{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:33:43Z","timestamp":1782761623049,"version":"3.54.5"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00c3\u00a7\u00c3\u00a3o de Aperfei\u00c3\u00a7oamento de Pessoal de N\u00c3\u00advel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Apoio ao Desenvolvimento do Ensino, Ci\u00c3\u00aancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3\u00adfico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3\u00adfico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.scitotenv.2016.08.139","type":"journal-article","created":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T00:30:44Z","timestamp":1472344244000},"page":"518-531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Tolfenamic acid degradation by direct photolysis and the UV-ABC\/H2O2 process: factorial design, kinetics, identification of intermediates, and toxicity evaluation"],"prefix":"10.1016","volume":"573","author":[{"given":"Lucas","family":"de Melo da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Pereira Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Fabbro Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Gozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Falcao Dantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Cesar","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-4647","authenticated-orcid":false,"suffix":"Junior","given":"Amilcar","family":"Machulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2016.08.139_bb0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jtice.2014.10.022","article-title":"Modeling and optimization of antidepressant drug Fluoxetine removal in aqueous media by ozone\/H2O2 process: Comparison of central composite design and artificial neural network approaches","volume":"48","author":"Aghaeinejad-Meybodi","year":"2015","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0010","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0043-1354(02)00460-8","article-title":"Paracetamol oxidation from aqueous solutions by means of ozonation and H2O2\/UV system","volume":"37","author":"Andreozzi","year":"2003","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb9000","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jphotochem.2014.06.006","article-title":"The role of reactive oxygen species in sulfamethazine degradation using UV-based Technologies and products identification","volume":"290","author":"Batista","year":"2014","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1081\/PFC-120035925","article-title":"Oxidation of MCPA and 2,4-D by UV Radiation, Ozone, and the Combinations UV\/H2O2 and O3\/H2O2","volume":"39","author":"Benitez","year":"2004","journal-title":"J. Environ. Sci. Health B"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0020","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.talanta.2008.05.019","article-title":"Response surface methodology (RSM) as a tool for optimization in analytical chemistry","volume":"76","author":"Bezerra","year":"2008","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jpba.2016.01.016","article-title":"Selected analytical challenges in the determination of pharmaceuticals in drinking\/marine waters and soil\/sediment samples","volume":"121","author":"Bia\u0142k-Bieli\u0144ska","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1155\/S1110662X02000119","article-title":"Direct phototransformation of aromatic pesticides in aqueous solution","volume":"4","author":"Boule","year":"2002","journal-title":"Int. J. Photogr."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0035","series-title":"Photochemical Technology Chischester","author":"Braun","year":"1991"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.chemosphere.2010.03.004","article-title":"Electrochemical incineration of diclofenac in neutral aqueous medium by anodic oxidation using Pt and boron-doped diamond anodes","volume":"79","author":"Brillas","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.apcatb.2012.08.043","article-title":"Chemometric assessment and investigation of mechanism involved in photo-Fenton and TiO2 photocatalytic degradation of the artificial sweetener sucralose in aqueous media","volume":"129","author":"Calza","year":"2013","journal-title":"Appl. Catal. B Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0050","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/es00007a020","article-title":"Transformation Kinetics of Phenols in Water: Photosensitization by Dissolved Natural Organic Material and Aromatic Ketones","volume":"29","author":"Canonica","year":"1995","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0055","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1007\/s11356-012-1110-y","article-title":"Application of Fenton, photo-Fenton, solar photo-Fenton, and UV\/H2O2 to degradation of the antineoplastic agent mitoxantrone and toxicological evaluation","volume":"20","author":"Cavalcante","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.apcatb.2015.04.007","article-title":"Photocatalytic treatment of metoprolol with B-doped TiO2: Effect of water matrix, toxicological evaluation and identification of intermediates","volume":"176-177","author":"Cavalcante","year":"2015","journal-title":"Appl. Catal. B Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.apcatb.2016.04.054","article-title":"Photocatalytic mechanism of metoprolol oxidation by photocatalysts TiO2 and TiO2 doped with 5%B: primary active species and intermediates","volume":"194","author":"Cavalcante","year":"2016","journal-title":"Appl. Catal. B Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0070","doi-asserted-by":"crossref","first-page":"12585","DOI":"10.1007\/s11356-015-4537-0","article-title":"Phototransformation of mefenamic acid induced by nitrite ions in water: mechanism, toxicity, and degradation pathways","volume":"22","author":"Chen","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0075","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ecoenv.2013.04.027","article-title":"Toxicity and endocrine disruptionin zebrafish (Danio rerio) and two fresh water invertebrates (Daphnia magna and Moina macrocopa) after chronic exposure to mefenamic acid","volume":"94","author":"Collard","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb9005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0147-6513(03)00141-6","article-title":"Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid","volume":"59","author":"Cleuvers","year":"2004","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0080","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/S0043-1354(98)00448-5","article-title":"A Kinetic model for H2O2\/UV process in a Completely mixed batch reactor","volume":"33","author":"Crittenden","year":"1999","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0085","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jhazmat.2007.05.034","article-title":"Sulfamethoxazole abatement by means of ozonation","volume":"150","author":"Dantas","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb9010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.scitotenv.2014.09.103","article-title":"Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis by products in zebrafish (Danio rerio)","volume":"505","author":"Diniz","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0090","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.chroma.2014.03.081","article-title":"Liquid chromatography\/mass spectrometry to study oxidative degradation of environmentally relevant pharmaceuticals by electrochemistry and ozonation","volume":"1343","author":"Faber","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0095","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.1021\/cr500310b","article-title":"Environmental Implications of Hydroxyl Radicals (\u2022OH)","volume":"115","author":"Gligorovski","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chemolab.2015.09.014","article-title":"Review Optimization of PEG\u2013salt aqueous two-phase systems by design of experiments","volume":"149","author":"Glyk","year":"2015","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0105","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1093-0191(03)00032-7","article-title":"A review of imperative technologies for wastewater treatment I: oxidation technologies at ambient conditions","volume":"8","author":"Gogate","year":"2004","journal-title":"Adv. Environ. Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0110","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.cej.2012.09.008","article-title":"Investigation of chlorimuron-ethyl degradation by Fenton, photo-Fenton and ozonation processes","volume":"210","author":"Gozzi","year":"2012","journal-title":"J. Chem. Eng."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jchromb.2012.01.020","article-title":"Experimental design in chromatography: A tutorial review","volume":"910","author":"Hibbert","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0120","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.chemosphere.2005.01.024","article-title":"Inactivation of antineoplastics in clinical wastewater by electrolysis","volume":"60","author":"Hirose","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0125","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chemosphere.2015.12.059","article-title":"Emerging pollutants and plants e Metabolic activation of diclofenac by peroxidases","volume":"146","author":"Huber","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.desal.2010.11.039","article-title":"Photooxidative decolorization of two organic dyes with different chemical structures by UV\/H2O2 process: Experimental design","volume":"270","author":"Kasiri","year":"2011","journal-title":"Desalination"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0135","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1021\/cr00018a003","article-title":"Photochemical processes for water treatment","volume":"93","author":"Legrini","year":"1993","journal-title":"Chem. Rev."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1010-6030(96)04360-2","article-title":"Hydroxyl radical induced decomposition of aliphatic acids in oxygenated and deoxygenated aqueous solutions","volume":"99","author":"Leitner","year":"1996","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0145","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.cej.2014.09.055","article-title":"Aquatic photolysis of florfenicol and thiamphenicol under direct UV irradiation, UV\/H2O2 and UV\/Fe(II) processes","volume":"260","author":"Liu","year":"2015","journal-title":"Chem. Eng. J."},{"issue":"29-33","key":"10.1016\/j.scitotenv.2016.08.139_bb0150","first-page":"2014","article-title":"Removal of the anti-inflammatory drug ibuprofen from water using homogeneous photocatalysis","volume":"224","author":"Loaiza-Ambuludia","year":"2014","journal-title":"Catal. Today"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb9900","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1010-6030(02)00435-5","article-title":"Kinetic investigation on UV and UV\/H2O2 degradations of pharmaceutical intermediates in aqueous solution","volume":"156","author":"Lopez","year":"2003","journal-title":"J. Photochem. Photobiol., A"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0160","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1021\/es071884q","article-title":"Abatement of the inhibitory effect of chloride anions in the photo-Fenton process","volume":"41","author":"Machulek","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0165","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.scitotenv.2014.11.017","article-title":"Application of non-thermal plasma reactor and Fenton reaction for degradation of ibuprofen","volume":"505","author":"Markovi\u0107","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0170","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1039\/b303312k","article-title":"Transformation of 4-tert-octylphenol by UV irradiation and by an H2O2\/UV process in aqueous solution","volume":"2","author":"Mazellier","year":"2003","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0175","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.aquatox.2015.03.014","article-title":"High surface adsorption properties of carbon-based nanomaterials are responsible for mortality, swimming inhibition, and biochemical responses in Artemia salina larvae","volume":"163","author":"Mesari\u010d","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0180","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0041-008X(92)90273-U","article-title":"Quinone Chemistry and Toxicity","volume":"112","author":"Monks","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0185","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.talanta.2004.10.001","article-title":"Simple and fast spectrophotometric determination of H2O2 in photo-Fenton reactions using metavanadate","volume":"66","author":"Nogueira","year":"2005","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0190","doi-asserted-by":"crossref","unstructured":"Passananti, M., Lavorgna, M., Iesce, M.R., Dellagreca, M., Brigante, M., Criscuolo, E., Cermola, F., Isidori, M., Photochemical fate and eco-genotoxicity assessment of the drug etodolac. Sci. Total Environ. 518-519, 258-265.","DOI":"10.1016\/j.scitotenv.2015.03.009"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0195","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.1021\/es050794n","article-title":"Photo-Fenton Degradation of Diclofenac: Identification of Main Intermediates and Degradation Pathway","volume":"39","author":"P\u00e9rez-Estrada","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/tox.10141","article-title":"A practical and user-friendly toxicity classification system with microbiotests for natural waters and wastewaters","volume":"18","author":"Persoone","year":"2003","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0205","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.chemosphere.2007.12.006","article-title":"ECOSAR model performance with a large test set of industrial chemicals","volume":"71","author":"Reuschenbach","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0210","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.chemosphere.2013.07.059","article-title":"Pharmaceuticals as emerging contaminants and their removal from water. A review","volume":"93","author":"Rivera-Utrilla","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0215","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1021\/es035413p","article-title":"Degradation of endocrine disrupting chemicals bisphenol A, ethinyl estradiol, and estradiol during UV photolysis and advanced oxidation processes","volume":"38","author":"Rosenfeldt","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0220","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1016\/j.watres.2008.05.034","article-title":"Removal of pharmaceutical compounds, nitroimidazoles, from waters by using the ozone\/carbon system","volume":"42","author":"Sanchez-Polo","year":"2008","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0225","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jenvman.2015.02.021","article-title":"Degradation of antibiotics norfloxacin by Fenton, UV and UV\/H2O2","volume":"154","author":"Santos","year":"2015","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0230","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.energy.2014.04.088","article-title":"Modeling and optimization of energy-efficient procedures for removing lead(II) and zinc(II) ions from aqueous solutions using the central composite design","volume":"77","author":"Savic","year":"2014","journal-title":"Energy"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0235","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s11356-013-1957-6","article-title":"Non-steroidal anti-inflammatory drugs in Indian rivers","volume":"21","author":"Shanmugam","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v22.i1.20","article-title":"Optimizing Drug Delivery Systems Using Systematic \u201cDesign of Experiments\u201d Part I: Fundamental Aspects","volume":"22","author":"Singh","year":"2004","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb9015","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jhazmat.2013.06.060","article-title":"Degradation of antipyrine by UV, UV\/H2O2 and UV\/PS","volume":"260","author":"Tan","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0245","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.watres.2005.03.003","article-title":"Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment","volume":"39","author":"Tauxe-Wuersch","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.scitotenv.2015.03.033","article-title":"Ozonation of ofloxacin in water: By-products, degradation pathway and ecotoxicity assessment","volume":"520","author":"Tay","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2015.03.047","article-title":"Decolorization and mineralization of Allura Red AC azo dye by solar photoelectro-Fenton: Identification of intermediates","volume":"136","author":"Thiam","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0260","series-title":"Guidance for Industry\u2014Environmental Assessment of Human Drug and Biologics Applications","author":"US Food and Drug Administration","year":"1998"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0265","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2010.11.010","article-title":"Metabolism related toxicity of diclofenac in yeast as model system","volume":"200","author":"van Leeuwen","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0270","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1016\/j.bmc.2014.06.022","article-title":"Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs","volume":"22","author":"Venkataraman","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00027-002-8068-7","article-title":"Phototransformation of aromatic pollutants in solar light: Photolysis versus photosensitized reactions under natural water conditions","volume":"64","author":"Vialaton","year":"2002","journal-title":"Aquat. Sci."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0280","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1010-6030(98)00401-8","article-title":"Phototransformation of 4-chloro-2-methylphenol in water: influence of humic substances on the reaction","volume":"119","author":"Vialaton","year":"1998","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0285","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1021\/jo025604v","article-title":"Advanced Oxidation Chemistry of Paracetamol. UV\/H2O2-Induced Hydroxylation\/Degradation Pathways and 15N-Aided Inventory of Nitrogenous Breakdown Products","volume":"67","author":"Vogna","year":"2002","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0290","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.watres.2003.09.028","article-title":"Advanced oxidation of the pharmaceutical drug diclofenac with UV\/H2O2 and ozone","volume":"38","author":"Vogna","year":"2004","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0295","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.watres.2012.03.036","article-title":"Review of photochemical reaction constants of organic micropollutants required for UV advanced oxidation processes in water","volume":"46","author":"Wols","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0300","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1016\/j.electacta.2009.02.059","article-title":"Electro-oxidation of diclofenac at boron doped diamond: Kinetics and mechanism","volume":"54","author":"Zhao","year":"2009","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0305","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jhazmat.2011.01.057","article-title":"Review - The occurrence and fate of anti-inflammatory and analgesic pharmaceuticals in sewage and fresh water: Treatability by conventional and non-conventional processes","volume":"187","author":"Ziylan","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0310","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.watres.2013.12.034","article-title":"Vacuum - UV radiation at 185 nm in water treatmente - A review","volume":"52","author":"Zoschke","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.08.139_bb0315","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chemosphere.2010.06.029","article-title":"Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites","volume":"81","author":"Zounkova","year":"2010","journal-title":"Chemosphere"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969716318411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969716318411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T19:09:31Z","timestamp":1758654571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969716318411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":67,"alternative-id":["S0048969716318411"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2016.08.139","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tolfenamic acid degradation by direct photolysis and the UV-ABC\/H2O2 process: factorial design, kinetics, identification of intermediates, and toxicity evaluation","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2016.08.139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}