{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:30:11Z","timestamp":1769304611336,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573118"],"award-info":[{"award-number":["81573118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673118"],"award-info":[{"award-number":["81673118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University Health Science Center"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.scitotenv.2018.11.074","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T12:00:53Z","timestamp":1541678453000},"page":"622-632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["LncRNA expression profiling and its relationship with DNA damage in Cr(VI)-treated 16HBE cells"],"prefix":"10.1016","volume":"655","author":[{"given":"Guiping","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changmao","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiancheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2018.11.074_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpc.2018.04.003","article-title":"Physical principles and new applications of comet assay","volume":"238","author":"Afanasieva","year":"2018","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0010","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm2694","article-title":"RNA granules: post-transcriptional and epigenetic modulators of gene expression","volume":"10","author":"Anderson","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0015","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.2337\/dc06-0996","article-title":"Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials","volume":"30","author":"Balk","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0020","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.freeradbiomed.2006.10.055","article-title":"Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide","volume":"42","author":"Borthiry","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0025","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.tig.2018.06.002","article-title":"Strategies to annotate and characterize long noncoding RNAs: advantages and pitfalls","volume":"34","author":"Cao","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0030","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41419-018-0575-0","article-title":"Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.scitotenv.2017.09.230","article-title":"Heavy metals in food crops, soil, and water in the Lihe River Watershed of the Taihu Region and their potential health risks when ingested","volume":"615","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0040","first-page":"188","article-title":"Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis","volume":"28","author":"Chiu","year":"2010","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/A:1015975218920","article-title":"Molecular mechanisms of Cr(VI)-induced carcinogenesis","volume":"234-235","author":"Ding","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10565-007-9029-7","article-title":"Oxidative stress as a component of chromium-induced cytotoxicity in rat calvarial osteoblasts","volume":"24","author":"Fu","year":"2008","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.toxlet.2016.10.015","article-title":"Gene expression profiling and bioinformatics analysis in 16HBE cells treated by chromium (VI)","volume":"264","author":"Hu","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxlet.2017.05.026","article-title":"Serum protein expression profiling and bioinformatics analysis in workers occupationally exposed to chromium (VI)","volume":"277","author":"Hu","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0065","first-page":"1","article-title":"Imbalance of oxidative and reductive species involved in chromium(VI)-induced toxic effects","volume":"7","author":"Hu","year":"2017","journal-title":"React. Oxygen Species"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0070","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.envpol.2018.03.046","article-title":"Cr(VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells","volume":"238","author":"Hu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0075","first-page":"1","article-title":"Chromium, nickel and welding","volume":"49","author":"IARC","year":"1990","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/mutage\/gex002","article-title":"The next three decades of the comet assay: a report of the 11th international comet assay workshop","volume":"32","author":"Koppen","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0085","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-005979","article-title":"Assessing the suitability of 8-OHdG and micronuclei as genotoxic biomarkers in chromate-exposed workers: a cross-sectional study","volume":"4","author":"Li","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2016.02.003","article-title":"miR-3940-5p enhances homologous recombination after DSB in Cr(VI) exposed 16HBE cell","volume":"344\u2013346","author":"Li","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0095","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.freeradbiomed.2012.03.013","article-title":"The effects of chromium(VI) on the thioredoxin system: implications for redox regulation","volume":"52","author":"Myers","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0100","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1002\/cncr.21870","article-title":"The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance","volume":"106","author":"Nakata","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/toxsci\/kfx203","article-title":"Editor's highlight: lncRNAL20992 regulates apoptotic proteins to promote lead-induced neuronal apoptosis","volume":"161","author":"Nan","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0110","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.scitotenv.2013.11.032","article-title":"Associations of neonatal lead, cadmium, chromium and nickel co-exposure with DNA oxidative damage in an electronic waste recycling town","volume":"472","author":"Ni","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0115","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.0272-4332.2004.00512.x","article-title":"Hexavalent chromium and lung cancer in the chromate industry: a quantitative risk assessment","volume":"24","author":"Park","year":"2004","journal-title":"Risk Anal."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0120","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1158\/0008-5472.CAN-13-3159","article-title":"PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer","volume":"74","author":"Prensner","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0125","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.tcb.2014.08.009","article-title":"Long noncoding RNAs: an emerging link between gene regulation and nuclear organization","volume":"24","author":"Quinodoz","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0130","series-title":"Epidemiology: an Introduction","author":"Rothman","year":"2012"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0135","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.15252\/embr.201540437","article-title":"A BRCA1-interacting lncRNA regulates homologous recombination","volume":"16","author":"Sharma","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0140","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/nar\/gkx1224","article-title":"LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA","volume":"46","author":"Shen","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 3","key":"10.1016\/j.scitotenv.2018.11.074_bb0145","first-page":"231","article-title":"Generation of hydroxyl radical by chromate in biologically relevant systems: role of Cr(V) complexes versus tetraperoxochromate(V)","volume":"102","author":"Shi","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0150","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ajhg.2014.01.007","article-title":"ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function","volume":"94","author":"Tummala","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0155","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0160","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.cellsig.2013.02.006","article-title":"Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway","volume":"25","author":"Wan","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0165","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.toxlet.2010.06.024","article-title":"Hexavalent chromium induced ROS formation, Akt, NF-kappaB, and MAPK activation, and TNF-alpha and IL-1alpha production in keratinocytes","volume":"198","author":"Wang","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0170","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/15384047.2018.1449610","article-title":"LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3\/INO80 pathway","volume":"19","author":"Wang","year":"2018","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0175","series-title":"Toxicological Profile for Chromium","author":"Wilbur","year":"2012"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1515\/REVEH.2008.23.1.39","article-title":"Hexavalent chromium-induced DNA damage and repair mechanisms","volume":"23","author":"Wise","year":"2008","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.taap.2008.10.010","article-title":"Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells","volume":"234","author":"Xie","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1289\/EHP21","article-title":"Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium","volume":"125","author":"Xie","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2458-11-224","article-title":"Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers","volume":"11","author":"Zhang","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.scitotenv.2018.11.074_bb0200","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nsmb.3211","article-title":"Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer","volume":"23","author":"Zhang","year":"2016","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969718344267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969718344267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:08:17Z","timestamp":1758701297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969718344267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":40,"alternative-id":["S0048969718344267"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2018.11.074","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA expression profiling and its relationship with DNA damage in Cr(VI)-treated 16HBE cells","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2018.11.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}