{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:03:45Z","timestamp":1783040625594,"version":"3.54.6"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["301304\/2017-3"],"award-info":[{"award-number":["301304\/2017-3"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["405520\/2018-2"],"award-info":[{"award-number":["405520\/2018-2"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["440010\/2018-7"],"award-info":[{"award-number":["440010\/2018-7"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["440015\/2018-9"],"award-info":[{"award-number":["440015\/2018-9"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPCB-007- FIO-18"],"award-info":[{"award-number":["VPPCB-007- FIO-18"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPIS-001-FIO18"],"award-info":[{"award-number":["VPPIS-001-FIO18"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008331","name":"Universidade Federal do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011676","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Gest\u00e3o da Inova\u00e7\u00e3o em Doen\u00e7as Negligenciadas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011676","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00727-16"],"award-info":[{"award-number":["APQ-00727-16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["PPM-00061-18"],"award-info":[{"award-number":["PPM-00061-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403006\/2016-3"],"award-info":[{"award-number":["403006\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.scitotenv.2020.140135","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:34:17Z","timestamp":1591922057000},"page":"140135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Hypervirulence and cross-resistance to a clinical antifungal are induced by an environmental fungicide in Cryptococcus gattii"],"prefix":"10.1016","volume":"740","author":[{"given":"Hellem Cristina Silva","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Wesley","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelly Queiroz","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Gouveia-Eufrasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marliete Carvalho","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Furtado Ferreira","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena V\u00edvien Neves","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Alves","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna Sobrino","family":"Joffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio L.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauber Ribeiro de Sousa","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Frases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeronimo Concei\u00e7\u00e3o","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f4natas Santos","family":"Abrah\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Resende-Stoianoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Assis","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2020.140135_bb0005","first-page":"27","article-title":"Effect of benomyl and diazinon on acquired azole resistance in Aspergillus flavus and expression of mdr1 and cyp51c genes","volume":"5","author":"Akbari Dana","year":"2019","journal-title":"Curr. Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0010","author":"Arysta Lifescience"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11908-008-0011-1","article-title":"The emergence of Cryptococcus gattii in British Columbia and the Pacific Northwest","volume":"10","author":"Bartlett","year":"2008","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0020","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/jac\/dku554","article-title":"Identification and properties of plasma membrane azole efflux pumps from the pathogenic fungi Cryptococcus gattii and Cryptococcus neoformans","volume":"70","author":"Basso","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0025","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01179-17","article-title":"Environmental triazole induces cross-resistance to clinical drugs and affects morphophysiology and virulence of Cryptococcus gattii and C. neoformans","volume":"62","author":"Bastos","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0030","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.scitotenv.2019.05.094","article-title":"From the environment to the host: how non-azole agrochemical exposure affects the antifungal susceptibility and virulence of Cryptococcus gattii","volume":"681","author":"Bastos","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0035","first-page":"29","article-title":"Factors influencing the adsorption, desorption, and movement of pesticides in soi","volume":"32","author":"Bayley","year":"1970","journal-title":"Residue Rev."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0040","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1128\/AAC.38.4.648","article-title":"Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene","volume":"38","author":"Ben-Yaacov","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0045","article-title":"African ST173 Cryptococcus deuterogattii strains are commonly less susceptible to fluconazole: an unclear mechanism of resistance","author":"Bertout","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0050","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1038\/s41598-019-41513-6","article-title":"Gene duplication associated with increased fluconazole tolerance in Candida auris cells of advanced generational age","volume":"9","author":"Bhattacharya","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/myc.12747","article-title":"A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species","volume":"61","author":"Bongomin","year":"2018","journal-title":"Mycoses"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/mmy\/myz018","article-title":"Effect of non-antifungal agrochemicals on the pathogenic fungus Cryptococcus gattii","volume":"58","author":"Carneiro","year":"2020","journal-title":"Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0022-1759(92)90209-C","article-title":"Monoclonal antibody based ELISAs for cryptococcal polysaccharide","volume":"154","author":"Casadevall","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0070","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01751-17","article-title":"Roles of three Cryptococcus neoformans and Cryptococcus gattii efflux pump-coding genes in response to drug treatment","volume":"62","author":"Chang","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tim.2011.07.010","article-title":"Cryptococcus gattii: a resurgent fungal pathogen","volume":"19","author":"Chaturvedi","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0080","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1128\/CMR.00126-13","article-title":"Cryptococcus gattii infections","volume":"27","author":"Chen","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12879-015-1023-8","article-title":"Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0090","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00166-17","article-title":"Microevolution of serial clinical isolates of Cryptococcus neoformans var. grubii and C. gattii","volume":"8","author":"Chen","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042835","article-title":"Time-course proteome analysis reveals the dynamic response of Cryptococcus gattii cells to fluconazole","volume":"7","author":"Chong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0100","series-title":"Documents\/Clinical and Laboratory Standards Institute","article-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts: approved standard","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"10.1016\/j.scitotenv.2020.140135_bb2005","series-title":"Reference Method for Broth DilutionAntifungal Susceptibility Testing of Yeasts: Fourth Informational Supplement, CLSIDocument M27- S4","author":"Clinical And Laboratory Standards Institute","year":"2012"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/fow045","article-title":"Environmental distribution of Cryptococcus neoformans and C. gattii around the Mediterranean basin","volume":"16","author":"Cogliati","year":"2016","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijmm.2016.03.010","article-title":"The absence of microbiota delays the inflammatory response to Cryptococcus gattii","volume":"306","author":"Costa","year":"2016","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0115","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa1110404","article-title":"Combination antifungal therapy for cryptococcal meningitis","volume":"368","author":"Day","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0120","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01464-14","article-title":"Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal","volume":"5","author":"Engelthaler","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0125","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00350-16","article-title":"Species in the Cryptococcus gattii complex differ in capsule and cell size following growth under capsule-inducing conditions","volume":"1","author":"Fernandes","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0130","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1128\/AAC.00466-15","article-title":"Heteroresistance to itraconazole alters the morphology and increases the virulence of Cryptococcus gattii","volume":"59","author":"Ferreira","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF00259685","article-title":"Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate","volume":"227","author":"Fling","year":"1991","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0140","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/EC.00142-09","article-title":"Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans","volume":"8","author":"Fonseca","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/mmy\/myw056","article-title":"A subdose of fluconazole alters the virulence of Cryptococcus gattii during murine cryptococcosis and modulates type I interferon expression","volume":"55","author":"Fontes","year":"2017","journal-title":"Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0150","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1128\/AAC.02287-12","article-title":"Azole resistance in Cryptococcus gattii from the Pacific Northwest: investigation of the role of ERG11","volume":"57","author":"Gast","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0155","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1185383","article-title":"Food security: the challenge of feeding 9 billion people","volume":"327","author":"Godfray","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0732-8893(02)00509-6","article-title":"In vitro evaluation of combination of terbinafine with itraconazole or amphotericin B against Zygomycota","volume":"45","author":"G\u00f3mez-L\u00f3pez","year":"2003","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0165","first-page":"6","article-title":"Environmental impact due to agricultural runoff containing heavy metals \u2013 a review","volume":"3","author":"Hariprasad","year":"2013"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0170","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.toxrep.2020.04.001","article-title":"Benomyl, a benzimidazole fungicide, induces oxidative stress and apoptosis in neural cells","volume":"7","author":"Kara","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrmicro2522","article-title":"Expanding fungal pathogenesis: Cryptococcus species break out of the opportunistic box","volume":"9","author":"Kronstad","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.scitotenv.2020.140135_bb0180","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2134\/jeq2004.1771","article-title":"Degradation of N,N\u2019-dibutylurea (DBU) in soils treated with only DBU and DBU-fortified benlate fungicides","volume":"33","author":"Lee","year":"2004","journal-title":"J. Environ. Qual."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0185","first-page":"94","article-title":"Effects of benomyl and identification of phytopathogens in ms medium in order to control contamination in micropropagation of anacardium humile (anacardiaceae)","volume":"23","author":"Londe","year":"2007","journal-title":"Biosci. J."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0190","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1128\/MCB.25.5.1860-1868.2005","article-title":"Early expression of yeast genes affected by chemical stress","volume":"25","author":"Lucau-Danila","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0195","series-title":"Brock Biology of Microorganisms","author":"Madigan","year":"2008"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.fgb.2006.07.010","article-title":"The volume and hydration of the Cryptococcus neoformans polysaccharide capsule","volume":"44","author":"Maxson","year":"2007","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0205","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/13693780902953886","article-title":"Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii","volume":"47","author":"Meyer","year":"2009","journal-title":"Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0210","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJMoa1710922","article-title":"Antifungal combinations for treatment of cryptococcal meningitis in Africa","volume":"378","author":"Molloy","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0215","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnx113","article-title":"Changes in bacterial community after application of three different herbicides","volume":"364","author":"Moretto","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016076","article-title":"Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver Island outbreak strains","volume":"6","author":"Ngamskulrungroj","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.scitotenv.2020.140135_bb0225","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0230","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fcimb.2017.00419","article-title":"Influenza A virus as a predisposing factor for Cryptococcosis","volume":"7","author":"Oliveira","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0235","series-title":"The Pesticides Encyclopedia","author":"Paranjape","year":"2014"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0240","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fgb.2014.10.003","article-title":"Cryptococcosis diagnosis and treatment: what do we know now","volume":"78","author":"Perfect","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0245","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0250","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1574-6968.1987.tb02552.x","article-title":"Variability of colonial morphology in benomyl-induced morphological mutants from Candida albicans","volume":"48","author":"Pom\u00e9s","year":"1987","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0255","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1590\/S1517-83822009000200018","article-title":"Fungicide resistance and genetic variability in plant pathogenic strains of Guignardia citricarpa","volume":"40","author":"Possiede","year":"2009","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0260","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0265","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jhazmat.2016.12.013","article-title":"Fungicides induced triazole-resistance in Aspergillus fumigatus associated with mutations of TR46\/Y121F\/T289A and its appearance in agricultural fields","volume":"326","author":"Ren","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0270","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ijantimicag.2017.04.005","article-title":"Atorvastatin as a promising anticryptococcal agent","volume":"49","author":"Ribeiro","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0275","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/fox027","article-title":"The genetic architecture in Saccharomyces cerevisiae that contributes to variation in drug response to the antifungals benomyl and ketoconazole","volume":"17","author":"Roberts","year":"2017","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0280","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/myc.12457","article-title":"Cross-resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?","volume":"59","author":"Rocha","year":"2016","journal-title":"Mycoses"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0285","first-page":"153","article-title":"Impact of resistance to fluconazole on virulence and morphological aspects of Cryptococcus neoformans and Cryptococcus gattii isolates","volume":"7","author":"Rossi","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0290","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1128\/AAC.06098-11","article-title":"Dynamic interaction between fluconazole and amphotericin B against Cryptococcus gattii","volume":"56","author":"Santos","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112669","article-title":"Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis","volume":"9","author":"Santos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0300","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1128\/AAC.04448-14","article-title":"Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors","volume":"59","author":"Schneider","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0305","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/1678-4499.0061","article-title":"Impact of sulfentrazone, isoxaflutole and oxyfluorfen on the microorganisms of two forest soils","volume":"73","author":"Silva","year":"2014","journal-title":"Bragantia"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0310","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1128\/AAC.01299-15","article-title":"Increased antifungal drug resistance in clinical isolates of Cryptococcus neoformans in Uganda","volume":"59","author":"Smith","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031801","article-title":"Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus","volume":"7","author":"Snelders","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0320","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.micinf.2015.08.017","article-title":"Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265","volume":"18","author":"Sorrell","year":"2016","journal-title":"Microbes Infect."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8040613","article-title":"New approaches for Cryptococcosis treatment","volume":"8","author":"Spadari","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0330","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/ps.4457","article-title":"Perspectives on the agrochemical industry and agrochemical discovery","volume":"73","author":"Sparks","year":"2017","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0335","first-page":"396","article-title":"In vivo development of fluconazole resistance in serial Cryptococcus gattii isolates from a cat","volume":"55","author":"Sykes","year":"2017","journal-title":"Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0340","author":"US Environmental Protection Agency (US EPA)"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0345","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/AAC.48.6.2014-2020.2004","article-title":"Effects of voriconazole on Cryptococcus neoformans","volume":"48","author":"Van Duin","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0350","doi-asserted-by":"crossref","DOI":"10.1093\/mmy\/myaa019","article-title":"High genetic variability of clinical and environmental Cryptococcus gattii isolates from Brazil","author":"Vilas-B\u00f4as","year":"2020","journal-title":"Med. Mycol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0355","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2016.167","article-title":"Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy","volume":"13","author":"Williamson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0360","series-title":"WHO|Rapid Advice: Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-infected Adults, Adolescents and Children [WWW Document]","author":"World Health Organization","year":"2011"},{"key":"10.1016\/j.scitotenv.2020.140135_bb0365","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1128\/AAC.01777-15","article-title":"Fluconazole susceptibility in Cryptococcus gattii is dependent on the ABC transporter Pdr11","volume":"60","author":"Yang","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2020.140135_bb0370","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.reprotox.2014.12.008","article-title":"Deleterious effects of benomyl and carbendazim on human placental trophoblast cells","volume":"51","author":"Zhou","year":"2015","journal-title":"Reprod. Toxicol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720336561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720336561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:43:38Z","timestamp":1758710618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969720336561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":75,"alternative-id":["S0048969720336561"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.140135","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypervirulence and cross-resistance to a clinical antifungal are induced by an environmental fungicide in Cryptococcus gattii","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.140135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"140135"}}