{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:22:04Z","timestamp":1787566924976,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.scitotenv.2019.133994","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T19:49:34Z","timestamp":1566244174000},"page":"133994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Perfluoroalkyl acids and thyroid hormones across stages of kidney function"],"prefix":"10.1016","volume":"696","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-7106","authenticated-orcid":false,"given":"Ram B.","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ducatman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2019.133994_bb0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envint.2016.10.015","article-title":"Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: a systematic review of epidemiologic studies","volume":"99","author":"Ballesteros","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/2230-8210.93737","article-title":"Interactions between thyroid disorders and kidney disease","volume":"16","author":"Basu","year":"2012","journal-title":"Ind. J. Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envint.2015.01.007","article-title":"Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach","volume":"77","author":"Berg","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0020","doi-asserted-by":"crossref","first-page":"A250","DOI":"10.1289\/ehp.115-a250","article-title":"Perfluoroalkyl acids: what is the evidence telling us?","volume":"115","author":"Betts","year":"2007","journal-title":"Environ. Health Prespect."},{"issue":"Pt A","key":"10.1016\/j.scitotenv.2019.133994_bb0025","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.envpol.2018.07.042","article-title":"Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort","volume":"242","author":"Blake","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0030","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1289\/ehp.9466","article-title":"Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in United States","volume":"114","author":"Blount","year":"2006","journal-title":"Environ. Health Perspect."},{"issue":"23","key":"10.1016\/j.scitotenv.2019.133994_bb0035","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1021\/acs.est.7b03969","article-title":"Treatment of aqueous film-forming foam by heat-activated persulfate under conditions representative of in situ chemical oxidation","volume":"51","author":"Bruton","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.scitotenv.2019.133994_bb0040","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0045","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.envres.2018.06.014","article-title":"Exposure to perfluoroalkyl substances and associations with serum thyroid hormones in a remote population of Alaska Natives","volume":"166","author":"Byrne","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.envint.2019.04.029","article-title":"Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in first nation children and youth from Quebec","volume":"128","author":"Caron-Beaudoin","year":"2019","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.133994_bb0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/0004563218797979","article-title":"Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes","volume":"56","author":"Das","year":"2019","journal-title":"Ann. Clin. Biochem."},{"issue":"Pt 5","key":"10.1016\/j.scitotenv.2019.133994_bb0060","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/000456328502200506","article-title":"The influence of age and sex on tests of thyroid function","volume":"22","author":"Franklyn","year":"1985","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.envint.2017.08.002","article-title":"Historical human exposure to perfluoroalkyl acids in the United States and Australia reconstructed from biomonitoring data using population-based pharmacokinetic modelling","volume":"108","author":"Gomis","year":"2017","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.scitotenv.2019.133994_bb0070","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/tx034005w","article-title":"Binding of perfluorooctanoic acid to rat and human plasma proteins","volume":"16","author":"Han","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0075","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","article-title":"KDOQI commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD","volume":"63","author":"Inker","year":"2014","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.133994_bb0080","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15386\/mpr-1091","article-title":"Evaluation of thyroid dysfunction in patients with nephrotic syndrome","volume":"92","author":"Jain","year":"2019","journal-title":"Med. Pharm. Rep."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envres.2013.08.006","article-title":"Association between thyroid profile and perfluoroalkyl acids: data from NHANES 2007-2008","volume":"126","author":"Jain","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0090","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.envres.2018.11.033","article-title":"Perfluoroalkyl substances follow inverted U-shaped distributions across various stages of glomerular function: implications for future research","volume":"169","author":"Jain","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0095","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1007\/s11356-019-04666-5","article-title":"Dynamics of associations between perfluoroalkyl substances and uric acid across the various stages of glomerular function","volume":"26","author":"Jain","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"5","key":"10.1016\/j.scitotenv.2019.133994_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197244","article-title":"Association between perfluoroalkyl substances exposure and thyroid function in adults: a meta-analysis","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.scitotenv.2019.133994_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207446","article-title":"Sex-specific genetic influence on thyroid-stimulating hormone and free thyroxine levels, and interactions between measurements: KNHANES 2013\u20132015","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2019.133994_bb0110","doi-asserted-by":"crossref","unstructured":"Levey AS, Stevens LA, Schmid CS, Zhang Y(L), Castro III AS, Feldman HI, Kusak JW, Eggers P, Van Lente F, Green T, Coresh J, MHS. A new equation to estimate glomerular filtration rate. Ann. Intern. Med.. 2009; 150:604\u2013612.","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"issue":"6","key":"10.1016\/j.scitotenv.2019.133994_bb0115","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.3390\/ijerph120606098","article-title":"Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012","volume":"12","author":"Lewis","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.scitotenv.2019.133994_bb0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"2018. Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup. Environ. Med."},{"issue":"4 Suppl 1","key":"10.1016\/j.scitotenv.2019.133994_bb0125","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1053\/ajkd.2001.27410","article-title":"Thyroid function in patients with chronic renal failure","volume":"38","author":"Lim","year":"2001","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.133994_bb0130","first-page":"60","article-title":"Low free triiodothyronine is associated with contrast-induced acute kidney injury and long-term outcome in elderly patients who underwent percutaneous coronary intervention","volume":"21","author":"Lin","year":"2019","journal-title":"Anatol. J. Cardiol."},{"issue":"7","key":"10.1016\/j.scitotenv.2019.133994_bb0135","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1289\/ehp.1104370","article-title":"Thyroid function and perfluoroalkyl acids in children living near a chemical plant","volume":"120","author":"Lopez-Espinosa","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0140","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired perfluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ Health Perspecs"},{"issue":"2","key":"10.1016\/j.scitotenv.2019.133994_bb0145","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000499201","article-title":"Relationships of chronic kidney disease and thyroid dysfunction in non-dialysis patients: a pilot study","volume":"44","author":"Pan","year":"2019","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0150","series-title":"Endotext [internet]","article-title":"Thyroid hormone serum transport proteins","author":"Refetoff","year":"2000"},{"issue":"5","key":"10.1016\/j.scitotenv.2019.133994_bb0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5414\/CN109008","article-title":"The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients","volume":"87","author":"Sanai","year":"2017","journal-title":"Clin. Nephrol."},{"issue":"4","key":"10.1016\/j.scitotenv.2019.133994_bb0160","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2105\/AJPH.81.4.505","article-title":"Report of an association between race and thyroid stimulating hormone level","volume":"81","author":"Schectman","year":"1991","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.scitotenv.2019.133994_bb0165","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.envint.2014.11.018","article-title":"Perfluoroalkyl substances and thyroid function in older adults","volume":"75","author":"Shrestha","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0170","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.chemosphere.2017.06.023","article-title":"Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes","volume":"184","author":"Siebenaler","year":"2017","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.scitotenv.2019.133994_bb0175","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/ijem.IJEM_475_17","article-title":"Correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease","volume":"22","author":"Srivastava","year":"2018","journal-title":"Indian J. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.scitotenv.2019.133994_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000497326","article-title":"Association of thyrotropin concentration with chronic kidney disease in a Japanese general population cohort","volume":"142","author":"Toda","year":"2019","journal-title":"Nephron"},{"key":"10.1016\/j.scitotenv.2019.133994_bb0185","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.envpol.2016.11.027","article-title":"Perfluoroalkyl substances and thyroid hormones in cord blood","volume":"222","author":"Tsai","year":"2017","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.scitotenv.2019.133994_bb0190","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1159\/000491069","article-title":"Association of thyroid function with the estimated glomerular filtration rate in a large Chinese euthyroid population","volume":"43","author":"Wang","year":"2018","journal-title":"Kidney Blood Press. Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.133994_bb0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1476-069X-12-76","article-title":"Association between perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study","volume":"12","author":"Wang","year":"2013","journal-title":"Environ. Health"},{"issue":"5","key":"10.1016\/j.scitotenv.2019.133994_bb0200","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1289\/ehp.1306925","article-title":"Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study","volume":"122","author":"Wang","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2019.133994_bb0205","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.envres.2014.06.012","article-title":"Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study","volume":"133","author":"Webster","year":"2014","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.scitotenv.2019.133994_bb0210","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1289\/ehp.1409589","article-title":"Cross-sectional associations of serum perfluoroalkyl acids and thyroid hormones in U.S. adults: variation according to TPOAb and iodine status (NHANES 2007\u20132008)","volume":"124","author":"Webster","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.scitotenv.2019.133994_bb0215","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0010-7824(02)00436-5","article-title":"Effect of four different oral contraceptives on various sex hormones and serum-binding globulins","volume":"67","author":"Wiegratz","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.scitotenv.2019.133994_bb0220","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1871530","article-title":"Relationship between thyroid function and kidney function in patients with type 2 diabetes","volume":"2018","author":"Zhang","year":"2018","journal-title":"Int. J. Endocrinol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969719339713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969719339713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:36:43Z","timestamp":1787560603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969719339713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":44,"alternative-id":["S0048969719339713"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.133994","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluoroalkyl acids and thyroid hormones across stages of kidney function","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.133994","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"133994"}}