{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:48:46Z","timestamp":1790772526756,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.scitotenv.2019.04.208","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T11:27:45Z","timestamp":1555414065000},"page":"72-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["PFOA and PFOS promote diabetic renal injury in vitro by impairing the metabolisms of amino acids and purines"],"prefix":"10.1016","volume":"676","author":[{"given":"Xun","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-7224","authenticated-orcid":false,"given":"Arthur C.K.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8724-7684","authenticated-orcid":false,"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/00365510903359229","article-title":"Effects of some modulators on purine nucleoside phosphorylase activity in myocardial tissue","volume":"70","author":"\u00c5berg","year":"2009","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2017.04.029","article-title":"GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells","volume":"400","author":"Abrego","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0015","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.2337\/diacare.27.2007.S79","article-title":"Nephropathy in diabetes","volume":"27","author":"Association AD","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0020","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/01.RES.86.9.960","article-title":"Hydrogen peroxide\u2013 and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells","volume":"86","author":"Ballinger","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0025","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant","author":"Barry","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0030","series-title":"Adenosine Deaminase-Deficient Mice Generated Using a Two-Stage Genetic Engineering Strategy Exhibit a Combined Immunodeficiency","author":"Blackburn","year":"1998"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0035","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2017030253","article-title":"Particulate matter air pollution and the risk of incident CKD and progression to ESRD","volume":"29","author":"Bowe","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/BJ20100308","article-title":"Prevention of diabetic nephropathy in Ins2+\/\u2212AkitaJmice by the mitochondria-targeted therapy MitoQ","volume":"432","author":"Chacko Balu","year":"2010","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0045","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1152\/ajprenal.00487.2009","article-title":"In vivo renal arginine release is impaired throughout development of chronic kidney disease","volume":"298","author":"Chen","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"23","key":"10.1016\/j.scitotenv.2019.04.208_bb0050","doi-asserted-by":"crossref","first-page":"13817","DOI":"10.1021\/acs.est.5b00488","article-title":"In vivo and in vitro isomer-specific biotransformation of perfluorooctane sulfonamide in common carp (Cyprinus carpio)","volume":"49","author":"Chen","year":"2015","journal-title":"Environmental Science & Technology"},{"issue":"10","key":"10.1016\/j.scitotenv.2019.04.208_bb0055","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/134.10.2801S","article-title":"Role of L-arginine in the pathogenesis and treatment of renal disease","volume":"134","author":"Cherla","year":"2004","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.scitotenv.2019.04.208_bb0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10934529.2016.1253402","article-title":"Perfluorooctanoic acid induces mitochondrial dysfunction in MC3T3-E1 osteoblast cells","volume":"52","author":"Choi","year":"2016","journal-title":"J. Environ. Sci. Health A"},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb0065","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/jdi.12707","article-title":"Tryptophan as a surrogate prognostic marker for diabetic nephropathy","volume":"9","author":"Chou","year":"2018","journal-title":"J Diabetes Investig"},{"issue":"5","key":"10.1016\/j.scitotenv.2019.04.208_bb0070","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1681\/ASN.2010080890","article-title":"A2B adenosine receptor-mediated induction of IL-6 promotes CKD","volume":"22","author":"Dai","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.scitotenv.2019.04.208_bb0075","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1096\/fj.03-0839rev","article-title":"Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy","volume":"18","author":"Danesh","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0080","doi-asserted-by":"crossref","DOI":"10.1177\/1178646917694600","article-title":"Tryptophan metabolism in patients with chronic kidney disease secondary to type 2 diabetes: relationship to inflammatory markers","volume":"10","author":"Debnath","year":"2017","journal-title":"Int J Tryptophan Res."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0085","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1021\/pr9000256","article-title":"Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies","volume":"8","author":"Ding","year":"2009","journal-title":"J. Proteome Res."},{"issue":"8","key":"10.1016\/j.scitotenv.2019.04.208_bb0090","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncpendmet0894","article-title":"The pathogenesis of diabetic nephropathy","volume":"4","author":"Dronavalli","year":"2008","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"issue":"11_suppl_1","key":"10.1016\/j.scitotenv.2019.04.208_bb0095","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/01.STR.0000143319.73503.38","article-title":"Effects of statins on endothelium and signaling mechanisms","volume":"35","author":"Endres","year":"2004","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/j.ajkd.2004.08.040","article-title":"Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function","volume":"45","author":"Epstein","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/928197","article-title":"Pathogenesis and novel treatment from the mouse model of type 2 diabetic nephropathy","volume":"2013","author":"Furukawa","year":"2013","journal-title":"Sci. World J."},{"issue":"4","key":"10.1016\/j.scitotenv.2019.04.208_bb0110","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clnu.2010.02.005","article-title":"Amino acid and protein metabolism in the human kidney and in patients with chronic kidney disease","volume":"29","author":"Garibotto","year":"2010","journal-title":"Clin. Nutr."},{"issue":"11","key":"10.1016\/j.scitotenv.2019.04.208_bb0115","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/aje\/kws392","article-title":"Positive association between perfluoroalkyl chemicals and hyperuricemia in children","volume":"177","author":"Geiger","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"16","key":"10.1016\/j.scitotenv.2019.04.208_bb0120","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1021\/es301168c","article-title":"Perfluorinated alkyl acids in blood serum from primiparous women in Sweden: serial sampling during pregnancy and nursing, and temporal trends 1996\u20132010","volume":"46","author":"Glynn","year":"2012","journal-title":"Environmental Science & Technology"},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ndt\/gfi210","article-title":"Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes","volume":"21","author":"Gu","year":"2006","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0130","series-title":"Argininosuccinate Synthase at the Center of Arginine Metabolism","author":"Haines","year":"2011"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3181\/0705-MR-134","article-title":"Diabetic nephropathy: mechanisms of renal disease progression","volume":"233","author":"Kanwar","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0140","series-title":"The Peroxisome Proliferator Activated Receltor a Reglulated Amino Acid Metabolism","author":"KERSTEN","year":"2018"},{"issue":"6","key":"10.1016\/j.scitotenv.2019.04.208_bb0145","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0272-6386(96)90388-1","article-title":"L-arginine metabolism in immune-mediated glomerulonephritis in the rat","volume":"28","author":"Ketteler","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0150","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.90735.2008","article-title":"Reactive oxygen species\/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice","volume":"297","author":"Kim","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6 Suppl 1","key":"10.1016\/j.scitotenv.2019.04.208_bb0155","article-title":"Phenylalanine and tyrosine metabolism in chronic kidney failure","volume":"137","author":"Kopple","year":"2007","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.scitotenv.2019.04.208_bb0160","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.semnephrol.2012.04.002","article-title":"TGF-beta\/Smad signaling in kidney disease","volume":"32","author":"Lan","year":"2012","journal-title":"Semin. Nephrol."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb0165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.taap.2003.11.031","article-title":"The developmental toxicity of perfluoroalkyl acids and their derivatives","volume":"198","author":"Lau","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb0170","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb0175","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0180","article-title":"Disease-syndrome combination modeling: metabolomic strategy for the pathogenesis of chronic kidney disease","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2019.04.208_bb0185","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jhazmat.2010.03.113","article-title":"Sensitivity of morphological change of Vero cells exposed to lipophilic compounds and its mechanism","volume":"179","author":"Liao","year":"2010","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.scitotenv.2019.04.208_bb0190","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1584\/jpestics.31.245","article-title":"Metabolomics methodoogies and applications in the environmental sciences","volume":"31","author":"LIN","year":"2006","journal-title":"J. Pestic. Sci."},{"issue":"19","key":"10.1016\/j.scitotenv.2019.04.208_bb0195","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: past, present, and future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0200","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.envpol.2016.04.089","article-title":"Toxicity of perfluorooctane sulfonate and perfluorooctanoic acid to Escherichia coli: membrane disruption, oxidative stress, and DNA damage induced cell inactivation and\/or death","volume":"214","author":"Liu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cbpa.2014.02.007","article-title":"Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals","volume":"171","author":"L\u00f3pez-Cruz","year":"2014","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0210","article-title":"Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway","author":"Mao","year":"2012","journal-title":"J. Appl. Toxicol."},{"issue":"9","key":"10.1016\/j.scitotenv.2019.04.208_bb0215","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00204-012-0822-6","article-title":"Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance","volume":"86","author":"Mariussen","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mehy.2017.12.016","article-title":"Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment","volume":"111","author":"Mazumder","year":"2018","journal-title":"Med. Hypotheses"},{"issue":"6","key":"10.1016\/j.scitotenv.2019.04.208_bb6025","doi-asserted-by":"crossref","first-page":"1602S","DOI":"10.1093\/jn\/137.6.1602S","article-title":"Arginine metabolism: boundaries of our knowledge","volume":"137","author":"Morris","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1289\/ehp.0901165","article-title":"Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population","volume":"118","author":"Nelson","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0230","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/msb4100095","article-title":"Global systems biology, personalized medicine and molecular epidemiology","volume":"2","author":"Nicholson","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0235","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.2337\/diabetes.52.10.2586","article-title":"Intercellular adhesion molecule 1 deficient mice are resistant against renal injury after induction of diabetes","volume":"52","author":"Okada","year":"2003","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.scitotenv.2019.04.208_bb0240","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.scitotenv.2019.04.208_bb0245","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1046\/j.1523-1755.2000.00927.x","article-title":"Tandem antifibrotic actions of L-arginine supplementation and low protein diet during the repair phase of experimental glomerulonephritis","volume":"57","author":"Peters","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb6000","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/15287391003689317","article-title":"Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability","volume":"73","author":"Qian","year":"2010","journal-title":"J. Toxicol. Env. Health"},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0250","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.watres.2013.10.045","article-title":"Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in drinking water treatment: a review","volume":"50","author":"Rahman","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0255","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2109.2009.02446.x","article-title":"Tyrosine and phenylalanine supplementation on Diplodus sarguslarvae: effect on growth and quality","author":"Saavedra","year":"2010","journal-title":"Aquac. Res."},{"issue":"10","key":"10.1016\/j.scitotenv.2019.04.208_bb0260","first-page":"635","article-title":"Glomerular changes in diabetes mellitus","volume":"30","author":"Schleicher","year":"1992","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0265","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxsci\/68.1.249","article-title":"Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys","volume":"68","author":"Seacat PJT","year":"2002","journal-title":"Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.scitotenv.2019.04.208_bb0270","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","article-title":"The podocyte's response to injury: role in proteinuria and glomerulosclerosis","volume":"69","author":"Shankland","year":"2006","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.04.208_bb6005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","journal-title":"Toxicol Sci."},{"issue":"4","key":"10.1016\/j.scitotenv.2019.04.208_bb0275","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1021\/es102769t","article-title":"Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia","volume":"45","author":"Shin","year":"2011","journal-title":"Environmental Science & Technology"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0280","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1568026023394498","article-title":"Metabonomic applications in toxicity screening and disease diagnosis","volume":"2","author":"Shockcor","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"issue":"7","key":"10.1016\/j.scitotenv.2019.04.208_bb0295","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/aje\/kwp212","article-title":"Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome","volume":"170","author":"Stein","year":"2009","journal-title":"Am. J. Epidemiol."},{"issue":"11","key":"10.1016\/j.scitotenv.2019.04.208_bb0300","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1681\/ASN.2006050420","article-title":"Renal fibroblasts and myofibroblasts in chronic kidney disease","volume":"17","author":"Strutz","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb6010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator\u2013activated receptors (a, b\/d, c) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol Sci."},{"issue":"21","key":"10.1016\/j.scitotenv.2019.04.208_bb0305","doi-asserted-by":"crossref","first-page":"12170","DOI":"10.1021\/es3027715","article-title":"Global liver proteome analysis using iTRAQ labeling quantitative proteomic technology to reveal biomarkers in mice exposed to perfluorooctane sulfonate (PFOS)","volume":"46","author":"Tan","year":"2012","journal-title":"Environmental Science & Technology"},{"issue":"8","key":"10.1016\/j.scitotenv.2019.04.208_bb0310","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1080\/0886022X.2016.1207054","article-title":"Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats","volume":"38","author":"Taskiran","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0315","series-title":"HMG-CoA Reductase Inhibitor Ameliorates Diabetic Nephropathy by Its Pleotropic Effects in Rats","author":"Usui","year":"2003"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.04.208_bb0320","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/pr500641b","article-title":"Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice","volume":"14","author":"Wang","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0325","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/pr7008059","article-title":"Proteomic analysis of hepatic protein profiles in rare minnow Gobiocypris rarus exposed to perfluorooctanoic acid","volume":"7","author":"Wei","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.scitotenv.2019.04.208_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2012.11.004","article-title":"Industrial source identification and emission estimation of perfluorooctane sulfonate in China","volume":"52","author":"Xie","year":"2013","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.scitotenv.2019.04.208_bb0335","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/pr500228d","article-title":"Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery","volume":"13","author":"Zhang","year":"2014","journal-title":"J. Proteome Res."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971931736X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896971931736X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:35:45Z","timestamp":1758702945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896971931736X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":69,"alternative-id":["S004896971931736X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.208","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PFOA and PFOS promote diabetic renal injury in vitro by impairing the metabolisms of amino acids and purines","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}