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/jcpe.12931","article-title":"Human intrabony defect regeneration with micrografts containing dental pulp stem cells: a randomized controlled clinical trial","volume":"45","author":"Ferrarotti","year":"2018","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.scib.2026.09.057_b0330","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13287-016-0288-1","article-title":"Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0335","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.oraloncology.2010.08.007","article-title":"Paradigm shifts in the management of osteoradionecrosis of the mandible","volume":"46","author":"Jacobson","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.scib.2026.09.057_b0340","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.clon.2016.03.002","article-title":"Current concepts in osteoradionecrosis after head and neck radiotherapy","volume":"28","author":"Dhanda","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.scib.2026.09.057_b0345","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1097\/PRS.0b013e3181f24164","article-title":"Regenerative facial reconstruction of terminal stage osteoradionecrosis and other advanced craniofacial diseases with adult cultured stem and progenitor cells","volume":"126","author":"Mendonca","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.scib.2026.09.057_b0350","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemphyslip.2014.02.001","article-title":"Mechanistic effects of protein palmitoylation and the cellular consequences thereof","volume":"180","author":"Blaskovic","year":"2014","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.scib.2026.09.057_b0355","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/TP.0b013e318291a2da","article-title":"Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study","volume":"95","author":"Orozco","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.scib.2026.09.057_b0360","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.arthro.2012.11.017","article-title":"Mesenchymal stem cell injections improve symptoms of knee osteoarthritis","volume":"29","author":"Koh","year":"2013","journal-title":"Arthroscopy"},{"key":"10.1016\/j.scib.2026.09.057_b0365","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12951-024-03088-x","article-title":"Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis","volume":"23","author":"Figueroa-Vald\u00e9s","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.scib.2026.09.057_b0370","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00441-020-03319-1","article-title":"Tgf-\u03b21-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6","volume":"384","author":"Wang","year":"2021","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.scib.2026.09.057_b0375","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s12951-024-02713-z","article-title":"Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos","volume":"22","author":"Zhou","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.scib.2026.09.057_b0380","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.scib.2026.09.057_b0385","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.scib.2026.09.057_b0390","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/ten.2005.11.913","article-title":"Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor","volume":"11","author":"Park","year":"2005","journal-title":"Tissue Eng"},{"key":"10.1016\/j.scib.2026.09.057_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.106565","article-title":"Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series","volume":"203","author":"Honmou","year":"2021","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.scib.2026.09.057_b0400","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13287-024-03842-w","article-title":"Safety and feasibility of intravenous administration of a single dose of allogenic-muse cells to treat human cervical traumatic spinal cord injury: a clinical trial","volume":"15","author":"Koda","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0405","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1089\/neu.2017.5063","article-title":"Systemic administration of exosomes released from mesenchymal stromal cells attenuates apoptosis, inflammation, and promotes angiogenesis after spinal cord injury in rats","volume":"34","author":"Huang","year":"2017","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.scib.2026.09.057_b0410","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s12015-021-10219-6","article-title":"MSC secreted extracellular vesicles carrying TGF-beta upregulate smad 6 expression and promote the regrowth of neurons in spinal cord injured rats","volume":"18","author":"Han","year":"2022","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.scib.2026.09.057_b0415","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13287-021-02248-2","article-title":"Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis","volume":"12","author":"Zhou","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0420","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1111\/jcmm.16965","article-title":"MSC derived EV loaded with miRNA-22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats","volume":"25","author":"Sheng","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.scib.2026.09.057_b0425","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/art.40396","article-title":"Abnormal B cell development in systemic lupus erythematosus: what the genetics tell us","volume":"70","author":"Karrar","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.scib.2026.09.057_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2019.06.009","article-title":"The contribution of macrophages to systemic lupus erythematosus","volume":"207","author":"Ma","year":"2019","journal-title":"Clin Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0435","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/0961203309345776","article-title":"Prevalence of community-acquired and nosocomial infections in hospitalized patients with systemic lupus erythematosus","volume":"19","author":"Navarro-Zarza","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.scib.2026.09.057_b0440","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/stem.68","article-title":"Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans","volume":"27","author":"Sun","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.scib.2026.09.057_b0445","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1002\/art.27548","article-title":"Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus","volume":"62","author":"Sun","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.scib.2026.09.057_b0450","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ymthe.2020.04.020","article-title":"Comprehensive molecular profiles of functionally effective MSC-derived extracellular vesicles in immunomodulation","volume":"28","author":"Kim","year":"2020","journal-title":"Mol Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0455","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/08820139.2022.2055478","article-title":"Mesenchymal stem cells-derived exosomes ameliorate lupus by inducing M2 macrophage polarization and regulatory T cell expansion in mrl\/lpr mice","volume":"51","author":"Sun","year":"2022","journal-title":"Immunol Invest"},{"key":"10.1016\/j.scib.2026.09.057_b0460","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/art.40142","article-title":"Bone marrow-derived mesenchymal stem cells from patients with systemic lupus erythematosus have a senescence-associated secretory phenotype mediated by a mitochondrial antiviral signaling protein-interferon-\u03b2 feedback loop","volume":"69","author":"Gao","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.scib.2026.09.057_b0465","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbmt.2018.09.031","article-title":"Characteristics of late fatal infections after allogeneic hematopoietic cell transplantation","volume":"25","author":"Norkin","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.scib.2026.09.057_b0470","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"Le Blanc","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.scib.2026.09.057_b0475","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12185-013-1399-4","article-title":"Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I\/II study","volume":"98","author":"Muroi","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1016\/j.scib.2026.09.057_b0480","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12185-015-1915-9","article-title":"Bone marrow-derived mesenchymal stem cells (jr-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II\/III study","volume":"103","author":"Muroi","year":"2016","journal-title":"Int J Hematol"},{"key":"10.1016\/j.scib.2026.09.057_b0485","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.scib.2026.09.057_b0490","first-page":"195","article-title":"Mesenchymal stem cell therapy in hematopoietic stem cell transplantation","volume":"59","author":"Goto","year":"2018","journal-title":"Rinsho Ketsueki"},{"key":"10.1016\/j.scib.2026.09.057_b0495","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/MPH.0000000000002065","article-title":"Potential use of mesenchymal multipotent cells for hemopoietic stem cell transplantation: pro and contra","volume":"43","author":"Kiselevskiy","year":"2021","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.scib.2026.09.057_b0500","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","article-title":"Challenges and advances in clinical applications of mesenchymal stromal cells","volume":"14","author":"Zhou","year":"2021","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.scib.2026.09.057_b0505","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-019-0723-8","article-title":"Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells","volume":"12","author":"Yang","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.scib.2026.09.057_b0510","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13045-018-0554-z","article-title":"Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells","volume":"11","author":"Wang","year":"2018","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.scib.2026.09.057_b0515","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0520","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/j.scib.2026.04.046","article-title":"A chemical cocktail rejuvenates senescent human mesenchymal stem cells and facilitates functional skin repair","volume":"71","author":"Xiang","year":"2026","journal-title":"Sci Bull (Beijing)"},{"key":"10.1016\/j.scib.2026.09.057_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.medp.2026.100142","article-title":"Electroactive materials for bioelectronics and regenerative medicine: mechanisms, interfaces, and applications","volume":"3","author":"Wang","year":"2026","journal-title":"Med Plus"},{"key":"10.1016\/j.scib.2026.09.057_b0530","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.actbio.2020.12.034","article-title":"Hypoxic pretreatment of small extracellular vesicles mediates cartilage repair in osteoarthritis by delivering miR-216a-5p","volume":"122","author":"Rong","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.scib.2026.09.057_b0535","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe0083","article-title":"Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis","volume":"7","author":"You","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.scib.2026.09.057_b0540","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70044","article-title":"Small extracellular vesicles engineered using click chemistry to express chimeric antigen receptors show enhanced efficacy in acute liver failure","volume":"14","author":"Lu","year":"2025","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.scib.2026.09.057_b0545","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.ymthe.2024.06.016","article-title":"CRISPR-mediated Sox9 activation and rela inhibition enhance cell therapy for osteoarthritis","volume":"32","author":"Zhao","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0550","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13287-021-02695-x","article-title":"Engineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis development","volume":"13","author":"Wu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0555","article-title":"Immunoaffinity-mimetic assembly of peptide-aptamer conjugates and stem cell-derived exosomes into hierarchical microgels for spinal cord injury repair","volume":"13","author":"Zheng","year":"2026","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.scib.2026.09.057_b0560","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202508072","article-title":"Engineered apoptotic extracellular vesicles for programmable regulation of neutrophil-macrophage-ROS pathogenic axis to reconstruct rheumatoid arthritis microenvironment","volume":"38","author":"Kang","year":"2026","journal-title":"Adv Mater (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.scib.2026.09.057_b0565","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.actbio.2020.04.017","article-title":"Functionally engineered extracellular vesicles improve bone regeneration","volume":"109","author":"Huang","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.scib.2026.09.057_b0570","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00018-023-05057-3","article-title":"Bioengineered MSCcxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1\/2 and STAT3 signaling in diabetic wound","volume":"81","author":"Choudhury","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.scib.2026.09.057_b0575","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jbm.b.34968","article-title":"Self-assembling human skeletal organoids for disease modeling and drug testing","volume":"110","author":"Abraham","year":"2022","journal-title":"J Biomed Mater Res B Appl Biomate"},{"key":"10.1016\/j.scib.2026.09.057_b0580","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1021\/acsbiomaterials.4c00574","article-title":"Hydroxyapatite nanoparticles promote the development of bone microtissues for accelerated bone regeneration by activating the FAK\/AKT pathway","volume":"10","author":"Li","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.scib.2026.09.057_b0585","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202414543","article-title":"Oriented cortical-bone-like silk protein lamellae effectively repair large segmental bone defects in pigs","volume":"37","author":"Shuai","year":"2025","journal-title":"Adv Mater (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.scib.2026.09.057_b0590","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCRESAHA.119.316155","article-title":"In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3d bioprinted, chambered organoid","volume":"127","author":"Kupfer","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.scib.2026.09.057_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121741","article-title":"High-efficient engineering of osteo-callus organoids for rapid bone regeneration within one month","volume":"288","author":"Xie","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.scib.2026.09.057_b0600","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.actbio.2018.08.029","article-title":"Cartilage regeneration using arthroscopic flushing fluid-derived mesenchymal stem cells encapsulated in a one-step rapid cross-linked hydrogel","volume":"79","author":"Li","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.scib.2026.09.057_b0605","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2024.05.209","article-title":"Enhancing bone regeneration and immunomodulation via gelatin methacryloyl hydrogel-encapsulated exosomes from osteogenic pre-differentiated mesenchymal stem cells","volume":"672","author":"Li","year":"2024","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.scib.2026.09.057_b0610","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1038\/ncomms11455","article-title":"RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix","volume":"7","author":"Li","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.scib.2026.09.057_b0615","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tcb.2025.03.008","article-title":"The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy","volume":"36","author":"Zhang","year":"2026","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.scib.2026.09.057_b0620","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/sctm.19-0398","article-title":"Pulp stem cells derived from human permanent and deciduous teeth: biological characteristics and therapeutic applications","volume":"9","author":"Shi","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.scib.2026.09.057_b0625","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s13287-021-02456-w","article-title":"Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis","volume":"12","author":"Fu","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0630","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/00220345241265676","article-title":"Apoptotic vesicles: therapeutic mechanisms and critical issues","volume":"103","author":"Ou","year":"2024","journal-title":"J Dent Res"},{"key":"10.1016\/j.scib.2026.09.057_b0635","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.ymthe.2025.02.033","article-title":"Lyophilized apoptotic vesicles improve hemostasis and bone regeneration in traumatic patients with impacted third molar extraction","volume":"33","author":"Jiang","year":"2025","journal-title":"Mol Ther"},{"key":"10.1016\/j.scib.2026.09.057_b0640","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7828","article-title":"Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation","volume":"9","author":"Galleu","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.scib.2026.09.057_b0645","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (misev2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.scib.2026.09.057_b0650","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41419-021-03883-6","article-title":"Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy","volume":"12","author":"Fu","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.scib.2026.09.057_b0655","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jare.2024.05.004","article-title":"Mesenchymal stem cell secretome for regenerative medicine: where do we stand?","volume":"70","author":"Trigo","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.scib.2026.09.057_b0660","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18340","article-title":"Comparative evaluation of bone marrow and dental pulp mesenchymal stem cells for motor functional recovery in rat sciatic nerve injury","volume":"28","author":"Uzunlu","year":"2024","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.scib.2026.09.057_b0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122542","article-title":"Mesenchymal stem cell-derived exosomes: characteristics and applications in disease pathology and management","volume":"342","author":"Padinharayil","year":"2024","journal-title":"Life Sci"},{"key":"10.1016\/j.scib.2026.09.057_b0670","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1654117","article-title":"How artificial intelligence can enable personalized mesenchymal stem cell-based therapeutic strategies in systemic lupus erythematosus","volume":"16","author":"Rajeev Kumar","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.scib.2026.09.057_b0675","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/jcmm.14788","article-title":"Pre-treatments enhance the therapeutic effects of mesenchymal stem cells in liver diseases","volume":"24","author":"Hu","year":"2020","journal-title":"J Cell Mol Med"}],"container-title":["Science Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326011400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095927326011400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:26:02Z","timestamp":1793132762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095927326011400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":135,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2095927326011400"],"URL":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.057","relation":{},"ISSN":["2095-9273"],"issn-type":[{"value":"2095-9273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem\/stromal cells and regenerative medicine","name":"articletitle","label":"Article Title"},{"value":"Science Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scib.2026.09.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Science China Press. Published by Elsevier B.V. and Science China Press.","name":"copyright","label":"Copyright"}]}}