{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:24:55Z","timestamp":1787261095751,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630087"],"award-info":[{"award-number":["81630087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871208"],"award-info":[{"award-number":["81871208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1600206"],"award-info":[{"award-number":["2017YFC1600206"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.scitotenv.2020.144380","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T01:26:25Z","timestamp":1608859585000},"page":"144380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["An exposomic approach with 138 chemical and non-chemical exposures to predict 32 biomarkers of male reproductive damages: A case study of college students in Chongqing, China"],"prefix":"10.1016","volume":"767","author":[{"given":"Yimeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niya","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2020.144380_bb0005","doi-asserted-by":"crossref","unstructured":"Albeitawi, S., Hamadneh, J., Al-Shatanawi, T.N., Al Mehaisen, L., Al-Zubi, M., 2020. Effect of hookah (water pipe) smoking on semen parameters. Andrologia, e13723. https:\/\/doi.org\/10.1111\/and.13723.","DOI":"10.1111\/and.13723"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0010","doi-asserted-by":"crossref","unstructured":"Anyanwu, B.O., Orisakwe, O.E., 2020. Current mechanistic perspectives on male reproductive toxicity induced by heavy metals, 2020. Journal of environmental science and health Part C, Toxicology and carcinogenesis, 1-41. https:\/\/doi.org\/10.1080\/26896583.2020.1782116.","DOI":"10.1080\/26896583.2020.1782116"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0015","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4103\/aja.aja_110_18","article-title":"Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men","volume":"21","author":"Boeri","year":"2019","journal-title":"Asian journal of andrology"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.envint.2017.12.039","article-title":"Alterations in male reproductive hormones in relation to environmental DDT exposure","volume":"113","author":"Bornman","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fertnstert.2011.10.011","article-title":"Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes","volume":"97","author":"Braga","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0030","doi-asserted-by":"crossref","unstructured":"Caporossi, L., Alteri, A., Campo, G., Paci, E., Tranfo, G., Capanna, S., Papaleo, E., Pigini, D., Vigan\u00f2, P., Papaleo, B., 2020. Cross sectional study on exposure to BPA and phthalates and semen parameters in men attending a fertility center. International journal of environmental research and public health, 17. https:\/\/doi.org\/10.3390\/ijerph17020489.","DOI":"10.3390\/ijerph17020489"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jhazmat.2013.01.061","article-title":"Association of exposure to phenols and idiopathic male infertility","volume":"250-251","author":"Chen","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5665\/sleep.5322","article-title":"Inverse U-shaped association between sleep duration and semen quality: longitudinal observational study (MARHCS) in Chongqing, China","volume":"39","author":"Chen","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0045","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2017.04.005","article-title":"Phthalate exposure, even below US EPA reference doses, was associated with semen quality and reproductive hormones: prospective MARHCS study in general population","volume":"104","author":"Chen","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0050","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/andr.12673","article-title":"The present crisis in male reproductive health: an urgent need for a political, social, and research roadmap","volume":"7","author":"De Jonge","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0055","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.envint.2015.07.017","article-title":"Human exposure to endocrine disrupting chemicals and fertility: a case-control study in male subfertility patients","volume":"84","author":"Den Hond","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0060","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.fertnstert.2018.01.010","article-title":"Dietary patterns are positively associated with semen quality","volume":"109","author":"Efrat","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0065","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.fertnstert.2008.12.018","article-title":"Semen quality in fertile men in relation to psychosocial stress","volume":"93","author":"Gollenberg","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0070","doi-asserted-by":"crossref","first-page":"110319","DOI":"10.1016\/j.ecoenv.2020.110319","article-title":"Effects of particulate matter exposure on semen quality: a retrospective cohort study","volume":"193","author":"Guan","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0075","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1289\/ehp.7212","article-title":"Temporal variability of urinary phthalate metabolite levels in men of reproductive age","volume":"112","author":"Hauser","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/reveh-2016-0032","article-title":"Future of environmental research in the age of epigenomics and exposomics","volume":"32","author":"Holland","year":"2017","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envint.2017.04.014","article-title":"Obesity aggravates toxic effect of BPA on spermatogenesis","volume":"105","author":"Hu","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0095","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fertnstert.2014.04.021","article-title":"Effects of work and life stress on semen quality","volume":"102","author":"Janevic","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0100","doi-asserted-by":"crossref","first-page":"i204","DOI":"10.1093\/bioinformatics\/btp218","article-title":"A multivariate regression approach to association analysis of a quantitative trait network","volume":"25","author":"Kim","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/eurpub\/ckv153","article-title":"Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure","volume":"26","author":"Le Moal","year":"2016","journal-title":"Eur. J. Pub. Health"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.envint.2016.08.001","article-title":"Shorter sperm telomere length in association with exposure to polycyclic aromatic hydrocarbons: results from the MARHCS cohort study in Chongqing, China and in vivo animal experiments","volume":"95","author":"Ling","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0115","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/humrep\/deaa101","article-title":"Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study","volume":"35","author":"Liu","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0120","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cryobiol.2016.04.004","article-title":"The effect of two cryopreservation methods on human sperm DNA damage","volume":"72","author":"Liu","year":"2016","journal-title":"Cryobiology"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0125","doi-asserted-by":"crossref","unstructured":"Liu, X., Jin, X., Su, R., Li, Z., The reproductive toxicology of male SD rats after PM2.5 exposure mediated by the stimulation of endoplasmic reticulum stress., 2017. Chemosphere, 189: 547\u2013555. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.09.082.","DOI":"10.1016\/j.chemosphere.2017.09.082"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.rbmo.2014.10.002","article-title":"Incidence of infertility and risk factors of impaired fecundity among newly married couples in a Chinese population","volume":"30","author":"Meng","year":"2015","journal-title":"Reprod. BioMed. Online"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0135","series-title":"2018","author":"Messerlian","year":"2018"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0140","series-title":"Impact of Psychological Stress Measured in Three Different Scales on Testis Function: A Cross-Sectional Study of 1362 Young Men","author":"Nordkap","year":"2020"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0145","doi-asserted-by":"crossref","first-page":"125402","DOI":"10.1016\/j.chemosphere.2019.125402","article-title":"Low-level lead exposure is associated with aberrant sperm quality and reproductive hormone levels in Chinese male individuals: results from the MARHCS study low-level lead exposure is associated with aberrant sperm quality","volume":"244","author":"Ren","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0150","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/0748730402239679","article-title":"Life between clocks: daily temporal patterns of human chronotypes","volume":"18","author":"Roenneberg","year":"2003","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0155","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.urology.2015.02.001","article-title":"Semen quality assessment in fertile men in Madrid during the last 3 decades","volume":"85","author":"Romero-Otero","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0160","doi-asserted-by":"crossref","first-page":"33990","DOI":"10.1007\/s11356-020-09617-z","article-title":"Interaction effect of polycyclic aromatic hydrocarbon metabolites and cadmium on semen quality in nonsmokers","volume":"27","author":"Shi","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0165","doi-asserted-by":"crossref","unstructured":"Thoma, M.E., McLain, A.C., Louis, J.F., King, R.B., Trumble, A.C., Sundaram, R., Buck Louis, G.M., 2013. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertility and sterility, 99:1324-1331.e1321. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.11.037.","DOI":"10.1016\/j.fertnstert.2012.11.037"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0170","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chemosphere.2018.12.155","article-title":"Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: a pilot study","volume":"220","author":"Tian","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0175","doi-asserted-by":"crossref","first-page":"140673","DOI":"10.1016\/j.scitotenv.2020.140673","article-title":"Phthalate exposure and semen quality in infertile male population from Tianjin, China: associations and potential mediation by reproductive hormones","volume":"744","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0180","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12615","article-title":"Sleep duration is associated with sperm chromatin integrity among young men in Chongqing, China","volume":"27","author":"Wang","year":"2018","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12978-020-00978-9","article-title":"The socioeconomic and lifestyle determinants of contraceptive use among Chinese college students: a cross-sectional study","volume":"17","author":"Wang","year":"2020","journal-title":"Reprod. Health"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0190","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO (World Health Organization)","year":"2010"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0195","article-title":"Lifestyles associated with human semen quality: results from MARHCS cohort study in Chongqing, China","volume":"94","author":"Yang","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0200","doi-asserted-by":"crossref","unstructured":"Yoav; Benjamini; Yosef; Hochberg., 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x.","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0205","doi-asserted-by":"crossref","unstructured":"Zhang, G., Jiang, F., Chen, Q., Yang, H., Zhou, N., Sun, L., Zou, P., Yang, W., Cao, J., Zhou, Z., Ao, L.,2020. Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity. Environment international, 136:105483. https:\/\/doi.org\/10.1016\/j.envint.2020.105483.","DOI":"10.1016\/j.envint.2020.105483"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.envint.2018.11.076","article-title":"Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: comparison of three statistical models","volume":"123","author":"Zhang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpsychores.2018.10.013","article-title":"Social support modifies an association between work stress and semen quality: results from 384 Chinese male workers","volume":"117","author":"Zou","year":"2019","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.scitotenv.2020.144380_bb0220","doi-asserted-by":"crossref","unstructured":"Zou, P., Wang, X., Yang, W., Liu, C., Chen, Q., Yang, H., Zhou, N., Zeng, Y., Chen, H., Zhang, G., Liu, J., Cao, J., Ao, L., Sun, L., 2019b. Mechanisms of stress-induced spermatogenesis impairment in male rats following unpredictable chronic mild stress (uCMS). International journal of molecular sciences, 20. https:\/\/doi.org\/10.3390\/ijms20184470.","DOI":"10.3390\/ijms20184470"},{"key":"10.1016\/j.scitotenv.2020.144380_bb0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720379110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969720379110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T20:39:43Z","timestamp":1787258383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969720379110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":44,"alternative-id":["S0048969720379110"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144380","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An exposomic approach with 138 chemical and non-chemical exposures to predict 32 biomarkers of male reproductive damages: A case study of college students in Chongqing, China","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"144380"}}