{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:36:51Z","timestamp":1782801411445,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23406018"],"award-info":[{"award-number":["23406018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19209021"],"award-info":[{"award-number":["19209021"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.scitotenv.2017.04.013","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T06:34:33Z","timestamp":1492151673000},"page":"842-848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in Vietnamese men"],"prefix":"10.1016","volume":"595","author":[{"given":"Xian Liang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Kido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seijiro","family":"Honma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitetsu","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Dung","family":"Manh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Maruzeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneko","family":"Nishijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takasuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Duc","family":"Nhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Ngoc","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Ke","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2017.04.013_bb0005","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/cncr.27941","article-title":"Agent Orange as a risk factor for high grade prostate cancer","volume":"119","author":"Ansbaugh","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000117714","article-title":"Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice","volume":"2","author":"Baba","year":"2008","journal-title":"Sex. Dev."},{"issue":"4 Suppl. 1","key":"10.1016\/j.scitotenv.2017.04.013_bb0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(03)00045-1","article-title":"The role of dihydrotestosterone in benign prostatic hyperplasia","volume":"61","author":"Carson","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0020","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1002\/cncr.23695","article-title":"Agent Orange exposure, Vietnam War veterans and risk of prostate cancer","volume":"113","author":"Chamie","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0025","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.cell.2013.07.029","article-title":"A gain of function mutation in DHT synthesis in castration resistant prostate cancer","volume":"154","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0030","first-page":"1410","article-title":"Endogenous sex hormones and prostate cancer risk: a case\u2013control study nested within the Carotene and Retinol Efficacy Trial","volume":"12","author":"Chen","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/tcm.1770050404","article-title":"Reproductive effects of herbicide exposure in Vietnam: recent studies by the Vietnamese and others","volume":"5","author":"Constable","year":"1985","journal-title":"Teratog. Carconog. Mutagen."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0040","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.urology.2010.01.086","article-title":"Sex hormones and the risk of incident prostate cancer","volume":"76","author":"Daniels","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0045","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/sj.bjc.6690445","article-title":"Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies","volume":"80","author":"Eaton","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0050","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0039-128X(92)90032-5","article-title":"Racial\/ethnic variations in male testosterone levels: a probable contributor to group differences in health","volume":"57","author":"Ellis","year":"1999","journal-title":"Steroids"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0055","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/oxfordjournals.aje.a009519","article-title":"Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men","volume":"147","author":"Ferrini","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0060","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/jnci\/88.16.1118","article-title":"Prospective study of sex steroid hormone levels and risk of prostate cancer","volume":"88","author":"Gann","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<312::AID-CNCR15>3.0.CO;2-7","article-title":"Serum testosterone and sex hormone-binding globulin concentrations and the risk of prostate carcinoma: a longitudinal study","volume":"86","author":"Heikkila","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0075","first-page":"293","article-title":"Studies on prostatic cancer: I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate","volume":"1","author":"Huggins","year":"1941","journal-title":"Cancer Res."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0080","series-title":"Veterans and Agent Orange: Update 1998","volume":"1999","author":"Institute of medicine","year":"1998"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0085","series-title":"Veterans and Agent Orange: Update 2008","volume":"2009","author":"Institute of medicine","year":"2008"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/EJE-13-0410","article-title":"High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women","volume":"170","author":"Kido","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0095","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.scitotenv.2016.01.025","article-title":"Inverse association of highly chlorinated dioxin congeners in maternal breast milk with dehydroepiandrosterone levels in three-year-old Vietnamese children","volume":"550","author":"Kido","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0100","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/toxsci\/kfi105","article-title":"PCB126 induces differential changes in androgen, cortisol, and aldosterone biosynthesis in human adrenocortical H295R cells","volume":"85","author":"Li","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0105","doi-asserted-by":"crossref","first-page":"E121","DOI":"10.1210\/jc.2009-1911","article-title":"A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the national cancer institute breast and prostate cancer cohort consortium","volume":"95","author":"Lindstrom","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0110","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1021\/es404853h","article-title":"Serum levels in Vietnamese men more than 40 years after herbicide spraying","volume":"48","author":"Manh","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0115","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.scitotenv.2014.12.083","article-title":"Levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam","volume":"511","author":"Manh","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0960-0760(90)90480-9","article-title":"The significance of steroid metabolism in human cancer","volume":"37","author":"Miller","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0125","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.steroids.2008.05.010","article-title":"Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth","volume":"73","author":"Moreira","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0130","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.eururo.2012.05.025","article-title":"Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the reduction by dutasteride of prostate cancer events trial","volume":"62","author":"Muller","year":"2012","journal-title":"Eur. Urol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0135","first-page":"216","article-title":"Androgen replacement therapy in the aging male","volume":"5","author":"Myers","year":"2003","journal-title":"Rev. Urol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0140","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/1055-9965.EPI-04-0715","article-title":"Serum testosterone and the risk of prostate cancer: potential implications for testosterone therpy","volume":"14","author":"Parsons","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0145","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.drudis.2011.12.012","article-title":"Abiraterone acetate: redefining hormone treatment for advanced prostate cancer","volume":"17","author":"Pezaro","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0150","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/0045-6535(91)90037-E","article-title":"Dioxin dibenzofurans and selected chlorinated organic compounds in human milk and blood from Cambodia, Germany, Thailand, the USA, the USSR and Vietnam","volume":"23","author":"Schecter","year":"1991","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0155","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ijc.11572","article-title":"High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study","volume":"108","author":"Stattin","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0160","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature01537","article-title":"The extent and patterns of usage of Agent Orange and other herbicides in Vietnam","volume":"422","author":"Stellman","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3109\/1354750X.2014.899626","article-title":"Relationship between dioxin and steroid hormones in sera of Vietnamese men","volume":"19","author":"Sun","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0170","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1007\/s11356-015-5931-3","article-title":"Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men","volume":"23","author":"Sun","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0013-9351(05)80238-5","article-title":"Chronic liver injury in phenoxy herbicide-exposed Vietnam veterans","volume":"59","author":"Tamburro","year":"1992","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jsbmb.2010.11.005","article-title":"CYP17 inhibitors for prostate cancer therapy","volume":"125","author":"Vasaitis","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0185","series-title":"Dioxins and Their Effects on Human Health","author":"WHO","year":"2010"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00001648-199501000-00005","article-title":"Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand","volume":"6","author":"Wolfe","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0195","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.steroids.2009.06.007","article-title":"Development of highly sensitive quantification method for testosterone and dihydrotestosterone in human serum and prostate tissue by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"74","author":"Yamashita","year":"2009","journal-title":"Steroids"},{"key":"10.1016\/j.scitotenv.2017.04.013_bb0200","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1002\/cncr.28961","article-title":"Agent Orange exposure and cancer incidence in Korean Vietnam veterans: a prospective cohort study","volume":"120","author":"Yi","year":"2014","journal-title":"Cancer"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969717308409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969717308409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T13:59:27Z","timestamp":1535896767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969717308409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":40,"alternative-id":["S0048969717308409"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2017.04.013","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in Vietnamese men","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2017.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}