{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:40:21Z","timestamp":1790800821014,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660726"],"award-info":[{"award-number":["31660726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972754"],"award-info":[{"award-number":["31972754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.scitotenv.2019.135915","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T02:24:38Z","timestamp":1575599078000},"page":"135915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Imidacloprid-induced liver fibrosis in quails via activation of the TGF-\u03b21\/Smad pathway"],"prefix":"10.1016","volume":"705","author":[{"given":"Yueying","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizheng","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangdong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-5850","authenticated-orcid":false,"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2019.135915_bb0005","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1089\/ars.2017.7064","article-title":"Role of platelet-derived transforming growth factor-\u03b21 and reactive oxygen species in radiation-induced organ fibrosis","volume":"27","author":"Ahamed","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0010","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.toxrep.2014.08.004","article-title":"Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice","volume":"1","author":"Arfat","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0015","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ecoenv.2018.06.046","article-title":"Luteolin-mediated PI3K\/AKT\/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury","volume":"161","author":"Baiyun","year":"2018","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-ento-120811-153645","article-title":"Neuroactive insecticides: targets, selectivity, resistance, and secondary effects","volume":"58","author":"Casida","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0025","first-page":"189","article-title":"Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells","volume":"11","author":"Chen","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0030","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1074\/jbc.M112.393363","article-title":"The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone","volume":"288","author":"Cho","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0035","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.jafc.9b00080","article-title":"Intestinal barrier function \u2014 non-alcoholic fatty liver disease interactions and possible role of gut microbiota","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agr. Food Chem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105681","article-title":"Astragalus polysaccharides attenuated inflammation and balanced the gut microflora in mice challenged with Salmonella typhimurium","volume":"74","author":"Dong","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.intimp.2019.03.019","article-title":"Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4\/MAPK pathway","volume":"71","author":"Dong","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pestbp.2009.11.008","article-title":"Acute oxidant and inflammatory effects of imidacloprid on the mammalian central nervous system and liver in rats","volume":"97","author":"Duzguner","year":"2010","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/iep.12207","article-title":"Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A-induced liver fibrosis in male rats","volume":"97","author":"Elswefy","year":"2016","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0060","doi-asserted-by":"crossref","first-page":"11694","DOI":"10.1007\/s11356-018-1481-9","article-title":"Antioxidant capacity of omega-3-fatty acids and vitamin E against imidacloprid-induced hepatotoxicity in Japanese quails","volume":"25","author":"Emam","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0065","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2147\/DDDT.S162950","article-title":"Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-\u03baB and TGF-\u03b21\/Smad3 pathways","volume":"12","author":"Feng","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0070","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1111\/jcmm.14543","article-title":"Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the hedgehog pathway during liver fibrosis","volume":"23","author":"Feng","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0075","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3892\/ijmm.2016.2728","article-title":"Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases","volume":"38","author":"Gangemi","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.freeradbiomed.2010.11.029","article-title":"Cysteine\/cystine redox signaling in cardiovascular disease","volume":"50","author":"Go","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0085","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1039\/C9FO01152H","article-title":"Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1\/Pgc-1\u03b1\/Nrf2 pathway","volume":"10","author":"Han","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0090","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/cvr\/cvv018","article-title":"Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II","volume":"105","author":"He","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.envpol.2017.03.001","article-title":"TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation","volume":"225","author":"He","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.scitotenv.2017.07.113","article-title":"Seasonal distribution of herbicide and insecticide residues in the water resources of the vineyard region of La Rioja (Spain)","volume":"609","author":"Herrero-Hern\u00e1ndez","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0105","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1021\/jf101303g","article-title":"Overview of the status and global strategy for neonicotinoids","volume":"59","author":"Jeschke","year":"2010","journal-title":"J. Agr. Food Chem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0120","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.chemosphere.2019.06.096","article-title":"Exploring the kidney hazard of exposure to mercuric chloride in mice: disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis","volume":"234","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4234061","article-title":"Insights into the role and interdependence of oxidative stress and inflammation in liver diseases","author":"Li","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jnutbio.2017.09.025","article-title":"Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT\/GSK-3\u03b2\/Fyn-mediated Nrf2 activation","volume":"52","author":"Liu","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.fct.2018.02.003","article-title":"Protective effects of dietary luteolin against mercuric chloride-induced lung injury in mice: involvement of AKT\/Nrf2 and NF-\u03baB pathways","volume":"113","author":"Liu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110698","article-title":"Melatonin protects against chromium (VI)-induced cardiac injury via activating the AMPK\/Nrf2 pathway","volume":"197","author":"Li","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12951-019-0478-y","article-title":"Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice","volume":"17","author":"Liu","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0140","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/acs.jafc.8b06359","article-title":"Sodium butyrate inhibits the inflammation of lipopolysaccharide-induced acute lung injury in mice by regulating the toll-like receptor 4\/nuclear factor \u03baB signaling pathway","volume":"67","author":"Liu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0145","article-title":"Oxymatrine inhibits renal tubular EMT induced by high glucose via upregulation of SnoN and inhibition of TGF-\u03b21\/Smad signaling pathway","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fct.2018.03.034","article-title":"Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK\/Nrf2\/p62 signaling axis","volume":"116","author":"Lu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0155","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1089\/jir.2013.0077","article-title":"OM85-BV induced the productions of IL-1\u03b2, IL-6, and TNF-\u03b1 via TLR4-and TLR2-mediated ERK1\/2\/NF-\u03baB pathway in RAW264. 7 cells","volume":"34","author":"Luan","year":"2014","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0160","doi-asserted-by":"crossref","first-page":"15595","DOI":"10.1073\/pnas.2136756100","article-title":"Epstein\u2013Barr virus latent membrane protein 1 activation of NF-\u03baB through IRAK1 and TRAF6","volume":"100","author":"Luftig","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1177\/0748233718778993","article-title":"Toxic effects of imidacloprid combined with arsenic: oxidative stress in rat liver","volume":"34","author":"Mahajan","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109505","article-title":"Benzo[a]pyrene and 2, 3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio)","volume":"183","author":"Meyer-Alert","year":"2019","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0175","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.2147\/DDDT.S186726","article-title":"Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-\u03b2\/Smad signaling pathway","volume":"12","author":"Mu","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chemosphere.2014.11.061","article-title":"The neonicotinoid pesticide imidacloprid and the dithiocarbamate fungicide mancozeb disrupt the pituitary\u2013thyroid axis of a wildlife bird","volume":"122","author":"Pandey","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201044","article-title":"Nrf2 protects stellate cells from Smad-dependent cell activation","volume":"13","author":"Prestigiacomo","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0190","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s11011-018-0377-1","article-title":"Neurological alterations induced by formulated imidacloprid toxicity in Japanese quails","volume":"34","author":"Rawi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0195","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4162\/nrp.2018.12.3.199","article-title":"GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine-and ethanol-induced dementia model mice","volume":"12","author":"Reid","year":"2018","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0200","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.alcohol.2009.11.002","article-title":"The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat","volume":"44","author":"Ronis","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.chemosphere.2013.10.051","article-title":"Detection and analysis of neonicotinoids in river waters\u2013development of a passive sampler for three commonly used insecticides","volume":"99","author":"S\u00e1nchez-Bayo","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4196\/kjpp.2010.14.2.99","article-title":"Differential expression of metabolism-related genes in liver of diabetic obese rats","volume":"14","author":"Seo","year":"2010","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6169128","article-title":"Baicalin ameliorates experimental liver cholestasis in mice by modulation of oxidative stress, inflammation, and NRF2 transcription factor","author":"Shen","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0220","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.scitotenv.2018.10.356","article-title":"Targeted and non-target screening of persistent organic pollutants and organophosphorus flame retardants in leachate and sediment from landfill sites in Gauteng Province, South Africa","volume":"653","author":"Sibiya","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0225","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.yexcr.2008.04.002","article-title":"Both IKK\u03b1 and IKK\u03b2 are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-\u03baB activity-independent manner","volume":"314","author":"Song","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0230","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jhazmat.2017.09.058","article-title":"A review on environmental monitoring of water organic pollutants identified by EU guidelines","volume":"344","author":"Sousa","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0235","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1002\/jcp.27473","article-title":"Pre-cold acclimation improves the immune function of trachea and resistance to cold stress in broilers","volume":"234","author":"Su","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0240","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000455101","article-title":"Make precision medicine work for chronic kidney disease","volume":"26","author":"Sun","year":"2017","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0245","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jinorgbio.2017.11.010","article-title":"Dietary luteolin protects against HgCl2-induced renal injury via activation of Nrf2-mediated signaling in rat","volume":"179","author":"Tan","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0250","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12302-019-0186-0","article-title":"Pesticides diazinon and diuron increase glutathione levels and affect multixenobiotic resistance activity and biomarker responses in zebrafish (Danio rerio) embryos and larvae","volume":"31","author":"Velki","year":"2019","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0255","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chemosphere.2017.12.077","article-title":"DNA damage and oxidative stress induced by imidacloprid exposure in different tissues of the Neotropical fish Prochilodus lineatus","volume":"195","author":"Vieira","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2019.135915_bb0260","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/0971-6580.172270","article-title":"A three generation study with effect of imidacloprid in rats: biochemical and histopathological investigation","volume":"22","author":"Vohra","year":"2015","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0265","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pestbp.2014.02.007","article-title":"Physiological, biochemical and histological alterations induced by administration of imidacloprid in female albino rats","volume":"110","author":"Vohra","year":"2014","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0270","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3389\/fphys.2018.01589","article-title":"Effects of acute cold stress after long-term cold stimulation on antioxidant status, heat shock proteins, inflammation and immune cytokines in broiler heart","volume":"9","author":"Wei","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0275","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.3748\/wjg.v22.i19.4695","article-title":"Qinggan Huoxue recipe suppresses epithelial-to-mesenchymal transition in alcoholic liver fibrosis through TGF-\u03b21\/Smad signaling pathway","volume":"22","author":"Wu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0280","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0285","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0290","article-title":"Regulation of Sirt1\/Nrf2\/TNF-\u03b1 signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep-UK."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0295","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.envpol.2018.02.035","article-title":"Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPAR\u03b1 signaling pathway","volume":"237","author":"Yang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jnutbio.2018.07.013","article-title":"Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation","volume":"62","author":"Yang","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0305","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1002\/jcp.27540","article-title":"MiR-448-5p inhibits TGF-\u03b21-induced epithelial-mesenchymal transition and pulmonary fibrosis by targeting Six1 in asthma","volume":"234","author":"Yang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0310","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1093\/jas\/skz209","article-title":"Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia","volume":"97","author":"Zhang","year":"2019","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0325","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1002\/jcb.27880","article-title":"A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0315","article-title":"Amelioratory effects of testosterone propionate on age-related renal fibrosis via suppression of TGF-\u03b21\/Smad signaling and activation of Nrf2-ARE signaling","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0330","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700016","article-title":"Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes","volume":"61","author":"Zhang","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0335","article-title":"Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1\u03b2, and tumor necrosis factor-\u03b1 via a NF-\u03baB-dependent mechanism in HaCaT keratinocytes","volume":"530429","author":"Zhou","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0340","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.3168\/jds.2018-16015","article-title":"Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows","volume":"102","author":"Zhu","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.scitotenv.2019.135915_bb0345","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.3748\/wjg.v25.i30.4222","article-title":"Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-\u03b2\/Smad signaling pathway","volume":"25","author":"Zou","year":"2019","journal-title":"World J. Gastro."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969719359108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969719359108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:03:09Z","timestamp":1777467789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969719359108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":68,"alternative-id":["S0048969719359108"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135915","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imidacloprid-induced liver fibrosis in quails via activation of the TGF-\u03b21\/Smad pathway","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135915"}}