{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:31:12Z","timestamp":1778689872234,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20170204045SF"],"award-info":[{"award-number":["20170204045SF"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.scitotenv.2020.139919","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T11:22:40Z","timestamp":1591183360000},"page":"139919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Let-7a inhibits Bcl-xl and YAP1 expression to induce apoptosis of trophoblast cells in early-onset severe preeclampsia"],"prefix":"10.1016","volume":"745","author":[{"given":"Wenhui","family":"Zha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-0664","authenticated-orcid":false,"given":"Fuju","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2020.139919_bb0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.preghy.2018.03.001","article-title":"Preeclamptic plasma stimulates the expression of miRNAs, leading to a decrease in endothelin-1 production in endothelial cells","volume":"12","author":"Caldeira-Dias","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0015","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1074\/jbc.C113.529362","article-title":"The Hippo pathway effectors TAZ\/YAP regulate dicer expression and microRNA biogenesis through Let-7","volume":"289","author":"Chaulk","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0020","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1172\/JCI66553","article-title":"CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia","volume":"123","author":"Chen","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0025","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/molehr\/gau046","article-title":"Genome-wide hypermethylation coupled with promoter hypomethylation in the chorioamniotic membranes of early onset pre-eclampsia","volume":"20","author":"Ching","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.cdd.4402226","article-title":"Yes-associated protein (YAP) is a critical mediator of c-Jun-dependent apoptosis","volume":"15","author":"Danovi","year":"2008","journal-title":"Cell Death Differ."},{"issue":"178","key":"10.1016\/j.scitotenv.2020.139919_bb0035","first-page":"e112","article-title":"Placental microRNA expression in pregnancies complicated by preeclampsia","volume":"204","author":"Enquobahrie","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0040","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.celrep.2016.02.075","article-title":"Merlin\/NF2-Lin28B-let-7 is a tumor-suppressive pathway that is cell-density dependent and hippo independent","volume":"14","author":"Hikasa","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2014.03.020","article-title":"The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras\/NF-kappaB","volume":"227","author":"Jiang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0050","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/bdrc.20053","article-title":"Molecular mechanisms of trophoblast survival: from implantation to birth","volume":"75","author":"Jurisicova","year":"2005","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/neuonc\/nox134","article-title":"Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells","volume":"20","author":"Levesley","year":"2018","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2016.08.018","article-title":"Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer","volume":"478","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1134\/S0006297915020029","article-title":"Methylation of miRNA genes and oncogenesis","volume":"80","author":"Loginov","year":"2015","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0070","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1158\/0008-5472.CAN-07-2544","article-title":"Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis","volume":"67","author":"Lu","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2017.11.005","article-title":"Dysregulated placental microRNAs in early and late onset preeclampsia","volume":"61","author":"Lykoudi","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3892\/mmr.2014.2692","article-title":"Let-7b binding site polymorphism in the B-cell lymphoma-extra large 3\u2032UTR is associated with fluorouracil resistance of hepatocellular carcinoma","volume":"11","author":"Ma","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4149\/neo_2018_180302N146","article-title":"Tumor suppressor let-7a inhibits breast cancer cell proliferation, migration and invasion by targeting MAGE-A1","volume":"66","author":"Mi","year":"2019","journal-title":"Neoplasma"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0090","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0095","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.placenta.2012.05.009","article-title":"MicroRNA expression profiles of trophoblastic cells","volume":"33","author":"Morales-Prieto","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrc3876","article-title":"The emerging roles of YAP and TAZ in cancer","volume":"15","author":"Moroishi","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0105","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ajpath.2012.06.019","article-title":"Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism","volume":"181","author":"Mousa","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1515\/jpm.2011.012","article-title":"miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia","volume":"39","author":"Noack","year":"2011","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5483\/BMBRep.2012.45.8.033","article-title":"MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis","volume":"45","author":"Qin","year":"2012","journal-title":"BMB Rep."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0125","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1096\/fj.12-222216","article-title":"Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1","volume":"27","author":"Schreurs","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1056\/NEJMe1515223","article-title":"Improving the prediction of preeclampsia","volume":"374","author":"Seely","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0135","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jhep.2009.12.024","article-title":"The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma","volume":"52","author":"Shimizu","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0140","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0145","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02948","article-title":"Two-signal requirement for growth-promoting function of Yap in hepatocytes","volume":"4","author":"Su","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0150","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/1933719117746784","article-title":"YAP is decreased in preeclampsia and regulates invasion and apoptosis of HTR-8\/SVneo","volume":"25","author":"Sun","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0155","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1111\/jcmm.13228","article-title":"Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/hmg\/ddx391","article-title":"Mining DNA methylation alterations towards a classification of placental pathologies","volume":"27","author":"Wilson","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0165","doi-asserted-by":"crossref","first-page":"293271","DOI":"10.1155\/2015\/293271","article-title":"Oxidative stress in placenta: health and diseases","volume":"2015","author":"Wu","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/10428194.2016.1187273","article-title":"Hypomethylation of let-7a-3 is associated with poor prognosis in myelodysplastic syndrome","volume":"58","author":"Wu","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0175","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/HYPERTENSIONAHA.113.02647","article-title":"Variations of microRNAs in human placentas and plasma from preeclamptic pregnancy","volume":"63","author":"Xu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.scitotenv.2020.139919_bb0180","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1002\/jcp.25661","article-title":"Let-7i-induced Atg4B suppression is essential for autophagy of placental trophoblast in preeclampsia","volume":"232","author":"Xu","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0190","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ejhg.2010.63","article-title":"DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia","volume":"18","author":"Yuen","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0195","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1742-4658.2010.07965.x","article-title":"Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis","volume":"278","author":"Zhou","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0200","doi-asserted-by":"crossref","first-page":"17532","DOI":"10.1074\/jbc.M112.439729","article-title":"Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1)","volume":"288","author":"Zhou","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2020.139919_bb0205","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00109-019-01785-x","article-title":"Regulation of osteoblast behaviors via cross-talk between Hippo\/YAP and MAPK signaling pathway under fluoride exposure","volume":"97","author":"Zhu","year":"2019","journal-title":"J. Mol. Med. (Berl)"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720334392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720334392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:48:05Z","timestamp":1758710885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969720334392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":41,"alternative-id":["S0048969720334392"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.139919","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Let-7a inhibits Bcl-xl and YAP1 expression to induce apoptosis of trophoblast cells in early-onset severe preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.139919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"139919"}}