{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:06:29Z","timestamp":1790615189707,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005220","name":"Agency for Toxic Substances and Disease Registry","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005220","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.scitotenv.2011.10.044","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T20:46:23Z","timestamp":1322772383000},"page":"81-89","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Common classification schemes for PCB congeners and the gene expression of CYP17, CYP19, ESR1 and ESR2"],"prefix":"10.1016","volume":"414","author":[{"given":"Jillian","family":"Warner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet Rose","family":"Osuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Karmaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita","family":"Taffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Mikucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Haan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2011.10.044_bb0005","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1095\/biolreprod62.6.1882","article-title":"Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture aroclor 1248","volume":"62","author":"Andric","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0010","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.envres.2009.01.003","article-title":"PCB body burdens in US women of childbearing age 2001\u20132002: an evaluation of alternate summary metrics of NHANES data","volume":"109","author":"Axelrad","year":"2009","journal-title":"Environ Res"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0300-483X(00)00368-1","article-title":"Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity","volume":"158","author":"Bonefeld-Jorgensen","year":"2001","journal-title":"Toxicology"},{"issue":"Suppl 4","key":"10.1016\/j.scitotenv.2011.10.044_bb0020","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1289\/ehp.99107s4639","article-title":"Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs","volume":"107","author":"Brouwer","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0960-0760(97)00023-X","article-title":"Auto-regulation of the estrogen receptor promoter","volume":"62","author":"Castles","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2005.12.004","article-title":"Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB","volume":"220","author":"Ceccatelli","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0040","series-title":"PCBs. Recent advances in environmental toxicology and health effects","first-page":"257","article-title":"Disruption of steroid hormone signaling by PCBs","author":"Cooke","year":"2001"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0035","series-title":"PCBs: Human and environmental disposition and toxicology","first-page":"139","article-title":"Cross-talk between the aryl hydrocarbon receptor and estrogen receptor signaling pathways","author":"Cooke","year":"2008"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.envint.2009.11.001","article-title":"POP levels in breast milk and maternal serum and thyroid hormone levels in mother\u2013child pairs from Uppsala, Sweden","volume":"36","author":"Darnerud","year":"2010","journal-title":"Environ Int"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0050","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.chemosphere.2005.11.057","article-title":"Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: the food chain as main source of contamination","volume":"64","author":"Donato","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/taap.1997.8307","article-title":"Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3","volume":"148","author":"Drenth","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0060","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1289\/ehp.9951","article-title":"Environmental exposures and gene regulation in disease etiology","volume":"115","author":"Edwards","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1191\/0748233701th097oa","article-title":"Effects of polychlorinated biphenyls on development and reproduction","volume":"17","author":"Faroon","year":"2001","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-069X-5-9","article-title":"Estrogen-like activity of seafood related to environmental chemical contaminants","volume":"5","author":"Garritano","year":"2006","journal-title":"Environ Health"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/es001067p","article-title":"Time trends in sport-caught Great Lakes fish consumption and serum polychlorinated biphenyl levels among Michigan Anglers, 1973\u20131993","volume":"35","author":"He","year":"2001","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0080","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/074823379601200321","article-title":"Michigan's fisheater cohorts: a prospective history of exposure","volume":"12","author":"Humphrey","year":"1996","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0270","series-title":"Interdisciplinary studies on environmental chemistry \u2014 environmental research in Asia","first-page":"99","article-title":"Ecological risk assessment using high resolution analysis of polychlorinated biphenyls (PCBs)","author":"Kannan","year":"2009"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00043764-200201000-00003","article-title":"Parental concentration of dichlorodiphenyl dichloroethene and polychlorinated biphenyls in Michigan fish eaters and sex ratio in offspring","volume":"44","author":"Karmaus","year":"2002","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0095","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0026-895X(25)13092-7","article-title":"Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes","volume":"33","author":"Korach","year":"1988","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0100","first-page":"410","article-title":"From environment to food: the case of PCB","volume":"42","author":"La Rocca","year":"2006","journal-title":"Ann Ist Super Sanita"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0110","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.tiv.2007.04.002","article-title":"Polychlorinated biphenyl exposure and CYP19 gene regulation in testicular and adrenocortical cell lines","volume":"21","author":"Li","year":"2007","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.envpol.2008.07.014","article-title":"PCBs in sediments of the Great Lakes \u2014 distribution and trends, homolog and chlorine patterns, and in situ degradation","volume":"157","author":"Li","year":"2009","journal-title":"Environ Pollut"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.lab.2005.10.005","article-title":"The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool","volume":"147","author":"Liew","year":"2006","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev.publhealth.18.1.211","article-title":"The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health","volume":"18","author":"Longnecker","year":"1997","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0125","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1289\/ehp.8748","article-title":"PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract","volume":"114","author":"Ma","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1289\/ehp.8981225","article-title":"Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: considerations for a congener-specific analysis","volume":"81","author":"McFarland","year":"1989","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/19396360903443658","article-title":"Exposure to polychlorinated biphenyls (PCBs) and male reproduction","volume":"56","author":"Meeker","year":"2010","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0140","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.taap.2007.11.003","article-title":"Activation of estrogen receptor signaling by the dioxin-like aryl hydrocarbon receptor agonist, 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126) in salmon in vitro system","volume":"227","author":"Mortensen","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1097-0274(199903)35:3<223::AID-AJIM2>3.0.CO;2-L","article-title":"An evaluation of proposed frameworks for grouping polychlorinated biphenyl (PCB) congener data into meaningful analytic units","volume":"35","author":"Moysich","year":"1999","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0150","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.reprotox.2008.04.003","article-title":"Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells","volume":"25","author":"Murugesan","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jaoac\/82.1.177","article-title":"Analysis of a mixture of polychlorinated biphenyls and chlorinated pesticides in human serum by column fractionation and dual-column capillary gas chromatography with electron capture detection","volume":"82","author":"Najam","year":"1999","journal-title":"J AOAC Int"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0160","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jsbmb.2008.03.003","article-title":"Sexual differentiation of the rodent hypothalamus: hormonal and environmental influences","volume":"109","author":"Negri-Cesi","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02977695","article-title":"Antiestrogenic potentials of ortho-PCB congeners by single or complex exposure","volume":"30","author":"Oh","year":"2007","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0170","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature01606","article-title":"Modulation of oestrogen receptor signalling by association with the activated dioxin receptor","volume":"423","author":"Ohtake","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/03014460903213845","article-title":"Association of age at menarche with adult leg length and trunk height: speculations in relation to breast cancer risk","volume":"37","author":"Osuch","year":"2010","journal-title":"Ann Hum Biol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0180","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0185","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1289\/ehp.7745","article-title":"Impact of polychlorinated biphenyls contamination on estrogenic activity in human male serum","volume":"113","author":"Pliskova","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.envres.2004.05.013","article-title":"Comparison of proposed frameworks for grouping polychlorinated biphenyl congener data applied to a case\u2013control pilot study of prostate cancer","volume":"98","author":"Ritchie","year":"2005","journal-title":"Environ Res"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/10408449409049308","article-title":"Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment","volume":"24","author":"Safe","year":"1994","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0195","first-page":"47","article-title":"PCBs: structure\u2013function relationships and mechanism of action","volume":"60","author":"Safe","year":"1985","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0205","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1289\/ehp.6126","article-title":"Effects of polychlorinated biphenyls on estrogen receptor-beta expression in the anteroventral periventricular nucleus","volume":"111","author":"Salama","year":"2003","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.physbeh.2009.09.015","article-title":"Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth","volume":"99","author":"Schell","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0215","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1021\/es061116j","article-title":"Temporal and spatial trends of atmospheric polychlorinated biphenyl concentrations near the Great Lakes","volume":"41","author":"Sun","year":"2007","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0220","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tox.2009.09.007","article-title":"AhR and ARNT modulate ER signaling","volume":"268","author":"Swedenborg","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tox.2005.10.008","article-title":"Selected polychlorobiphenyls congeners bind to estrogen receptor alpha in human umbilical vascular endothelial (HUVE) cells modulating angiogenesis","volume":"218","author":"Tavolari","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0230","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.chemosphere.2006.05.124","article-title":"A study on PCB, PCDD\/PCDF industrial contamination in a mixed urban\u2013agricultural area significantly affecting the food chain and the human exposure. Part I: soil and feed","volume":"67","author":"Turrio-Baldassarri","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0275","series-title":"Health effects of PCBs","author":"U.S. Environmental Protection Agency","year":"2008"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0280","series-title":"Polychlorinated biphenyls (PCBs)","author":"U.S. Environmental Protection Agency","year":"2009"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/eje.1.02102","article-title":"Aromatase is differentially expressed in peripheral blood leukocytes from children, and adult female and male subjects","volume":"154","author":"Vottero","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0250","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1289\/ehp.8809","article-title":"Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women","volume":"114","author":"Wang","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1289\/ehp.9710513","article-title":"Proposed PCB congener groupings for epidemiological studies","volume":"105","author":"Wolff","year":"1997","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0260","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2004.04.009","article-title":"Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221","volume":"152","author":"Woodhouse","year":"2004","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.scitotenv.2011.10.044_bb0265","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.chemosphere.2005.08.013","article-title":"Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells","volume":"63","author":"Xu","year":"2006","journal-title":"Chemosphere"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971101237X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971101237X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T17:42:31Z","timestamp":1741974151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896971101237X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":53,"alternative-id":["S004896971101237X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2011.10.044","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}