{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:30:04Z","timestamp":1790731804708,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"am","delay-in-days":288,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000203","name":"U.S. Geological Survey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008638","name":"Environment and Climate Change Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.scitotenv.2018.11.485","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T02:26:13Z","timestamp":1543803973000},"page":"1205-1216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Use of blood clotting assays to assess potential anticoagulant rodenticide exposure and effects in free-ranging birds of prey"],"prefix":"10.1016","volume":"657","author":[{"given":"Sofi","family":"Hindmarch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnett A.","family":"Rattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2018.11.485_bb0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00244-009-9402-z","article-title":"Anticoagulant rodenticides in three owl species from Western Canada, 1988-2003","volume":"58","author":"Albert","year":"2010","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000137881","article-title":"Dispositional and pharmacodynamics characteristics of brodifacoum in warfarin-sensitive rats","volume":"27","author":"Bachman","year":"1983","journal-title":"Pharmacology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0015","article-title":"Assessing Anticoagulant Resistance in Rats and Coagulation Effects in Birds Using Small-Volume Blood Samples","volume":"249","author":"Bailey","year":"2005"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0020","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"319","article-title":"Anticoagulants and risk mitigation","author":"Buckle","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0025","series-title":"Canadian Wildlife Service Occasional Paper Number 65","first-page":"73","article-title":"The birds of the Fraser River Delta: Populations, ecology, and international significance","author":"Butler","year":"1987"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0030","series-title":"Clinical and Laboratory Standards Institute's (CLSI) newly revised document Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline\u2014 Third Edition (EP28-A3)","author":"CLSI","year":"2010"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0035","series-title":"Rodent Control: A Practical Guide for Pest Management Professionals","author":"Corrigan","year":"2001"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0040","series-title":"Island Press","first-page":"199","article-title":"Raptor mortality in urban landscapes","author":"Dwyer","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0045","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/jwmg.233","article-title":"Density-dependence in the survival and reproduciton of bald eagles: linkages to chum salmon","volume":"75","author":"Elliott","year":"2011","journal-title":"J. Wildl. Manag."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0050","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/biosci\/biw028","article-title":"Paying the pipers: mitigating the impact of anticoagulant rodenticides on predators and scavengers","volume":"66","author":"Elliott","year":"2016","journal-title":"Bioscience"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0055","series-title":"Guidelines to the Use of Wild Birds in Research","first-page":"215","author":"Fair","year":"2010"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0060","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1182\/blood.V93.6.1798.406k22_1798_1808","article-title":"Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid","volume":"93","author":"Furie","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040163","article-title":"Anticoagulant rodenticides on our public and community lands: spatial distribution of exposure and poisoning of a rare forest carnivore","volume":"7","author":"Gabriel","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3356\/jrr-14-00012.1","article-title":"When owls go to town: the diet of urban barred owls","volume":"49","author":"Hindmarch","year":"2015","journal-title":"J. Raptor Res."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0075","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10646-016-1662-6","article-title":"Increased rodenticide exposure rate and risk of toxicosis in barn owls (Tyto alba) from southwestern Canada and linkage with demographic but not genetic factors","volume":"25","author":"Huang","year":"2016","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0080","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"11","article-title":"Use of anticoagulant rodenticides in different applications around the world","author":"Jacob","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0085","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"159","article-title":"Secondary exposure of anticoagulant rodenticides and effects in predators","author":"L\u00f3pez-Perea","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0090","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ajcp\/43.5.475","article-title":"The fibrometer system for routine coagulation tests","volume":"43","author":"Miale","year":"1965","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1647\/2001-045","article-title":"Estimation of prothrombin times of Hispaniolan amazon parrots (Amazona ventralis) and umbrella cockatoos (Cacatua alba)","volume":"17","author":"Morrisey","year":"2003","journal-title":"J. Avian Med. Surg."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0100","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1476-5381.1991.tb12463.x","article-title":"The long-term effects of rodenticide, brodifacoum, on coagulation and vitamin K metabolism in rats","volume":"535","author":"Mosterd","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0105","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.2460\/ajvr.1983.44.11.2009","article-title":"Mechanism of diphacinone rodenticide toxicosis in the dog and its therapeutic implications","author":"Mount","year":"1983","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1638\/2010-0188.1","article-title":"Anticoagulant rodenticide exposure and toxicosis in four species of birds of prey presented to a wildlife clinic in Massachusetts, 2006\u20132010","volume":"42","author":"Murray","year":"2011","journal-title":"J. Zoo Wildl. Med."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0115","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s10646-017-1832-1","article-title":"Anticoagulant rodenticide exposure and toxicosis in four species of birds of prey in Massachusetts, USA, 2012\u20132016, in relation to use of rodenticides by pest management professionals","volume":"26","author":"Murray","year":"2017","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0120","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"109","article-title":"Ante-mortem and post-mortem signs of anticoagulant rodenticide toxicosis in birds of prey","author":"Murray","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1647\/2007-012R.1","article-title":"Diagnosis and treatment of secondary anticoagulant rodenticide toxicosis in a red-tailed hawk (Buteo jamaicensis)","volume":"22","author":"Murray","year":"2008","journal-title":"J. Avian Med. Surg."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0130","series-title":"How to Define and Determine Reference Intervals in the Clinical Laboratory; Approved Guideline","author":"NCCLS","year":"2000"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0135","series-title":"Wildlife and Pollution: 1997\/98 Annual Report","author":"Newton","year":"1999"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0140","series-title":"Advances in Vertebrate Pest Management","first-page":"347","article-title":"Empirical evidence of side-effects of rodenticides on some predatory birds and mammals","author":"Newton","year":"1999"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0145","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"45","article-title":"Anticoagulant rodenticide toxicity to non-target wildlife under controlled exposure conditions","author":"Rattner","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0150","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ecoenv.2010.05.021","article-title":"Acute toxicity of diphacinone in northern bobwhite: effects on survival and blood clotting","volume":"73","author":"Rattner","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0155","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/etc.490","article-title":"Acute toxicity, histopathology, and coagulopathy in American kestrels (Falco sparverius) following administration of the rodenticide diphacinone","volume":"30","author":"Rattner","year":"2011","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0160","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s10646-011-0844-5","article-title":"Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using eastern screech-owls (Megascops asio)","volume":"21","author":"Rattner","year":"2012","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0165","series-title":"Proceeding 25th Vertebr Pest Conf","first-page":"124","article-title":"Comparative risk assessment of the first-generation anticoagulant rodenticide diphacinone to raptors","author":"Rattner","year":"2012"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0170","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1021\/es501740n","article-title":"Adverse outcome pathway and risks of anticoagulant rodenticides to predatory wildlife","volume":"48","author":"Rattner","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/etc.2390","article-title":"Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in eastern screech-owls (Megascops asio)","volume":"33","author":"Rattner","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0180","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s10646-015-1418-8","article-title":"Toxicity reference values for chlorophacinone and their application for assessing anticoagulant rodenticide risk to raptors","volume":"24","author":"Rattner","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0185","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cvex.2007.12.004","article-title":"Raptor toxicology","volume":"11","author":"Redig","year":"2008","journal-title":"Vet. Clin. Exot. Anim. Pract."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0190","series-title":"Veterinary and Clinical Treatment of Vertebrate Pesticide Poisoning \u2013 A Technical Review","author":"Shlosberg","year":"2006"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0195","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tvjl.2012.06.006","article-title":"Bruising encounters in veterinary forensics","volume":"194","author":"Stroud","year":"2012","journal-title":"Vet. J."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0200","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0021-9975(77)90034-2","article-title":"Blood coagulation studies in some wild Indian birds: effects of different tissue thromboplastins","volume":"87","author":"Tahira","year":"1977","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0205","author":"The University of Minnesota"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0210","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.envint.2011.03.010","article-title":"Second generation anticoagulant rodenticides in predatory birds: probabilistic characterisation of toxic liver concentrations and implications for predatory bird populations in Canada","volume":"37","author":"Thomas","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0215","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2885.2008.00979.x","article-title":"Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration","volume":"31","author":"Vandenbroucke","year":"2008","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0220","author":"Walker"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0225","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10646-015-1449-1","article-title":"Assessment of toxicity and coagulopathy of brodifacoum in Japanese quail and testing in wild owls","volume":"24","author":"Webster","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0230","series-title":"Anticoagulant Rodenticides and Wildlife","first-page":"357","article-title":"Perspectives on existing and potential new alternatives to anticoagulant rodenticides and the implications for intergrated pest management","author":"Witmer","year":"2018"},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0235","article-title":"Effects of preanalytical frozen storage time and temperature on screening coagulation tests and factors VIII and IX activity","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2018.11.485_bb0240","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ajcp\/24.1.39","article-title":"Some effects of disodium ethylenediamine tetraacetate on blood coagulation","volume":"24","author":"Zucker","year":"1954","journal-title":"Am. J. Clin. Pathol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971834840X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971834840X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:16:18Z","timestamp":1758701778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896971834840X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"alternative-id":["S004896971834840X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2018.11.485","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of blood clotting assays to assess potential anticoagulant rodenticide exposure and effects in free-ranging birds of prey","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2018.11.485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}