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Sci."},{"key":"10.1016\/j.scitotenv.2020.144354_bb0450","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1166\/jnn.2018.14542","article-title":"Systemic toxicity and teratogenicity of copper oxide","volume":"18","author":"Kadammattil","year":"2018","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.scitotenv.2020.144354_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-25924-5","article-title":"Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis","volume":"8","author":"Kakiuchi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2020.144354_bb0460","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.2589995","article-title":"Nanotechnology in Asia: a preliminary assessment of the existing legal framework","author":"Karim","year":"2015","journal-title":"SSRN Electron. 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