{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:16:13Z","timestamp":1781842573358,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009882","name":"Regione Lombardia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.scitotenv.2020.136660","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T11:00:10Z","timestamp":1578740410000},"page":"136660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Polychlorinated biphenyls (PCBs) and risk of hypertension: A population-based cohort study in a North Italian highly polluted area"],"prefix":"10.1016","volume":"714","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-3986","authenticated-orcid":false,"given":"Elena","family":"Raffetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-6125","authenticated-orcid":false,"given":"Giuseppe","family":"De Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sileo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Magoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2020.136660_bb0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/JOE-13-0302","article-title":"Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction","volume":"219","author":"Ahmed","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0010","first-page":"37","article-title":"Association of blood pressure and PCB level in Yusho patients","volume":"59","author":"Akagi","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.chemosphere.2005.02.034","article-title":"Assessment of reference values for polychlorinated biphenyl concentration in human blood","volume":"61","author":"Apostoli","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.envres.2015.02.018","article-title":"Historical exposure to persistent organic pollutants and risk of incident hypertension","volume":"138","author":"Arrebola","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0025","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.chemosphere.2009.05.026","article-title":"Distribution of persistent organochlorine pollutants in maternal and foetal tissues: data from an Italian polluted urban area","volume":"76","author":"Bergonzi","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.envint.2012.01.004","article-title":"Blood levels of dioxins, furans, dioxin-like PCBs, and TEQs in general populations: a review, 1989\u20132010","volume":"44","author":"Consonni","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chemosphere.2008.02.059","article-title":"Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in human liver and adipose tissue samples from Belgium","volume":"73","author":"Covaci","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0040","series-title":"Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products","article-title":"Production, property and usage of polychlorinated biphenyls","author":"De Voogt","year":"1989"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0045","series-title":"List of MAK and BAT Values 2015-Chapter II","first-page":"45","author":"DFG","year":"2015"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0050","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.chemosphere.2005.11.057","article-title":"Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: the food chain as main source of contamination","volume":"64","author":"Donato","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0055","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/HYPERTENSIONAHA.117.10691","article-title":"Persistent organochlorine pollutants in plasma, blood pressure, and hypertension in a longitudinal study","volume":"71","author":"Donat-Vargas","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.envres.2008.05.006","article-title":"Association of polychlorinated biphenyls with hypertension in the 1999\u20132002 National Health and Nutrition Examination Survey","volume":"108","author":"Everett","year":"2008","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0065","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/jat.3460","article-title":"Evidence for persistent organochlorine pollutants in the human adrenal cortex","volume":"37","author":"Fommei","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0070","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1097\/HJH.0b013e32833c5f3e","article-title":"Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama","volume":"28","author":"Goncharov","year":"2010","journal-title":"J. Hypertens."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1289\/ehp.1002830","article-title":"Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides","volume":"119","author":"Goncharov","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0080","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/jhh.2008.124","article-title":"Association between serum concentrations of persistent organic pollutants and prevalence of newly diagnosed hypertension: results from the National Health and Nutrition Examination Survey 1999\u20132002","volume":"23","author":"Ha","year":"2009","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/taap.2002.9408","article-title":"Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence","volume":"181","author":"Hennig","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0090","series-title":"Polychlorinated Biphenyls and Polybrominated Biphenyls","article-title":"Evaluation of carcinogenic risks to humans","volume":"107","author":"IARC-Monograph","year":"2016"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0095","doi-asserted-by":"crossref","first-page":"e15977","DOI":"10.1371\/journal.pone.0015977","article-title":"Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0100","first-page":"137","article-title":"Brescia Local Health Autority Population Database: a method based on current data for monitoring chronic diseases and management","volume":"32","author":"Lonati","year":"2008","journal-title":"Epidemiol. Prev."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0105","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.chemosphere.2007.03.052","article-title":"A summary of the 209 PCB congener nomenclature","volume":"68","author":"Mills","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0110","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1080\/15287390701457688","article-title":"Age-specific reference ranges for polychlorinated biphenyls (PCB) based on the NHANES 2001-2002 survey","volume":"70","author":"Nichols","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s40572-017-0122-7","article-title":"Lipid and creatinine adjustment to evaluate health effects of environmental exposures","volume":"4","author":"O\u2019Brien","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0120","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1007\/s11356-015-4479-6","article-title":"Polychlorinated biphenyls and links to cardiovascular disease","volume":"23","author":"Perkins","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF01055015","article-title":"Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding","volume":"18","author":"Phillips","year":"1989","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijheh.2017.01.002","article-title":"Temporal trends of polychlorinated biphenyls serum levels in subjects living in a highly polluted area from 2003 to 2015: a follow-up study","volume":"220","author":"Raffetti","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.envint.2018.08.022","article-title":"Polychlorinated biphenyls (PCBs) exposure and cardiovascular, endocrine and metabolic diseases: a population-based cohort study in a North Italian highly polluted area","volume":"120","author":"Raffetti","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/JOM.0000000000000757","article-title":"Associations between fish consumption and contaminant biomarkers with cardiovascular conditions among older male anglers in Wisconsin","volume":"58","author":"Raymond","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0145","first-page":"47","article-title":"PCBs: structure-function relationships and mechanism of action","volume":"60","author":"Safe","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0150","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/14779072.2018.1540301","article-title":"Pathophysiology of essential hypertension: an update","volume":"16","author":"Saxena","year":"2018","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0155","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/add.13827","article-title":"Life-time risk of mortality due to different levels of alcohol consumption in seven European countries: implications for low-risk drinking guidelines","volume":"112","author":"Shield","year":"2017","journal-title":"Addiction"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0160","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.chemosphere.2006.05.124","article-title":"A study on PCB, PCDD\/PCDF industrial contamination in a mixed urban-agricultural area significantly affecting the food chain and the human exposure. Part I: soil and feed","volume":"67","author":"Turrio-Baldassarri","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.136660_bb0165","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.envint.2013.06.019","article-title":"Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik","volume":"59","author":"Valera","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0170","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-value","volume":"167","author":"Vanderweele","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0175","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/obr.12463","article-title":"Do environmental pollutants increase obesity risk in humans?","volume":"17","author":"Wang","year":"2016","journal-title":"Obes. Rev."},{"key":"10.1016\/j.scitotenv.2020.136660_bb0180","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/tox.20676","article-title":"PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels","volume":"27","author":"Yilmaz","year":"2012","journal-title":"Environ. Toxicol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720301704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720301704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:53:18Z","timestamp":1758707598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969720301704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":36,"alternative-id":["S0048969720301704"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.136660","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polychlorinated biphenyls (PCBs) and risk of hypertension: A population-based cohort study in a North Italian highly polluted area","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.136660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136660"}}