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Harmful Algae, Proceedings of the VIII International Conference on Harmful Algae, (June 1999, Vigo, Spain), pp. 66\u201367","article-title":"Gymnodinium catenatum Graham blooms on Moroccan waters","author":"Tahri Joutei","year":"1998"},{"issue":"39","key":"10.1016\/j.scitotenv.2020.142542_bb0710","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0041-0101(01)00167-2","article-title":"Study of paralytic shellfish poisoning toxin profile in shellfish from the Mediterranean shore of Morocco","volume":"2001","author":"Taleb","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.scitotenv.2020.142542_bb0715","series-title":"Toxic Dinoflagellates: 11\u201326","article-title":"The taxonomy and relntionships of red tides dinoflagellates","author":"Taylor","year":"1985"},{"key":"10.1016\/j.scitotenv.2020.142542_bb0720","unstructured":"Taylor F. J. R., 1991. The species problem and its itnpact on hartnfiil phytoplankton studies, with emphasis on Dinoflagellate morphology. 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