{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:18:56Z","timestamp":1782548336746,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41401583"],"award-info":[{"award-number":["41401583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81511130088"],"award-info":[{"award-number":["81511130088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373014"],"award-info":[{"award-number":["81373014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.scitotenv.2017.07.160","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T16:46:30Z","timestamp":1501260390000},"page":"694-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Are concentrations of alkaline earth elements in maternal hair associated with risk of neural tube defects?"],"prefix":"10.1016","volume":"609","author":[{"given":"Zhenjiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2017.07.160_bb0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00001648-200201000-00021","article-title":"Folic acid alone prevents neural tube defects: evidence from the China study","volume":"13","author":"Berry","year":"2002","journal-title":"Epidemiology"},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jech.35.2.102","article-title":"The incidence of anencephalus in the Fylde peninsula 1956-76 and changes in water hardness","volume":"35","author":"Bound","year":"1981","journal-title":"J. Epidemiol. Community Health"},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0015","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/adc.76.2.107","article-title":"Involvement of deprivation and environmental lead in neural tube defects: a matched case-control study","volume":"76","author":"Bound","year":"1997","journal-title":"Arch. Dis. Child."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0306-9877(02)00402-4","article-title":"Diet quality and risk of neural tube defects","volume":"60","author":"Carmichael","year":"2003","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0025","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.etap.2005.03.004","article-title":"Inter-element interactions in human hair","volume":"20","author":"Chojnacka","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3109\/14767058.2014.999037","article-title":"Maternal serum vitamin D levels in pregnancies complicated by neural tube defects","volume":"29","author":"Daglar","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"7","key":"10.1016\/j.scitotenv.2017.07.160_bb0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2007-993887","article-title":"Amniotic fluid B12, calcium, and lead levels associated with neural tube defects","volume":"16","author":"Dawson","year":"1999","journal-title":"Am. J. Perinatol."},{"issue":"5","key":"10.1016\/j.scitotenv.2017.07.160_bb0040","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/oxfordjournals.aje.a112405","article-title":"Anencephalus and drinking water composition","volume":"105","author":"Elwood","year":"1977","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0045","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/dbio.1993.1253","article-title":"Calcium regulation of neural fold formation: visualization of the actin cytoskeleton in living chick embryos","volume":"159","author":"Ferreira","year":"1993","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/hr.2009.221","article-title":"Differences in metal and metalloid content in the hair of normo- and hypertensive postmenopausal women","volume":"33","author":"Gonzalez-Munoz","year":"2010","journal-title":"Hypertens. Res."},{"issue":"6","key":"10.1016\/j.scitotenv.2017.07.160_bb0055","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/jn\/134.6.1516","article-title":"Low maternal dietary intakes of iron, magnesium, and niacin are associated with spina bifida in the offspring","volume":"134","author":"Groenen","year":"2004","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1090-0233(02)00310-6","article-title":"The role of essential trace elements in embryonic and fetal development in livestock","volume":"166","author":"Hostetler","year":"2003","journal-title":"Vet. J."},{"key":"10.1016\/j.scitotenv.2017.07.160_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10967-011-1174-z","article-title":"Relationship between the level of essential metal elements in human hair and coronary heart disease","volume":"290","author":"Hsieh","year":"2011","journal-title":"J. Radioanal. Nucl. Chem."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0070","first-page":"94","article-title":"Effect of exposure to trace elements in the soil on the prevalence of neural tube defects in a high-risk area of China","volume":"24","author":"Huang","year":"2011","journal-title":"Biomed. Environ. Sci."},{"issue":"9","key":"10.1016\/j.scitotenv.2017.07.160_bb0075","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/jn\/106.9.1254","article-title":"Teratogenic effects of magnesium deficiency in rats","volume":"106","author":"Hurley","year":"1976","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.scitotenv.2017.07.160_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066681","article-title":"Comparison of barium and arsenic concentrations in well drinking water and in human body samples and a novel remediation system for these elements in well drinking water","volume":"8","author":"Kato","year":"2013","journal-title":"PLoS One"},{"issue":"6255","key":"10.1016\/j.scitotenv.2017.07.160_bb0085","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1136\/bmj.281.6255.1592","article-title":"Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling","volume":"281","author":"Laurence","year":"1980","journal-title":"Br. Med. J."},{"issue":"9","key":"10.1016\/j.scitotenv.2017.07.160_bb0090","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1007\/BF01951721","article-title":"Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick","volume":"41","author":"Lee","year":"1985","journal-title":"Experientia"},{"issue":"1","key":"10.1016\/j.scitotenv.2017.07.160_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-3016.2006.00694.x","article-title":"A population-based case-control study of risk factors for neural tube defects in four high-prevalence areas of Shanxi province, China","volume":"20","author":"Li","year":"2006","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"4","key":"10.1016\/j.scitotenv.2017.07.160_bb0100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/aje\/kwr108","article-title":"Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China","volume":"174","author":"Li","year":"2011","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb0105","doi-asserted-by":"crossref","first-page":"756S","DOI":"10.1093\/jn\/126.suppl_3.756S","article-title":"Homocysteine and neural tube defects","volume":"126","author":"Mills","year":"1996","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb0110","first-page":"463","article-title":"Distribution of potassium, calcium, magnesium, and sodium levels in biological samples of Pakistani hypertensive patients and control subjects","volume":"60","author":"Panhwar","year":"2014","journal-title":"Clin. Lab."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2017.07.160_bb0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.scitotenv.2004.01.017","article-title":"Scalp hair analysis as a tool in assessing human exposure to heavy metals (S. Domingos mine, Portugal)","volume":"327","author":"Pereira","year":"2004","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.scitotenv.2017.07.160_bb0120","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1471-0528.1979.tb10826.x","article-title":"The composition of amniotic fluid in pregnancies complicated by fetal anencephaly or spina bifida","volume":"86","author":"Pettit","year":"1979","journal-title":"Br. J. Obstet. Gynaecol."},{"issue":"6","key":"10.1016\/j.scitotenv.2017.07.160_bb0125","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00001648-199911000-00011","article-title":"Periconceptional nutrient intake and risk for neural tube defect-affected pregnancies","volume":"10","author":"Shaw","year":"1999","journal-title":"Epidemiology"},{"issue":"6","key":"10.1016\/j.scitotenv.2017.07.160_bb0130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02723245","article-title":"Association between lower hair zinc levels and neural tube defects","volume":"68","author":"Srinivas","year":"2001","journal-title":"Indian J. Pediatr."},{"issue":"1","key":"10.1016\/j.scitotenv.2017.07.160_bb0135","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0890-6238(98)00058-6","article-title":"Maternal trace elements, vitamin B12, vitamin A, folic acid, and fetal malformations","volume":"13","author":"Stoll","year":"1999","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12011-010-8650-0","article-title":"Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance","volume":"139","author":"Suliburska","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2017.07.160_bb0145","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/sj.ejcn.1601795","article-title":"Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women","volume":"58","author":"Tapola","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"issue":"6123","key":"10.1016\/j.scitotenv.2017.07.160_bb0150","doi-asserted-by":"crossref","first-page":"1222002","DOI":"10.1126\/science.1222002","article-title":"The continuing challenge of understanding, preventing, and treating neural tube defects","volume":"339","author":"Wallingford","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2017.07.160_bb0155","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.envpol.2009.03.010","article-title":"Use of scalp hair as indicator of human exposure to heavy metals in an electronic waste recycling area","volume":"157","author":"Wang","year":"2009","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.scitotenv.2017.07.160_bb0160","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/EDE.0000000000000129","article-title":"Indoor air pollution and neural tube defects: effect modification by maternal genes","volume":"25","author":"Wang","year":"2014","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.scitotenv.2017.07.160_bb0165","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/es503990v","article-title":"Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2017.07.160_bb0170","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrm1149","article-title":"Calcium signalling during embryonic development","volume":"4","author":"Webb","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2017.07.160_bb0175","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12011-013-9840-3","article-title":"Are metals accumulated in human hair affected by naturally occurring asbestos fiber contamination? A case study from a rural area of China","volume":"156","author":"Wei","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2017.07.160_bb0180","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ije\/19.4.978","article-title":"Central nervous system congenital malformations, especially neural tube defects in 29 provinces, metropolitan cities and autonomous regions of China: Chinese birth defects monitoring program","volume":"19","author":"Xiao","year":"1990","journal-title":"Int. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb9100","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/bdra.23594","article-title":"Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring","volume":"109","author":"Yan","year":"2016","journal-title":"Birth Defects Res. A"},{"issue":"1","key":"10.1016\/j.scitotenv.2017.07.160_bb0185","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00381-010-1198-7","article-title":"A population-based case-control study of risk factors for neural tube defects in Shenyang, China","volume":"27","author":"Yin","year":"2011","journal-title":"Childs Nerv. Syst."},{"issue":"3","key":"10.1016\/j.scitotenv.2017.07.160_bb0190","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.scitotenv.2010.10.019","article-title":"Links between environmental geochemistry and rate of birth defects: Shanxi Province, China","volume":"409","author":"Yu","year":"2011","journal-title":"Sci. Total Environ."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969717318636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969717318636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T19:20:20Z","timestamp":1758655220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969717318636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":39,"alternative-id":["S0048969717318636"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2017.07.160","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are concentrations of alkaline earth elements in maternal hair associated with risk of neural tube defects?","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2017.07.160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}