{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:26:18Z","timestamp":1792117578009,"version":"4.4.0"},"reference-count":166,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Union's Seventh Framework Programme","award":["603437"],"award-info":[{"award-number":["603437"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.scitotenv.2016.10.104","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T06:45:34Z","timestamp":1477637134000},"page":"720-737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":361,"special_numbering":"C","title":["Towards the review of the European Union Water Framework Directive: Recommendations for more efficient assessment and management of chemical contamination in European surface water resources"],"prefix":"10.1016","volume":"576","author":[{"given":"Werner","family":"Brack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Dulio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"\u00c5gerstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Altenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Cousins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate I.","family":"Escher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix J.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Mark","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Hilscherov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Hollender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Hollert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Klauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lindim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L\u00f3pez","family":"Herr\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cil","family":"Mi\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Munthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5879-5692","authenticated-orcid":false,"given":"Simon","family":"O'Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-5499","authenticated-orcid":false,"given":"Leo","family":"Posthuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"R\u00fcdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf B.","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Sengl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-0063","authenticated-orcid":false,"given":"Foppe","family":"Smedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"van de Meent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-4347","authenticated-orcid":false,"given":"Paul J.","family":"van den Brink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"van Gils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie P.","family":"van Wezel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Dick","family":"Vethaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Vermeirssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"von der Ohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Vrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2016.10.104_bb0005","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1539-6924.2010.01426.x","article-title":"Science and decisions: advancing risk assessment","volume":"30","author":"Abt","year":"2010","journal-title":"Risk Anal."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.scitotenv.2014.12.057","article-title":"Future water quality monitoring \u2014 adapting tools to deal with mixtures of pollutants in water resource management","volume":"512\u2013513","author":"Altenburger","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0015","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/etc.5620190926","article-title":"Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: mixtures composed of similarly acting chemicals","volume":"19","author":"Altenburger","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0020","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0025","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1021\/es2034125","article-title":"Predictive environmental risk assessment of chemical mixtures: a conceptual framework","volume":"46","author":"Backhaus","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ieam.118","article-title":"Framework for interpreting sediment quality triad data","volume":"8","author":"Bay","year":"2012","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1897\/IEAM_2008-090.1","article-title":"Environmental persistence of organic pollutants: guidance for development and review of POP risk profiles","volume":"5","author":"Boethling","year":"2009","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acs.est.5b04050","article-title":"Passive sampling in regulatory chemical monitoring of nonpolar organic compounds in the aquatic environment","volume":"50","author":"Booij","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0045","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1021\/es405428t","article-title":"Identification of photosynthesis inhibitors of pelagic marine algae using 96-well plate microfractionation for enhanced throughput in effect-directed analysis","volume":"48","author":"Booij","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0050","author":"Botta"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00216-003-2139-z","article-title":"Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures","volume":"377","author":"Brack","year":"2003","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0060","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/etc.3046","article-title":"The challenge: prioritization of emerging pollutants","volume":"34","author":"Brack","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0065","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.scitotenv.2015.11.102","article-title":"Effect-directed analysis supporting monitoring of aquatic environments - an in-depth overview","volume":"544","author":"Brack","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.scitotenv.2014.05.143","article-title":"The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management","volume":"503\u2013504","author":"Brack","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/2190-4715-24-29","article-title":"The NORMAN network and its activities on emerging environmental substances with a focus on effect-directed analysis of complex environmental contamination","volume":"24","author":"Brack","year":"2012","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.envint.2013.02.003","article-title":"Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays","volume":"55","author":"Brand","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0085","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1039\/c2em30259d","article-title":"Screening organic chemicals in commerce for emissions in the context of environmental and human exposure","volume":"14","author":"Breivik","year":"2012","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.aquatox.2014.03.021","article-title":"Physiologically-based toxicokinetic models help identifying the key factors affecting contaminant uptake during flood events","volume":"152","author":"Brinkmann","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquatox.2015.07.010","article-title":"Towards science-based sediment quality standards-effects of field-collected sediments in rainbow trout (Oncorhynchus mykiss)","volume":"166","author":"Brinkmann","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0100","series-title":"EPA\/600\/R-02\/012","article-title":"Equilibrium partitioning sediment benchmarks (ESBs) for the protection of benthic organisms: procedures for the determination of the freely dissolved interstitial water concentrations of nonionic organics","author":"Burgess","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0105","series-title":"Deriving Sediment Interstitial Water Remediation Goals (IWRGs) for the Protection of Benthic Organisms from Direct Toxicity","author":"Burkhard","year":"2015"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/etc.3460","article-title":"Micropollutants in European rivers: a mode of action survey to support the development of effect-based tools for water monitoring","author":"Busch","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0115","series-title":"Monitoring-based Exercise: Second Review of the Priority Substances List Under the Water Framework Directive, Draft","author":"Carvalho","year":"2016"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/toxsci\/kfu118","article-title":"Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?","volume":"141","author":"Carvalho","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0125","series-title":"OSPAR Practical Study 2005 on Whole Effluent Assessment","author":"Commission O. OSPAR Hazardous Substances Committee","year":"2007"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.watres.2015.05.061","article-title":"Towards spatially smart abatement of human pharmaceuticals in surface waters: defining impact of sewage treatment plants on susceptible functions","volume":"81","author":"Coppens","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.envint.2014.10.012","article-title":"Theoretically exploring direct and indirect chemical effects across ecological and exposure scenarios using mechanistic fate and effects modelling","volume":"74","author":"De Laender","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0140","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1890\/1051-0761(2006)016[1295:PMAEOF]2.0.CO;2","article-title":"Predictive models attribute effects on fish assemblages to toxicity and habitat alteration","volume":"16","author":"de Zwart","year":"2006","journal-title":"Ecol. Appl."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0145","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1897\/04-639R.1","article-title":"Complex mixture toxicity for single and multiple species: proposed methodologies","volume":"24","author":"De Zwart","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2016.08.018","article-title":"Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring","author":"Di Paolo","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0155","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/etc.5620101203","article-title":"Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium paritioning","volume":"10","author":"Di Toro","year":"1991","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envint.2015.02.001","article-title":"Exploring the planetary boundary for chemical pollution","volume":"78","author":"Diamond","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0165","first-page":"394","article-title":"Identifying toxicity pathways with ToxCast high-throughput screening and applications to predicting developmental toxicity","volume":"85","author":"Dix","year":"2009","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0170","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature03192","article-title":"Chemical space and biology","volume":"432","author":"Dobson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0175","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/etc.3048","article-title":"In response: the NORMAN perspectives on prioritization of emerging pollutants","volume":"34","author":"Dulio","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0180","author":"Dulio"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0185","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s11368-013-0668-4","article-title":"The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments","volume":"13","author":"Eichbaum","year":"2013","journal-title":"J. Soils Sediments"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0190","article-title":"Bioanalytical and instrumental screening of the uptake of sediment-borne, dioxin-like compounds in roach (Rutilus rutilus)","volume":"1\u201315","author":"Eichbaum","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0195","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.etap.2004.01.011","article-title":"Toxicological evaluation of complex mixtures: fingerprinting and multivariate analysis","volume":"18","author":"Eide","year":"2004","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0200","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/1521-3773(20020201)41:3<414::AID-ANIE414>3.0.CO;2-N","article-title":"10 years after Rio - concepts on the contribution of chemistry to a sustainable development","volume":"41","author":"Eissen","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0205","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S1466046613000458","article-title":"Environmental reviews and case studies: biological effects\u2013based tools for monitoring impacted surface waters in the Great Lakes: a multiagency program in support of the Great Lakes restoration initiative","volume":"15","author":"Ekman","year":"2013","journal-title":"Environ. Pract."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0210","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.1021\/es503369t","article-title":"Applications of polyparameter linear free energy relationships in environmental chemistry","volume":"48","author":"Endo","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0215","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1021\/es403899t","article-title":"Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays","volume":"48","author":"Escher","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0220","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.watres.2015.05.049","article-title":"Effect-based trigger values for in vitro bioassays: reading across from existing water quality guideline values","volume":"81","author":"Escher","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0225","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1021\/es304793h","article-title":"Most oxidative stress response in water samples comes from unknown chemicals: the need for effect-based water quality trigger values","volume":"47","author":"Escher","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0230","series-title":"Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7b: Endpoint Specific Guidance","author":"European Chemicals Agency","year":"2014"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0235","series-title":"Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use. Committee for Medicinal Products for Human Use. EMEA\/CHMP\/SWP\/4447\/00 corr21","author":"European Medicines Agency","year":"2006"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0240","series-title":"Guideline on Environmental Impact Assessment for Veterinary Medicinal Products Phase II. Committee for Medicinal Products for Veterinary Use (CVMP). CVMP\/VICH\/790\/03-FINAL","author":"European Medicines Agency","year":"2008"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0245","series-title":"Council Directive of 12 June 1986 on the Protection of the Environment, and in Particular of the Soil, when Sewage sludge is Used in Agriculture (86\/278\/EEC)","first-page":"6","author":"European Union","year":"1986"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb9000","series-title":"Council Directive 98\/83\/EC of 3 November 1998 on the quality of water intended for human consumption","author":"European Union","year":"1998"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0250","series-title":"Directive 2000\/60\/EC of the European Parliament and of the Council of 23 October 2000 Establishing a Framework for Community Action in the Field of Water Policy","first-page":"1","author":"European Union","year":"2000"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0255","series-title":"Common Implementation Strategy for the Water Framework Directive (2000\/60\/EC). Guidance Document No 7. Monitoring under the Water Framework Directive","author":"European Union","year":"2003"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0260","series-title":"Directive 2002\/95\/EC of the European Parliament and of the Council of 27 January 2003 on the restriction of the use of certain hazardous substances in electrical and electronic equipment","first-page":"19","author":"European Union","year":"2003"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0265","first-page":"19","article-title":"Directive 2006\/118\/EC of the European Parliament and of the Council of 12 December 2006 on the protection of groundwater against pollution and deterioration","volume":"2006","author":"European Union","year":"2006","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0270","series-title":"Directive 2008\/56\/EC of the European Parliament and of the Council of 17 June 2008 Establishing a Framework for Community Action in the Field of Marine Environmental Policy (Marine Strategy Framework Directive)","first-page":"19","author":"European Union","year":"2008"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0275","first-page":"84","author":"European Union","year":"2008"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0280","series-title":"Commission Directive 2009\/90\/EC of 31 July 2009 Laying Down, Pursuant to Directive 2000\/60\/EC of the European Parliament and of the Council, Technical Specifications for Chemical Analysis and Monitoring of Water Status OJ L201","first-page":"36","author":"European Union","year":"2009"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0285","series-title":"Directive 2009\/128\/EC of the European Parliament and of the Council Establishing a Framework for Community Action to Achieve the Sustainable Use of Pesticides, OJ L309","first-page":"71","author":"European Union","year":"2009"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0295","series-title":"Directive 2010\/75\/EU of the European Parliament and of the Council of 24 November 2010 on industrial emissions (integrated pollution prevention and control) (Recast), OJ L334","first-page":"17","author":"European Union","year":"2010"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0300","first-page":"74","author":"European Union","year":"2010"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0305","series-title":"Commission Implementing Regulation (EU) No 540\/2011 of 25 May 2011 implementing Regulation (EC) No 1107\/2009 of the European Parliament and of the Council as Regards the List of Approved Active Substances. 2011R540-EN-03.09.2015\u2013021.001-1","author":"European Union","year":"2011"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0310","series-title":"Technical Report 2011-055","article-title":"WFD-CIS guidance document no. 27 technical guidance on deriving environmental quality standards","author":"European Union","year":"2011"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0315","series-title":"The Combination Effects of Chemicals \u2013 Chemical mixtures. Communication from the Commission to the Council, COM(2012) 252 Final, Brussels, 31.5.2012","author":"European Union","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0320","series-title":"Directive 2012\/19\/EU of the Parliament and of the Council of 4 July 2012 on Waste Electrical and Electronic Equipment (WEEE). OJ L197, 24.7.2012","first-page":"38","author":"European Union","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0325","series-title":"Regulation (EU) No 528\/2012 of the European Parliament and the Council of 22 May 2012 Concerning the Making Available on the Market and Use of Biocidal Products. OJ L167, 27.6.2012","first-page":"1","author":"European Union","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0330","series-title":"Decision No 1386\/2013\/EU of the European Parliament and the Council of 20 November 2013 on a General Union Environment Action Programme to 2020 \u201cLiving Well, Within the Limits of Our Planet\u201d. OJ L345. 28.12.2013","first-page":"171","author":"European Union","year":"2013"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0335","series-title":"Directive 2013\/39\/EU of the European Parliament and the Council of 12. August 2013 Amending Directives 2000\/60\/EC and 2008\/105\/EC as Regards Priority Substances in the Field of water policy. OJ L226, 24.8.2013","first-page":"1","author":"European Union","year":"2013"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0340","series-title":"Commission Directive 2014\/80\/EU of 20 June 2014 Amending Annex II to Directive 2006\/118\/EC of the European Parliament and the Council on the Protection of Groundwater Against Pollution and Deterioration. OJ L182, 21.6.2014","first-page":"52","author":"European Union","year":"2014"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0345","series-title":"Technical Report \u2013 2014 \u2013 077","article-title":"Technical report on aquatic effect-based monitoring","author":"European Union","year":"2014"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0350","first-page":"18","author":"European Union","year":"2014"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0355","series-title":"Commission Implementing Decision (EU) 2015\/495 of 20 March 2015. OJ L78, 24.3.2015","first-page":"40","author":"European Union","year":"2015"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0360","series-title":"Common Implementation Strategy for the Water Framework Directive (2000\/60\/EC) and the Floods Directive (2007\/60\/EC). Work Programme 2016\u20132018 as Agreed by Water Directors at Their Meeting in Luxembourg on 25 November 2015","author":"European Union","year":"2015"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0365","author":"European Union"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0370","author":"European Union"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0375","author":"European Union Joint Research Centre"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0380","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ecolind.2013.08.017","article-title":"Theoretical exploration for the combination of the ecological, energy, carbon, and water footprints: overview of a footprint family","volume":"36","author":"Fang","year":"2014","journal-title":"Ecol. Indic."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0385","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0166-445X(02)00133-9","article-title":"Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action","volume":"63","author":"Faust","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0390","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/etc.3049","article-title":"In response: prioritization and standard setting for pollutant mixtures in the aquatic environment: a business consultant's perspective","volume":"34","author":"Faust","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0395","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/10807039.2011.588142","article-title":"\u201cSolution-focused risk assessment\u201d: a proposal for the fusion of environmental analysis and action","volume":"17","author":"Finkel","year":"2011","journal-title":"Hum. Ecol. Risk Assess. Int. J."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0400","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/etc.2502","article-title":"A simulation study on effects of exposure to a combination of pesticides used in an orchard and tuber crop on the recovery time of a vulnerable aquatic invertebrate","volume":"33","author":"Focks","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0405","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ecolmodel.2013.09.023","article-title":"Integrating chemical fate and population-level effect models for pesticides at landscape scale: new options for risk assessment","volume":"280","author":"Focks","year":"2014","journal-title":"Ecol. Model."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0410","doi-asserted-by":"crossref","DOI":"10.1186\/s12302-016-0075-8","article-title":"Dioxin in the Elbe river basin: policy and science under the water framework directive 2000\u20132015 and toward 2021","volume":"28","author":"F\u00f6rstner","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0415","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1039\/B805746J","article-title":"Results of a \u201cwhole effluent assessment\u201d study from different industrial sectors in Germany according to OSPAR's WEA strategy","volume":"11","author":"Gartiser","year":"2009","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0420","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ieam.1507","article-title":"Passive sampling methods for contaminated sediments: practical guidance for selection, calibration, and implementation","volume":"10","author":"Ghosh","year":"2014","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0425","author":"Government of Canada"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0430","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ieam.1395","article-title":"Expert opinion on toxicity profiling\u2014report from a NORMAN expert group meeting","volume":"9","author":"Hamers","year":"2013","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0435","doi-asserted-by":"crossref","DOI":"10.1186\/2190-4715-23-15","article-title":"Endocrine disruptor screening: regulatory perspectives and needs","volume":"23","author":"Hecker","year":"2011","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0440","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/etc.3047","article-title":"In response: a regulatory perspective on prioritization of emerging pollutants in the context of the water framework directive","volume":"34","author":"Heiss","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0445","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.scitotenv.2014.06.106","article-title":"Managing aquatic ecosystems and water resources under multiple stress - an introduction to the MARS project","volume":"503","author":"Hering","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0450","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhazmat.2014.08.006","article-title":"Advancing towards universal screening for organic pollutants in waters","volume":"282","author":"Hern\u00e1ndez","year":"2015","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0455","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1897\/07-195.1","article-title":"Altered reproduction in fish exposed to pulp and paper mill effluents: roles of individual compounds and mill operating conditions","volume":"27","author":"Hewitt","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0460","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mrrev.2005.02.001","article-title":"Analytical methods in environmental effects-directed investigations of effluents","volume":"589","author":"Hewitt","year":"2005","journal-title":"Mut. Res. Rev. Mut. Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0465","doi-asserted-by":"crossref","DOI":"10.1002\/wat2.1155","article-title":"Transit times\u2014the link between hydrology and water quality at the catchment scale","author":"Hrachowitz","year":"2016","journal-title":"WIREs Water"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0470","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1021\/es00048a028","article-title":"Lipid-containing semipermeable membrane devices for monitoring organic contaminants in water","volume":"27","author":"Huckins","year":"1993","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0475","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.chemosphere.2015.05.072","article-title":"Linking mutagenic activity to micropollutant concentrations in wastewater samples by partial least square regression and subsequent identification of variables","volume":"138","author":"Hug","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0480","author":"Institut National de l'Environnement Industriel et des Risques","year":"2009"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0485","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1021\/acs.est.5b04687","article-title":"Strategies for transferring mixtures of organic contaminants from aquatic environments into bioassays","volume":"50","author":"Jahnke","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0490","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/etc.2557","article-title":"Developing a foundation for eco-epidemiological assessment of aquatic ecological status over large geographic regions utilizing existing data resources and models","volume":"33","author":"Kapo","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0495","author":"Kase"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0500","series-title":"SPIN, Substances in Preparations in Nordic Countries","volume":"2014","author":"KEMI Swedish Chemical Agency","year":"2014"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0505","series-title":"Studie im Auftrag desw Bundesamtes f\u00fcr Umwelt (BAFU)","article-title":"Grobbeurteilung der Wasserqualit\u00e4t von abwasserbelasteten Gew\u00e4ssern anhand von \u00f6kotoxikologischen Biotests","author":"Kienle","year":"2015"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0510","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1087057111413921","article-title":"High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology","volume":"16","author":"Kool","year":"2011","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0515","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpba.2014.11.018","article-title":"In vitro bioassays to screen for endocrine active pharmaceuticals in surface and waste waters","volume":"106","author":"Kunz","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0520","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.envpol.2015.08.050","article-title":"Estimating emissions of PFOS and PFOA to the Danube River catchment and evaluating them using a catchment-scale chemical transport and fate model","volume":"207","author":"Lindim","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0525","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.watres.2016.07.024","article-title":"Europe-wide estuarine export and surface water concentrations of PFOS and PFOA","volume":"103","author":"Lindim","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0530","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.chemosphere.2015.09.051","article-title":"A large-scale model for simulating the fate and transport of organic contaminants in river basins","volume":"144","author":"Lindim","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0535","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1897\/03-400","article-title":"Dependency of polychlorinated biphenyl and polycyclic aromatic hydrocarbon bioaccumulation in Mya arenaria on both water column and sediment bed chemical activities","volume":"23","author":"Lohmann","year":"2004","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0540","series-title":"JRC Scientific and Policy Reports","article-title":"Analytical methods relevant to the European Commission's 2012 proposal on priority substances under the Water Framework Directive","author":"Loos","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0545","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.envpol.2008.09.020","article-title":"EU-wide survey of polar organic persistent pollutants in European river waters","volume":"157","author":"Loos","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0550","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.envint.2012.01.010","article-title":"Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments","volume":"44","author":"L\u00fcbcke-von Varel","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0555","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1021\/es103381y","article-title":"Polar compounds dominate in vitro effects of sediment extracts","volume":"45","author":"L\u00fcbcke-von Varel","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0560","doi-asserted-by":"crossref","first-page":"9549","DOI":"10.1073\/pnas.1321082111","article-title":"Organic chemicals jeopardise freshwater ecosystems health on the continental scale","volume":"111","author":"Malaj","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0565","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/10934529.2011.579850","article-title":"Effluent monitoring at a bleached kraft mill: directions for best management practices for eliminating effects on fish reproduction","volume":"46","author":"Martel","year":"2011","journal-title":"J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0570","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ieam.1508","article-title":"Passive sampling methods for contaminated sediments: scientific rationale supporting use of freely dissolved concentrations","volume":"10","author":"Mayer","year":"2014","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0575","doi-asserted-by":"crossref","first-page":"184A","DOI":"10.1021\/es032433i","article-title":"Equilibrium sampling devices","volume":"37","author":"Mayer","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0580","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.teac.2015.07.001","article-title":"Position paper on passive sampling techniques for the monitoring of contaminants in the aquatic environment \u2013 achievements to date and perspectives","volume":"8","author":"Mi\u00e8ge","year":"2015","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0585","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/etc.3259","article-title":"CRED: criteria for reporting and evaluating ecotoxicity data","volume":"35","author":"Moermond","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0590","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.scitotenv.2012.07.021","article-title":"Are chemicals in articles an obstacle for reaching environmental goals? - missing links in EU chemical management","volume":"435","author":"Molander","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0595","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/es500371t","article-title":"How a complete pesticide screening changes the assessment of surface water quality","volume":"48","author":"Moschet","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0600","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13593-013-0176-3","article-title":"Pesticide transfer models in crop and watershed systems: a review","volume":"34","author":"Mottes","year":"2014","journal-title":"Agron. Sustain. Dev."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0605","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1897\/08-376.1","article-title":"A review of potential methods of determining critical effect size for designing environmental monitoring programs","volume":"28","author":"Munkittrick","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0610","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1021\/acs.est.5b04083","article-title":"Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling","volume":"49","author":"Neale","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0615","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1021\/es501961k","article-title":"Beyond safe operating space: finding chemical Footprinting feasible","volume":"48","author":"Posthuma","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0620","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/etc.1923","article-title":"Predicted mixture toxic pressure relates to observed fraction of benthic macrofauna species impacted by contaminant mixtures","volume":"31","author":"Posthuma","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0625","series-title":"Water Systems Analysis with the Ecological Key Factor \u2018Toxicity\u2019. Part 2. Calibration. Toxic Pressure and Ecological Effects on Macrofauna in the Netherlands","author":"Posthuma","year":"2016"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0630","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.scitotenv.2016.06.242","article-title":"Eco-epidemiology of aquatic ecosystems: separating chemicals from multiple stressors","volume":"573","author":"Posthuma","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0635","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.scitotenv.2014.08.001","article-title":"Can POCIS be used in Water Framework Directive (2000\/60\/EC) monitoring networks? A study focusing on pesticides in a French agricultural watershed","volume":"497\u2013498","author":"Poulier","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0640","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10937404.2013.802265","article-title":"Potential changes in disease patterns and pharmaceutical use in response to climate change","volume":"16","author":"Redshaw","year":"2013","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0645","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1897\/05-458R.1","article-title":"Two complementary sides of bioavailability: accessibility and chemical activity of organic contaminants in sediments and soils","volume":"25","author":"Reichenberg","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0650","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jenvman.2015.01.053","article-title":"The conceptual foundation of environmental decision support","volume":"154","author":"Reichert","year":"2015","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0655","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.scitotenv.2014.07.119","article-title":"Assessing the ecological status in the context of the European Water Framework Directive: where do we go now?","volume":"497","author":"Reyjol","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0660","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/etc.3008","article-title":"Evaluating aquatic invertebrate vulnerability to insecticides based on intrinsic sensitivity, biological traits, and toxic mode of action","volume":"34","author":"Rico","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0665","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/461472a","article-title":"A safe operating space for humanity","volume":"461","author":"Rockstr\u00f6m","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0670","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5751\/ES-03180-140232","article-title":"Planetary boundaries: exploring the safe operating space for humanity","volume":"14","author":"Rockstr\u00f6m","year":"2009","journal-title":"Ecol. Soc."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0675","doi-asserted-by":"crossref","first-page":"6167","DOI":"10.1021\/es2013006","article-title":"Occurrence and toxicity of 331 organic pollutants in large rivers of north Germany over a decade (1994 to 2004)","volume":"45","author":"Sch\u00e4fer","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0680","series-title":"Groundwater threshold values. In-depth assessment of the differences in groundwater threshold values established by Member States","author":"Scheidleder","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0685","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1890\/12-0591.1","article-title":"Bridging the gap between theoretical ecology and real ecosystems: modeling invertebrate community composition in streams","volume":"94","author":"Schuwirth","year":"2013","journal-title":"Ecology"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0690","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.trac.2012.08.008","article-title":"Identification of river basin specific pollutants and derivation of environmental quality standards: a case study in the Slovak Republic","volume":"41","author":"Slobodnik","year":"2012","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0695","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s11356-012-1059-x","article-title":"Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays","volume":"20","author":"Smital","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0700","doi-asserted-by":"crossref","DOI":"10.1039\/C6EM90023B","article-title":"The dilemma in prioritizing chemicals for environmental analysis: known versus unknown hazards","author":"Sobek","year":"2016","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0705","series-title":"ETC\/ICM Technical Report 1\/2012","article-title":"Ecological and chemical status and pressures in European waters","author":"Solheim","year":"2012"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0710","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1081\/ESE-200045531","article-title":"The Elbe flood in august 2002 - organic contaminants in sediment samples taken after the flood event","volume":"40","author":"Stachel","year":"2005","journal-title":"J. Environ. Sci. Health A"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0715","doi-asserted-by":"crossref","DOI":"10.1126\/science.1259855","article-title":"Planetary boundaries: guiding human development on a changing planet","volume":"347","author":"Steffen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0720","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00395083","article-title":"Changes in valued \u201ccapacities\u201d of soils and sediments as indicators of nonlinear and time-delayed environmental effects","volume":"10","author":"Stigliani","year":"1988","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0725","series-title":"IIASA Executive Reports","article-title":"Chemical time bombs: definition, concepts, and examples","author":"Stigliani","year":"1991"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0730","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/etc.2580","article-title":"Realistic environmental mixtures of micropollutants in surface, drinking, and receycled water: herbicides dominate the mixture toxicity toward algae","volume":"33","author":"Tang","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0735","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1016\/j.watres.2013.03.011","article-title":"Mixture effects of organic micropollutants present in water: towards the development of effect-based water quality trigger values for baseline toxicity","volume":"47","author":"Tang","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0740","series-title":"Temporal and Spatial Trends of Pharmaceuticals in the Rhine","author":"Ter Laak","year":"2009"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0745","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/icesjms\/fsn120","article-title":"Contaminants in marine ecosystems: developing an integrated indicator framework using biological-effect techniques","volume":"65","author":"Thain","year":"2008","journal-title":"ICES J. Mar. Sci. J. du Conseil"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0750","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1021\/es950512r","article-title":"Association of linear alkylbenzenesulfonates with dissolved humic substances and its effect on bioavailability","volume":"30","author":"Traina","year":"1996","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0755","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2166\/wst.2011.120","article-title":"Demographic projections of future pharmaceutical consumption in the Netherlands","volume":"63","author":"Van der Aa","year":"2011","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0760","series-title":"Background document on Effect-Based Trigger Values for Environmental Water Quality","article-title":"Watersysteemanalyse met de Ecologische Sleutelfactor Toxiciteit. Deel 5","author":"Van der Oost","year":"2016"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0765","article-title":"Operationalising solutions-focused risk assessment: A discussion paper on mitigation options for chemicals of emerging concern in surface waters","author":"Van Wezel","year":"2016","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0770","article-title":"Integrated indicator framework and methodology for monitoring and assessment of hazardous substances and their effects in the marine environment","author":"Vethaak","year":"2016","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0775","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.trac.2008.10.013","article-title":"Pollutant partitioning for monitoring surface waters","volume":"28","author":"Vignati","year":"2009","journal-title":"Trac-Trends Anal. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0780","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1897\/IEAM_2008-043.1","article-title":"Towards an integrated assessment of the ecological and chemical status of European River Basins","volume":"5","author":"Von der Ohe","year":"2009","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0785","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.scitotenv.2011.01.054","article-title":"A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive","volume":"409","author":"Von der Ohe","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0790","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.scitotenv.2012.12.001","article-title":"Distinguishing the effects of habitat degradation and pesticide stress on benthic invertebrates using stressor-specific metrics","volume":"444","author":"Von der Ohe","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0795","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.trac.2005.06.006","article-title":"Passive sampling techniques for monitoring pollutants in water","volume":"24","author":"Vrana","year":"2005","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0800","series-title":"JRC Technical Reports","article-title":"NORMAN interlaboratory study (ILS) on passive sampling of emerging pollutants; EUR 27655 EN","author":"Vrana","year":"2016"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0805","series-title":"Final Synthesis","article-title":"Informal meeting of water and marine directors of the European Union, candidate and EFTA countries. Vilnius, 4th and 5th of December 2013","author":"Water and Marine Directors of the European Union, Candidate and EFTA Countries","year":"2013"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-015-0039-4","article-title":"The European technical report on aquatic effect-based monitoring tools under the water framework directive","volume":"27","author":"Wernersson","year":"2015","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0815","author":"WFD Navigation Task Group"},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0820","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1021\/es500629f","article-title":"Definition and applications of a versatile chemical pollution footprint methodology","volume":"48","author":"Zijp","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0825","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.envint.2016.03.006","article-title":"Definition and use of solution-focused sustainability assessment: a novel approach to generate, explore and decide on sustainable solutions for wicked problems","volume":"91","author":"Zijp","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2016.10.104_bb0830","series-title":"Presentation at SETAC Europe 25th Annual Meeting, 3\u20137 May 2015, Barcelona. Abstract Book","first-page":"61","article-title":"Development of a miniaturized AMES assay for high-throughput effect-directed analysis of water samples using microfractionation","author":"Zwart","year":"2015"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969716322860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969716322860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T08:26:29Z","timestamp":1589703989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969716322860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":166,"alternative-id":["S0048969716322860"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2016.10.104","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards the review of the European Union Water Framework Directive: Recommendations for more efficient assessment and management of chemical contamination in European surface water resources","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2016.10.104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}