{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:53:35Z","timestamp":1792439615138,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.scitotenv.2007.02.002","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T07:16:30Z","timestamp":1174979790000},"page":"165-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Biomonitoring of the adverse effects induced by the chronic exposure to lead and cadmium on kidney function: Usefulness of alpha-glutathione S-transferase"],"prefix":"10.1016","volume":"377","author":[{"given":"Guillaume","family":"Gar\u00e7on","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Leleu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Marez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Zerimech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Haguenoer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Furon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirouz","family":"Shirali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2007.02.002_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0065-2423(08)60198-5","article-title":"Glutathione S-transferases: biomedical applications","volume":"30","author":"Beckett","year":"1993","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/02772249009357558","article-title":"Early markers of cadmium nephrotoxicity: biological significance and predictive value","volume":"27","author":"Bernard","year":"1990","journal-title":"Toxicol Environ Chem"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s002040050613","article-title":"Glutathione S-transferase-alpha as a marker for tubular damage after trichloroethylene exposure","volume":"73","author":"Bruning","year":"1999","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/15287390306384","article-title":"Biomarkers of renal effects in children and adults with low environmental exposure to heavy metals","volume":"66","author":"Burbure","year":"2003","journal-title":"J Toxicol Environ Health Part A"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s002440010102","article-title":"A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fischer 344 rats","volume":"39","author":"Ercal","year":"2000","journal-title":"Arch Environ Contam Toxicol"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1568026013394831","article-title":"Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage","volume":"1","author":"Ercal","year":"2001","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib7","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/ndt\/13.9.2248","article-title":"Adverse effects of chronic low level lead exposure on kidney function \u2014 a risk group study in children","volume":"13","author":"Fels","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3835(01)00474-8","article-title":"Benzo(a)pyrene-coated onto Fe2O3 particles-induced lung tissue injury: role of free radicals","volume":"167","author":"Gar\u00e7on","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(01)00461-9","article-title":"Antioxidant defense disruption by polycyclic aromatic hydrocarbons-coated onto Fe2O3 particles in human lung cells (A549)","volume":"166","author":"Gar\u00e7on","year":"2001","journal-title":"Toxicology (Amst)"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/01.jom.0000141665.22881.69","article-title":"Biological markers of oxidative stress and nephrotoxicity as studied in biomonitoring of adverse effects of occupational exposure to lead and cadmium","volume":"46","author":"Gar\u00e7on","year":"2004","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0891-5849(00)00413-5","article-title":"Can antioxidants be beneficial in the treatment of lead poisoning?","volume":"29","author":"Gurer","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0300-483X(98)00074-2","article-title":"Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats","volume":"128","author":"Gurer","year":"1998","journal-title":"Toxicology (Amst)"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib13","doi-asserted-by":"crossref","unstructured":"Gurer-Ohran, H., Sabir, H.U., Ozgunes, H., 2004 Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology (Amst) 2000; 195: 147\u2013154.","DOI":"10.1016\/j.tox.2003.09.009"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5271\/sjweh.175","article-title":"Blood cadmium as an indicator of dose in a long follow-up of workers previously exposed to cadmium","volume":"23","author":"J\u00e4rup","year":"1997","journal-title":"Scand J Work Environ & Health"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib36","first-page":"S29","article-title":"Urinary enzymes and low molecular weight proteins as markers of tubular dysfunction","volume":"46","author":"Jung","year":"1994","journal-title":"Kidney Int"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1385\/BTER:102:1-3:061","article-title":"Activity of glutathione peroxidase, glutathione reductase, and lipid peroxidation in erythrocytes in workers exposed to lead","volume":"102","author":"Kasperczyk","year":"2004","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.1860050102","article-title":"Semi-automated fluorometric assay for urinary total and B N-acetyl-beta-d-glucosaminidase: analytical investigation","volume":"5","author":"Kristz","year":"1991","journal-title":"J Clin Lab"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib17","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/clinchem\/40.7.1391","article-title":"Cadmium: exposure markers as predictors of nephrotoxic effects","volume":"40","author":"Lauwerys","year":"1994","journal-title":"Clin Chem"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib18","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1289\/ehp.97105928","article-title":"Renal effects of environmental and occupational lead exposure","volume":"105","author":"Loghman-Adham","year":"1997","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/(SICI)1098-2280(1998)31:4<352::AID-EM8>3.0.CO;2-K","article-title":"Lead and mercury mutagenesis: role of H2O2, superoxide dismutase, and xanthine oxidase","volume":"31","author":"Maria","year":"1998","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib20","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/00043764-199810000-00009","article-title":"Blood lead concentration and biological effects in workers exposed to very low lead levels","volume":"40","author":"Masci","year":"1998","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1289\/ehp.98106227","article-title":"New approaches for detecting thresholds of human nephrotoxicity using cadmium as an example","volume":"106","author":"Mueller","year":"1998","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1289\/ehp.021101185","article-title":"Cadmium in blood and urine \u2014 impact of sex, age, dietary intake, iron status, and former smoking \u2014 association of renal effects","volume":"110","author":"Olsson","year":"2002","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib23","first-page":"755","article-title":"Health significance of cadmium induced renal dysfunction: a five-year follow-up","volume":"46","author":"Roels","year":"1989","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib24","first-page":"365","article-title":"Assessment of the filtration reserve capacity of the kidney in workers with incipient tubular dysfunction after reduction of exposure","volume":"48","author":"Roels","year":"1991","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0378-4274(83)90156-X","article-title":"The critical level of cadmium in human cortex: a re-evaluation","volume":"15","author":"Roels","year":"1993","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/(SICI)1097-0274(199705)31:5<645::AID-AJIM21>3.0.CO;2-Y","article-title":"Reversibility of microproteinuria in cadmium workers with incipient tubular dysfunction after reduction of exposure","volume":"31","author":"Roels","year":"1997","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/08860229909085087","article-title":"Usefulness of biomarkers of exposure to inorganic mercury, lead, or cadmium in controlling occupational and environmental risks of nephrotoxicity","volume":"21","author":"Roels","year":"1999","journal-title":"Ren Fail"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-4274(02)00381-8","article-title":"A global perspective on cadmium pollution and toxicity in non-occupationally exposed population","volume":"137","author":"Satarug","year":"2003","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1520-670X(1998)11:2\/3<289::AID-JTRA17>3.0.CO;2-N","article-title":"Lead \u2014 biological monitoring of exposure and effects","volume":"11","author":"Skerfving","year":"1998","journal-title":"J Trace Elem Exp Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1989","journal-title":"Anal Biochem"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib31","first-page":"239","article-title":"Lipid peroxidation and concentration of glutathione in erythrocytes from workers exposed to lead","volume":"48","author":"Sugawara","year":"1991","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib32","first-page":"293","article-title":"Glutathione S-transferases in the urine: sensitive methods for detection of kidney damage induced by nephrotoxic agents in humans","volume":"102","author":"Sundberg","year":"1994","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/ki.1995.329","article-title":"ELISA procedures for the quantification of glutathione S-transferases in the urine","volume":"48","author":"Sundberg","year":"1995","journal-title":"Kidney Int"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0009-8981(61)90145-0","article-title":"Standardization of hemoglobinometry II. The hemoglobincyanide method","volume":"6","author":"Van Kampen","year":"1991","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.scitotenv.2007.02.002_bib35","first-page":"287","article-title":"Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers","volume":"11","author":"Wu","year":"2002","journal-title":"Cancer Epidemiol Biomark Prev"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969707002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969707002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:59:53Z","timestamp":1785502793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969707002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":36,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0048969707002161"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2007.02.002","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomonitoring of the adverse effects induced by the chronic exposure to lead and cadmium on kidney function: Usefulness of alpha-glutathione S-transferase","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2007.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}